Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Secretory Immunoglobulin A Antibodies Reactive with Streptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, and Enterococcus faecalis during the First Two Years of Life
Identifieur interne : 000A15 ( Pmc/Corpus ); précédent : 000A14; suivant : 000A16Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Secretory Immunoglobulin A Antibodies Reactive with Streptococcus mitis biovar 1, Streptococcus oralis, Streptococcus mutans, and Enterococcus faecalis during the First Two Years of Life
Auteurs : Michael F. Cole ; Stacey Bryan ; Mishell K. Evans ; Cheryl L. Pearce ; Michael J. Sheridan ; Patricia A. Sura ; Raoul L. Wientzen ; George H. W. BowdenSource :
- Infection and Immunity [ 0019-9567 ] ; 1999.
Abstract
Secretory immunoglobulin A (SIgA) antibodies reactive with the pioneer oral streptococci
Url:
PubMed: 10085031
PubMed Central: 96541
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PMC:96541Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Secretory Immunoglobulin A Antibodies Reactive with <italic>Streptococcus mitis</italic> biovar 1, <italic>Streptococcus oralis</italic>, <italic>Streptococcus mutans</italic>, and <italic>Enterococcus faecalis</italic> during the First Two Years of Life</title><author><name sortKey="Cole, Michael F" sort="Cole, Michael F" uniqKey="Cole M" first="Michael F." last="Cole">Michael F. Cole</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Bryan, Stacey" sort="Bryan, Stacey" uniqKey="Bryan S" first="Stacey" last="Bryan">Stacey Bryan</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Evans, Mishell K" sort="Evans, Mishell K" uniqKey="Evans M" first="Mishell K." last="Evans">Mishell K. Evans</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Pearce, Cheryl L" sort="Pearce, Cheryl L" uniqKey="Pearce C" first="Cheryl L." last="Pearce">Cheryl L. Pearce</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Sheridan, Michael J" sort="Sheridan, Michael J" uniqKey="Sheridan M" first="Michael J." last="Sheridan">Michael J. Sheridan</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Sura, Patricia A" sort="Sura, Patricia A" uniqKey="Sura P" first="Patricia A." last="Sura">Patricia A. Sura</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Wientzen, Raoul L" sort="Wientzen, Raoul L" uniqKey="Wientzen R" first="Raoul L." last="Wientzen">Raoul L. Wientzen</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Bowden, George H W" sort="Bowden, George H W" uniqKey="Bowden G" first="George H. W." last="Bowden">George H. W. Bowden</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10085031</idno><idno type="pmc">96541</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96541</idno><idno type="RBID">PMC:96541</idno><date when="1999">1999</date><idno type="wicri:Area/Pmc/Corpus">000A15</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Secretory Immunoglobulin A Antibodies Reactive with <italic>Streptococcus mitis</italic> biovar 1, <italic>Streptococcus oralis</italic>, <italic>Streptococcus mutans</italic>, and <italic>Enterococcus faecalis</italic> during the First Two Years of Life</title><author><name sortKey="Cole, Michael F" sort="Cole, Michael F" uniqKey="Cole M" first="Michael F." last="Cole">Michael F. Cole</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Bryan, Stacey" sort="Bryan, Stacey" uniqKey="Bryan S" first="Stacey" last="Bryan">Stacey Bryan</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Evans, Mishell K" sort="Evans, Mishell K" uniqKey="Evans M" first="Mishell K." last="Evans">Mishell K. Evans</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Pearce, Cheryl L" sort="Pearce, Cheryl L" uniqKey="Pearce C" first="Cheryl L." last="Pearce">Cheryl L. Pearce</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Sheridan, Michael J" sort="Sheridan, Michael J" uniqKey="Sheridan M" first="Michael J." last="Sheridan">Michael J. Sheridan</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Sura, Patricia A" sort="Sura, Patricia A" uniqKey="Sura P" first="Patricia A." last="Sura">Patricia A. Sura</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Wientzen, Raoul L" sort="Wientzen, Raoul L" uniqKey="Wientzen R" first="Raoul L." last="Wientzen">Raoul L. Wientzen</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author><author><name sortKey="Bowden, George H W" sort="Bowden, George H W" uniqKey="Bowden G" first="George H. W." last="Bowden">George H. W. Bowden</name><affiliation><nlm:aff id="N0x8c1f030.0x9d7de88"></nlm:aff></affiliation></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Secretory immunoglobulin A (SIgA) antibodies reactive with the pioneer oral streptococci <italic>Streptococcus mitis</italic> biovar 1 and <italic>Streptococcus oralis</italic>, the late oral colonizer <italic>Streptococcus mutans</italic>, and the pioneer enteric bacterium <italic>Enterococcus faecalis</italic> in saliva samples from 10 human infants from birth to age 2 years were analyzed. Low levels of salivary SIgA1 and SIgA2 antibodies reactive with whole cells of all four species were detected within the first month after birth, even though <italic>S. mutans</italic> and <italic>E. faecalis</italic> were not recovered from the mouths of the infants during the study period. Although there was a fivefold increase in the concentration of SIgA between birth and age 2 years, there were no differences between the concentrations of SIgA1 and SIgA2 antibodies reactive with the four species over this time period. When the concentrations of SIgA1 and SIgA2 antibodies reactive with all four species were normalized to the concentrations of SIgA1 and SIgA2 in saliva, SIgA1 and SIgA2 antibodies reactive with these bacteria showed a significant decrease from birth to 2 years of age. Adsorption of each infant’s saliva with cells of one species produced a dramatic reduction of antibodies recognizing the other three species. Sequential adsorption of saliva samples removed all SIgA antibody to the bacteria, indicating that the SIgA antibodies were directed to antigens shared by all four species. The induction by the host of a limited immune response to common antigens that are likely not involved in adherence may be among the mechanisms that commensal streptococci employ to persist in the oral cavity.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id><journal-id journal-id-type="publisher-id">INFECT IMMUN</journal-id><journal-title>Infection and Immunity</journal-title><issn pub-type="ppub">0019-9567</issn><issn pub-type="epub">1098-5522</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10085031</article-id><article-id pub-id-type="pmc">96541</article-id><article-id pub-id-type="publisher-id">1042</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbial Immunity and Vaccines</subject></subj-group></article-categories><title-group><article-title>Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Secretory Immunoglobulin A Antibodies Reactive with <italic>Streptococcus mitis</italic> biovar 1, <italic>Streptococcus oralis</italic>, <italic>Streptococcus mutans</italic>, and <italic>Enterococcus faecalis</italic> during the First Two Years of Life</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cole</surname><given-names>Michael F.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">1</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib><contrib contrib-type="author"><name><surname>Bryan</surname><given-names>Stacey</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">1</xref></contrib><contrib contrib-type="author"><name><surname>Evans</surname><given-names>Mishell K.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">1</xref></contrib><contrib contrib-type="author"><name><surname>Pearce</surname><given-names>Cheryl L.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">1</xref></contrib><contrib contrib-type="author"><name><surname>Sheridan</surname><given-names>Michael J.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">1</xref></contrib><contrib contrib-type="author"><name><surname>Sura</surname><given-names>Patricia A.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">1</xref></contrib><contrib contrib-type="author"><name><surname>Wientzen</surname><given-names>Raoul L.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">2</xref></contrib><contrib contrib-type="author"><name><surname>Bowden</surname><given-names>George H. W.</given-names></name><xref ref-type="aff" rid="N0x8c1f030.0x9d7de88">3</xref></contrib></contrib-group><aff id="N0x8c1f030.0x9d7de88"> Departments of Microbiology and Immunology<sup>1</sup> and Pediatrics,<sup>2</sup> Georgetown University Medical Center, Washington, D.C. 20007, and Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba R3E OW2, Canada<sup>3</sup></aff><contrib-group><contrib contrib-type="editor"><name><surname>Moore</surname><given-names>R. N.</given-names></name></contrib></contrib-group><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Med Dent Bldg., Rm. S.E. 308A, 3900 Reservoir Rd., N.W., Washington, DC 20007. Phone: (202) 687-1817. Fax: (202) 687-4973. E-mail: <email>colem@gunet.georgetown.edu</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>1999</year></pub-date><volume>67</volume><issue>4</issue><fpage>1878</fpage><lpage>1886</lpage><history><date date-type="received"><day>7</day><month>8</month><year>1998</year></date><date date-type="rev-request"><day>14</day><month>10</month><year>1998</year></date><date date-type="accepted"><day>12</day><month>1</month><year>1999</year></date></history><copyright-statement>Copyright © 1999, American Society for Microbiology</copyright-statement><copyright-year>1999</copyright-year><abstract><p>Secretory immunoglobulin A (SIgA) antibodies reactive with the pioneer oral streptococci <italic>Streptococcus mitis</italic> biovar 1 and <italic>Streptococcus oralis</italic>, the late oral colonizer <italic>Streptococcus mutans</italic>, and the pioneer enteric bacterium <italic>Enterococcus faecalis</italic> in saliva samples from 10 human infants from birth to age 2 years were analyzed. Low levels of salivary SIgA1 and SIgA2 antibodies reactive with whole cells of all four species were detected within the first month after birth, even though <italic>S. mutans</italic> and <italic>E. faecalis</italic> were not recovered from the mouths of the infants during the study period. Although there was a fivefold increase in the concentration of SIgA between birth and age 2 years, there were no differences between the concentrations of SIgA1 and SIgA2 antibodies reactive with the four species over this time period. When the concentrations of SIgA1 and SIgA2 antibodies reactive with all four species were normalized to the concentrations of SIgA1 and SIgA2 in saliva, SIgA1 and SIgA2 antibodies reactive with these bacteria showed a significant decrease from birth to 2 years of age. Adsorption of each infant’s saliva with cells of one species produced a dramatic reduction of antibodies recognizing the other three species. Sequential adsorption of saliva samples removed all SIgA antibody to the bacteria, indicating that the SIgA antibodies were directed to antigens shared by all four species. The induction by the host of a limited immune response to common antigens that are likely not involved in adherence may be among the mechanisms that commensal streptococci employ to persist in the oral cavity.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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