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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiolucent lesions of the mandible: a pattern-based approach to diagnosis</title>
<author><name sortKey="Avril, Laurene" sort="Avril, Laurene" uniqKey="Avril L" first="Laurène" last="Avril">Laurène Avril</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lombardi, Tommaso" sort="Lombardi, Tommaso" uniqKey="Lombardi T" first="Tommaso" last="Lombardi">Tommaso Lombardi</name>
<affiliation><nlm:aff id="Aff2">Department of Maxillo-Facial Surgery, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ailianou, Angeliki" sort="Ailianou, Angeliki" uniqKey="Ailianou A" first="Angeliki" last="Ailianou">Angeliki Ailianou</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burkhardt, Karim" sort="Burkhardt, Karim" uniqKey="Burkhardt K" first="Karim" last="Burkhardt">Karim Burkhardt</name>
<affiliation><nlm:aff id="Aff3">Department of Clinical Pathology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Varoquaux, Arthur" sort="Varoquaux, Arthur" uniqKey="Varoquaux A" first="Arthur" last="Varoquaux">Arthur Varoquaux</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scolozzi, Paolo" sort="Scolozzi, Paolo" uniqKey="Scolozzi P" first="Paolo" last="Scolozzi">Paolo Scolozzi</name>
<affiliation><nlm:aff id="Aff2">Department of Maxillo-Facial Surgery, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Becker, Minerva" sort="Becker, Minerva" uniqKey="Becker M" first="Minerva" last="Becker">Minerva Becker</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24323536</idno>
<idno type="pmc">3948901</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948901</idno>
<idno type="RBID">PMC:3948901</idno>
<idno type="doi">10.1007/s13244-013-0298-9</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000E39</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E39</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiolucent lesions of the mandible: a pattern-based approach to diagnosis</title>
<author><name sortKey="Avril, Laurene" sort="Avril, Laurene" uniqKey="Avril L" first="Laurène" last="Avril">Laurène Avril</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lombardi, Tommaso" sort="Lombardi, Tommaso" uniqKey="Lombardi T" first="Tommaso" last="Lombardi">Tommaso Lombardi</name>
<affiliation><nlm:aff id="Aff2">Department of Maxillo-Facial Surgery, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ailianou, Angeliki" sort="Ailianou, Angeliki" uniqKey="Ailianou A" first="Angeliki" last="Ailianou">Angeliki Ailianou</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burkhardt, Karim" sort="Burkhardt, Karim" uniqKey="Burkhardt K" first="Karim" last="Burkhardt">Karim Burkhardt</name>
<affiliation><nlm:aff id="Aff3">Department of Clinical Pathology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Varoquaux, Arthur" sort="Varoquaux, Arthur" uniqKey="Varoquaux A" first="Arthur" last="Varoquaux">Arthur Varoquaux</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Scolozzi, Paolo" sort="Scolozzi, Paolo" uniqKey="Scolozzi P" first="Paolo" last="Scolozzi">Paolo Scolozzi</name>
<affiliation><nlm:aff id="Aff2">Department of Maxillo-Facial Surgery, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Becker, Minerva" sort="Becker, Minerva" uniqKey="Becker M" first="Minerva" last="Becker">Minerva Becker</name>
<affiliation><nlm:aff id="Aff1">Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Insights into Imaging</title>
<idno type="eISSN">1869-4101</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>Radiolucent mandibular lesions seen on panoramic radiographs develop from both odontogenic and non-odontogenic structures. They represent a broad spectrum of lesions with a varying degree of malignant potential. The purpose of this review is to illustrate the characteristic imaging findings—as well as the clinical and histological features—of common and uncommon radiolucent lesions of the mandible.</p>
</sec>
<sec><title>Methods</title>
<p>This review article is based on the retrospective evaluation of 11,725 panoramic radiographs seen in our institution during the past 6 years. It provides a comprehensive, practical approach to the radiological interpretation of radiolucent lesions of the mandible. To facilitate the diagnostic approach, we have classified radiolucent lesions into two groups: lesions with well-defined borders and those with ill-defined borders.</p>
</sec>
<sec><title>Results</title>
<p>Lesion prevalence, age of manifestation, location within the mandible, relationship to dental structures, effect on adjacent structures and characteristic findings at computed tomography (CT), cone beam CT (CBCT) and magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) are discussed. Pitfalls including malignant lesions mimicking benign disease and pseudo-lesions are equally addressed.</p>
</sec>
<sec><title>Conclusion</title>
<p>Knowledge of the characteristic imaging features of radiolucent mandibular lesions narrows the differential diagnosis and is crucial for the identification of those lesions, where biopsy is indicated for definitive histology.</p>
</sec>
<sec><title>Teaching points</title>
<p>• <italic>Panoramic X-rays, CT and MRI are essential for the work-up of radiolucent mandibular lesions.</italic>
</p>
<p>• <italic>Lesion borders, location within the mandible, relationship to dental structures and tissue characteristics on cross-sectional imaging are indispensable to narrow the differential diagnosis.</italic>
</p>
<p>• <italic>High-resolution CT and CBCT play a major role for the assessment of lesion margins and their relationship to important anatomic structures, such as the inferior alveolar nerve.</italic>
</p>
<p>• <italic>Although most radiolucent lesions with well-defined sclerotic borders are benign, MRI may reveal clinically unsuspected malignant disease.</italic>
</p>
</sec>
</div>
</front>
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</author>
<author><name sortKey="Scolozzi, P" uniqKey="Scolozzi P">P Scolozzi</name>
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</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Insights Imaging</journal-id>
<journal-id journal-id-type="iso-abbrev">Insights Imaging</journal-id>
<journal-title-group><journal-title>Insights into Imaging</journal-title>
</journal-title-group>
<issn pub-type="epub">1869-4101</issn>
<publisher><publisher-name>Springer Berlin Heidelberg</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24323536</article-id>
<article-id pub-id-type="pmc">3948901</article-id>
<article-id pub-id-type="publisher-id">298</article-id>
<article-id pub-id-type="doi">10.1007/s13244-013-0298-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Pictorial Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Radiolucent lesions of the mandible: a pattern-based approach to diagnosis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Avril</surname>
<given-names>Laurène</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lombardi</surname>
<given-names>Tommaso</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ailianou</surname>
<given-names>Angeliki</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Burkhardt</surname>
<given-names>Karim</given-names>
</name>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Varoquaux</surname>
<given-names>Arthur</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scolozzi</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Becker</surname>
<given-names>Minerva</given-names>
</name>
<address><phone>+41-22-3727001</phone>
<fax>+41-22-3727072</fax>
<email>Minerva.Becker@hcuge.ch</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><label></label>
Department of Radiology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</aff>
<aff id="Aff2"><label></label>
Department of Maxillo-Facial Surgery, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</aff>
<aff id="Aff3"><label></label>
Department of Clinical Pathology, University Hospital of Geneva, University of Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland</aff>
</contrib-group>
<pub-date pub-type="epub"><day>10</day>
<month>12</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>12</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="collection"><month>2</month>
<year>2014</year>
</pub-date>
<volume>5</volume>
<issue>1</issue>
<fpage>85</fpage>
<lpage>101</lpage>
<history><date date-type="received"><day>20</day>
<month>9</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>1</day>
<month>11</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>6</day>
<month>11</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2013</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Objectives</title>
<p>Radiolucent mandibular lesions seen on panoramic radiographs develop from both odontogenic and non-odontogenic structures. They represent a broad spectrum of lesions with a varying degree of malignant potential. The purpose of this review is to illustrate the characteristic imaging findings—as well as the clinical and histological features—of common and uncommon radiolucent lesions of the mandible.</p>
</sec>
<sec><title>Methods</title>
<p>This review article is based on the retrospective evaluation of 11,725 panoramic radiographs seen in our institution during the past 6 years. It provides a comprehensive, practical approach to the radiological interpretation of radiolucent lesions of the mandible. To facilitate the diagnostic approach, we have classified radiolucent lesions into two groups: lesions with well-defined borders and those with ill-defined borders.</p>
</sec>
<sec><title>Results</title>
<p>Lesion prevalence, age of manifestation, location within the mandible, relationship to dental structures, effect on adjacent structures and characteristic findings at computed tomography (CT), cone beam CT (CBCT) and magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) are discussed. Pitfalls including malignant lesions mimicking benign disease and pseudo-lesions are equally addressed.</p>
</sec>
<sec><title>Conclusion</title>
<p>Knowledge of the characteristic imaging features of radiolucent mandibular lesions narrows the differential diagnosis and is crucial for the identification of those lesions, where biopsy is indicated for definitive histology.</p>
</sec>
<sec><title>Teaching points</title>
<p>• <italic>Panoramic X-rays, CT and MRI are essential for the work-up of radiolucent mandibular lesions.</italic>
</p>
<p>• <italic>Lesion borders, location within the mandible, relationship to dental structures and tissue characteristics on cross-sectional imaging are indispensable to narrow the differential diagnosis.</italic>
</p>
<p>• <italic>High-resolution CT and CBCT play a major role for the assessment of lesion margins and their relationship to important anatomic structures, such as the inferior alveolar nerve.</italic>
</p>
<p>• <italic>Although most radiolucent lesions with well-defined sclerotic borders are benign, MRI may reveal clinically unsuspected malignant disease.</italic>
</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Mandible</kwd>
<kwd>Radiolucent lesions</kwd>
<kwd>Panoramic radiography</kwd>
<kwd>Computed tomography (CT)</kwd>
<kwd>Magnetic resonance imaging (MRI)</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2014</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body><sec id="Sec1" sec-type="introduction"><title>Introduction</title>
<p>Conventional radiography may reveal a variety of radiolucent lesions in the mandible. These represent a broad spectrum of odontogenic and non-odontogenic lesions with a varying degree of malignant potential. Interpretation of radiolucent lesions of the mandible can be challenging either because the clinical presentation may be non-specific or because the lesion may be detected incidentally [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR2">2</xref>
]. In some cases, the diagnosis will be mainly made based on clinical symptoms. In other cases, although a thorough clinical evaluation is mandatory, clinical findings are non-contributory, as the lesion cannot be seen or palpated and laboratory findings are not abnormal. Imaging is essential not only for the diagnosis of mandibular lesions but also to guide therapy and to monitor treatment response. Although common, mandibular lesions are not frequently imaged by radiologists. Nevertheless, their recognition is essential for a rapid and correct diagnosis. This review provides a comprehensive, practical approach to the radiological interpretation of radiolucent lesions of the mandible and discusses their clinical presentation and pathophysiology. It focuses on the radiological techniques used and their respective role for the assessment of these lesions.</p>
</sec>
<sec id="Sec2"><title>Imaging modalities</title>
<p>Due to the easy access and low radiation dose, conventional radiographs such as panoramic radiographs (orthopantomographies [OPTs] or panoramix X-rays) as well as dental intraoral radiographs traditionally form the backbone in the diagnosis of osseous changes in the mandible [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR3">3</xref>
]. In addition, the introduction of digital radiographs has lead to further dose reduction (up to 80 %) with the possibility of densitometric and subtraction techniques [<xref ref-type="bibr" rid="CR4">4</xref>
]. Conventional radiographs of the mandible, typically OPTs, may reveal radiolucent, radiodense or mixed pattern lesions [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR3">3</xref>
]. In many cases, such as in radicular cysts, the diagnosis is straightforward and no additional imaging is required for diagnosis and treatment. As conventional radiographs are two-dimensional projections of three-dimensional structures, they have a limited value for the assessment of lesion size, lesion margins, as well as extension into important anatomic structures or soft tissues. Computed tomography (CT), cone beam CT (CBCT), magnetic resonance imaging (MRI) and positron emission tomography combined with CT (PET/CT) and more recently positron emission tomography combined with MRI (PET/MRI) complement conventional radiographs overcoming the above-mentioned limitations and providing more specific information in terms of diagnosis and therapeutic options.</p>
<p>Thin-slice (1-mm), high-resolution CT with bone window settings is mainly used pre-operatively to precisely assess lesion size, margins, destruction and expansion patterns, as well as the relationship of the lesion to the mandibular canal. Although coronal slices are sufficient in many situations, dental CT with orthoradial and panoramic reconstructions are superior to standard coronal reconstructions for the evaluation of the relationship of a lesion to the dental structures and to the mandibular canal. Intravenous contrast material is mainly used in cases of suspected jaw infection or in neoplastic diseases to assess the intraosseous and extraosseous involvement. Although CBCT has gained increasing popularity over the past years, it does not allow evaluation of extraosseous structures; use of CBCT may therefore lead to underestimation of disease extent.</p>
<p>High-resolution MRI is mainly used as a complementary tool to CT or CBCT, as it allows precise depiction of intraosseous and extraosseous lesion components, cyst wall architecture (thin versus irregular walls, mural nodules, papillary projections), enhancement patterns after intravenous administration of gadolinium chelates (mild to strong), and type of soft tissue involvement (displacement versus infiltration) [<xref ref-type="bibr" rid="CR5">5</xref>
]. In inflammatory and infectious lesions, MRI is more sensitive than CT or CBCT for the detection of bone marrow involvement [<xref ref-type="bibr" rid="CR6">6</xref>
].</p>
<p>Diffusion weighted imaging (DWI) is a functional MRI technique based on the assessment of random (Brownian) motion of water molecules. Biological barriers can impair the free displacement of water molecules, thus resulting in restricted diffusivity. Restricted diffusivity is seen in a variety of conditions, including stroke, tumours with increased cellularity, infection and inflammation, as well as abscesses. Diffusion in biological tissues can be quantified using the apparent diffusion coefficient (ADC). ADC measurements (in mm<sup>2</sup>
/s) have been shown to be reproducible with excellent intraobserver and interobserver reproducibility in the head and neck [<xref ref-type="bibr" rid="CR7">7</xref>
]. MRI with DWI and ADC measurements helps in the differential diagnosis of cysts, ameloblastomas and malignant tumours (see below). Although ADC values cannot predict the histological grade in head and neck squamous cell carcinoma (SCC), lower values are observed in poorly differentiated lesions whereas higher values are seen in well-differentiated tumours [<xref ref-type="bibr" rid="CR7">7</xref>
]. In lymphomas, ADC measurements typically yield very low values (see below).</p>
<p>As a general rule, PET/CT is uncommonly used for the work-up of mandibular lesions. Nevertheless, it may be employed as a complementary examination for the staging of malignant tumours invading the mandible, such as SCC of the oral cavity with secondary mandibular invasion, in primary intraosseous SCC or in mandibular lymphoma. In cases of metastases to the mandible, PET/CT may reveal the location of the primary tumour—if unknown—or may effectively show involvement of multiple organs. The most commonly used radiotracer is <sup>18</sup>
F-fluorodeoxyglucose (FDG). FDG is a glucose analogue that is taken up by metabolically active tumour cells using facilitated glucose transport. In clinical routine, quantification of tracer uptake is performed using the standardised uptake value (SUV). High SUVs reflect high glucose metabolism mainly seen in aggressive tumours (typically SCC and lymphoma), while lower SUV values are rather seen in slowly growing, less aggressive tumours, in tumours with large areas of necrosis or in inflammatory conditions. The recent implementation of integrated hybrid PET/MRI systems in clinical head and neck oncology [<xref ref-type="bibr" rid="CR8">8</xref>
] holds promise as it combines morphological, functional and molecular information at the same time, thereby providing additional diagnostic gain. However, research into the potential clinical role of PET/MRI in comparison with PET/CT, MRI with DWI or the combination thereof, is still ongoing.</p>
<p>This review article is based on the retrospective evaluation of 11,725 panoramic radiographs seen during a period of 6 years at our institution. From a practical point of view, radiolucent mandibular lesions can be divided into lesions with well-defined borders and lesions with poorly defined borders.</p>
</sec>
<sec id="Sec3"><title>Radiolucent lesions with well-defined borders</title>
<sec id="Sec4"><title>Radicular cyst</title>
<p>Odontogenic cysts are true cysts arising from the epithelium left over from tooth development. Radicular cysts, also called periapical cysts or apical periodontal cysts, are the most common odontogenic cysts [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR2">2</xref>
]. Tooth infection may lead to necrosis of the pulp cavity and may spread to the tooth apex with ulterior development of a periapical granuloma or periapical abscess. The latter may subsequently give rise to a radicular cyst. Radicular cysts arise from epithelial cell rests of the periodontal ligament, which are stimulated by the inflammatory products. Most often, radicular cysts are asymptomatic. They may be seen in all age groups, however, more often between 30 and 60 years of age and are typically associated with a non-vital tooth. Imaging features are straightforward and include a unilocular periapical lesion with well-defined, sclerotic borders in close vicinity of the apical portion of the root of a non-vital tooth. No contrast material enhancement is seen on CT or MRI. In atypical cases with latero-dental location, CT or CBCT is very helpful for the correct diagnosis (Fig. <xref rid="Fig1" ref-type="fig">1</xref>
). Treatment options include apical surgery, tooth extraction and endodontic treatment.<fig id="Fig1"><label>Fig. 1</label>
<caption><p>Radicular cyst. <bold>a</bold>
OPT. Unilocular radiolucent lesion with well-defined borders (<italic>asterisk</italic>
) displacing teeth 33 and 34. <bold>b</bold>
CT, sagittal oblique 2D MPR with bone windows. Cystic lesion surrounding the root (<italic>dashed arrow</italic>
) of the non-vital tooth 34. Associated large caries with pulpal necrosis (<italic>arrow</italic>
). <bold>c</bold>
Histology (haematoxylin-eosin stain, original magnification 20×): fibrous connective wall containing a dense chronic inflammatory infiltrate and congested vessels (<italic>asterisk</italic>
) lined by irregular non-keratinised stratified squamous epithelium. Spongiotic epithelium (<italic>arrows</italic>
) penetrated by neutrophils</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig1_HTML" id="d30e527"></graphic>
</fig>
</p>
</sec>
<sec id="Sec5"><title>Residual cyst</title>
<p>Residual cysts are periapical cysts retained in the jaw after surgical removal of a non-vital tooth [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR3">3</xref>
]. Residual cysts are common and have similar clinical and radiological features as radicular cysts. However, there is always a missing tooth (Fig. <xref rid="Fig2" ref-type="fig">2</xref>
). Most residual cysts are less than 1 cm in size. Occasionally, enlarging cysts may cause displacement of the adjacent teeth, as well as bone expansion.<fig id="Fig2"><label>Fig. 2</label>
<caption><p>Residual cyst. <bold>a</bold>
OPT. Unilocular well-defined lesion with sclerotic borders (<italic>arrow</italic>
) and missing tooth 36 above. <bold>b</bold>
Histology (haematoxylin-eosin stain, original magnification 20×): non-keratinised stratified squamous epithelium (<italic>arrow</italic>
) with mild inflammation</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig2_HTML" id="d30e562"></graphic>
</fig>
</p>
</sec>
<sec id="Sec6"><title>Dentigerous cyst</title>
<p>Follicular cysts, also called dentigerous cysts or pericoronal cysts, are the second most common odontogenic mandibular cysts and the most common developmental cysts of odontogenic origin. They are typically seen in patients aged 20–40. Once fluid accumulates between the enamel organ remnants and the tooth crown, a cyst forms around the crown of the unerupted tooth (typically the lower third molar). Imaging features of follicular cysts are characteristic and include a unilocular, well-defined radiolucent lesion with sclerotic borders around an unerupted tooth crown (Fig. <xref rid="Fig3" ref-type="fig">3</xref>
). Small follicular cysts may be difficult to differentiate from a normal dental follicle. It has been suggested that when the distance between the crown and the dental sac is superior to 3 mm, the diagnosis of a follicular cyst should be made. The cyst is most often attached to the neck of the unerupted and displaced tooth, and the crown generally protrudes into the cyst while the roots remain outside the lesion (Fig. <xref rid="Fig3" ref-type="fig">3</xref>
). Follicular cysts may become very large [<xref ref-type="bibr" rid="CR9">9</xref>
] and may remodel the mandible, predisposing the patient to pathological fracture and infection. They may thin the cortical layer of the mandible and may insinuate around the mandibular canal, making surgical excision risky. CT and CBCT are used to determine the relationship of the cyst to the mandibular canal prior to surgery and to assess cyst contents, as well as integrity of the cortical rim (Fig. <xref rid="Fig3" ref-type="fig">3</xref>
). MRI is indicated only in atypical cases to differentiate follicular cysts from other cystic mandibular lesions [<xref ref-type="bibr" rid="CR5">5</xref>
]. Follicular cysts will often be found incidentally in patients undergoing head and neck MRI for other indications. MRI findings include variable signal intensity on T1 due to variable protein content within the cyst, high signal on T2 and occasionally slight enhancement of the thin cyst wall. Although most cysts show no significant FDG uptake on PET/CT, mild tracer uptake may be seen in the presence of infection or inflammation [<xref ref-type="bibr" rid="CR10">10</xref>
]. Treatment options include enucleation in smaller lesions and marsupialisation in larger cysts. Rarely, SCC (<italic>see</italic>
“Pitfalls”) or ameloblastoma may arise from the epithelium of the cyst wall [<xref ref-type="bibr" rid="CR11">11</xref>
–<xref ref-type="bibr" rid="CR13">13</xref>
]. Multiple follicular cysts are very rare and may be seen in cleidocranial dysplasia, muccopolysaccharidosis type 4 [<xref ref-type="bibr" rid="CR9">9</xref>
] and in the Gorlin-Goltz syndrome.<fig id="Fig3"><label>Fig. 3</label>
<caption><p>Dentigerous cyst. <bold>a</bold>
OPT, <bold>b</bold>
axial CT with bone windows and <bold>c</bold>
dentascan reconstruction. Unilocular well-defined radiolucent lesion (<italic>thick arrows</italic>
) surrounding an unerupted tooth. Immediate vicinity of the mandibular canal (<italic>dashed arrow</italic>
) to the impacted tooth. <bold>d</bold>
Three-dimensional reconstruction, lateral view showing the relationship of the cyst (<italic>blue</italic>
), the unerupted tooth (<italic>green</italic>
) and the mandibular canal (<italic>red</italic>
). The cyst is attached at the level of the tooth neck and surrounds the crown. <bold>e</bold>
Surgical specimen. Characteristic attachment of the cyst at the tooth neck (<italic>arrows</italic>
). <bold>f</bold>
Histology (haematoxylin-eosin stain, original magnification 20×): non keratinising thin epithelial lining (<italic>arrow</italic>
) without rete pegs. Fibrous wall (<italic>asterisks</italic>
) almost completely devoid of inflammatory cells</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig3_HTML" id="d30e651"></graphic>
</fig>
</p>
</sec>
<sec id="Sec7"><title>Keratocyst</title>
<p>Keratocysts, also called primordial cysts, keratinising cysts or keratocystic odontogenic tumours (KCOTs), are benign intraosseous tumours arising from the dental lamina [<xref ref-type="bibr" rid="CR11">11</xref>
]. They are lined by stratified keratinising epithelium. Due to their potentially aggressive, infiltrative behaviour, they have a high recurrence rate after surgery (up to 60 %) [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR14">14</xref>
, <xref ref-type="bibr" rid="CR15">15</xref>
]. KCOTs are often asymptomatic. They are often misdiagnosed as periapical cysts, follicular cysts, lateral periodontal cysts or ameloblastoma [<xref ref-type="bibr" rid="CR14">14</xref>
]. According to the literature, KCOT have a periapical position in 33 % of cases, a pericoronal position in 21 % of cases, a lateral root position in 19 % of cases and are not related to any dental structures in 27 % of cases [<xref ref-type="bibr" rid="CR14">14</xref>
]. KCOTs essentially occur in the 2nd and 3rd decade in the posterior body or in the ascending ramus of the mandible. Lesions in the molar and premolar area or in the anterior mandible are less common. Men are affected more commonly than women, most KCOTs occurring in Caucasian populations of Northern European decent. As KCOTs may become very large, they tend to remodel, hollow and expand the mandible (Fig. <xref rid="Fig4" ref-type="fig">4</xref>
). Smaller lesions tend to be unilocular, while larger lesions tend to be multilocular. KCOTs show well-delineated, sclerotic or scalloped borders, soft-tissue extension and daughter cysts. The adjacent teeth are only rarely resorbed; however, when this is the case, differentiation from ameloblastoma may be very difficult on OPT, CT or CBCT. As KCOTs contain a cheese-like material, they typically show soft tissue density (up to 50 HU) on CT (Fig. <xref rid="Fig4" ref-type="fig">4</xref>
), while on MRI, due to the variable protein content, a low to high signal intensity may be seen on T1 and a heterogeneous signal on T2. T2 relaxation times in KCOT have been reported to be shorter than in ameloblastoma [<xref ref-type="bibr" rid="CR5">5</xref>
]. Weak enhancement of the uniformly thin and regular cyst walls is noted after injection of gadolinium chelates, thereby facilitating differentiation from ameloblastoma [<xref ref-type="bibr" rid="CR5">5</xref>
].<fig id="Fig4"><label>Fig. 4</label>
<caption><p>Histologically proven KCOT. <bold>a</bold>
OPT. Axial CT image with bone window (<bold>b</bold>
) and soft tissue window (<bold>c</bold>
). Multilocular well-defined radiolucent lesion (<italic>asterisk</italic>
) with thin, sclerotic borders, cortical scalloping (<italic>arrow</italic>
) and resorption of teeth roots. Cyst contents with attenuation values of 40–50 HU mimicking solid tissue. <bold>d</bold>
Posterior view of a 3D reconstruction showing the relationship between the keratocyst (<italic>blue</italic>
), the partially resorbed teeth (<italic>green</italic>
) and the mandibular canal (<italic>red</italic>
). The mandibular canal can be seen only in the posterior mandible, as it is encased by the keratocyst</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig4_HTML" id="d30e724"></graphic>
</fig>
</p>
<p>Multiple KCOTs are seen in the nevoid basal cell carcinoma syndrome (Gorlin-Goltz syndrome), the oral-facial-digital syndrome, the Ehlers Danlos and in the Noonan syndrome [<xref ref-type="bibr" rid="CR2">2</xref>
, <xref ref-type="bibr" rid="CR16">16</xref>
]. The Gorlin-Golz syndrome is an autosomal dominant disorder manifesting with mental retardation, multiple KCOTs (Fig. <xref rid="Fig5" ref-type="fig">5</xref>
), basocellular carcinomas, bone defects, subcutaneous and falx cerebri calcifications. Patients typically have large calvaria, midface hypoplasia, high-arched eyebrows and hypertelorism. The treatment of choice in KCOTs is complete surgical removal of the lesion itself, including the commonly associated tooth. Careful clinical and radiological post-operative follow-up is essential due to the high recurrence rate.<fig id="Fig5"><label>Fig. 5</label>
<caption><p>Basal cell nevus syndrome. <bold>a</bold>
OPG. Multiple mandibular and maxillary KCOTs (<italic>asterisks</italic>
) associated with impacted teeth. <bold>b</bold>
Intraoperative view showing cheese-like material within the angulo-mandibular lesion (<italic>arrow</italic>
). <bold>c</bold>
Surgical specimen showing the KCOT (<italic>asterisk</italic>
) and the associated tooth (<italic>thin long arrow</italic>
). <bold>d</bold>
Histology (haematoxylin-eosin stain, original magnification 40×): corrugated (<italic>dashed arrows</italic>
) parakeratinised epithelium with distinct basal columnar cells with inverted polarity (<italic>arrows</italic>
) and flat connective tissue interface</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig5_HTML" id="d30e775"></graphic>
</fig>
</p>
</sec>
<sec id="Sec8"><title>Ameloblastoma</title>
<p>Ameloblastomas are benign but locally invasive, slowly growing odontogenic tumours arising from remnants of the dental lamina and dental organ or, less frequently, from the epithelial lining of an odontogenic cyst [<xref ref-type="bibr" rid="CR12">12</xref>
]. They represent 10 % of all odontogenic tumours, most lesions being located in the mandible (posterior body and ramus region). Most tumours tend to occur during the 4th–6th decade and there is no sex predilection. Clinical features are non-specific and patients may complain of unilateral painless swelling. Very often, ameloblastomas are detected incidentally. Although classic amelobastomas do not have distant metastases, variants with metastatic behaviour despite histologically benign features (so-called “malignant ameloblastoma”), as well as tumours with histologically malignant features but without metastatic potential (so-called “ameloblastic carcinomas”) have been described in the literature [<xref ref-type="bibr" rid="CR3">3</xref>
]. Ameloblastomas may be subdivided into four histological types: unicystic, multicystic, extraosseous, and desmoplastic [<xref ref-type="bibr" rid="CR12">12</xref>
]. The radiological appearance depends on the histological type and includes unilocular or multilocular radiolucent lesions (“soap bubble” or “honeycomb” appearance) with sclerotic borders, displaced adjacent teeth with root resorption and/or extensive bone expansion (Figs. <xref rid="Fig6" ref-type="fig">6</xref>
and <xref rid="Fig7" ref-type="fig">7</xref>
). CT and MRI are used to assess tumour contents, integrity of the mandibular cortical rim, relationship to the mandibular canal and precise intraosseous and soft tissue extension (Figs. <xref rid="Fig6" ref-type="fig">6</xref>
and <xref rid="Fig7" ref-type="fig">7</xref>
). In multicystic ameloblastoma, MRI reveals cysts with variable protein content. Typically, after injection of gadolinium chelates, MRI shows enhancement of solid nodular components, of irregularly thick septations and of papillary projections (Fig. <xref rid="Fig6" ref-type="fig">6</xref>
). Although differentiation between benign and malignant ameloblastoma may be impossible with CT and MRI, a very high FDG uptake on PET/CT strongly suggests malignant ameloblastoma or ameloblastic carcinoma [<xref ref-type="bibr" rid="CR17">17</xref>
]. Treatment consists in complete surgical excision and careful post-operative follow-up with imaging is mandatory.<fig id="Fig6"><label>Fig. 6</label>
<caption><p>Histologically proven multilocular ameloblastoma. <bold>a</bold>
Axial bone window CT image. <bold>b</bold>
Three-dimensional reconstruction, frontal view. <bold>c</bold>
T1-weighted axial image. <bold>d</bold>
T1-weighted axial image after injection of gadolinium chelates. Multilocular expansile radiolucency with characteristic “soap bubble” appearance (<italic>asterisks</italic>
) and major facial deformation. Cystic components with variable signal intensity on the unenhnanced T1-weighted image suggesting variable protein content. Note variable enhancement of solid components ranging from thin enhancing walls to thick enhancing solid portions (<italic>arrows</italic>
)</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig6_HTML" id="d30e836"></graphic>
</fig>
<fig id="Fig7"><label>Fig. 7</label>
<caption><p>Recurrent multilocular ameloblastoma. <bold>a</bold>
OPT showing a well-defined, multilocular radiolucency (<italic>arrows</italic>
) with sclerotic borders. <bold>b</bold>
Resected specimen and <bold>c</bold>
specimen radiograph clearly show bony expansion, destruction of the alveolar ridge and characteristic multilocular appearance. <bold>d</bold>
Histology (haematoxylin-eosin stain, original magnification 20×): follicular ameloblastoma with squamous metaplasia (<italic>red asterisks</italic>
) within follicles (<italic>arrows</italic>
). Largely fibrous stroma (<italic>black asterisks</italic>
) containing scattered lymphocytes</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig7_HTML" id="d30e870"></graphic>
</fig>
</p>
</sec>
<sec id="Sec9"><title>Simple bone cyst</title>
<p>The simple bone cyst (SBC), also known as solitary bone cyst, traumatic bone cyst, haemorrhagic cyst or idiopathic bone cavity is filled with serous or haemorrhagic fluid and is characterised by the absence of an epithelial lining. Therefore, SBC is not a true cyst but rather a pseudocyst. SBC of the mandible usually occurs secondary to trauma, typically after tooth extraction with subsequent intramedullary haemorrhage. Most SBCs occur before the age of 20 with female predominance [<xref ref-type="bibr" rid="CR18">18</xref>
]. In up to 75 % of all cases, SBCs are seen in the marrow of the posterior mandible. Most lesions are asymptomatic and discovered incidentally on dental radiographs. SBC occurs in close proximity to a vital tooth and is not associated with bone swelling unless there is associated infection. Surgical exploration may be necessary in selected cases to exclude other unilocular radiolucent lesions, such as keratocysts. On imaging, most SBCs appear as unilocular, well-defined radiolucent lesions that vary in size. Rarely, poorly defined borders are observed. Extension to the cortical bone is rare and usually there is no tooth displacement [<xref ref-type="bibr" rid="CR18">18</xref>
]. The superior margins are irregular and scallop around teeth roots. CT and MRI can provide information on the haemorrhagic content but the density or signal intensity, respectively, may vary depending on the age of the haemorrhage. On MRI, the cysts display a homogeneous intermediate signal on T1, homogeneous high signal on T2, and no enhancement after injection of intravenous contrast media. Treatment consists of bone curettage, leading to bleeding with subsequent scar formation.</p>
</sec>
<sec id="Sec10"><title>Eosinophilic granuloma of the mandible</title>
<p>Eosinophilic granuloma (EG) is a benign disease related to any of the three forms of Langerhans cell histiocytosis (LCH). Depending upon the number of lesions and lesion distribution, LCH comprises the following groups: unifocal LCH (also called EG), multifocal unisystem and multifocal multisystem. The combination of diabetes insipidus, lytic bone lesions and exophtalmus is known as Hand-Schüller-Christian triad, whereas the multifocal multisystem LCH is also called Abt-Letterer-Siwe disease (with typical abdominal involvement and poor prognosis) [<xref ref-type="bibr" rid="CR19">19</xref>
]. LCH is caused by clonal proliferation of activated dendritic cells and macrophages [<xref ref-type="bibr" rid="CR20">20</xref>
]. Any bone can be affected, such as the skull, mandible, ribs and long bones, as well as any organ system (lung, skin, spleen, lymph nodes, central nervous system). Therefore, cross-sectional whole-body imaging is essential for the initial work-up of patients with active disease and for post-therapeutic follow-up purposes.</p>
<p>The incidence of mandibular EG constitutes less than 10 % of all LCH cases. LCH often affects males in the 1st–3rd decade, although most cases are seen in children younger than 15 years of age. Mandibular involvement is seen preferentially in the body or angle (Fig. <xref rid="Fig8" ref-type="fig">8</xref>
). Clinical presentation can be silent or non-specific including pain, swelling, fever, general malaise, gingival hypertrophy, ulcers of the buccal mucosa, limitation of mouth opening or tooth hypermobility and loosening. Pathological fracture may ensue. Radiologically, EG presents as a well-defined radiolucent lesion, with or without reactive sclerosis on OPT; however, an accompanying periosteal reaction is typically seen on CT or CBCT. Occasionally, this periosteal reaction may show a sunburst appearance, suggesting a more aggressive biological behaviour. If the alveolar crest is invaded, a “scooped out” appearance is seen; when the alveolar bone is destroyed, a “floating tooth” appearance is observed. EG is often associated with a soft tissue mass surrounding the mandible and invading the muscles of mastication. Morphological MRI findings include hypointense signal on T1, hyperintense signal on T2 and marked enhancement after intravenous gadolinium (Fig. <xref rid="Fig8" ref-type="fig">8</xref>
). In our experience, ADC values in EG are usually slightly higher than in malignant lesions (≥1.2 × 10<sup>−3</sup>
mm<sup>2</sup>
/s versus ±1 × 10<sup>−3</sup>
mm<sup>2</sup>
/s). In cases with atypical periosteal reaction and poorly defined margins, the differential diagnosis includes malignant tumours, such as osteosarcoma, Ewing sarcoma or metastases. Nevertheless, well-defined margins on CT, the high signal intensity on T2, the strong enhancement, the large area of inflammatory oedema and the moderately high ADC values rather suggest a lesion with benign histology (Fig. <xref rid="Fig8" ref-type="fig">8</xref>
). The value of MRI in patients with EG lies in its high sensitivity especially when used in conjunction with DWI [<xref ref-type="bibr" rid="CR20">20</xref>
]. PET/CT has been shown to provide valuable information for the detection of EG lesions due to their high FDG uptake (Fig. <xref rid="Fig8" ref-type="fig">8</xref>
) and it has been suggested that hybrid PET/MRI may play a pivotal role for the primary investigation of paediatric histiocytosis allowing accurate detection of multifocal multiorgan involvement and for monitoring treatment response [<xref ref-type="bibr" rid="CR20">20</xref>
]. Despite the relatively characteristic imaging findings, definitive diagnosis of EG is made on samples obtained by biopsy. Treatment modalities include surgery, chemotherapy and intralesional injection of corticosteroids.<fig id="Fig8"><label>Fig. 8</label>
<caption><p>Histologically proven eosinophilic granuloma. <bold>a</bold>
OPT-like curved thick slab reconstruction, <bold>b</bold>
axial CT bone window and (<bold>c</bold>
) 3D reconstruction from CT data set show a well-defined radiolucent lesion (<italic>arrows</italic>
) located in the angle of the mandible. Sharply delineated slightly sclerotic borders. Periosteal reaction (<italic>dashed arrow</italic>
). <bold>d</bold>
PET/CT showing that high FDG uptake within the posterior mandible and perimandibular soft tissues (<italic>arrow</italic>
). SUVmean = 6, SUVmax = 9. <bold>e</bold>
Axial T2 and <bold>f</bold>
sagittal T1 after intravenous gadolinium show a large extraosseous component (<italic>arrows</italic>
) with invasion of the masseter muscle. Close vicinity to the submandibulat gland. Note high signal intensity on T2 and strong enhancement after gadolinium. <bold>g</bold>
Fused T2 and <italic>b</italic>
1,000 showing restricted diffusion. <bold>h</bold>
ADC map showing a moderately low ADC value (ADC = 1.21 × 10<sup>−3</sup>
mm<sup>2</sup>
/s, <italic>arrow</italic>
) within the lesion. Note inflammatory oedema around the lesion with high ADC values (<italic>asterisk</italic>
)</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig8_HTML" id="d30e987"></graphic>
</fig>
</p>
</sec>
<sec id="Sec11"><title>Giant cell granuloma</title>
<p>Giant cell granuloma (GCG) is a benign but occasionally aggressive proliferative intraosseous lesion with fibrous tissue, haemorrhage and haemosiderin deposits, as well as characteristic osteoclast-like giant cells. GCG is a rare lesion occurring preferentially in young girls or women [<xref ref-type="bibr" rid="CR1">1</xref>
, <xref ref-type="bibr" rid="CR21">21</xref>
]. The posterior mandible is affected more often than the anterior mandible. Multifocal involvement is seen in hyperparathyroidism, cherubism or Noonan syndrome [<xref ref-type="bibr" rid="CR21">21</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. The most common clinical features are pain, swelling, facial asymmetry and paresthesia. Differential diagnosis includes giant cell tumour, radicular cyst, ameloblastoma, odontogenic tumour and fibrous dysplasia. The typical radiological appearance is that of a multilocular (less often unilocular) well-defined radiolucent lesion. However, ill-defined lesions have also been reported. In some cases, bone may be expanded or teeth can be displaced or resorbed. CT, CBCT and MRI are useful for describing bony involvement and for evaluating extension into the adjacent soft tissues. On MRI, GCG has a homogeneous or slightly heterogeneous intermediate signal on T1, T2 and STIR (short TI inversion recovery) and shows moderate to strong contrast enhancement after administration of gadolinium. However, it is important to note that only very few data regarding the imaging characteristics of GCG are currently available in the literature. The treatment of choice is surgery (enucleation and curettage in well-defined GCG or en bloc resection in aggressive GCG) and medical treatment (intralesional corticosteroid or calcitonin injections) [<xref ref-type="bibr" rid="CR21">21</xref>
]. Recurrence may occur in up to 15 % of cases.</p>
</sec>
</sec>
<sec id="Sec12"><title>Radiolucent lesions with ill-defined borders</title>
<sec id="Sec13"><title>Osteomyelitis</title>
<p>Despite the introduction of antibiotics and improved medical care, osteomyelitis of the jaws is still relatively common. The mandible is affected more often than the maxilla. Depending on the clinical course, osteomyelitis of the mandible can be classified into three forms: acute, secondary chronic and primary chronic [<xref ref-type="bibr" rid="CR23">23</xref>
, <xref ref-type="bibr" rid="CR24">24</xref>
]. The acute and secondary chronic forms are manifestations of the same disease entity separated by the arbitrary time limit of 1 month. These two forms are typically caused by bacterial infection in the setting of pulpal or periodontal infection, mandibular foreign bodies, sepsis or trauma. In dental infection, pulpal infection extends into the bone marrow and there is compression of blood vessels from periapical lesions. Acute forms present with severe symptoms such as pain, swelling, fever, lymphadenopathy or a mobile tooth sensitive to percussion. They may also present with paresthesia in the lower lip (V3 nerve), trismus or fistula with pus and—in advanced stages—osteomyelitis may also be revealed by pathological fractures. The chronic forms are clinically silent but often include painful periods. Predisposing factors are diabetes, immunosuppression, radiotherapy and bisphosphonates.</p>
<p>While the diagnosis of osteomyelitis can be made clinically in many cases, imaging is especially helpful to define the extent and assess the severity of the lesion. The radiological appearance of osteomyelitis depends on the stage of disease. It consists of an ill-defined osteolytic lesion (Fig. <xref rid="Fig9" ref-type="fig">9</xref>
), with bone sequestra, and—in subacute cases—is often associated sclerosis and periosteal new bone formation. CT is helpful to analyse the bone structure, to search for associated abscesses and to identify soft tissue extension (myositis, fasciitis, cellulitis). MRI findings in osteomyelitis are similar to those in osteoradionecrosis (Fig. <xref rid="Fig9" ref-type="fig">9</xref>
) and the differentiation between the two entities is based on the clinical context. MRI is more sensitive than CT in detecting marrow and soft tissue involvement [<xref ref-type="bibr" rid="CR25">25</xref>
]. In addition, MRI allows earlier diagnosis of osteomyelitis than CT, CBCT or conventional radiographs. In general, the disease extent appears larger on MRI than on CT; therefore, a combined MRI and CT assessment is most often required pre-operatively. Osteomyelitis lesions show low signal on T1, and high signal on T2 and STIR images due to oedema of the bony marrow; variable degrees of contrast enhancement of the marrow itself and of adjacent soft tissues are equally observed (Fig. <xref rid="Fig9" ref-type="fig">9</xref>
). The signal intensity of bone sequestrae, however, is very low on all sequences. Treatment consists of a combination of antibiotics and surgical debridement.<fig id="Fig9"><label>Fig. 9</label>
<caption><p>Osteomyelitis after tooth extraction. <bold>a</bold>
OPT. <bold>b</bold>
Contrast-enhanced, axial CT image with bone window settings. <bold>c</bold>
Three-dimensional reconstruction. Ill-defined osteolytic area (<italic>asterisks</italic>
) extending into the ascending ramus of the mandible, with cortical destruction (<italic>arrows</italic>
in <bold>b</bold>
and <bold>c</bold>
). <bold>d</bold>
Axial T1-weighted image before (<bold>d</bold>
) and after (<bold>e</bold>
) injection of gadolinium chelates. Hypointense signal of the mandible (<italic>arrows</italic>
in <bold>d</bold>
) due to marrow oedema and strong enhancement (<italic>arrows</italic>
in <bold>e</bold>
) due to hyperaemia. Myositis of the masseter muscle (<italic>thick dashed arrow</italic>
) and streaky enhancement of the subcutaneous fat and platysma muscle (<italic>thin dashed arrow</italic>
) suggesting a phlegmon. <bold>f</bold>
Histology (haematoxylin-eosin stain, original magnification 20×): non-viable trabeculae (<italic>large asterisks</italic>
) with bone resorption and destroyed osteoblasts. Inflammatory infiltrate (<italic>small asterisks</italic>
) with neutrophils and lymphocytes as well as increased vascularisation within the fatty marrow</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig9_HTML" id="d30e1104"></graphic>
</fig>
</p>
</sec>
<sec id="Sec14"><title>Bisphosphonate osteonecrosis</title>
<p>Bisphosphonate treatment, similar to radiotherapy, may cause bone necrosis. Bisphosphonates are widely used for the treatment of cancer-related symptoms. Their benefits consist in reducing hypercalcaemia, limiting progression of bone lesions and preventing pathological fractures in bone metastases from breast, prostate and lung cancer, as well as multiple myeloma [<xref ref-type="bibr" rid="CR26">26</xref>
]. In short, bisphosphonates are widely indicated to improve the quality of life in a large number of patients. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was defined by the American Association of Oral and Maxillofacial Surgeons (AAOMS) based on three criteria: past or current bisphosphonate treatment, osteonecrosis lasting for at least 8 weeks and no history of radiotherapy to the jaw. [<xref ref-type="bibr" rid="CR26">26</xref>
]. BRONJ most often occurs in the mandible rather than the maxilla, especially in the molar region, and is frequently triggered by a pre-existing focal lesion. Clinical features include painful swelling, signs of infection (fever, oozing pus, abscess and soft tissue inflammation) and a mobile tooth sensitive to percussion. Occasionally, there is paresthesia in the lower lip (whenever V3 is affected) or trismus. Imaging features of BRONJ are the same as for osteoradionecrosis (Fig. <xref rid="Fig10" ref-type="fig">10</xref>
). MRI can show signal changes on T1 and T2 images according to the stage of the disease. Although radiological findings are easily identified, they are non-specific and the final diagnosis is made by combining imaging findings with the clinical context [<xref ref-type="bibr" rid="CR27">27</xref>
].<fig id="Fig10"><label>Fig. 10</label>
<caption><p>Biphosphonate osteonecrosis. <bold>a</bold>
OPT; <bold>b</bold>
3D reconstruction anteo-lateral view. Contrast-enhanced axial CT image with bone window settings (<bold>c</bold>
) and soft tissue settings (<bold>d</bold>
). Poorly defined osteolytic lesion of the left mandibular body (<italic>thick white arrows</italic>
) with partly sclerotic margins (<italic>thin arrows</italic>
in <bold>a</bold>
) and large osseous defect (<italic>red arrows</italic>
in <bold>b</bold>
). Bone sequestra (<italic>dashed arrows</italic>
). Associated subperiosteal phlegmon and myositis of the platysma (<italic>open arrows</italic>
). <bold>e</bold>
Histology (haematoxylin-eosin stain, original magnification 20×): necrotic bone (<italic>large asterisk</italic>
) with inflammatory infiltration of the fatty marrow (<italic>small asterisks</italic>
). Gingival mucosa (<italic>arrows</italic>
)</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig10_HTML" id="d30e1177"></graphic>
</fig>
</p>
</sec>
<sec id="Sec15"><title>Osteoradionecrosis</title>
<p>Osteoradionecrosis (ORN) is a serious uncommon complication (2.6-15 %) of radiotherapy in head and neck cancer patients. It usually occurs 5-15 years after radiotherapy. The risk of developing ORN increases with poor oral hygiene, alcohol and tobacco use after radiotherapy, tooth extraction or periodontal disease prior to radiotherapy: ORN is also related to the nutritional status of the patient. ORN preferentially affects the molar, premolar and retromolar region. Depending on the radiation portal and the administered radiation dose, osteoradionecrosis may affect the mandible unilaterally or bilaterally. Combined treatment options (radiation therapy, surgery and chemotherapy) appear to predispose to ORN [<xref ref-type="bibr" rid="CR28">28</xref>
]. Clinical manifestations include pain, limitation of mouth opening and deep ulcerations with denuded bone. In advanced stages, trismus, fistulas and pathological fractures have also been reported. CT usually reveals a patchy radiopaque-radiolucent ill-defined lesion with cortical bone destruction, usually without periosteal reaction (Fig. <xref rid="Fig11" ref-type="fig">11</xref>
). Typical MRI findings are a mixture of marrow oedema (increased signal on T2) and marrow sclerosis (reduced signal on T2) with fragmentation of bone and sequestration (very low signal on all sequences), as well as contrast enhancement after injection of gadolinium (Fig. <xref rid="Fig12" ref-type="fig">12</xref>
). The differential diagnosis includes tumour recurrence, which can be differentiated from ORN with DWI (high ADC values in necrosis as opposed to low ADC values in tumours). The presence of a mass lesion within soft tissues does not necessarily suggest a tumour, as it may also be caused by a phlegmon, abscess or areas of fibrosis [<xref ref-type="bibr" rid="CR29">29</xref>
]. Treatment is both medical and surgical, but an important element in the management of ORN is prevention through avoidance of risk factors. The choice of treatment must take key factors, such as defect size, patient symptoms, and aesthetic and functional impairment into consideration. Medical therapy includes oral care, local debridement, nutritional follow-up, topical creams and hyperbaric oxygen therapy. If medical treatment fails, surgical management is indicated. It consists of resection of the necrotic bone and reconstruction with myocutaneous flaps [<xref ref-type="bibr" rid="CR30">30</xref>
].<fig id="Fig11"><label>Fig. 11</label>
<caption><p>CT aspect of osteoradionecrosis 5 years after radiotherapy of a floor of the mouth SCC. <bold>a</bold>
OPT. <bold>b</bold>
Axial bone window CT image. <bold>c</bold>
Three-dimensional reconstruction, posterior view obtained after removing the bony structures of the cervical spine. Characteristic osteolytic bone defect (<italic>arrows</italic>
) with poorly defined partly sclerotic margins and soft tissue ulceration (<italic>dashed arrow</italic>
). Follow-up confirmed absence of tumour</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig11_HTML" id="d30e1222"></graphic>
</fig>
<fig id="Fig12"><label>Fig. 12</label>
<caption><p>MRI aspect of osteoradionecrosis 2 years after chemoradiotherapy of a tonsillar SCC. <bold>a</bold>
Axial T1-weighted image. <bold>b</bold>
Contrast-enhanced sagittal oblique T1-weighted image and ADC map (<italic>small image</italic>
in <bold>b</bold>
). Bilateral hypointensity of the bony marrow. Large osseous defect with cortical destruction on the left (<italic>arrow</italic>
in <bold>a</bold>
). Marked, non-specific contrast enhancement, bony destruction and necrotic hypointense sequestrae (<italic>arrow</italic>
in <bold>b</bold>
). Note high ADC value (<italic>red circle</italic>
) measured at 1.53 × 10<sup>−3</sup>
mm<sup>2</sup>
/s suggesting inflammation and absent recurrence. <bold>c</bold>
Macroscopic resection specimen. The necrotic area is indicated by arrows. <bold>d</bold>
Histology (haematoxylin-eosin stain, original magnification 40×): necrotic bone trabeculae with inflammatory infiltrative changes in the bony marrow</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig12_HTML" id="d30e1272"></graphic>
</fig>
</p>
</sec>
<sec id="Sec16"><title>Osteoblastoma</title>
<p>Osteoblastoma is a mesenchymal well-vascularised benign bone tumour with production of osteoid; it involves the skull in only 10 % of cases [<xref ref-type="bibr" rid="CR31">31</xref>
]. It is uncommon and has a predilection for the posterior mandible, affecting mainly young people with a mean age below 20 years. The clinical symptoms include pain and swelling. The radiological presentation comprises an ill-defined (rarely well-defined) radiolucent or mixed radiolucent-osteosclerotic lesion. The tumour usually measures less than 4 cm and may be partially calcified. The borders are typically coarse and sclerotic (Fig. <xref rid="Fig13" ref-type="fig">13</xref>
). Osteoblastoma has an expansile growth pattern and may cause teeth displacement but typically never leads to fusion with cementoma, a feature allowing differentiation from cementoblastoma [<xref ref-type="bibr" rid="CR31">31</xref>
]. On MRI, osteoblastoma displays major contrast enhancement after injection of gadolinium chelates (Fig. <xref rid="Fig13" ref-type="fig">13</xref>
). The main differential diagnosis includes osteoid osteoma, ossifying fibroma, periapical cemental dysplasia, fibrous dysplasia, as well as other fibro-osseous lesions. Osteoid osteoma typically presents with pain and a nidus can be identified at CT or CBCT. Ossifying fibroma most commonly occurs in the posterior mandible during the 3rd–4th decades [<xref ref-type="bibr" rid="CR1">1</xref>
]. Depending on the degree of calcification, the radiological appearance includes well-defined radiolucent, radiopaque or mixed opacity lesions [<xref ref-type="bibr" rid="CR1">1</xref>
]. Commonly, a radiolucent margin is seen on CT or CBCT, allowing differentiation from fibrous dysplasia. Periapical cemental dysplasia typically occurs in women during the 4th and 5th decades. It is the consequence of connective tissue proliferation within the periodontal membrane; therefore, the lesions are typically located in vicinity of tooth apices [<xref ref-type="bibr" rid="CR1">1</xref>
]. Initially, the lesions are radiolucent and with increasing maturity, there is advanced calcification. As opposed to mandibular osteoblastoma and osteoid osteoma, many fibro-osseous lesions do not cause pain despite their large size or associated teeth displacement. In addition, the age of presentation, the multiplicity of lesions and the relationship to tooth apices are further elements that help in the differential diagnosis. The treatment of choice in osteoblastoma is surgery and recurrence is rare [<xref ref-type="bibr" rid="CR31">31</xref>
]. Some cases of spontaneous regression have been reported, especially in young patients.<fig id="Fig13"><label>Fig. 13</label>
<caption><p>Osteoblastoma. <bold>a</bold>
OPT. <bold>b</bold>
Axial CT with bone window. <bold>c</bold>
Sagittal oblique contrast-enhanced fat-saturated T1-weighted image. Ill-defined radiolucent lesion (<italic>arrows</italic>
in <bold>a</bold>
and <bold>b</bold>
) with coarse sclerotic borders and calcifications (<italic>dashed arrow</italic>
). Major contrast enhancement (<italic>arrow</italic>
in <bold>c</bold>
). <bold>d</bold>
Histology (haematoxylin-eosin stain, original magnification 64×). Osteoid and woven bone (<italic>asterisk</italic>
) with plump osteoblast-like cells (<italic>arrows</italic>
), interposed fibroblasts and some inflammatory cells</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig13_HTML" id="d30e1349"></graphic>
</fig>
</p>
</sec>
<sec id="Sec17"><title>SCC with mandibular invasion</title>
<p>SCC, also known as epidermoid carcinoma, is a malignant neoplasm arising from the mucosa of the oral cavity [<xref ref-type="bibr" rid="CR32">32</xref>
, <xref ref-type="bibr" rid="CR33">33</xref>
]. It is the most common tumour of the oral cavity and preferentially affects men over the age of 50. SCC most often occurs in the mucosa overlying the posterior mandible, and it is related to the consumption of alcohol and tobacco. It has high metastatic potential. Clinical symptoms include pain, swelling, paresthesia (due to V3 invasion) and dental disorders. In advanced stages, SCC may be discovered in the context of a pathological fracture. The radiological appearance is that of an aggressive soft-tissue lesion with invasion of the floor of the mouth, alveolar ridge or retromolar trigone [<xref ref-type="bibr" rid="CR33">33</xref>
]. In advanced stages, secondary bone invasion can occur leading to the appearance of an ill-defined radiolucent lesion of the mandible on conventional X-rays; in advanced lesions, the “floating teeth” sign may be equally observed due to extensive mandibular infiltration. On MRI, SCC displays a low to intermediate signal on T1, a moderately high signal on T2 and STIR sequences, and a moderate enhancement after injection of contrast media (Fig. <xref rid="Fig14" ref-type="fig">14</xref>
). ADC values are typically low (usually around 1–1.1 × 10<sup>−3</sup>
mm<sup>2</sup>
/s). Whenever large areas of necrosis are present within the tumour, ADC values may, however, be higher. This is particularly true in necrotic lymph node metastases (Fig. <xref rid="Fig14" ref-type="fig">14</xref>
). Lymph node metastases in SCC of the oral cavity are common, especially in level I and II nodes. On FDG PET/CT or PET/MRI, SUV values are typically high due to the high glucose metabolism (Fig. <xref rid="Fig14" ref-type="fig">14</xref>
). The final diagnosis and the pre-therapeutic work-up in SCC of the oral cavity are made by a combined clinical, imaging and histological work-up. The main role of imaging consists in precisely depicting deep tumour spread, as well as detecting lymph node and distant metastases. Surgery with or without radiotherapy is the treatment of choice. Prognosis depends on the histological type and on the presence or absence of lymph node metastases.<fig id="Fig14"><label>Fig. 14</label>
<caption><p>SCC with mandibular invasion. Precise pre-operative assessment with MRI and PET/CT. <bold>a</bold>
OPT. Poorly defined bony destruction (<italic>arrow</italic>
) of the edentulous mandible. <bold>b</bold>
Contrast-enhanced axial CT. Aggressive soft-tissue lesion (<italic>arrow</italic>
) with secondary bone invasion. <bold>c</bold>
Sagittal oblique PET/CT image. High metabolism of the tumour (<italic>black asterisk</italic>
, SUVmean = 18, SUVmax = 22) and of two metastatic level I lymph nodes (<italic>arrows</italic>
, SUVmean = 10, SUVmax = 15). <bold>d</bold>
T2-weighted axial image. Tumour (<italic>asterisk</italic>
) with marrow invasion and extensive infiltration of the floor of the mouth (<italic>dashed arrow</italic>
). Note two metastatic level I lymph nodes (<italic>arrows</italic>
). <bold>e</bold>
The <italic>b</italic>
1,000 and <bold>f</bold>
ADC map show restricted diffusion within the tumour (<italic>circle</italic>
, ADC = 0.98 × 10<sup>−3</sup>
mm<sup>2</sup>
/s). Variable ADC values within the metastatic lymph nodes due to the presence of necrosis (<italic>arrows</italic>
in <bold>f</bold>
). <bold>g</bold>
Sagittal histological whole-organ slice of the resected specimen. Tumour (<italic>dashed black line</italic>
) invading the mandible (<italic>black arrows</italic>
) and the muscles (<italic>asterisk</italic>
) of the floor of the mouth. The histological slice has the same orientation as (<bold>c</bold>
)</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig14_HTML" id="d30e1464"></graphic>
</fig>
</p>
</sec>
<sec id="Sec18"><title>Metastases</title>
<p>Metastases to the jaw are an uncommon entity, affecting the mandible more often than the maxilla [<xref ref-type="bibr" rid="CR34">34</xref>
]. The most common primaries vary depending upon gender. Lung, prostate, kidney and liver tumours are the most common primaries in men, whereas breast, adrenal, gynaecological and colorectal tumours are the most common primaries in women [<xref ref-type="bibr" rid="CR34">34</xref>
]. Typical clinical symptoms include pain (Fig. <xref rid="Fig15" ref-type="fig">15</xref>
), swelling, paresthesia, temporomandibular joint derangement, but in some cases metastases to the jaw are clinically silent and found incidentally. The radiological appearance includes ill-defined radiolucent lesions with no periosteal reaction on conventional X-rays, CT and CBCT [<xref ref-type="bibr" rid="CR35">35</xref>
]. MRI reveals moderately hyperintense masses on T2-weighted and STIR images, hypointense signal on T1-weighted images and variable degrees of contrast enhancement. In general, the surrounding soft tissues lack relevant oedema and enhancement unless tumour extension beyond the mandible has occurred (Fig. <xref rid="Fig15" ref-type="fig">15</xref>
). On PET/CT, focal areas of increased FDG uptake are typically observed and measured SUVs are high (Fig. <xref rid="Fig15" ref-type="fig">15</xref>
). Although the imaging aspect is not specific, in the presence of a patient with a history of cancer, the diagnosis of mandibular metastasis should be considered in the differential diagnosis first, particularly when the lesion shows no relationship to dental structures.<fig id="Fig15"><label>Fig. 15</label>
<caption><p>Condylar metastasis from adenocarcinoma. OPT (<bold>a</bold>
) with osteolytic ill-defined lesion of the mandibular condyle (<italic>arrow</italic>
). <bold>b</bold>
Sagittal PET/CT image shows high metabolism with SUV = 12 (<italic>arrow</italic>
). <bold>c</bold>
Axial, contrast-enhanced, fat-saturated T1-weighted image. The infiltrative, bulky lesion invades the condyle (<italic>arrow</italic>
), the internal pterygoid muscle (<italic>dashed arrow</italic>
) and part of the parotid gland (<italic>thin arrow</italic>
). <bold>d</bold>
Intraoperative view. Extensive condylar involvement. <bold>e</bold>
Histology (haematoxylin-eosin stain, original magnification 80×): large atypical polygonal cells, some with several nuclei (<italic>arrow</italic>
)</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig15_HTML" id="d30e1531"></graphic>
</fig>
</p>
</sec>
</sec>
<sec id="Sec19"><title>Pitfalls</title>
<sec id="Sec20"><title>Pseudolesions</title>
<sec id="Sec21"><title>Stafne cyst</title>
<p>Stafne cyst, also called static bone cavity or salivary gland inclusion defect, is a pseudocyst arising from bone remodelling caused by the adjacent submandibular gland. Therefore, it does not present any epithelial lining. Stafne cysts are often incidental findings, as patients are asymptomatic (Fig. <xref rid="Fig16" ref-type="fig">16</xref>
). The lesions are more common in men than in women. The radiological aspect includes ovoid, well-defined radiolucent cortical defects on the lingual surface of the posterior mandible usually measuring less than 2 cm. This location is typical and the lesion contains fat or salivary gland tissue. An OPT is sufficient for diagnosis but occasionally CT or MRI can be performed in cases of atypical presentation to exclude an ameloblastoma or a traumatic bone cyst [<xref ref-type="bibr" rid="CR2">2</xref>
]. No treatment is recommended; however, a follow-up examination at 3–6 months can be performed to ascertain lesion stability [<xref ref-type="bibr" rid="CR3">3</xref>
].<fig id="Fig16"><label>Fig. 16</label>
<caption><p>Stafne cyst discovered incidentally. <bold>a</bold>
OPT-like reconstruction from CBCT data set showing a well-defined, unilocular radiolucency (<italic>arrow</italic>
) with sclerotic borders in the region of 37 and 38. No relationship to teeth. <bold>b</bold>
Axial, <bold>c</bold>
coronal and <bold>d</bold>
3D reconstruction, posterior view. Bony defect (<italic>arrows</italic>
) in characteristic location</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig16_HTML" id="d30e1579"></graphic>
</fig>
</p>
</sec>
</sec>
<sec id="Sec22"><title>Malignant lesions mimicking benign disease</title>
<sec id="Sec23"><title>Intraosseous mucoepidermoid carcinoma</title>
<p>The vast majority of mucoepidermoid carcinomas arise within the major or minor salivary glands. Primary intraosseous mucoepidermoid carcinoma is an extremely rare tumour constituting less than 2 % of all mucoepidermoid carcinomas. It arises centrally within the angle or posterior mandible [<xref ref-type="bibr" rid="CR36">36</xref>
]. Its aetiopathogenesis is not yet completely understood. Due to the paucity of cases reported in the literature, little is known regarding age of presentation and sex distribution. Clinical features include swelling and pain, as well as trismus. Imaging features are unilocular or multilocular, well-defined lesions with sclerotic borders, mimicking a benign cyst, a keratocyst or an ameloblastoma on OPT, CT and CBCT [<xref ref-type="bibr" rid="CR37">37</xref>
]. On MRI, the cystic tumour components display a low signal on T1, a high signal on T2 and no enhancement, whereas the nodular solid tumour components present a low signal on T2 and contrast material enhancement. Extension into the muscles of mastication is common, as well as loco-regional lymph node metastases. MRI essential to narrow the differential diagnosis, as OPT and CT are non-specific. The presence of a destructive, infiltrative pattern with enhancing nodules within the cyst wall, as well as the presence of metastatic lymph nodes strongly suggests a malignant tumour, thus making biopsy mandatory.</p>
</sec>
<sec id="Sec24"><title>Primary intraosseous SCC</title>
<p>Primary intraosseous SCC is a very rare neoplasm resulting from the malignant transformation of the epithelial lining of a residual cyst, follicular cyst or a keratocyst [<xref ref-type="bibr" rid="CR13">13</xref>
, <xref ref-type="bibr" rid="CR38">38</xref>
]. In consequence, as a general rule, following enucleation of any cystic lesion in the mandible, a thorough examination of the entire surgical specimen is mandatory to exclude the possibility of an intramural SCC that may have been overlooked pre-operatively [<xref ref-type="bibr" rid="CR39">39</xref>
, <xref ref-type="bibr" rid="CR40">40</xref>
]. Primary intraosseous SCC has a predilection for men and typically occurs in the 6th–8th decade. There are less than 120 cases described in the literature. These tumours are aggressive lesions with a high metastatic potential. Due to the non-specific clinical findings, most intraosseous SCCs tend to be diagnosed at later stages. Panoramic radiographs, CT and CBCT findings mimic benign follicular cysts (Fig. <xref rid="Fig17" ref-type="fig">17</xref>
) or radicular cysts. MRI and PET/CT are the only modalities suggesting a malignant tumour. Imaging findings on MRI are similar to those of intraosseous mucoepidermoid carcinoma: solid tumour portions have lower signal on T2, whereas cystic portions display a high signal. Enhancement of solid portions is typically seen after injection of contrast material, as well as infiltration into the perimandibular soft-tissues. ADC values of solid parts are low, suggesting tumour components with high cellularity (Fig. <xref rid="Fig17" ref-type="fig">17</xref>
). On PET/CT, a high FDG uptake may be seen similar to SCC arising from the mucosa of the upper aero-digestive tract. Treatment consists of surgery with and without additional radiotherapy.<fig id="Fig17"><label>Fig. 17</label>
<caption><p>Intracystic carcinoma. <bold>a</bold>
Sagittal oblique and <bold>b</bold>
axial CBCT image displaying the characteristic aspect of a dentigerous cyst with well-defined cyst borders (<italic>arrows</italic>
). The cyst surrounds the crown of an impacted tooth. <bold>c</bold>
T2-weighted image: solid intracystic component with moderately high signal intensity (<italic>arrows</italic>
). Fluid with high signal intensity within the cyst (<italic>dashed arrow</italic>
). Oedema in the masseter muscle (<italic>asterisk</italic>
). <bold>d</bold>
ADC map with low ADC values (<italic>circle</italic>
) of solid parts (ADC = 0.89 × 10<sup>−3</sup>
mm<sup>2</sup>
/s) suggesting an intracystic malignant tumour despite the benign appearance on CBCT. Histology revealed SCC arising within a dentigerous cyst</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig17_HTML" id="d30e1660"></graphic>
</fig>
</p>
</sec>
</sec>
<sec id="Sec25"><title>Malignant lesions that may be missed on OPT</title>
<sec id="Sec26"><title>Mandibular lymphoma</title>
<p>Lymphomas are malignant tumours developed from cells of the lymphatic system and can therefore affect any organ containing lymphoid tissue. While Hodgkin lymphomas (HL) most often involve lymph nodes in the head and neck, non-Hodgkin lymphomas (NHL) can equally affect extra-nodal sites [<xref ref-type="bibr" rid="CR41">41</xref>
] such as the lacrimal glands, salivary glands, muscles and soft tissues of the orbit, thyroid gland, maxilla and mandible. Mandibular NHL is very rare. As it is frequently mistaken for dental infection, a prolonged delay in diagnosis can occur. All age groups can be affected, however adults tend to be affected more often than children. There is no gender predilection. The clinical features of mandibular NHL are not specific and include pain, jaw swelling, ulceration, tooth mobility and cervical lymphadenopathy. On panoramic views, mandibular NHLs appear as ill-defined radiolucent lesions. Despite their large size, the tumours can be easily missed on conventional X-rays (Fig. <xref rid="Fig18" ref-type="fig">18</xref>
). Radiological findings can be quite subtle such as teeth displacement in the occlusal direction and loss of the lamina dura with widening of the periodontal ligament space [<xref ref-type="bibr" rid="CR41">41</xref>
]. Rarely, mandibular NHL can present with minor osteolysis or with unilateral enlargement of the mandibular canal and mental foramen (Fig. <xref rid="Fig18" ref-type="fig">18</xref>
). Enlargement of the mandibular canal and mental foramen is rare and has been reported in neurogenic tumours affecting the inferior alveolar nerve (schwannoma and neurofibroma), in perineural spread of disease (mainly from SCC, adenoid cystic carcinoma and lymphoma) and as an anatomic variant mimicking pathology [<xref ref-type="bibr" rid="CR42">42</xref>
]. In our experience, in mandibular NHL, CT and MRI typically show minor or no destruction of the cortical bone despite extensive infiltration of the bony marrow and of the perimandibular soft tissues (Fig. <xref rid="Fig18" ref-type="fig">18</xref>
). As suggested in the literature, MRI provides superior visualisation of submucosal tumour extension and improved assessment of marrow infiltration compared with CT or CBCT [<xref ref-type="bibr" rid="CR43">43</xref>
]. Low signal on T1 and T2, homogenous contrast enhancement after injection of gadolinium chelates, absent areas of necrosis despite the large size (Fig. <xref rid="Fig18" ref-type="fig">18</xref>
) and low ADC values (typically 0.6–0.8 × 10<sup>−3</sup>
mm<sup>2</sup>
/s) are characteristic findings. On PET/CT, mandibular NHL display high FDG uptake and high SUV values (usually ≥10–15), similar to lymphomas in other locations in the body. The differential diagnosis of mandibular NHL includes other infiltrative processes such as myeloma, leukaemia and bone metastases, making biopsy mandatory for the correct histological diagnosis. Treatment in mandibular NHL is done with chemo(radio)therapy.<fig id="Fig18"><label>Fig. 18</label>
<caption><p>Mandibular NHL. <bold>a</bold>
OPT. Difficulty to accurately identify the lesion due its median and paramedian position and the typical anterior OPT artefact (<italic>arrowheads</italic>
) masking the lesion. Subtle enlargement of the right mental foramen (<italic>long arrow</italic>
) compared with the normal contralateral side (<italic>short arrow</italic>
). <bold>b</bold>
, <bold>c</bold>
T1-weighted unenhanced axial images. <bold>d</bold>
T1-weighted fat-saturated contrast-enhanced sagittal image. Large infiltrative lesion (<italic>asterisks</italic>
) extending from the vestibule through the mandible into the floor of the mouth (<italic>arrows</italic>
). The mandibular cortical rim is mostly preserved although the lesion shows diffuse marrow infiltration</p>
</caption>
<graphic xlink:href="13244_2013_298_Fig18_HTML" id="d30e1736"></graphic>
</fig>
</p>
</sec>
</sec>
</sec>
<sec id="Sec27" sec-type="conclusion"><title>Conclusions</title>
<p>The vast majority of radiolucent lesions of the mandible seen on conventional radiographs represent benign lesions that require no further work-up. Nevertheless, certain radiological features, such as large lesion size, bone scalloping, relationship to an impacted tooth or the mandibular canal, tooth resorption, as well as ill-defined lesion borders, require further radiological work-up. CT, CBCT, MRI and PET/CT are of additional help if the nature of the lesion is unclear and for the identification of those lesions, where biopsy is indicated for definitive histology.</p>
</sec>
</body>
<back><glossary><title>Abbreviations</title>
<def-list><def-item><term>ADC</term>
<def><p>Apparent diffusion coefficient</p>
</def>
</def-item>
<def-item><term>AAOMS</term>
<def><p>American Association of Oral and Maxillofacial Surgeons</p>
</def>
</def-item>
<def-item><term>BRONJ</term>
<def><p>Bisphosphonate-related osteonecrosis of the jaw</p>
</def>
</def-item>
<def-item><term>CBCT</term>
<def><p>Cone beam computed tomography</p>
</def>
</def-item>
<def-item><term>CT</term>
<def><p>Computed tomography</p>
</def>
</def-item>
<def-item><term>DWI</term>
<def><p>Diffusion-weighted imaging</p>
</def>
</def-item>
<def-item><term>EG</term>
<def><p>Eospinophilic granuloma</p>
</def>
</def-item>
<def-item><term>GCG</term>
<def><p>Giant cell granuloma</p>
</def>
</def-item>
<def-item><term>HL</term>
<def><p>Hodgkin lymphoma</p>
</def>
</def-item>
<def-item><term>KCOT</term>
<def><p>Keratocystic odontogenic tumour</p>
</def>
</def-item>
<def-item><term>LCH</term>
<def><p>Langerhans cell histiocytosis</p>
</def>
</def-item>
<def-item><term>MRI</term>
<def><p>Magnetic resonance imaging</p>
</def>
</def-item>
<def-item><term>NHL</term>
<def><p>Non-Hodgkin lymphoma</p>
</def>
</def-item>
<def-item><term>OPT</term>
<def><p>Orthopantomography</p>
</def>
</def-item>
<def-item><term>ORN</term>
<def><p>Osteoradionecrosis</p>
</def>
</def-item>
<def-item><term>PET/CT</term>
<def><p>Positron emission tomography combined with CT</p>
</def>
</def-item>
<def-item><term>PET/MRI</term>
<def><p>Positron emission tomography combined with MRI</p>
</def>
</def-item>
<def-item><term>SBC</term>
<def><p>Simple bone cyst</p>
</def>
</def-item>
<def-item><term>SCC</term>
<def><p>Squamous cell carcinoma</p>
</def>
</def-item>
<def-item><term>SUV</term>
<def><p>Standardised uptake value</p>
</def>
</def-item>
</def-list>
</glossary>
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