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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature</title>
<author><name sortKey="Afrogheh, Amir" sort="Afrogheh, Amir" uniqKey="Afrogheh A" first="Amir" last="Afrogheh">Amir Afrogheh</name>
<affiliation><nlm:aff id="Aff1">Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schneider, Johann" sort="Schneider, Johann" uniqKey="Schneider J" first="Johann" last="Schneider">Johann Schneider</name>
<affiliation><nlm:aff id="Aff2">Division of Anatomical Pathology, NHLS, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohamed, Noor" sort="Mohamed, Noor" uniqKey="Mohamed N" first="Noor" last="Mohamed">Noor Mohamed</name>
<affiliation><nlm:aff id="Aff2">Division of Anatomical Pathology, NHLS, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hille, Jos" sort="Hille, Jos" uniqKey="Hille J" first="Jos" last="Hille">Jos Hille</name>
<affiliation><nlm:aff id="Aff1">Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24037599</idno>
<idno type="pmc">4022942</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022942</idno>
<idno type="RBID">PMC:4022942</idno>
<idno type="doi">10.1007/s12105-013-0490-8</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000862</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000862</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature</title>
<author><name sortKey="Afrogheh, Amir" sort="Afrogheh, Amir" uniqKey="Afrogheh A" first="Amir" last="Afrogheh">Amir Afrogheh</name>
<affiliation><nlm:aff id="Aff1">Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schneider, Johann" sort="Schneider, Johann" uniqKey="Schneider J" first="Johann" last="Schneider">Johann Schneider</name>
<affiliation><nlm:aff id="Aff2">Division of Anatomical Pathology, NHLS, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mohamed, Noor" sort="Mohamed, Noor" uniqKey="Mohamed N" first="Noor" last="Mohamed">Noor Mohamed</name>
<affiliation><nlm:aff id="Aff2">Division of Anatomical Pathology, NHLS, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hille, Jos" sort="Hille, Jos" uniqKey="Hille J" first="Jos" last="Hille">Jos Hille</name>
<affiliation><nlm:aff id="Aff1">Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Head and Neck Pathology</title>
<idno type="ISSN">1936-055X</idno>
<idno type="eISSN">1936-0568</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Clear cell calcifying epithelial odontogenic tumour (CCEOT) is a rare variant of calcifying epithelial odontogenic tumor (CEOT). While it is not surprising to find clear cells in odontogenic lesions, the exact nature of the clear cells in CCEOT has not been elucidated. Herein, we report a case of peripheral CCEOT of anterior mandible in a 37 year old black female. Histologically, the tumour consisted of cords and small nests of clear cells surrounded by dense deposits of amyloid and basophilic calcifications. The cells possessed abundant clear cytoplasm and eccentrically located indented nuclei. Admixed with the clear cells were eosinophilic cuboidal to polyhedral cells. The clear cells were PAS negative and immunoreactive for S100 protein, CD1a and Langerin. The clear cells were negative for MNF-116, SMA, Desmin and CK-19. It is therefore recommended to recognize two variants of CCEOT, namely, CEOT with clear cell change and CEOT with clear Langerhans cells (LC). We further suggest that the contradictory term “<italic>non</italic>
-<italic>calcifying</italic>
variant of <italic>calcifying</italic>
epithelial odontogenic tumour with LC” to be abandoned, as the current case clearly indicates that LC could be seen in CEOT irrespective of the presence or absence of calcifications.</p>
</div>
</front>
</TEI>
<pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Head Neck Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Head Neck Pathol</journal-id>
<journal-title-group><journal-title>Head and Neck Pathology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1936-055X</issn>
<issn pub-type="epub">1936-0568</issn>
<publisher><publisher-name>Springer US</publisher-name>
<publisher-loc>Boston</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24037599</article-id>
<article-id pub-id-type="pmc">4022942</article-id>
<article-id pub-id-type="publisher-id">490</article-id>
<article-id pub-id-type="doi">10.1007/s12105-013-0490-8</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Calcifying Epithelial Odontogenic Tumour with Clear Langerhans Cells: A Novel Variant, Report of a Case and Review of the Literature</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Afrogheh</surname>
<given-names>Amir</given-names>
</name>
<address><phone>+27-21-9384085</phone>
<email>amir.afrogheh@nhls.ac.za</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schneider</surname>
<given-names>Johann</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mohamed</surname>
<given-names>Noor</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hille</surname>
<given-names>Jos</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><label></label>
Department of Oral Pathology, NHLS, Tygerberg Hospital, University of the Western Cape, Cape Town, South Africa</aff>
<aff id="Aff2"><label></label>
Division of Anatomical Pathology, NHLS, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa</aff>
</contrib-group>
<pub-date pub-type="epub"><day>14</day>
<month>9</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="collection"><month>6</month>
<year>2014</year>
</pub-date>
<volume>8</volume>
<issue>2</issue>
<fpage>214</fpage>
<lpage>219</lpage>
<history><date date-type="received"><day>27</day>
<month>6</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>6</day>
<month>9</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© Springer Science+Business Media New York 2013</copyright-statement>
</permissions>
<abstract id="Abs1"><p>Clear cell calcifying epithelial odontogenic tumour (CCEOT) is a rare variant of calcifying epithelial odontogenic tumor (CEOT). While it is not surprising to find clear cells in odontogenic lesions, the exact nature of the clear cells in CCEOT has not been elucidated. Herein, we report a case of peripheral CCEOT of anterior mandible in a 37 year old black female. Histologically, the tumour consisted of cords and small nests of clear cells surrounded by dense deposits of amyloid and basophilic calcifications. The cells possessed abundant clear cytoplasm and eccentrically located indented nuclei. Admixed with the clear cells were eosinophilic cuboidal to polyhedral cells. The clear cells were PAS negative and immunoreactive for S100 protein, CD1a and Langerin. The clear cells were negative for MNF-116, SMA, Desmin and CK-19. It is therefore recommended to recognize two variants of CCEOT, namely, CEOT with clear cell change and CEOT with clear Langerhans cells (LC). We further suggest that the contradictory term “<italic>non</italic>
-<italic>calcifying</italic>
variant of <italic>calcifying</italic>
epithelial odontogenic tumour with LC” to be abandoned, as the current case clearly indicates that LC could be seen in CEOT irrespective of the presence or absence of calcifications.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>CEOT</kwd>
<kwd>Langerhans cells</kwd>
<kwd>Immunohistochemistry</kwd>
<kwd>CD1a</kwd>
<kwd>Clear cells</kwd>
<kwd>S100</kwd>
<kwd>Non calcifying CEOT</kwd>
<kwd>Langerin</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer Science+Business Media New York 2014</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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