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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bilateral osteoporotic bone marrow defects of the mandible: a case report</title><author><name sortKey="Bravo Calder N, Diego Mauricio" sort="Bravo Calder N, Diego Mauricio" uniqKey="Bravo Calder N D" first="Diego Mauricio" last="Bravo-Calder N">Diego Mauricio Bravo-Calder N</name><affiliation><nlm:aff id="I1">Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9–75, Bauru, 17012-901, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Oliveira, Denise Tostes" sort="Oliveira, Denise Tostes" uniqKey="Oliveira D" first="Denise Tostes" last="Oliveira">Denise Tostes Oliveira</name><affiliation><nlm:aff id="I2">Private Practice, Rua Almirante Barroso, 1433, Ji-Paraná, 76900-079, RO, Brazil</nlm:aff></affiliation></author><author><name sortKey="Martins Dos Santos, Wagner Humberto" sort="Martins Dos Santos, Wagner Humberto" uniqKey="Martins Dos Santos W" first="Wagner Humberto" last="Martins Dos Santos">Wagner Humberto Martins Dos Santos</name><affiliation><nlm:aff id="I3">Bauru School of Dentistry, Department of Stomatology, Area of Pathology, Alameda Octávio Pinheiro Brisolla, 9–75 CEP 17012–901, Bauru, São Paulo, Brazil</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22873712</idno><idno type="pmc">3489784</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489784</idno><idno type="RBID">PMC:3489784</idno><idno type="doi">10.1186/1746-160X-8-22</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001965</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001965</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bilateral osteoporotic bone marrow defects of the mandible: a case report</title><author><name sortKey="Bravo Calder N, Diego Mauricio" sort="Bravo Calder N, Diego Mauricio" uniqKey="Bravo Calder N D" first="Diego Mauricio" last="Bravo-Calder N">Diego Mauricio Bravo-Calder N</name><affiliation><nlm:aff id="I1">Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9–75, Bauru, 17012-901, SP, Brazil</nlm:aff></affiliation></author><author><name sortKey="Oliveira, Denise Tostes" sort="Oliveira, Denise Tostes" uniqKey="Oliveira D" first="Denise Tostes" last="Oliveira">Denise Tostes Oliveira</name><affiliation><nlm:aff id="I2">Private Practice, Rua Almirante Barroso, 1433, Ji-Paraná, 76900-079, RO, Brazil</nlm:aff></affiliation></author><author><name sortKey="Martins Dos Santos, Wagner Humberto" sort="Martins Dos Santos, Wagner Humberto" uniqKey="Martins Dos Santos W" first="Wagner Humberto" last="Martins Dos Santos">Wagner Humberto Martins Dos Santos</name><affiliation><nlm:aff id="I3">Bauru School of Dentistry, Department of Stomatology, Area of Pathology, Alameda Octávio Pinheiro Brisolla, 9–75 CEP 17012–901, Bauru, São Paulo, Brazil</nlm:aff></affiliation></author></analytic><series><title level="j">Head & Face Medicine</title><idno type="eISSN">1746-160X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Osteoporotic bone marrow defect of the jaws has been reported as a poorly demarcated radiolucency that affect mainly posterior mandible of middle-aged woman. The incidence of this condition is not exactly established and its pathogenesis remains unknown. An additional unusual case of osteoporotic bone marrow defects occurring bilaterally in the mandibular edentulous regions of a 32-year-old white woman is presented reinforcing its diagnostic criteria and histopathological findings.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Makek, M" uniqKey="Makek M">M Makek</name></author><author><name sortKey="Lello, Ge" uniqKey="Lello G">GE Lello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, Lc" uniqKey="Schneider L">LC Schneider</name></author><author><name sortKey="Mesa, Ml" uniqKey="Mesa M">ML Mesa</name></author><author><name sortKey="Fraenkel, D" uniqKey="Fraenkel D">D Fraenkel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipani, Cs" uniqKey="Lipani C">CS Lipani</name></author><author><name sortKey="Natiella, Jr" uniqKey="Natiella J">JR Natiella</name></author><author><name sortKey="Greene, Gw" uniqKey="Greene G">GW Greene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shankland, We" uniqKey="Shankland W">WE Shankland</name></author><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author><author><name sortKey="Stevenson, G" uniqKey="Stevenson G">G Stevenson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waldron, Ca" uniqKey="Waldron C">CA Waldron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, J" uniqKey="Bouquot J">J Bouquot</name></author><author><name sortKey="Rohrer, M" uniqKey="Rohrer M">M Rohrer</name></author><author><name sortKey="Mcmahon, R" uniqKey="Mcmahon R">R McMahon</name></author><author><name sortKey="Makek, M" uniqKey="Makek M">M Makek</name></author><author><name sortKey="Boc, T" uniqKey="Boc T">T Boc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sewell, Cmd" uniqKey="Sewell C">CMD Sewell</name></author><author><name sortKey="Almeida, Op" uniqKey="Almeida O">OP Almeida</name></author><author><name sortKey="Passeri, La" uniqKey="Passeri L">LA Passeri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanner, Jr" uniqKey="Sanner J">JR Sanner</name></author><author><name sortKey="Ramin, Je" uniqKey="Ramin J">JE Ramin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gurevitch, O" uniqKey="Gurevitch O">O Gurevitch</name></author><author><name sortKey="Slavin, S" uniqKey="Slavin S">S Slavin</name></author><author><name sortKey="Resnick, I" uniqKey="Resnick I">I Resnick</name></author><author><name sortKey="Khitrin, S" uniqKey="Khitrin S">S Khitrin</name></author><author><name sortKey="Feldman, A" uniqKey="Feldman A">A Feldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Bk" uniqKey="Lee B">BK Lee</name></author><author><name sortKey="Choi, Sj" uniqKey="Choi S">SJ Choi</name></author><author><name sortKey="Mack, D" uniqKey="Mack D">D Mack</name></author><author><name sortKey="Oh, Sh" uniqKey="Oh S">SH Oh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Head Face Med</journal-id><journal-id journal-id-type="iso-abbrev">Head Face Med</journal-id><journal-title-group><journal-title>Head & Face Medicine</journal-title></journal-title-group><issn pub-type="epub">1746-160X</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22873712</article-id><article-id pub-id-type="pmc">3489784</article-id><article-id pub-id-type="publisher-id">1746-160X-8-22</article-id><article-id pub-id-type="doi">10.1186/1746-160X-8-22</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Bilateral osteoporotic bone marrow defects of the mandible: a case report</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Bravo-Calderón</surname><given-names>Diego Mauricio</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>diegomauriciobc@usp.br</email></contrib><contrib contrib-type="author" corresp="yes" id="A2"><name><surname>Oliveira</surname><given-names>Denise Tostes</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>denisetostes@usp.br</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Martins dos Santos</surname><given-names>Wagner Humberto</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>wagnerhms@gmail.com</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Stomatology, Area of Pathology, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisolla, 9–75, Bauru, 17012-901, SP, Brazil</aff><aff id="I2"><label>2</label>Private Practice, Rua Almirante Barroso, 1433, Ji-Paraná, 76900-079, RO, Brazil</aff><aff id="I3"><label>3</label>Bauru School of Dentistry, Department of Stomatology, Area of Pathology, Alameda Octávio Pinheiro Brisolla, 9–75 CEP 17012–901, Bauru, São Paulo, Brazil</aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>8</day><month>8</month><year>2012</year></pub-date><volume>8</volume><fpage>22</fpage><lpage>22</lpage><history><date date-type="received"><day>12</day><month>6</month><year>2012</year></date><date date-type="accepted"><day>30</day><month>7</month><year>2012</year></date></history><permissions><copyright-statement>Copyright ©2012 Bravo-Calderón et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>Bravo-Calderón et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.head-face-med.com/content/8/1/22"></self-uri><abstract><p>Osteoporotic bone marrow defect of the jaws has been reported as a poorly demarcated radiolucency that affect mainly posterior mandible of middle-aged woman. The incidence of this condition is not exactly established and its pathogenesis remains unknown. An additional unusual case of osteoporotic bone marrow defects occurring bilaterally in the mandibular edentulous regions of a 32-year-old white woman is presented reinforcing its diagnostic criteria and histopathological findings.</p></abstract><kwd-group><kwd>Mandible</kwd><kwd>Bone marrow pathology</kwd><kwd>Radiography</kwd></kwd-group></article-meta></front><body><sec><title>Background</title><p>In adult life the presence of hematopoietic marrow in the jaws is usually restricted to the angle of the mandible, the maxillary tuberosity and the condylar process [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref>]. Osteoporotic bone marrow defect is a radiolucent area that corresponds to the uncommon presence of hematopoietic tissue found in others regions of the jaws [<xref ref-type="bibr" rid="B2">2</xref>]. The defect is generally asymptomatic and is discovered incidentally during radiographic analysis. Radiographically, it is a localized radiolucency that varies in size, shape, trabeculae and border definition [<xref ref-type="bibr" rid="B2">2</xref>-<xref ref-type="bibr" rid="B4">4</xref>].</p><p>Since the osteoporotic bone marrow defect is rarely included in the differential diagnosis of radiolucent lesions of the jaws, the knowledge of the clinical, radiographic and histopathological characteristics in association with an accurate examination, are mandatory, in order to distinguish it from other most common intrabony lesions as odontogenic tumors or cysts, pseudocysts or primary or metastatic malignancies.</p><p>This paper describes an unusual case of bilateral bone marrow defects and discusses the characteristics and etiopathogeny of this condition.</p></sec><sec><title>Case report</title><p>A 32-year-old white woman was referred to private dental clinic for routine prosthodontic treatment. Intraoral examination revealed healthy mucosa and there was not any sign of infection. Her past medical history was unremarkable. Panoramic radiography of the jaws showed 4 cm x 3 cm radiolucencies with quite ill-defined and irregular borders located bilaterally in molar edentulous regions (Figure <xref ref-type="fig" rid="F1">1</xref>). Two small sclerotic flecks were associated with left radiolucent area. The lesions were asymptomatic and no expansion of the cortical jawbone was detected. A provisional diagnosis of odontogenic cyst or tumor was made and focal osteoporotic bone marrow defect was considered as a differential diagnosis based on age, site, clinical and radiographic findings. Under local anesthesia, a biopsy specimen was performed from the both edentulous molar regions and the tissues submitted to the Bauru School of Dentistry Oral Pathology Biopsy Service of the University of São Paulo. The histopathological examination revealed normal hematopoietic bone marrow characterized by erythroid, granulocytic, monocytic and lymphocytic series (Figure <xref ref-type="fig" rid="F2">2</xref>). In addition, megakaryocytes, fat cells and bone trabeculae were also observed (Figure <xref ref-type="fig" rid="F3">3</xref>). Abnormal morphology of the hematopoietic cells or malignant cells was not seen. The histopathological findings confirmed the diagnosis of osteoporotic bone marrow defects of the mandible.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Panoramic radiography demonstrating ill-defined radiolucent areas located bilaterally in the molar edentulous regions (white arrows).</p></caption><graphic xlink:href="1746-160X-8-22-1"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p><bold>Histopathologic findings.</bold> Normal hematopoietic cells, fat cells and bone trabeculae. (Hematoxylin and eosin. Original magnification X200).</p></caption><graphic xlink:href="1746-160X-8-22-2"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p><bold>Microscopic details of the bone marrow.</bold> Erythroid, granulocytic, monocytic and lymphocytic series are illustrated, as well as megakaryocytes. (Hematoxylin and eosin. Original magnification X400).</p></caption><graphic xlink:href="1746-160X-8-22-3"></graphic></fig></sec><sec sec-type="discussion"><title>Discussion</title><p>The osteoporotic bone marrow defect of the jaws has been reported as an unusual radiolucency often detected fortuitously in the posterior mandible of the middle-aged woman [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B4">4</xref>-<xref ref-type="bibr" rid="B6">6</xref>]. Radiographically, this radiolucency varies in size from several millimeters to centimeters, the shape and borders are ill defined [<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B6">6</xref>]. The condition frequently occurs in an edentulous region where tooth extraction was previously performed [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B4">4</xref>]. Clinically, some osteoporotic bone marrow defects are multifocal, others bilateral and few of them are symptomatic [<xref ref-type="bibr" rid="B1">1</xref>-<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B7">7</xref>].</p><p>The present case confirms many of the findings described above but bilateral mandibular involvement of the osteoporotic bone marrow is not frequently found in the literature [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B7">7</xref>-<xref ref-type="bibr" rid="B9">9</xref>]. Of the 20 cases of osteoporotic bone marrow defect described by [<xref ref-type="bibr" rid="B1">Makek and Lello 1</xref>] only one was bilaterally located in the molar areas of the mandible and we found one case reported, in Brazil, of this condition involving bilateral edentulous mandibular regions of a 54-year-old-woman [<xref ref-type="bibr" rid="B8">8</xref>]. According to study conducted by Bouquot and collaborators [<xref ref-type="bibr" rid="B7">7</xref>] based in the literature review and report of 596 new cases, the bilateral occurrence of osteoporotic bone marrow defect within the jaws affected 3 % of patients.</p><p>There are many reported about this issue but the real incidence of osteoporotic bone marrow defect is not accurately established, probably due to the fact that most cases, including our case reported, are asymptomatic and discovered in radiographic exam for diagnosis of oral conditions [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B6">6</xref>,<xref ref-type="bibr" rid="B8">8</xref>,<xref ref-type="bibr" rid="B9">9</xref>]. In addition, larger studies about this osteoporotic defect fail to mention the number of cases with available radiographs [<xref ref-type="bibr" rid="B2">2</xref>].</p><p>Previous osteoporotic bone marrow defects documented in the English literature [<xref ref-type="bibr" rid="B1">1</xref>-<xref ref-type="bibr" rid="B5">5</xref>] indicate that, frequently, its radiographic appearance may be confused with other intraosseous pathologic conditions. As described in the present report, the bilateral radiolucent areas with indistinct margins suggested the presence of the mandibular benign cysts or tumors. Based on age, site, clinical and radiographic findings, the osteoporotic bone marrow defect was considered as a differential diagnosis. The final diagnosis of osteoporotic bone marrow defect should be established on microscopic features rather than clinical parameters [<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B4">4</xref>]. Microscopically, the presence of hematopoietic marrow composed of erythroid, granulocytic, monocytic and lymphocytic series, as well as megakaryocytes associated with fatty marrow is required for diagnosis of this condition [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B4">4</xref>-<xref ref-type="bibr" rid="B6">6</xref>]. In the case reported, the association of histopathological and clinical features allowed the precise diagnosis of the osteoporotic bone marrow defect.</p><p>Regarding the etiopathogenesis of osteoporotic bone marrow defect of the jaws, three major theories have been proposed. First, it was thought in the possible persistence in adult life of red embrionary marrow that had no conversion to fatty marrow [<xref ref-type="bibr" rid="B2">2</xref>]. However, many authors [<xref ref-type="bibr" rid="B1">1</xref>,<xref ref-type="bibr" rid="B2">2</xref>] have ruled out this suggestion because if it were possible, this condition would have similar distribution between adults and adolescents or children, but it affect frequently patients in the fourth to six decade of life. Second theory proposed that the compensatory bone marrow hyperplasia were caused by increased functional demand for erythrocytes that occurs in systemic diseases including sickle cell anemia [<xref ref-type="bibr" rid="B2">2</xref>,<xref ref-type="bibr" rid="B9">9</xref>]. However, of the series of cases reported in the literature only few found relationship between osteoporotic bone marrow defects and anemia [<xref ref-type="bibr" rid="B2">2</xref>], and only Sanner and Ramin [<xref ref-type="bibr" rid="B9">9</xref>] documented a case of a 48-year-old man with a bilateral osteoporotic bone marrow defect associated to sickle cell anemia. In our case reported, the haematological examination no revealed any systemic alteration in the patient. The third hypothesis regards to deficiencies in bone repair in areas of previous trauma such as a tooth extraction [<xref ref-type="bibr" rid="B2">2</xref>], where the transient ischemia induce the osteoporotic bone marrow defects [<xref ref-type="bibr" rid="B4">4</xref>]. According to literature, yellow bone marrow contains mesenchymal progenitor cells capable of producing haematopoietic microenvironment [<xref ref-type="bibr" rid="B10">10</xref>] and these cells were recently isolated from mandibular marrow aspirates [<xref ref-type="bibr" rid="B11">11</xref>]. In this context, this theory seems to be the most feasible in the present case, due to the close proximity of the two lesions with edentulous regions.</p><p>In conclusion, this case reported of uncommon bilateral osteoporotic bone marrow defects reinforces that, although the treatment is not required, the radiographic findings are not sufficient to establish an exact diagnosis and histopathological examination is indicate for suspected radiolucencies in the jaws.</p></sec><sec><title>Consent</title><p>Written informed consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.</p></sec><sec><title>Competing interests</title><p>The authors declare that the article-processing charges were supported by Pós-graduação FOB-USP – Proap/Capes and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq – grant #142790/2011-7).</p></sec><sec><title>Authors’ contributions</title><p>DMB-C and DTO prepared the case report, discussion and manuscript, WHMS collected the clinical data and performed the surgical procedures, DMB-C and DTO did the histopathological analysis. All authors have read and approved the final manuscript.</p></sec></body><back><ref-list><ref id="B1"><mixed-citation publication-type="journal"><name><surname>Makek</surname><given-names>M</given-names></name><name><surname>Lello</surname><given-names>GE</given-names></name><article-title>Focal osteoporotic bone marrow defects of the jaws</article-title><source>J Oral Maxillofac Surg</source><year>1986</year><volume>44</volume><fpage>268</fpage><lpage>273</lpage><pub-id pub-id-type="doi">10.1016/0278-2391(86)90077-7</pub-id><pub-id pub-id-type="pmid">3457122</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><name><surname>Schneider</surname><given-names>LC</given-names></name><name><surname>Mesa</surname><given-names>ML</given-names></name><name><surname>Fraenkel</surname><given-names>D</given-names></name><article-title>Osteoporotic bone marrow defect: radiographic features and pathogenic factors</article-title><source>Oral Surg Oral Med Oral Pathol</source><year>1988</year><volume>65</volume><fpage>127</fpage><lpage>129</lpage><pub-id pub-id-type="doi">10.1016/0030-4220(88)90206-X</pub-id><pub-id pub-id-type="pmid">3277106</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><name><surname>Lipani</surname><given-names>CS</given-names></name><name><surname>Natiella</surname><given-names>JR</given-names></name><name><surname>Greene</surname><given-names>GW</given-names></name><article-title>The hematopoietic defect of the jaws: a report of sixteen cases</article-title><source>J Oral Pathol</source><year>1982</year><volume>11</volume><fpage>411</fpage><lpage>416</lpage><pub-id pub-id-type="doi">10.1111/j.1600-0714.1982.tb00184.x</pub-id><pub-id pub-id-type="pmid">6819349</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><name><surname>Shankland</surname><given-names>WE</given-names></name><name><surname>Bouquot</surname><given-names>JE</given-names></name><article-title>Focal osteoporotic marrow defect: report of 100 new cases with ultrasonography scans</article-title><source>Cranio</source><year>2004</year><volume>22</volume><fpage>314</fpage><lpage>319</lpage><pub-id pub-id-type="pmid">15532316</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><name><surname>Bouquot</surname><given-names>JE</given-names></name><name><surname>Stevenson</surname><given-names>G</given-names></name><article-title>Oral and maxillofacial pathology case of the month. Focal osteoporotic marrow defect (Hematopotic bone marrow defect; focal hematopoietic hyperplasia)</article-title><source>Tex Dent J</source><year>2006</year><volume>123</volume><fpage>1061</fpage><lpage>1062</lpage><comment>1066–1068</comment><pub-id pub-id-type="pmid">17214416</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="book"><name><surname>Waldron</surname><given-names>CA</given-names></name><person-group person-group-type="editor">Neville BW, Damm DD, Allen CM, Bouquot JE</person-group><article-title>Bone pathology</article-title><source>Oral and maxillofacial pathology</source><year>2009</year><edition>3</edition><publisher-name>St. Louis: Saunders-Elsevier</publisher-name><fpage>613</fpage><lpage>677</lpage></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><name><surname>Bouquot</surname><given-names>J</given-names></name><name><surname>Rohrer</surname><given-names>M</given-names></name><name><surname>McMahon</surname><given-names>R</given-names></name><name><surname>Makek</surname><given-names>M</given-names></name><name><surname>Boc</surname><given-names>T</given-names></name><article-title>Focal osteoporotic marrow defect-an ischemic or past-ischemic phenomenon? literature review and evaluation of 596 new cases</article-title><source>Oral Surg Oral Med Oral Pathol</source><year>2002</year><volume>94</volume><fpage>211</fpage></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="journal"><name><surname>Sewell</surname><given-names>CMD</given-names></name><name><surname>Almeida</surname><given-names>OP</given-names></name><name><surname>Passeri</surname><given-names>LA</given-names></name><article-title>Defeito osteoporótico-medula óssea</article-title><source>Rev Assoc Paul Cir Dent</source><year>1990</year><volume>44</volume><fpage>321</fpage><lpage>323</lpage></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><name><surname>Sanner</surname><given-names>JR</given-names></name><name><surname>Ramin</surname><given-names>JE</given-names></name><article-title>Osteoporotic, hematopoietic mandibular marrow defect: an osseous manifestation of sickle cell anemia</article-title><source>J Oral Surg</source><year>1977</year><volume>35</volume><fpage>986</fpage><lpage>988</lpage><pub-id pub-id-type="pmid">270567</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><name><surname>Gurevitch</surname><given-names>O</given-names></name><name><surname>Slavin</surname><given-names>S</given-names></name><name><surname>Resnick</surname><given-names>I</given-names></name><name><surname>Khitrin</surname><given-names>S</given-names></name><name><surname>Feldman</surname><given-names>A</given-names></name><article-title>Mesenchymal progenitor cells in red and yellow bone marrow</article-title><source>Folia Biol (Praha)</source><year>2009</year><volume>55</volume><fpage>27</fpage><lpage>34</lpage><pub-id pub-id-type="pmid">19445844</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="other"><name><surname>Lee</surname><given-names>BK</given-names></name><name><surname>Choi</surname><given-names>SJ</given-names></name><name><surname>Mack</surname><given-names>D</given-names></name><name><surname>Oh</surname><given-names>SH</given-names></name><article-title>Isolation of mesenchymal stem cells from the mandibular marrow aspirates</article-title><source>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</source><year>2011</year></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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