Impaired growth hormone secretion in the adult population: relation to age and adiposity.
Identifieur interne : 001567 ( Pmc/Corpus ); précédent : 001566; suivant : 001568Impaired growth hormone secretion in the adult population: relation to age and adiposity.
Auteurs : D. Rudman ; M H Kutner ; C M Rogers ; M F Lubin ; G A Fleming ; R P BainSource :
- Journal of Clinical Investigation [ 0021-9738 ] ; 1981.
Abstract
Growth hormone (GH) release was studied in adults of normal stature, ages 21-86 yr. The subjects were 85-115% of ideal body weight, between the 5th and 95th percentiles in height, and free of active or progressive disease. 9 to 12 individuals in each decade from thirds to ninth were evaluated. The following criteria of GH status were measured: serum GH concentration, analyzed by radioimmunoassay at half-hour intervals for 4 h after onset of sleep, and at 1-h intervals from 8 a.m. to 4 p.m. in 52 subjects; daily retention of N, P, and K in response to 0.168 U human (h)GH/kg body wt3/4/day in 18 subjects; and plasma somatomedin C (SmC) level before and during exogenous hGH treatment in 18 subjects. All 10 individuals, 20-29 yr old, released substantial amounts of endogenous GH during both day and night (average peak serum GH obtained during day and night was 7.3 and 20.3 ng/ml, respectively); average plasma SmC was 1.43 U/ml (95% tolerance limits, 0.64-2.22 U/ml). There was no significant effect of exogenous hGH on elemental balances or on plasma SmC. In contrast, 6 of 12 individuals 60-79 yr old showed the following evidences of impaired GH release; peak waking and sleeping serum GH less than 4 ng/ml; plasma SmC less than 0.38 U/ml; a significant retention in N, P, and K; and a significant rise in plasma SmC, in response to exogenous hGH. Plasma SmC, serum GH during sleep, serum GH during the day, retentions of N, P, and K in response to exogenous hGH, and rise in plasma SmC in response to hGH were all intercorrelated (P less than 0.05). Plasma SmC less than 0.38 U/ml corresponded to peak nocturnal serum GH less than 4 ng/ml. The prevalence of plasma SmC less than 0.38 U/ml increased progressively from age 20 to 90: third decade, 0%; fourth, 11%; fifth, 20%; sixth, 22%; seventh, 42%; eight, 55%; and ninth, 55%. Within each decade, plasma SmC was inversely related to adiposity.
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PubMed: 7194884
PubMed Central: 370702
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PMC:370702Le document en format XML
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<author><name sortKey="Rudman, D" sort="Rudman, D" uniqKey="Rudman D" first="D" last="Rudman">D. Rudman</name>
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<author><name sortKey="Kutner, M H" sort="Kutner, M H" uniqKey="Kutner M" first="M H" last="Kutner">M H Kutner</name>
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<author><name sortKey="Rogers, C M" sort="Rogers, C M" uniqKey="Rogers C" first="C M" last="Rogers">C M Rogers</name>
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<author><name sortKey="Lubin, M F" sort="Lubin, M F" uniqKey="Lubin M" first="M F" last="Lubin">M F Lubin</name>
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<author><name sortKey="Fleming, G A" sort="Fleming, G A" uniqKey="Fleming G" first="G A" last="Fleming">G A Fleming</name>
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<author><name sortKey="Bain, R P" sort="Bain, R P" uniqKey="Bain R" first="R P" last="Bain">R P Bain</name>
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<series><title level="j">Journal of Clinical Investigation</title>
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<front><div type="abstract" xml:lang="en"><p>Growth hormone (GH) release was studied in adults of normal stature, ages 21-86 yr. The subjects were 85-115% of ideal body weight, between the 5th and 95th percentiles in height, and free of active or progressive disease. 9 to 12 individuals in each decade from thirds to ninth were evaluated. The following criteria of GH status were measured: serum GH concentration, analyzed by radioimmunoassay at half-hour intervals for 4 h after onset of sleep, and at 1-h intervals from 8 a.m. to 4 p.m. in 52 subjects; daily retention of N, P, and K in response to 0.168 U human (h)GH/kg body wt3/4/day in 18 subjects; and plasma somatomedin C (SmC) level before and during exogenous hGH treatment in 18 subjects. All 10 individuals, 20-29 yr old, released substantial amounts of endogenous GH during both day and night (average peak serum GH obtained during day and night was 7.3 and 20.3 ng/ml, respectively); average plasma SmC was 1.43 U/ml (95% tolerance limits, 0.64-2.22 U/ml). There was no significant effect of exogenous hGH on elemental balances or on plasma SmC. In contrast, 6 of 12 individuals 60-79 yr old showed the following evidences of impaired GH release; peak waking and sleeping serum GH less than 4 ng/ml; plasma SmC less than 0.38 U/ml; a significant retention in N, P, and K; and a significant rise in plasma SmC, in response to exogenous hGH. Plasma SmC, serum GH during sleep, serum GH during the day, retentions of N, P, and K in response to exogenous hGH, and rise in plasma SmC in response to hGH were all intercorrelated (P less than 0.05). Plasma SmC less than 0.38 U/ml corresponded to peak nocturnal serum GH less than 4 ng/ml. The prevalence of plasma SmC less than 0.38 U/ml increased progressively from age 20 to 90: third decade, 0%; fourth, 11%; fifth, 20%; sixth, 22%; seventh, 42%; eight, 55%; and ninth, 55%. Within each decade, plasma SmC was inversely related to adiposity.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id>
<journal-title>Journal of Clinical Investigation</journal-title>
<issn pub-type="ppub">0021-9738</issn>
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<article-meta><article-id pub-id-type="pmid">7194884</article-id>
<article-id pub-id-type="pmc">370702</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
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<title-group><article-title>Impaired growth hormone secretion in the adult population: relation to age and adiposity.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rudman</surname>
<given-names>D</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Kutner</surname>
<given-names>M H</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Rogers</surname>
<given-names>C M</given-names>
</name>
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<contrib contrib-type="author"><name><surname>Lubin</surname>
<given-names>M F</given-names>
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<contrib contrib-type="author"><name><surname>Fleming</surname>
<given-names>G A</given-names>
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<contrib contrib-type="author"><name><surname>Bain</surname>
<given-names>R P</given-names>
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<pub-date pub-type="ppub"><month>5</month>
<year>1981</year>
</pub-date>
<volume>67</volume>
<issue>5</issue>
<fpage>1361</fpage>
<lpage>1369</lpage>
<abstract><p>Growth hormone (GH) release was studied in adults of normal stature, ages 21-86 yr. The subjects were 85-115% of ideal body weight, between the 5th and 95th percentiles in height, and free of active or progressive disease. 9 to 12 individuals in each decade from thirds to ninth were evaluated. The following criteria of GH status were measured: serum GH concentration, analyzed by radioimmunoassay at half-hour intervals for 4 h after onset of sleep, and at 1-h intervals from 8 a.m. to 4 p.m. in 52 subjects; daily retention of N, P, and K in response to 0.168 U human (h)GH/kg body wt3/4/day in 18 subjects; and plasma somatomedin C (SmC) level before and during exogenous hGH treatment in 18 subjects. All 10 individuals, 20-29 yr old, released substantial amounts of endogenous GH during both day and night (average peak serum GH obtained during day and night was 7.3 and 20.3 ng/ml, respectively); average plasma SmC was 1.43 U/ml (95% tolerance limits, 0.64-2.22 U/ml). There was no significant effect of exogenous hGH on elemental balances or on plasma SmC. In contrast, 6 of 12 individuals 60-79 yr old showed the following evidences of impaired GH release; peak waking and sleeping serum GH less than 4 ng/ml; plasma SmC less than 0.38 U/ml; a significant retention in N, P, and K; and a significant rise in plasma SmC, in response to exogenous hGH. Plasma SmC, serum GH during sleep, serum GH during the day, retentions of N, P, and K in response to exogenous hGH, and rise in plasma SmC in response to hGH were all intercorrelated (P less than 0.05). Plasma SmC less than 0.38 U/ml corresponded to peak nocturnal serum GH less than 4 ng/ml. The prevalence of plasma SmC less than 0.38 U/ml increased progressively from age 20 to 90: third decade, 0%; fourth, 11%; fifth, 20%; sixth, 22%; seventh, 42%; eight, 55%; and ninth, 55%. Within each decade, plasma SmC was inversely related to adiposity.</p>
</abstract>
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