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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mobility and Muscle Strength Together are More Strongly Correlated with Falls in Suburb-Dwelling Older Chinese</title><author><name sortKey="Wang, Xiuyang" sort="Wang, Xiuyang" uniqKey="Wang X" first="Xiuyang" last="Wang">Xiuyang Wang</name><affiliation><nlm:aff id="a1"><institution>Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Ma, Yixuan" sort="Ma, Yixuan" uniqKey="Ma Y" first="Yixuan" last="Ma">Yixuan Ma</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Jiazhong" sort="Wang, Jiazhong" uniqKey="Wang J" first="Jiazhong" last="Wang">Jiazhong Wang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Han, Peipei" sort="Han, Peipei" uniqKey="Han P" first="Peipei" last="Han">Peipei Han</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Dong, Renwei" sort="Dong, Renwei" uniqKey="Dong R" first="Renwei" last="Dong">Renwei Dong</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Kang, Li" sort="Kang, Li" uniqKey="Kang L" first="Li" last="Kang">Li Kang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Zhang, Wen" sort="Zhang, Wen" uniqKey="Zhang W" first="Wen" last="Zhang">Wen Zhang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Shen, Suxing" sort="Shen, Suxing" uniqKey="Shen S" first="Suxing" last="Shen">Suxing Shen</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Li, Dongfang" sort="Li, Dongfang" uniqKey="Li D" first="Dongfang" last="Li">Dongfang Li</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Zhou, Maoran" sort="Zhou, Maoran" uniqKey="Zhou M" first="Maoran" last="Zhou">Maoran Zhou</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Liancheng" sort="Wang, Liancheng" uniqKey="Wang L" first="Liancheng" last="Wang">Liancheng Wang</name><affiliation><nlm:aff id="a3"><institution>Department of Rehabilitation Medicine, Tianjin Hospital</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Niu, Kaijun" sort="Niu, Kaijun" uniqKey="Niu K" first="Kaijun" last="Niu">Kaijun Niu</name><affiliation><nlm:aff id="a4"><institution>Nutritional Epidemiology Institute, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="a5"><institution>School of Public Health, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Guo, Qi" sort="Guo, Qi" uniqKey="Guo Q" first="Qi" last="Guo">Qi Guo</name><affiliation><nlm:aff id="a1"><institution>Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27146721</idno><idno type="pmc">4857074</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857074</idno><idno type="RBID">PMC:4857074</idno><idno type="doi">10.1038/srep25420</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000833</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000833</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mobility and Muscle Strength Together are More Strongly Correlated with Falls in Suburb-Dwelling Older Chinese</title><author><name sortKey="Wang, Xiuyang" sort="Wang, Xiuyang" uniqKey="Wang X" first="Xiuyang" last="Wang">Xiuyang Wang</name><affiliation><nlm:aff id="a1"><institution>Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Ma, Yixuan" sort="Ma, Yixuan" uniqKey="Ma Y" first="Yixuan" last="Ma">Yixuan Ma</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Jiazhong" sort="Wang, Jiazhong" uniqKey="Wang J" first="Jiazhong" last="Wang">Jiazhong Wang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Han, Peipei" sort="Han, Peipei" uniqKey="Han P" first="Peipei" last="Han">Peipei Han</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Dong, Renwei" sort="Dong, Renwei" uniqKey="Dong R" first="Renwei" last="Dong">Renwei Dong</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Kang, Li" sort="Kang, Li" uniqKey="Kang L" first="Li" last="Kang">Li Kang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Zhang, Wen" sort="Zhang, Wen" uniqKey="Zhang W" first="Wen" last="Zhang">Wen Zhang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Shen, Suxing" sort="Shen, Suxing" uniqKey="Shen S" first="Suxing" last="Shen">Suxing Shen</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Li, Dongfang" sort="Li, Dongfang" uniqKey="Li D" first="Dongfang" last="Li">Dongfang Li</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Zhou, Maoran" sort="Zhou, Maoran" uniqKey="Zhou M" first="Maoran" last="Zhou">Maoran Zhou</name><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Wang, Liancheng" sort="Wang, Liancheng" uniqKey="Wang L" first="Liancheng" last="Wang">Liancheng Wang</name><affiliation><nlm:aff id="a3"><institution>Department of Rehabilitation Medicine, Tianjin Hospital</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Niu, Kaijun" sort="Niu, Kaijun" uniqKey="Niu K" first="Kaijun" last="Niu">Kaijun Niu</name><affiliation><nlm:aff id="a4"><institution>Nutritional Epidemiology Institute, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="a5"><institution>School of Public Health, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author><author><name sortKey="Guo, Qi" sort="Guo, Qi" uniqKey="Guo Q" first="Qi" last="Guo">Qi Guo</name><affiliation><nlm:aff id="a1"><institution>Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation><affiliation><nlm:aff id="a2"><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></nlm:aff></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Falls are common in older adults and result in adverse outcomes. Impaired mobility and poor muscle strength have been consistently identified as the main contributors to falls. We choose three easy-to-perform tests (i.e. Timed Up and Go test (TUGT), walking speed (WS) and grip strength (GS)) in order to assess mobility and muscle strength to further define their relationship with falls. This study is cross-sectional, consisting of 1092 residents over 60-year-old; 589 were female. 204 (18.68%) participants reported falling at least once in the past year. It was found that, of the three tests evaluated independently, a TUGT < 9.1750 s had the strongest association with fewer falls. When evaluating these tests as pairs, the combination of a TUGT < 9.1750 s and a WS < 0.9963 m/s was the best protective indicator of falls after adjusting for age, sex and other variables. When evaluating all three tests in conjunction with each other, the combination of a TUGT < 9.1750 s, a WS < 0.9963 m/s, and a GS > 0.3816 was most correlated with less possibility of falls. The combination of a better TUGT performance, a stronger GS, and a slower WS is the most strongly correlated with less possibility of falls.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sattin, R W" uniqKey="Sattin R">R. W. Sattin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tinetti, M E" uniqKey="Tinetti M">M. E. Tinetti</name></author><author><name sortKey="Williams, C S" uniqKey="Williams C">C. S. Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevens, J A" uniqKey="Stevens J">J. A. Stevens</name></author><author><name sortKey="Corso, P S" uniqKey="Corso P">P. S. Corso</name></author><author><name sortKey="Finkelstein, E A" uniqKey="Finkelstein E">E. A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27146721</article-id><article-id pub-id-type="pmc">4857074</article-id><article-id pub-id-type="pii">srep25420</article-id><article-id pub-id-type="doi">10.1038/srep25420</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Mobility and Muscle Strength Together are More Strongly Correlated with Falls in Suburb-Dwelling Older Chinese</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Xiuyang</given-names></name><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Yixuan</given-names></name><xref ref-type="aff" rid="a2">2</xref><xref ref-type="author-notes" rid="n1">*</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jiazhong</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Han</surname><given-names>Peipei</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Dong</surname><given-names>Renwei</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Wen</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Shen</surname><given-names>Suxing</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Jing</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Dongfang</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Maoran</given-names></name><xref ref-type="aff" rid="a2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Liancheng</given-names></name><xref ref-type="aff" rid="a3">3</xref></contrib><contrib contrib-type="author"><name><surname>Niu</surname><given-names>Kaijun</given-names></name><xref ref-type="aff" rid="a4">4</xref><xref ref-type="aff" rid="a5">5</xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Qi</given-names></name><xref ref-type="corresp" rid="c1">a</xref><xref ref-type="aff" rid="a1">1</xref><xref ref-type="aff" rid="a2">2</xref></contrib><aff id="a1"><label>1</label><institution>Department of Rehabilitation Medicine, TEDA International Cardiovascular Hospital, Cardiovascular Clinical College of Tianjin Medical University</institution>, Tianjin,<country>China</country></aff><aff id="a2"><label>2</label><institution>Department of Rehabilitation and Sports Medicine, Tianjin Medical University</institution>, Tianjin,<country>China</country></aff><aff id="a3"><label>3</label><institution>Department of Rehabilitation Medicine, Tianjin Hospital</institution>, Tianjin,<country>China</country></aff><aff id="a4"><label>4</label><institution>Nutritional Epidemiology Institute, Tianjin Medical University</institution>, Tianjin,<country>China</country></aff><aff id="a5"><label>5</label><institution>School of Public Health, Tianjin Medical University</institution>, Tianjin,<country>China</country></aff></contrib-group><author-notes><corresp id="c1"><label>a</label><email>guoqijp@gmail.com</email></corresp><fn id="n1"><label>*</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="epub"><day>05</day><month>05</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>6</volume><elocation-id>25420</elocation-id><history><date date-type="received"><day>15</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016, Macmillan Publishers Limited</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Macmillan Publishers Limited</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link></license-p></license></permissions><abstract><p>Falls are common in older adults and result in adverse outcomes. Impaired mobility and poor muscle strength have been consistently identified as the main contributors to falls. We choose three easy-to-perform tests (i.e. Timed Up and Go test (TUGT), walking speed (WS) and grip strength (GS)) in order to assess mobility and muscle strength to further define their relationship with falls. This study is cross-sectional, consisting of 1092 residents over 60-year-old; 589 were female. 204 (18.68%) participants reported falling at least once in the past year. It was found that, of the three tests evaluated independently, a TUGT < 9.1750 s had the strongest association with fewer falls. When evaluating these tests as pairs, the combination of a TUGT < 9.1750 s and a WS < 0.9963 m/s was the best protective indicator of falls after adjusting for age, sex and other variables. When evaluating all three tests in conjunction with each other, the combination of a TUGT < 9.1750 s, a WS < 0.9963 m/s, and a GS > 0.3816 was most correlated with less possibility of falls. The combination of a better TUGT performance, a stronger GS, and a slower WS is the most strongly correlated with less possibility of falls.</p></abstract></article-meta></front><body><p>One-third of adults living independently in residential community older than 65 years falls each year<xref ref-type="bibr" rid="b1">1</xref>. Falls result in major adverse outcomes in older adults including injury, institutionalization, and death<xref ref-type="bibr" rid="b2">2</xref><xref ref-type="bibr" rid="b3">3</xref>. Because of the high rate of falls in older adults and the severe consequences of falls, it is very important to find the factors correlated with falls in older adults to help us achieve better understanding, develop a screening tool and develop prevention strategies for falls. Although various factors are correlated with falls, impaired balance and mobility have been consistently identified as the main factors<xref ref-type="bibr" rid="b4">4</xref>.</p><p>The Timed Up and Go test (TUGT) require the individual to stand up from a chair, walk 3 m, turn around, walk back to the chair and sit down again. Walking speed (WS) require participants to stand with both feet touching the starting line and to begin walking 4 m at their usual pace after a verbal command. Both TUGT and WS are two simple clinical tests usually used to measure balance and mobility. Muscle strength is also an important factor for balance and mobility ability<xref ref-type="bibr" rid="b5">5</xref><xref ref-type="bibr" rid="b6">6</xref><xref ref-type="bibr" rid="b7">7</xref>. The TUGT is commonly used as a screening tool for fall risk in community-dwelling older adults. The longer time the TUGT takes, the lower the mobility of the participant, and the higher the risk of falls<xref ref-type="bibr" rid="b8">8</xref><xref ref-type="bibr" rid="b9">9</xref>. WS is another physical index that has been found to be correlated with the risk of falls in previous studies. Many studies found quicker WS represented better mobility<xref ref-type="bibr" rid="b10">10</xref><xref ref-type="bibr" rid="b11">11</xref> and some studies even found it is better to assess functional skills like walking speed rather than the TUGT<xref ref-type="bibr" rid="b12">12</xref>. Muscle strength also plays an important role in fall prevention. Grip strength (GS) is an indicator of trunk muscle strength and lower limb muscle strength<xref ref-type="bibr" rid="b13">13</xref><xref ref-type="bibr" rid="b14">14</xref>, and can also be used to identify the risk of falling among the elderly<xref ref-type="bibr" rid="b15">15</xref>.</p><p>Although previous studies have proved these three tests may be correlated with fall risk, it hard to identify a single test that can predict the multiple factors involved in falls, and there are also studies that suggest a single tool does not have sufficient power to predict falls in independently living senior adults<xref ref-type="bibr" rid="b8">8</xref><xref ref-type="bibr" rid="b16">16</xref>. Specific diseases and impairments may also affect specific aspects of function, which may then determine the characteristics of an individual’s likelihood of falling.</p><p>Measuring with different types of measurement increases reliability<xref ref-type="bibr" rid="b17">17</xref>, thus measurement accuracy may be gained by using multiple methods to measure fall risk. However, some research found quicker WS with good muscle strength may lead to more falls than normal<xref ref-type="bibr" rid="b18">18</xref><xref ref-type="bibr" rid="b19">19</xref>, which indicates that the role WS plays could change depending on what combination of tests are used. Therefore, this study investigated suburb-dwelling older adults age ≥60 years in Hangu, Tianjin, China. In China, more than 70% of the older adults live in suburban areas. Older individuals have a relatively low level of medical treatment and display poor health<xref ref-type="bibr" rid="b20">20</xref>, which is why particular attention should be given to those living in the suburbs<xref ref-type="bibr" rid="b21">21</xref>. The purpose of this study is to discover whether the TUGT, WS, GS, or some combination of the aforementioned tests has the strongest association with falls in suburban community-dwelling older adults.</p><sec disp-level="1"><title>Materials and Method</title><sec disp-level="2"><title>Ethics statement</title><p>This research was approved by the Ethics Committee at Tianjin Medical University, and the methods were carried out in accordance with the principles of the Declaration of Helsinki. All records were anonymized and no individual information can be identified.</p></sec><sec disp-level="2"><title>Subject</title><p>Our study population consisted of residents of the Hangu area of Tianjin, China who were adults aged ≥60 years old and who had joined China’s national free physical examination program. All potential subjects were invited to participate in a comprehensive geriatric assessment. Individuals who needed assistance with their daily activities were included as long as they were able to finish the study’s tasks without assistance. If these individuals required assistance to complete the tasks, they were excluded. Cancer patients were also excluded because cancer’s progressive nature can markedly affect physical performance. Individuals with visual impairments (i.e. glaucoma, cataracts, and myopia and presbyopia that were not adequately corrected) who reported their impairments interfered with their daily activities were also excluded. Individuals taking medications that can cause falls (i.e. psychotropic drugs, cardiovascular drugs, hypoglycemic agents, non-steroidal anti-inflammatory drugs, analgesics, dopaminergic drugs, Parkinson’s disease drugs, or more than four kinds of complex drugs) in the past year were also excluded. Of those invited, 1181 agreed to participate in the survey and gave their informed written consent. 89 individuals were excluded, and the final study population consisted of 1092 subjects (average age: 67.35 ± 5.93 y; 44.23% male).</p></sec><sec disp-level="2"><title>Definition of Fall</title><p>In this study, a fall is defined as any event that results in a bodily change that forces an individual to inadvertently land on the ground or a lower level; the fall cannot be caused by a violent blow, loss of consciousness, sudden onset paralysis, or epileptic seizure. Participants reported falls by themselves and who reported at least one fall in the past 1 year were categorized as “fallers”.</p></sec><sec disp-level="2"><title>Performance-based assessment</title><p>The performance-based assessments consisted of three physical tests: the TUGT, a test evaluating WS, and a test evaluating GS. All tests were conducted by postgraduate students in the healthcare field who received special training to perform these assessments. The TUGT assesses the number of seconds needed for an individual to stand up from a chair, walk 3 m at his usual pace past a line on the floor, turn around, walk back to the chair, and sit down again with his back against the chair. WS was assessed with the 4-m walk test; participants were instructed to stand with both feet touching the starting line and to begin walking at their usual pace after a verbal command. The time between activation of the first and second photocells was recorded. The shorter time of two trials was used for analyses. The participants were allowed to use a gait-assistance device. Grip strength (kg) was used as a measure of muscle strength and was quantified using a handheld dynamometer (GRIP-D; Takei Ltd, Niigata, Japan). Participants were asked to exert their maximum effort twice using their dominant hand; the stronger grip strength was used for analyses. In this study, hand grip strength was adjusted in accordance with the participant’s body weight (GS = grip strength (kg)/body weight (kg)). Grip strength is correlated with the muscle strength of the lower limbs<xref ref-type="bibr" rid="b14">14</xref> and body size<xref ref-type="bibr" rid="b22">22</xref>, while leg strength/body weight (weight bearing index, WBI) is predictive of functional ability in older adults<xref ref-type="bibr" rid="b23">23</xref>, therefore, we used body weight to adjust grip strength in order to ensure we were evaluating muscle strength independent of body size. This method of standardization has been previously recommended in order to normalize and improve physical function testing results<xref ref-type="bibr" rid="b24">24</xref><xref ref-type="bibr" rid="b25">25</xref>.</p></sec><sec disp-level="2"><title>Assessment of other variables</title><p>All the participants were invited to a face-to-face interview to answer a standardized questionnaire after they completed their medical examination. The questionnaire included questions about age, sex, marital status, smoking habits (current smoker or not), and drinking habits (drinking alcohol once a week, drinking in the past, and never drinking were all considered as no drinking). Height and weight were recorded using a standard protocol. Body mass index was calculated as weight in kilograms divided by height in meters squared. Participants self-reported their past medical history (e.g. diabetes). The prevalence of specific medical conditions was established using standardized criteria that combined information from participants’ self-reported medical history, physicians’ diagnoses, and current and past medications and therapies. The subjects did not receive a physical exam. As described in previous literature, physical activity was assessed using the short form of the International Physical Activity Questionnaire (IPAQ) in the Chinese language<xref ref-type="bibr" rid="b26">26</xref>. We used the Geriatric Depression Scale (GDS) to evaluate the degree of depression of participants; GDS scores of 0–10 were classified as having no depression, scores of 11–20 were classified as slight depression, and scores of 21–30 were classified as moderate to severe depression. An Electrical Bioimpedance Measurement (Inbody 720, Biospace Ltd, Korea) was used to analyze participants’ body compositions including muscle mass. Quantitative ultrasound (OsteoPro UBD2002A, BMTECH. WorldWide Co., Ltd, Korea) was used to measure bone mineral density. T > −1 was defined as normal bone mineral density, −2.51 < T ≤ −1 was defined as osteopenia, and T ≤ −2.5 was defined as osteoporosis.</p></sec><sec disp-level="2"><title>Statistics</title><p>SPSS17.0 software for Windows was used for statistical analyses. Hand grip strength was standardized by weight. Chi-square tests were used for categorical variables, and ANVOA analyses were used for continuous variables to compare the faller and non-faller groups. The receiver operating characteristic curve (ROC) was used to determine the cutoff points for falls based on the TUGT, WS, and GS. Binary logistic regression analyses were used to assess the associations and interactions between a history of falling, TUGT, WS, and GS. Only age and sex were included in the logistic regression analysis in model 1, while in model 2, all variables that had significant relationships with falls were included in the logistic regression analysis. Significance was set at two-tailed P < 0.05 for Chi-square tests, ANVOA analyses and logistic regression analysis.</p></sec></sec><sec disp-level="1"><title>Result</title><sec disp-level="2"><title>Comparison of characteristics according to falls in past 12 months</title><p>There were 1092 adults (589 females and 503 males), all of whom were above 60 years of age, in this study. 204 of all participants reported falling at least once in the past year. <xref ref-type="table" rid="t1">Tables 1</xref> and <xref ref-type="table" rid="t2">2</xref> summarize the statistically significant characteristics of the faller and non-faller groups. The average age of the faller group is significantly older than the non-faller group. Older individuals have more falls (15.6% of 60–64.9 year-old, 17.2% of 65–69.9 year-old, 25.9% of 70–74.9 year-old and 26.4% older than 75 years fell in the past year). The faller group had significantly more females, more subjects with depression, and more subjects with diabetes than the non-faller group. The faller group was less likely to be living with a spouse than the non-faller group. The faller group had less muscle mass than the non-faller group. Regarding physical performance, the non-faller group took shorter time for TUGT, had stronger GS and slower walking speed than the faller group. All of the variables shown in <xref ref-type="table" rid="t1">Tables 1</xref> and <xref ref-type="table" rid="t2">2</xref> are included in model 2.</p></sec><sec disp-level="2"><title>The cutoff point of TUGT, GS and WS according to ROC curve</title><p>According to the receiver operating characteristic curve (ROC), the cutoff point of TUGT for fall is 9.7150 s, and the Area Under the Curve (AUC) is 0.609. The cutoff point of TUGT for falls increases with age: 9.05 seconds for 60–64.9 years old, 9.77 seconds for 65–69.9 years old, 9.96 seconds for 70–74.9 years old, and 10.86 seconds for 75 years or older. The cutoff point of GS for falls is 0.3816, and the AUC is 0.594. The cutoff point of WS for falls is 0.9963 m/s, and the AUC is 0.586 (<xref ref-type="table" rid="t3">Table 3</xref>). According to the cutoff points, we defined good performance on the tests as “+”, and bad performance as “−” (TUGT+: TUGT < 9.7150 s; TUGT−: TUGT > 9.7150 s; GS+: GS > 0.3816; GS−: GS < 0.3816; WS+: WS > 0.9973 m/s; WS−: WS < 0.9963 m/s).</p></sec><sec disp-level="2"><title>Logistic regression analysis of the relationship between falls and TUGT, WS, GS and their combination</title><p>Variables shown in <xref ref-type="table" rid="t1">Table 1</xref> are all included in model 2. When evaluating these tests independently, TUGT+ had the strongest association with less possibility of falls of the three physical tests results (odd ratio (OR) values of crude, model 1 and model 2 are 0.534, 0.609 and 0.622 respectively) (<xref ref-type="table" rid="t4">Table 4</xref>). When evaluating these tests as pairs, the combination of TUGT+ and GS+ has the strongest relationship with fewer falls (OR = 0.390), while in model 1 and model 2, the combination of TUGT+ and WS− has the strongest relationship with fewer falls (OR values are 0.510 and 0.555 respectively) (<xref ref-type="table" rid="t4">Table 4</xref>). When compared to the results of each test evaluated independently and in pairs, the combination of all three test results had the strongest relationship with a lower possibility of falls when TUGT+, GS+ and WS− (OR values are 0.291, 0.398 and 0.394 respectively) (<xref ref-type="table" rid="t4">Table 4</xref>).</p></sec></sec><sec disp-level="1"><title>Discussion</title><p>In our study, we examined three tests commonly used to predict falls, including the TUGT, GS and WS. The study indicated that the combination of TUGT+, GS+ and WS− is most closely correlated with fewer falls. When using only two tests, the combination of TUGT+ and WS− is most often correlated with fewer falls. When comparing three test results independently, TUGT+ was the best protective indicator of falls.</p><p>According to our study, the prevalence of falls during a single year was 18.68%, which was similar to the result in previous studies among mainly Chinese populations (between 16.3–21.3%)<xref ref-type="bibr" rid="b27">27</xref><xref ref-type="bibr" rid="b28">28</xref><xref ref-type="bibr" rid="b29">29</xref>. The prevalence of falls in female was 22.2%, and the prevalence of falls in male was 14.3%. Older age is positively correlated to falls. The rate was lower than the reported annual falls (35–40%) in community-dwelling older people in western countries<xref ref-type="bibr" rid="b30">30</xref>. Although the age and gender composition between the two groups are similar, culture, lifestyle, daily life activities, family structure and the social system may be responsibility for the difference, perhaps because older people in western countries are more independent in daily life and outdoor activities.</p><p>The TUGT has been widely adopted in both hospitalized and community-dwelling populations to measure balance and screening fall risk in older adults according to the literatures<xref ref-type="bibr" rid="b9">9</xref><xref ref-type="bibr" rid="b31">31</xref><xref ref-type="bibr" rid="b32">32</xref>. In our study, the TUGT has the best AUC for fall among the three physical tests-TUGT, GS and WS, and continued to have the strongest association with falls after adjusting for age, sex and other variables. As a short and simple clinical balance test, the success of TUGT in predicting falls is likely related to the sequencing of several important mobility skills, such as turning and sit-to-stand transitions that require balance control, as well as straight-ahead gait<xref ref-type="bibr" rid="b33">33</xref>. However, the TUGT suffers from the same limitations as the other functional clinical scales, since it is not possible to separate which balance and gait subcomponents are affected<xref ref-type="bibr" rid="b34">34</xref>. A recent systematic review and meta-analysis indicated that the TUGT is more useful at ruling out the possibility of falls rather than positively identifying individuals classified as high risk, thus demonstrating that the diagnostic accuracy of the TUGT test is limited. The literature also suggests TUGT should not be used in isolation to identify individuals at high risk of falls<xref ref-type="bibr" rid="b8">8</xref>.</p><p>The cutoff point of TUGT for falls is 9.7150 seconds in our study, while another Chinese population based study in Hong Kong found older adults who take longer than 14 seconds to complete the TUGT have a high risk for falls<xref ref-type="bibr" rid="b35">35</xref>. This difference may be caused by age. In our study, the average age of individuals was 67.35 ± 5.93 years while in of the Hong Kong study, the average age of individuals was 73.17 ± 6.26 years. Older age participants could potentially take a longer time to complete TUGT than those of younger age. Additionally, our participants were more active and independent while participants in that Hong Kong study were ambulatory cared.</p><p>Hand grip strength is an estimation of isometric strength in the upper extremity, but also correlates with strength in other muscle groups, and therefore, is considered an estimate of the overall strength<xref ref-type="bibr" rid="b22">22</xref>. Greater muscle strength can provide more stable support during walking, and previous studies show that reduced muscle strength plays an important role in falls in older adults<xref ref-type="bibr" rid="b13">13</xref><xref ref-type="bibr" rid="b14">14</xref>. Furthermore, exercises which improve muscle strength will help to reduce the fear of falls, and may have positive outcome in reducing falls in future<xref ref-type="bibr" rid="b36">36</xref>. But in our study, after adjusting for age, sex and other variables, data analysis shows that GS and falls are weakly correlated. Other randomized controlled studies also have reached the same result<xref ref-type="bibr" rid="b37">37</xref><xref ref-type="bibr" rid="b38">38</xref>. In those studies, although muscle strength increased in an exercise group, it did not result in a significant difference between the exercise group and control group in falls during the follow-up period. This may explained by the complex causes of falls. A systematic review of resistance training also suggested that muscle strengthening alone might not improve balance<xref ref-type="bibr" rid="b39">39</xref>.</p><p>In this cross-sectional study, data shows WS has no relationship with falls in older adults after adjusting for other variables. Some previous studies found slower WS could lead to an increase of falls<xref ref-type="bibr" rid="b6">6</xref><xref ref-type="bibr" rid="b11">11</xref><xref ref-type="bibr" rid="b40">40</xref>. A 20-month cohort study found that each 10 cm/s decrease in gait speed was correlated with a 7% increased risk for falls, and the cutoff point of walking speed was 0.7 m/s<xref ref-type="bibr" rid="b11">11</xref>. Our participants are comparatively younger than those of that study (67.4 years vs. 79.6 years) and the cutoff point of WS we record was 0.9963 m/s.</p><p>The fact that WS and falls are independent of one another in our study may be explained by a previous study which found there is a non-linear relationship between WS and falls. This study indicated a greater risk of outdoor falls in faster walkers and greater risk of indoor falls in slower walkers<xref ref-type="bibr" rid="b18">18</xref>. In addition, our data reaches similar conclusions. When we combined the TUGT and WS tests to study fall risk, the non-faller group shows slower WS than the faller group, which may be because the TUGT performance signifies good mobility and WS is part of the TUGT. Thus, walking speed will vary with change in mobility. For example, in older adults who have good mobility, a person who walks more carefully and slowly may have fewer chances to fall than one who is rushed. Pavol <italic>et al.</italic><xref ref-type="bibr" rid="b19">19</xref> has confirmed this in his study, which indicated individuals who had more muscle strength and a higher walking velocity had a higher risk of falling. He believes stronger muscle strength and a higher walking velocity would cause a during-step or elevating-response fall rather than an after-step fall. Given all this, one must take other mobility tests into account when using WS to study falls.</p><p>The mechanisms underlying falls are complex; for example, age, body shape, vestibular sense, proprioception, muscle strength, vision, drug use, oral health, and environment are all contributors. Similar to our result, many literature have found older age leads to more falls<xref ref-type="bibr" rid="b41">41</xref><xref ref-type="bibr" rid="b42">42</xref>. Body shape also plays an important role in falls, as Mitchell <italic>et al.</italic> found obese individuals (BMI ≥ 30 kg/m<sup>2</sup>) have a 31% higher fall risk than healthy weight participants (18.5 kg/m<sup>2</sup> ≤ BMI ≤ 24.9 kg/m<sup>2</sup>)<xref ref-type="bibr" rid="b43">43</xref>. Clear and precise vision provides the necessary information to navigate effectively through the world and to control the movement of the body, which in turn helps control upright posture. Input from the eyes is used by the central nervous system (CNS) to create a spatial map of the environment, through which we can quickly assess the speed and direction of moving objects and locate hazards in our path. With impoverished visual input, balance control and obstacle avoidance abilities become impaired due to misjudgment of distances and misinterpretation of spatial information<xref ref-type="bibr" rid="b44">44</xref>. The vestibulo-ocular reflex helps maintain visual fixation during head movements by generating compensatory short latency eye rotations. Vestibulospinal reflexes stabilize the head and help maintain upright stance, by triggering muscle activity in the neck, trunk and extremities<xref ref-type="bibr" rid="b45">45</xref>. Older people with vestibular hypofunction often have obvious impairments in posture and gait, which is characterized by postural instability and a broad-based, staggering gait pattern with unsteady turns<xref ref-type="bibr" rid="b46">46</xref>. Proprioception provides information to help coordinate each step and achieve the ideal foot placement through joint and muscle mechanoreceptors during walking, and quantitatively assessed impairments in tactile sensitivity at the ankle, vibration sense at the knee and knee joint position sense to be significant and independent risk factors for falls in a population of older people<xref ref-type="bibr" rid="b47">47</xref>. Muscle strength, drug use, oral health and environment also play an important role in falls in elderly<xref ref-type="bibr" rid="b13">13</xref><xref ref-type="bibr" rid="b14">14</xref><xref ref-type="bibr" rid="b48">48</xref><xref ref-type="bibr" rid="b49">49</xref>. TUGT, WS and GS are performance based tests. GS can partly test the function of musculoskeletal system<xref ref-type="bibr" rid="b13">13</xref><xref ref-type="bibr" rid="b14">14</xref>, while TUGT and WS are mobility and balance tests<xref ref-type="bibr" rid="b9">9</xref><xref ref-type="bibr" rid="b11">11</xref> which can be affected by internal factors for falls such as age, body shape, vestibular sense, proprioception, muscle strength and vision<xref ref-type="bibr" rid="b46">46</xref><xref ref-type="bibr" rid="b47">47</xref>. Therefore, the influence of these internal factors of falls could be addressed by our tests. On the other hand, the influence of external factors of falls, for example, environment, can’t be presented by our tests. Also further researches should focus on how these factors affect the performance based tests and lead to falls, and the influence of external factors on falls.</p><p>It is still uncertain whether a single test can adequately predict adverse outcomes in high-functioning elderly persons. Specific diseases and impairments may affect certain aspects of function and may have an identical performance. Furthermore, using multiple measures increases reliability<xref ref-type="bibr" rid="b17">17</xref>, so some measurement accuracy may be gained by using multiple methods. Certain attempts have been made before to discover if using a combination of tests would more accurately predict falls<xref ref-type="bibr" rid="b50">50</xref><xref ref-type="bibr" rid="b51">51</xref>, yet the best study is currently inconclusive. In this way, our hypothesis is that the three most widely-used simple clinical physical tests—TUGT, GS and WS—would have stronger relationship with falls when combined. The final outcome confirmed this hypothesis. In addition, studying the combined use of tests helped us understand the role of WS in falls. According to our result, we suggest practioners develop and use some combination of these three tests as a screening tool for falls in older adults. Moreover, the prevention of falls should be accessed from multiple perspectives.</p><p>Our study has several limitations. First, this is a cross-sectional study, from which it is impossible to draw a definitive causal relationship. Therefore, investigation of the validity of the combination of the TUGT, GS and WS in predicting the risk of fall in older people using a prospective study design is recommended. Secondly, our study population is suburb-dwelling older adults in Hangu, Tianjin, China, which is narrow and not representative of all elderly.</p><p>In this cross sectional study, we found that the combination of better TUGT performance, greater GS and slower WS was correlated with the lowest possibility of falls in community-dwelling older adults. Further cohort research is needed to determine if the combination of these tests can serve as a simple but effective screening tool for fall risk. 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Q.G., J.W., L.W. and K.N. conceived and designed research. Y.M., P.H., R.D. and L.K. analyzed the data. W.Z. and S.S. discussed the results. J.W., D.L. and M.Z. did the most research. All authors reviewed the manuscript.</p></fn></fn-group></back><floats-group><table-wrap position="float" id="t1"><label>Table 1</label><caption><title>Comparison of characteristics according to falls in past 12 months (only shows the statistically significant data).</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50">Variables</th><th align="center" valign="top" charoff="50">Fall (n = 204)</th><th align="center" valign="top" charoff="50">Not fall (n = 888)</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">Sex, female, n (%)</td><td align="center" valign="top" charoff="50">135 (66.18)</td><td align="center" valign="top" charoff="50">474 (53.39)</td></tr><tr><td align="left" valign="top" charoff="50">Age (years)</td><td align="center" valign="top" charoff="50">68.91 ± 5.93</td><td align="center" valign="top" charoff="50">66.96 ± 5.92</td></tr><tr><td align="left" valign="top" charoff="50">Height (cm)</td><td align="center" valign="top" charoff="50">161.34 ± 9.16</td><td align="center" valign="top" charoff="50">163.24 ± 9.16</td></tr><tr><td align="left" valign="top" charoff="50">Cohabit with spouse, n (%)</td><td align="center" valign="top" charoff="50">152 (74.51)</td><td align="center" valign="top" charoff="50">720 (81.08)</td></tr><tr><td align="left" valign="top" charoff="50">Diabetes, n (%)</td><td align="center" valign="top" charoff="50">37 (18.10)</td><td align="center" valign="top" charoff="50">103 (11.60)</td></tr><tr><td colspan="3" align="left" valign="top" charoff="50">GDS degree, n (%)</td></tr><tr><td align="left" valign="top" charoff="50"> None</td><td align="center" valign="top" charoff="50">169 (82.76)</td><td align="center" valign="top" charoff="50">832 (93.67)</td></tr><tr><td align="left" valign="top" charoff="50"> Slight depression</td><td align="center" valign="top" charoff="50">32 (15.76)</td><td align="center" valign="top" charoff="50">52 (5.88)</td></tr><tr><td align="left" valign="top" charoff="50"> Moderate to severe depression</td><td align="center" valign="top" charoff="50">3 (1.48)</td><td align="center" valign="top" charoff="50">4 (0.45)</td></tr><tr><td align="left" valign="top" charoff="50"> Muscle mass (kg/m<sup>2</sup>)</td><td align="center" valign="top" charoff="50">6.84 ± 1.03</td><td align="center" valign="top" charoff="50">7.07 ± 1.52</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>GDS: Geriatric Depression Scale.</p></fn><fn id="t1-fn2"><p>Continuous variable are presented as mean ± SD, categorical variable are represented as number (%).</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t2"><label>Table 2</label><caption><title>Comparison of physical performance tests according to falls in past 12 months.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50">Variables</th><th align="center" valign="top" charoff="50">Fall (n = 204)</th><th align="center" valign="top" charoff="50">Not fall (n = 888)</th><th align="center" valign="top" charoff="50">P value</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">GS</td><td align="center" valign="top" charoff="50">0.35 ± 0.12</td><td align="center" valign="top" charoff="50">0.40 ± 0.12</td><td align="center" valign="top" charoff="50"><0.05</td></tr><tr><td align="left" valign="top" charoff="50">TUGT (s)</td><td align="center" valign="top" charoff="50">10.99 ± 4.62</td><td align="center" valign="top" charoff="50">9.65 ± 2.51</td><td align="center" valign="top" charoff="50"><0.05</td></tr><tr><td align="left" valign="top" charoff="50">WS (m/s)</td><td align="center" valign="top" charoff="50">0.95 ± 0.20</td><td align="center" valign="top" charoff="50">1.03 ± 0.20</td><td align="center" valign="top" charoff="50"><0.05</td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><p>GS: grip strength/weight; TUGT: timed up and go test; WS: walking speed. Variable are presented as mean ± SD.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t3"><label>Table 3</label><caption><title>Cutoff point of TUGT, GS and WS according to ROC curve.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50">Variable</th><th align="center" valign="top" charoff="50">Cutoff point</th><th align="center" valign="top" charoff="50">Sensibility</th><th align="center" valign="top" charoff="50">Specificity</th><th align="center" valign="top" charoff="50">AUC</th><th align="center" valign="top" charoff="50">95%CI</th><th align="center" valign="top" charoff="50">P value</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">TUGT</td><td align="center" valign="top" charoff="50">9.7150</td><td align="center" valign="top" charoff="50">0.578</td><td align="center" valign="top" charoff="50">0.577</td><td align="center" valign="top" charoff="50">0.609</td><td align="center" valign="top" charoff="50">0.566–0.652</td><td align="center" valign="top" charoff="50"><0.05</td></tr><tr><td align="left" valign="top" charoff="50">GS</td><td align="center" valign="top" charoff="50">0.3816</td><td align="center" valign="top" charoff="50">0.549</td><td align="center" valign="top" charoff="50">0.547</td><td align="center" valign="top" charoff="50">0.594</td><td align="center" valign="top" charoff="50">0.551–0.637</td><td align="center" valign="top" charoff="50"><0.05</td></tr><tr><td align="left" valign="top" charoff="50">WS</td><td align="center" valign="top" charoff="50">0.9963</td><td align="center" valign="top" charoff="50">0.561</td><td align="center" valign="top" charoff="50">0.566</td><td align="center" valign="top" charoff="50">0.586</td><td align="center" valign="top" charoff="50">0.541–0.632</td><td align="center" valign="top" charoff="50"><0.05</td></tr></tbody></table><table-wrap-foot><fn id="t3-fn1"><p>GS: grip strength/weight; TUGT: timed up and go test; WS: walking speed.</p></fn></table-wrap-foot></table-wrap><table-wrap position="float" id="t4"><label>Table 4</label><caption><title>Logistic regression analysis of the relationship between falls and TUGT, WS, GS and their combination.</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th rowspan="2" align="left" valign="bottom" charoff="50">Variables</th><th rowspan="2" align="center" valign="bottom" charoff="50">Faller, n (%)</th><th colspan="2" align="center" valign="top" charoff="50">Crude<hr></hr></th><th colspan="2" align="center" valign="top" charoff="50">Model 1<hr></hr></th><th colspan="2" align="center" valign="top" charoff="50">Model 2<hr></hr></th></tr><tr><th align="center" valign="top" charoff="50">OR</th><th align="center" valign="top" charoff="50">95%CI</th><th align="center" valign="top" charoff="50">OR</th><th align="center" valign="top" charoff="50">95%CI</th><th align="center" valign="top" charoff="50">OR</th><th align="center" valign="top" charoff="50">95%CI</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50">TUGT+</td><td align="center" valign="top" charoff="50">86 (14.38)</td><td align="center" valign="top" charoff="50">0.534<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.392–0.726</td><td align="center" valign="top" charoff="50">0.609</td><td align="center" valign="top" charoff="50">0.444–0.837</td><td align="center" valign="top" charoff="50">0.622<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.436–0.889</td></tr><tr><td align="left" valign="top" charoff="50">GS+</td><td align="center" valign="top" charoff="50">88 (15.25)</td><td align="center" valign="top" charoff="50">0.662<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.487–0.900</td><td align="center" valign="top" charoff="50">0.971</td><td align="center" valign="top" charoff="50">0.673–1.400</td><td align="center" valign="top" charoff="50">1.063</td><td align="center" valign="top" charoff="50">0.703–1.607</td></tr><tr><td align="left" valign="top" charoff="50">WS+</td><td align="center" valign="top" charoff="50">88 (15.02)</td><td align="center" valign="top" charoff="50">0.598<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.439–0.813</td><td align="center" valign="top" charoff="50">0.844</td><td align="center" valign="top" charoff="50">0.577–1.120</td><td align="center" valign="top" charoff="50">0.908</td><td align="center" valign="top" charoff="50">0.628–1.131</td></tr><tr><td align="left" valign="top" charoff="50">TUGT−, GS+</td><td align="center" valign="top" charoff="50">45 (18.99)</td><td align="center" valign="top" charoff="50">0.635<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.416–0.971</td><td align="center" valign="top" charoff="50">0.945</td><td align="center" valign="top" charoff="50">0.587–1.521</td><td align="center" valign="top" charoff="50">0.940</td><td align="center" valign="top" charoff="50">0.554–1.595</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, GS−</td><td align="center" valign="top" charoff="50">43 (16.73)</td><td align="center" valign="top" charoff="50">0.506<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.331–0.773</td><td align="center" valign="top" charoff="50">0.574<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.372–0.885</td><td align="center" valign="top" charoff="50">0.563<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.341–0.930</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, GS+</td><td align="center" valign="top" charoff="50">43 (15.61)</td><td align="center" valign="top" charoff="50">0.390<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.256–0.593</td><td align="center" valign="top" charoff="50">0.623<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.389–0.996</td><td align="center" valign="top" charoff="50">0.702</td><td align="center" valign="top" charoff="50">0.412–1.193</td></tr><tr><td align="left" valign="top" charoff="50">TUGT−, WS+</td><td align="center" valign="top" charoff="50">34 (17.62)</td><td align="center" valign="top" charoff="50">0.556<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.355–0.871</td><td align="center" valign="top" charoff="50">0.725</td><td align="center" valign="top" charoff="50">0.455–1.155</td><td align="center" valign="top" charoff="50">0.858</td><td align="center" valign="top" charoff="50">0.519–1.419</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, WS−</td><td align="center" valign="top" charoff="50">32 (15.61)</td><td align="center" valign="top" charoff="50">0.481<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.306–0.758</td><td align="center" valign="top" charoff="50">0.510<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.322–0.808</td><td align="center" valign="top" charoff="50">0.555<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.325–0.949</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, WS+</td><td align="center" valign="top" charoff="50">54 (13.74)</td><td align="center" valign="top" charoff="50">0.415<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.283–0.608</td><td align="center" valign="top" charoff="50">0.573<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.380–0.864</td><td align="center" valign="top" charoff="50">0.645</td><td align="center" valign="top" charoff="50">0.406–1.027</td></tr><tr><td align="left" valign="top" charoff="50">WS−, GS+</td><td align="center" valign="top" charoff="50">37 (17.62)</td><td align="center" valign="top" charoff="50">0.620<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.400–0.961</td><td align="center" valign="top" charoff="50">0.747</td><td align="center" valign="top" charoff="50">0.475–1.174</td><td align="center" valign="top" charoff="50">0.794</td><td align="center" valign="top" charoff="50">0.475–1.327</td></tr><tr><td align="left" valign="top" charoff="50">WS+, GS−</td><td align="center" valign="top" charoff="50">37 (18.31)</td><td align="center" valign="top" charoff="50">0.712</td><td align="center" valign="top" charoff="50">0.458–1.107</td><td align="center" valign="top" charoff="50">0.956</td><td align="center" valign="top" charoff="50">0.593–1.539</td><td align="center" valign="top" charoff="50">0.956</td><td align="center" valign="top" charoff="50">0.554–1.649</td></tr><tr><td align="left" valign="top" charoff="50">WS+, GS+</td><td align="center" valign="top" charoff="50">51 (13.64)</td><td align="center" valign="top" charoff="50">0.483<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.326–0.715</td><td align="center" valign="top" charoff="50">0.836</td><td align="center" valign="top" charoff="50">0.526–1.330</td><td align="center" valign="top" charoff="50">0.981</td><td align="center" valign="top" charoff="50">0.587–1.641</td></tr><tr><td align="left" valign="top" charoff="50">TUGT−, GS−, WS+</td><td align="center" valign="top" charoff="50">17 (26.98)</td><td align="center" valign="top" charoff="50">0.869</td><td align="center" valign="top" charoff="50">0.461–1.638</td><td align="center" valign="top" charoff="50">0.984</td><td align="center" valign="top" charoff="50">0.516–1.877</td><td align="center" valign="top" charoff="50">1.176</td><td align="center" valign="top" charoff="50">0.581–2.380</td></tr><tr><td align="left" valign="top" charoff="50">TUGT−, GS+, WS−</td><td align="center" valign="top" charoff="50">28 (25.93)</td><td align="center" valign="top" charoff="50">0.929</td><td align="center" valign="top" charoff="50">0.544–1.586</td><td align="center" valign="top" charoff="50">1.298</td><td align="center" valign="top" charoff="50">0.732–2.301</td><td align="center" valign="top" charoff="50">1.208</td><td align="center" valign="top" charoff="50">0.636–2.294</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, GS−, WS−</td><td align="center" valign="top" charoff="50">23 (20.91)</td><td align="center" valign="top" charoff="50">0.632</td><td align="center" valign="top" charoff="50">0.363–1.100</td><td align="center" valign="top" charoff="50">0.676</td><td align="center" valign="top" charoff="50">0.385–1.187</td><td align="center" valign="top" charoff="50">0.724</td><td align="center" valign="top" charoff="50">0.379–1.383</td></tr><tr><td align="left" valign="top" charoff="50">TUGT−, GS+, WS+</td><td align="center" valign="top" charoff="50">17 (13.18)</td><td align="center" valign="top" charoff="50">0.402<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.221–0.733</td><td align="center" valign="top" charoff="50">0.690</td><td align="center" valign="top" charoff="50">0.732–2.301</td><td align="center" valign="top" charoff="50">0.779</td><td align="center" valign="top" charoff="50">0.384–1.577</td></tr><tr><td align="left" valign="top" charoff="50">TUGT−, GS−, WS+</td><td align="center" valign="top" charoff="50">20 (31.75)</td><td align="center" valign="top" charoff="50">0.396<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.225–0.698</td><td align="center" valign="top" charoff="50">0.500</td><td align="center" valign="top" charoff="50">0.358–1.327</td><td align="center" valign="top" charoff="50">0.476<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.238–0.952</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, GS+, WS−</td><td align="center" valign="top" charoff="50">9 (9.57)</td><td align="center" valign="top" charoff="50">0.291<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.136–0.621</td><td align="center" valign="top" charoff="50">0.398<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.279–0.897</td><td align="center" valign="top" charoff="50">0.394<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.153–0.996</td></tr><tr><td align="left" valign="top" charoff="50">TUGT+, GS+, WS+</td><td align="center" valign="top" charoff="50">34 (13.88)</td><td align="center" valign="top" charoff="50">0.416<xref ref-type="fn" rid="t4-fn6">*</xref></td><td align="center" valign="top" charoff="50">0.257–0.672</td><td align="center" valign="top" charoff="50">0.747</td><td align="center" valign="top" charoff="50">0.433–1.290</td><td align="center" valign="top" charoff="50">0.867</td><td align="center" valign="top" charoff="50">0.472–1.594</td></tr></tbody></table><table-wrap-foot><fn id="t4-fn1"><p>GS: grip strength/weight; TUGT: timed up and go test; WS: walking speed.</p></fn><fn id="t4-fn2"><p>Model 1adjusted age and sex.</p></fn><fn id="t4-fn3"><p>Model 2 adjusted variables in Model 1 and height, cohabit with spouse, GDS, diabetes and muscle mass.</p></fn><fn id="t4-fn4"><p>TUGT+: TUGT < 9.7150 s; TUGT−: TUGT > 9.7150 s; GS+: GS > 0.3816; GS−: GS < 0.3816; WS+: WS > 0.9973 m/s; WS−: WS < 0.9963 m/s</p></fn><fn id="t4-fn5"><p>OR: odd ratio; CI: confidence Interval.</p></fn><fn id="t4-fn6"><p><sup>*</sup>means P < 0.05.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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