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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations</title>
<author><name sortKey="Rabelo, Gustavo Davi" sort="Rabelo, Gustavo Davi" uniqKey="Rabelo G" first="Gustavo Davi" last="Rabelo">Gustavo Davi Rabelo</name>
<affiliation><nlm:aff id="Aff1">UFR de Médecine Lyon-Est Domaine Laennec, INSERM UMR 1033, Université de Lyon, 7-11 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4">A. C. Camargo Cancer Center, Fundação Antonio Prudente, Rua Professor Antônio Prudente 211, São Paulo, 01509-900 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Assuncao, Jose Narciso Rosa" sort="Assuncao, Jose Narciso Rosa" uniqKey="Assuncao J" first="José Narciso Rosa" last="Assunção">José Narciso Rosa Assunção</name>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3">Santos Metropolitan University, Rua da Constituição 374, Vila Nova, Santos, 11015-470 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chavassieux, Pascale" sort="Chavassieux, Pascale" uniqKey="Chavassieux P" first="Pascale" last="Chavassieux">Pascale Chavassieux</name>
<affiliation><nlm:aff id="Aff1">UFR de Médecine Lyon-Est Domaine Laennec, INSERM UMR 1033, Université de Lyon, 7-11 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Soares, Haroldo Arid" sort="Soares, Haroldo Arid" uniqKey="Soares H" first="Haroldo Arid" last="Soares">Haroldo Arid Soares</name>
<affiliation><nlm:aff id="Aff3">Santos Metropolitan University, Rua da Constituição 374, Vila Nova, Santos, 11015-470 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alves, Fabio Abreu" sort="Alves, Fabio Abreu" uniqKey="Alves F" first="Fabio Abreu" last="Alves">Fabio Abreu Alves</name>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4">A. C. Camargo Cancer Center, Fundação Antonio Prudente, Rua Professor Antônio Prudente 211, São Paulo, 01509-900 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lemos, Celso Augusto" sort="Lemos, Celso Augusto" uniqKey="Lemos C" first="Celso Augusto" last="Lemos">Celso Augusto Lemos</name>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26225065</idno>
<idno type="pmc">4511882</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511882</idno>
<idno type="RBID">PMC:4511882</idno>
<idno type="doi">10.1007/s12663-014-0707-8</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000B17</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B17</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations</title>
<author><name sortKey="Rabelo, Gustavo Davi" sort="Rabelo, Gustavo Davi" uniqKey="Rabelo G" first="Gustavo Davi" last="Rabelo">Gustavo Davi Rabelo</name>
<affiliation><nlm:aff id="Aff1">UFR de Médecine Lyon-Est Domaine Laennec, INSERM UMR 1033, Université de Lyon, 7-11 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4">A. C. Camargo Cancer Center, Fundação Antonio Prudente, Rua Professor Antônio Prudente 211, São Paulo, 01509-900 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Assuncao, Jose Narciso Rosa" sort="Assuncao, Jose Narciso Rosa" uniqKey="Assuncao J" first="José Narciso Rosa" last="Assunção">José Narciso Rosa Assunção</name>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff3">Santos Metropolitan University, Rua da Constituição 374, Vila Nova, Santos, 11015-470 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chavassieux, Pascale" sort="Chavassieux, Pascale" uniqKey="Chavassieux P" first="Pascale" last="Chavassieux">Pascale Chavassieux</name>
<affiliation><nlm:aff id="Aff1">UFR de Médecine Lyon-Est Domaine Laennec, INSERM UMR 1033, Université de Lyon, 7-11 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Soares, Haroldo Arid" sort="Soares, Haroldo Arid" uniqKey="Soares H" first="Haroldo Arid" last="Soares">Haroldo Arid Soares</name>
<affiliation><nlm:aff id="Aff3">Santos Metropolitan University, Rua da Constituição 374, Vila Nova, Santos, 11015-470 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Alves, Fabio Abreu" sort="Alves, Fabio Abreu" uniqKey="Alves F" first="Fabio Abreu" last="Alves">Fabio Abreu Alves</name>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff4">A. C. Camargo Cancer Center, Fundação Antonio Prudente, Rua Professor Antônio Prudente 211, São Paulo, 01509-900 Brazil</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lemos, Celso Augusto" sort="Lemos, Celso Augusto" uniqKey="Lemos C" first="Celso Augusto" last="Lemos">Celso Augusto Lemos</name>
<affiliation><nlm:aff id="Aff2">Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Maxillofacial & Oral Surgery</title>
<idno type="ISSN">0972-8279</idno>
<idno type="eISSN">0974-942X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>Bisphosphonate (BP) therapy in the treatment of bone diseases and malignancy may induce a major side effect known as bisphosphonate-related osteonecrosis of the jaws (BRONJ). A particular view of this condition is reported in this case series investigating eight patients. The aim of the study was to evaluate the BRONJ lesions concerning their aspects and progression. Also, identify if it is possible to predict the degree of severity in these cases.</p>
</sec>
<sec><title>Methods</title>
<p>Patients were evaluated by their condition and systemic health. The lesions were evaluated in clinical and radiographic aspects. The patients were followed-up for 2 years.</p>
</sec>
<sec><title>Results</title>
<p>The patients presented with specific peculiarities, and the BRONJ lesions varied in several characteristics. The BRONJ lesions ranged from simple to severe conditions, and the complicated cases presented with major pain, swelling, secondary infection and an extensive necrotic area, classified with high grade of severity.</p>
</sec>
<sec><title>Conclusions</title>
<p>The patients presented here confirm the existence of a relation between multiple features and BRONJ and to understand the whole process of aggravation, all systemic and local information have to be taken into account, together with all data related to the BP utilized. Regardless of the low incidence of this side effect in relation to osteoporosis treatment, in some cases, the BRONJ may become a severe condition and compromise the patient’s quality of life.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Maxillofac Oral Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">J Maxillofac Oral Surg</journal-id>
<journal-title-group><journal-title>Journal of Maxillofacial & Oral Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">0972-8279</issn>
<issn pub-type="epub">0974-942X</issn>
<publisher><publisher-name>Springer India</publisher-name>
<publisher-loc>New Delhi</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26225065</article-id>
<article-id pub-id-type="pmc">4511882</article-id>
<article-id pub-id-type="publisher-id">707</article-id>
<article-id pub-id-type="doi">10.1007/s12663-014-0707-8</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Bisphosphonate-Related Osteonecrosis of the Jaws and Its Array of Manifestations</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Rabelo</surname>
<given-names>Gustavo Davi</given-names>
</name>
<address><phone>+55 11 3091 7902</phone>
<email>drgustavorabelo@yahoo.com.br</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
<xref ref-type="aff" rid="Aff2"></xref>
<xref ref-type="aff" rid="Aff4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Assunção</surname>
<given-names>José Narciso Rosa</given-names>
<suffix>Jr.</suffix>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chavassieux</surname>
<given-names>Pascale</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soares</surname>
<given-names>Haroldo Arid</given-names>
</name>
<xref ref-type="aff" rid="Aff3"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alves</surname>
<given-names>Fabio Abreu</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
<xref ref-type="aff" rid="Aff4"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lemos</surname>
<given-names>Celso Augusto</given-names>
<suffix>Jr.</suffix>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<aff id="Aff1"><label></label>
UFR de Médecine Lyon-Est Domaine Laennec, INSERM UMR 1033, Université de Lyon, 7-11 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France</aff>
<aff id="Aff2"><label></label>
Department of Stomatology, Faculty of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227, Cidade Universitária, São Paulo, CEP 05508-000 Brazil</aff>
<aff id="Aff3"><label></label>
Santos Metropolitan University, Rua da Constituição 374, Vila Nova, Santos, 11015-470 Brazil</aff>
<aff id="Aff4"><label></label>
A. C. Camargo Cancer Center, Fundação Antonio Prudente, Rua Professor Antônio Prudente 211, São Paulo, 01509-900 Brazil</aff>
</contrib-group>
<pub-date pub-type="epub"><day>15</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>9</month>
<year>2015</year>
</pub-date>
<volume>14</volume>
<issue>3</issue>
<fpage>699</fpage>
<lpage>705</lpage>
<history><date date-type="received"><day>17</day>
<month>3</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>19</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© The Association of Oral and Maxillofacial Surgeons of India 2014</copyright-statement>
</permissions>
<abstract id="Abs1"><sec><title>Purpose</title>
<p>Bisphosphonate (BP) therapy in the treatment of bone diseases and malignancy may induce a major side effect known as bisphosphonate-related osteonecrosis of the jaws (BRONJ). A particular view of this condition is reported in this case series investigating eight patients. The aim of the study was to evaluate the BRONJ lesions concerning their aspects and progression. Also, identify if it is possible to predict the degree of severity in these cases.</p>
</sec>
<sec><title>Methods</title>
<p>Patients were evaluated by their condition and systemic health. The lesions were evaluated in clinical and radiographic aspects. The patients were followed-up for 2 years.</p>
</sec>
<sec><title>Results</title>
<p>The patients presented with specific peculiarities, and the BRONJ lesions varied in several characteristics. The BRONJ lesions ranged from simple to severe conditions, and the complicated cases presented with major pain, swelling, secondary infection and an extensive necrotic area, classified with high grade of severity.</p>
</sec>
<sec><title>Conclusions</title>
<p>The patients presented here confirm the existence of a relation between multiple features and BRONJ and to understand the whole process of aggravation, all systemic and local information have to be taken into account, together with all data related to the BP utilized. Regardless of the low incidence of this side effect in relation to osteoporosis treatment, in some cases, the BRONJ may become a severe condition and compromise the patient’s quality of life.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Bisphosphonate</kwd>
<kwd>Cancer</kwd>
<kwd>Jaws</kwd>
<kwd>Osteonecrosis</kwd>
<kwd>Osteoporosis</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Association of Oral and Maxillofacial Surgeons of India 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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