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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lateral Ridge Augmentation with Autogenous Bone Harvested Using Trephine Drills: A Noninvasive Technique</title><author><name sortKey="Arab, H R" sort="Arab, H R" uniqKey="Arab H" first="H. R." last="Arab">H. R. Arab</name><affiliation><nlm:aff id="aff1">Dental Research Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Moeintaghavi, A" sort="Moeintaghavi, A" uniqKey="Moeintaghavi A" first="A." last="Moeintaghavi">A. Moeintaghavi</name><affiliation><nlm:aff id="aff2">Maxillofacial Disease Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Taheri, M" sort="Taheri, M" uniqKey="Taheri M" first="M." last="Taheri">M. Taheri</name><affiliation><nlm:aff id="aff1">Dental Research Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Sargolzaie, N" sort="Sargolzaie, N" uniqKey="Sargolzaie N" first="N." last="Sargolzaie">N. Sargolzaie</name><affiliation><nlm:aff id="aff3">Dental Material Research Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Aghasizadeh, D" sort="Aghasizadeh, D" uniqKey="Aghasizadeh D" first="D." last="Aghasizadeh">D. Aghasizadeh</name><affiliation><nlm:aff id="aff4">Dental School, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Shiezadeh, F" sort="Shiezadeh, F" uniqKey="Shiezadeh F" first="F." last="Shiezadeh">F. Shiezadeh</name><affiliation><nlm:aff id="aff5">Department of Periodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27006718</idno><idno type="pmc">4780509</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780509</idno><idno type="RBID">PMC:4780509</idno><idno type="doi">10.2174/1874210601610010001</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000745</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000745</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lateral Ridge Augmentation with Autogenous Bone Harvested Using Trephine Drills: A Noninvasive Technique</title><author><name sortKey="Arab, H R" sort="Arab, H R" uniqKey="Arab H" first="H. R." last="Arab">H. R. Arab</name><affiliation><nlm:aff id="aff1">Dental Research Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Moeintaghavi, A" sort="Moeintaghavi, A" uniqKey="Moeintaghavi A" first="A." last="Moeintaghavi">A. Moeintaghavi</name><affiliation><nlm:aff id="aff2">Maxillofacial Disease Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Taheri, M" sort="Taheri, M" uniqKey="Taheri M" first="M." last="Taheri">M. Taheri</name><affiliation><nlm:aff id="aff1">Dental Research Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Sargolzaie, N" sort="Sargolzaie, N" uniqKey="Sargolzaie N" first="N." last="Sargolzaie">N. Sargolzaie</name><affiliation><nlm:aff id="aff3">Dental Material Research Center, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Aghasizadeh, D" sort="Aghasizadeh, D" uniqKey="Aghasizadeh D" first="D." last="Aghasizadeh">D. Aghasizadeh</name><affiliation><nlm:aff id="aff4">Dental School, Mashhad University of Medical Sciences, Iran</nlm:aff></affiliation></author><author><name sortKey="Shiezadeh, F" sort="Shiezadeh, F" uniqKey="Shiezadeh F" first="F." last="Shiezadeh">F. Shiezadeh</name><affiliation><nlm:aff id="aff5">Department of Periodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran</nlm:aff></affiliation></author></analytic><series><title level="j">The Open Dentistry Journal</title><idno type="eISSN">1874-2106</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose:</title><p>The aim of this pilot study was to evaluate the
success rate of a chairside ridge augmentation procedure using bone autografts
harvested with trephine drills and placed without the use of screws.</p></sec><sec><title>Methods:</title><p>Thirty patients were recruited for the study. After the
surgical site was anesthetized and a crestal incision was made, an envelope flap
was retracted using blunt dissection limited to the graft site, and the
periosteum was raised intact and undamaged from the bone. The flap was extended
laterally to obtain sufficient space for the bone graft. At the donor site, bone
was obtained from the external oblique ridge area. A #5 or #6 trephine drill was
used to harvest one or two pieces of bone. The bone blocks were placed inside
the envelope flap at the recipient site, which was then sutured and covered with
periodontal dressing. Antibiotics, analgesics, and mouthwash were prescribed.
Measurements of ridge width were performed using CBCT before and 3 months after
surgery. The pre- and post operative results were compared using paired t test.</p></sec><sec><title>Results:</title><p>Pre- and post-operative mean ridge widths were 2.23 ±
0.79 and 5.16 ± 0.68 mm, respectively. The mean increase in width was 2.92 ±
0.89 mm(<italic>P</italic> < 0.001).</p></sec><sec><title>Conclusion:</title><p>This non-invasive and
simple technique provided an acceptable increase in ridge width. As the sample
was small, we recommend further clinical investigation with larger samples to
confirm that this technique may be used successfully as an alternative to
current invasive augmentation methods.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fu, J H" uniqKey="Fu J">J.H. Fu</name></author><author><name sortKey="Wang, H L" uniqKey="Wang H">H.L. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acocella, A" uniqKey="Acocella A">A. Acocella</name></author><author><name sortKey="Bertolai, R" uniqKey="Bertolai R">R. Bertolai</name></author><author><name sortKey="Colafranceschi, M" uniqKey="Colafranceschi M">M. Colafranceschi</name></author><author><name sortKey="Sacco, R" uniqKey="Sacco R">R. Sacco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Misch, C M" uniqKey="Misch C">C.M. Misch</name></author><author><name sortKey="Misch, C E" uniqKey="Misch C">C.E. Misch</name></author><author><name sortKey="Resnik, R R" uniqKey="Resnik R">R.R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Open Dent J</journal-id><journal-id journal-id-type="iso-abbrev">Open Dent J</journal-id><journal-id journal-id-type="publisher-id">TODENTJ</journal-id><journal-title-group><journal-title>The Open Dentistry Journal</journal-title></journal-title-group><issn pub-type="epub">1874-2106</issn><publisher><publisher-name>Bentham Open</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27006718</article-id><article-id pub-id-type="pmc">4780509</article-id><article-id pub-id-type="publisher-id">TODENTJ-10-1</article-id><article-id pub-id-type="doi">10.2174/1874210601610010001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Lateral Ridge Augmentation with Autogenous Bone Harvested Using Trephine Drills: A Noninvasive Technique</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Arab</surname><given-names>H. R.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Moeintaghavi</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Taheri</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sargolzaie</surname><given-names>N.</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Aghasizadeh</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Shiezadeh</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Dental Research Center, Mashhad University of Medical Sciences, Iran</aff><aff id="aff2"><label>2</label>Maxillofacial Disease Center, Mashhad University of Medical Sciences, Iran</aff><aff id="aff3"><label>3</label>Dental Material Research Center, Mashhad University of Medical Sciences, Iran</aff><aff id="aff4"><label>4</label>Dental School, Mashhad University of Medical Sciences, Iran</aff><aff id="aff5"><label>5</label>Department of Periodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran</aff><author-notes><corresp id="cor1"><label>*</label>Address correspondence to this author at the Department of Periodontics, Dental School, Mashhad University of Medical Sciences, Vakilabad Blvd., Mashhad, Iran; Tel: 0098 511 6012189; Fax: 0098 511 8829500;
E-mail:
<email xlink:href="Moeentaghavia@mums.ac.ir">Moeentaghavia@mums.ac.ir</email></corresp></author-notes><pub-date pub-type="epub"><day>29</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>10</volume><fpage>1</fpage><lpage>11</lpage><history><date date-type="received"><day>25</day><month>12</month><year>2014</year></date><date date-type="rev-recd"><day>9</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>10</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© Arab <italic>et al.</italic> ; Licensee <italic>Bentham Open.</italic></copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Arab</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/legalcode"><license-p>This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0)
(<uri xlink:type="simple" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/legalcode">https://creativecommons.org/licenses/by-nc/4.0/legalcode</uri>), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the
work is properly cited. </license-p></license></permissions><abstract><sec><title>Purpose:</title><p>The aim of this pilot study was to evaluate the
success rate of a chairside ridge augmentation procedure using bone autografts
harvested with trephine drills and placed without the use of screws.</p></sec><sec><title>Methods:</title><p>Thirty patients were recruited for the study. After the
surgical site was anesthetized and a crestal incision was made, an envelope flap
was retracted using blunt dissection limited to the graft site, and the
periosteum was raised intact and undamaged from the bone. The flap was extended
laterally to obtain sufficient space for the bone graft. At the donor site, bone
was obtained from the external oblique ridge area. A #5 or #6 trephine drill was
used to harvest one or two pieces of bone. The bone blocks were placed inside
the envelope flap at the recipient site, which was then sutured and covered with
periodontal dressing. Antibiotics, analgesics, and mouthwash were prescribed.
Measurements of ridge width were performed using CBCT before and 3 months after
surgery. The pre- and post operative results were compared using paired t test.</p></sec><sec><title>Results:</title><p>Pre- and post-operative mean ridge widths were 2.23 ±
0.79 and 5.16 ± 0.68 mm, respectively. The mean increase in width was 2.92 ±
0.89 mm(<italic>P</italic> < 0.001).</p></sec><sec><title>Conclusion:</title><p>This non-invasive and
simple technique provided an acceptable increase in ridge width. As the sample
was small, we recommend further clinical investigation with larger samples to
confirm that this technique may be used successfully as an alternative to
current invasive augmentation methods.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Augmentation</kwd><kwd>autogenous bone</kwd><kwd>bone graft</kwd><kwd>implant</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Endosseous implants have become a trusted treatment modality for completely or partially edentulous patients. In recent years, patients and doctors have become more aware of the favorable aesthetic and functional characteristics of implants, which necessitate implant placement in the prosthetic, rather than surgical, position. Prosthetic implantation requires the presence of sufficient high-quality bone.</p><p>The presence of teeth preserves the alveolar processes of the maxilla and mandible, and natural bone resorption begins following tooth loss. Severe resorption may prohibit implant placement in the prosthetic position, necessitating a ridge augmentation procedure to obtain sufficient bone [<xref rid="R1" ref-type="bibr">1</xref>]. Several previous studies have evaluated the success of implant placement after ridge augmentation [<xref rid="R2" ref-type="bibr">2</xref>-<xref rid="R4" ref-type="bibr">4</xref>]. Various techniques have been introduced for lateral ridge augmentation, as a procedure performed simultaneously with implantation or as a separate surgery [<xref rid="R5" ref-type="bibr">5</xref>-<xref rid="R7" ref-type="bibr">7</xref>]. Although these techniques have had high success rates, they are usually invasive and expensive. Autografts harvested intra- or extraorally, in block or particulated form, have been recommended as the best materials for this procedure specially for limited ridge augmentations. They can be obtained in a number of ways and from several donor sites. In an animal study, Von Arx <italic>et al.</italic> observed greater ridge enlargement (horizontal bone gain) at autograft + expanded polytetrafluoroethylene sites than at sites prepared with other materials [<xref rid="R8" ref-type="bibr">8</xref>]. Maiorana <italic>et al.</italic> covered autogenous corticocancellous onlay graft with a thin layer of anorganic bovine bone granules and collagen membrane to reduce graft resorbtion. Histomorphometric analaysis showed proposed technique was able to maintain the original bone volume of the blocks [<xref rid="R9" ref-type="bibr">9</xref>]. </p><p>Laino <italic>et al.</italic> studied bone formation in atrophic posterior mandibles augmented by autologous bone block harvested from chin and compared this technique with corticocancellous bone block allograft. Histological analysis showed no statistically significant differences between the two groups regarding the percentage of newly formed bone [<xref rid="R10" ref-type="bibr">10</xref>].In an examination of donor-site morbidity in bone harvesting from the iliac crest, Cricchio and Lundgren observed a high success rate but prolonged complications in more than 25% of patients. Steigmann <italic>et al.</italic> proposed periosteal pocket flap for horizontal bone regeneration and reported periosteal pocket flap design could be a predictable alternative flap approach for correction of severe or localized horizontal bone deficiencies [<xref rid="R11" ref-type="bibr">11</xref>]. </p><p>The use of growth factors such as recombinant human bone morphogenic protein-2 (rhBMP-2) impregnated with absorbable collagen sponge and titanium mesh showed good result in treating of large bone defects [<xref rid="R12" ref-type="bibr">12</xref>].</p><p>Cicciue <italic>et al.</italic> developed a new bone technique reconstruction not involving autogenous bone graft. they used rhBMP-2 with carrier consisted of an absorbable collagen sponge and reported excellent newly formed bone of treated area [<xref rid="R13" ref-type="bibr">13</xref>].</p><p>Because routine ridge augmentation techniques are complicated and the materials are expensive and require lengthy healing periods, we aimed in this pilot study to evaluate changes in the alveolar ridge following a new chairside ridge augmentation procedure using autografts harvested with trephine drills and placed without screws.</p></sec><sec sec-type="materials|methods"><title>MATERIALS AND METHODS</title><sec><title>Patient Selection</title><p>This “before and after” quasi-experimental interventional study involved 30 patients referred to the Department of Implantology, Mashhad Dental School, Iran. The institutional review board of Mashhad Dental School and the ethical review board of the Mashad University of Medical Sciences approved this study, and all participants provided written informed consent. The medical protocol and ethical considerations followed the guidelines of the Declaration of Helsinki. The study protocol was registered in the Iran Registry of Clinical Trials (<uri xlink:type="simple" xlink:href="www.irct.ir">www.irct.ir</uri>; ID: IRCT138902201601N3). Selection criteria were: 1) lack of contra-indication to dental implant placement or oral surgery; 2) suitable occlusal relationships at the implant placement site; 3) lack of periodontal disease or infection in any other teeth, especially around the treatment site; 4) sufficient bone height but insufficient width at the treatment site; and 5) absence of a single tooth.</p></sec><sec><title>Surgical Procedure</title><p>In the present study, the recipient sites were limited in size, and trephine drills (Fig. <bold><xref ref-type="fig" rid="F1">1</xref></bold>) were used to obtain bone grafts. Primary evaluations were performed by cone beam computed tomography (CBCT; Fig. <bold><xref ref-type="fig" rid="F2">2</xref></bold>). After anesthetizing the operation site with lidocaine (1:100000; Daroopakhsh,Tehran, Iran), a crestal incision was performed. A second practitioner measured bone width. An envelope flap was retracted using blunt dissection to limit it to the graft site, with no excessive extension (Fig. <bold><xref ref-type="fig" rid="F3">3</xref></bold>). The periosteum was raised, intact and undamaged, from the bone. The flap was extended laterally to obtain sufficient space for the bone graft, and no vertical incision was made. Bone was obtained from the external oblique ridge area. A buccal sulcular incision was made to expose the donor site from the distal end of the first molar to the distal aspect of the second (or third, if present) molar (Fig. <bold><xref ref-type="fig" rid="F4">4</xref></bold>). A #5 or #6 trephine drill (Hager & Meisinger GmbH, Neuss, Germany) was used as needed to harvest one or two pieces of bone (Fig. <bold><xref ref-type="fig" rid="F5">5</xref></bold>).</p><p>Next, the donor site was sutured and compressed with damp gauze sponge. The bone blocks were placed inside the envelope flap at the recipient site (Fig. <bold><xref ref-type="fig" rid="F6">6</xref></bold>). In some cases, the shape of the bone graft was adjusted to enhance its adaptation to the recipient site. Due to the limited extension of the flap and the orderly setting of the bone blocks, the use of screws to secure the bone grafts in place was not necessary.</p><p>The recipient site was then sutured and covered with periodontal dressing (Coe-pak; GC America,IL, USA). From 24 h prior to the operation, patients were administered amoxicillin (500 mg) every 6 h, and the treatment continued for 5-7 days. Chlorhexidine mouthwash (0.2% solution) was prescribed for 2 weeks to all patients. Patients were also prescribed acetaminophen plus codeine one tablet each 4-6 hours(300 mg Acetaminophen+10 mg Codeine phosphate, Abidi Co, Tehran, Iran). Sutures were removed 1 week postoperatively. Three months later, another CBCT examination was performed, the recipient site was reopened, bone width was measured (Figs. <bold><xref ref-type="fig" rid="F7">7</xref></bold>-<bold><xref ref-type="fig" rid="F9">9</xref></bold>), and the implants were placed (Fig. <bold><xref ref-type="fig" rid="F10">10</xref></bold>).</p></sec><sec><title>Statistical Analysis</title><p>The Kolmogorov-Smirnov test was used to evaluate the normality of data. As data distribution was normal, the paired <italic>t</italic>-test was used to assess mean changes in bone width.</p></sec></sec><sec><title>RESULTS </title><p>The study sample comprised 17 women and 13 men (mean age, 45.6 ± 5.3 years). Five patients were excluded from the study due to graft failure (<italic>n</italic> = 2; one man and one woman) or refusal to continue the study (<italic>n</italic> = 3). The results of the remaining 25 patients were analyzed. Table <bold><xref ref-type="table" rid="T1">1</xref></bold> shows pre- and post-treatment bone widths. The mean preoperative and postoperative ridge widths were 2.23 ± 0.79 mm and 5.16 ± 0.68 mm, respectively. The mean increase in ridge width (2.92 ±0.89 mm) was significant (<italic>P</italic> < .001, <italic>t</italic> = 16.383; Table <bold><xref ref-type="table" rid="T2">2</xref></bold>, Fig. <bold><xref ref-type="fig" rid="F11">11</xref></bold>). </p><p>In cases in which the periosteum was damaged during flap elevation, the bone grafts were partially resorbed. However, We were able to place implants after 3 months in all cases.</p><p>Figs. (<bold><xref ref-type="fig" rid="F12">12</xref></bold> and <bold><xref ref-type="fig" rid="F13">13</xref></bold>) show different patients treated with this technique. As this was a pilot study and we did not calculate the adequate sample size, we calculated the power of our finding and it was 85%.</p></sec><sec><title>DISCUSSION </title><p>Titanium endosseous implants have become a successful treatment for tooth loss and are predictably associated with a good prognosis. In some cases, implant placement is difficult or even impossible due to bone resorption. In such situations, the use of bone grafts, especially autogenous grafts, is an excellent solution with many advantages. </p><p>Autografts are considered to be the gold standard for bone transplantation because they are osteogenic, osteoconductive, and osteoinductive [<xref rid="R14" ref-type="bibr">14</xref>]. Autografts can be taken from an extraoral (<italic>e.g.</italic>, eggs, iliac crest) or intraoral (<italic>e.g.</italic>, chin or ramus) source. Although they are highly advantageous due to a minimal or no risk of infectious disease transmission [<xref rid="R15" ref-type="bibr">15</xref>] and lack of immune response after grafting [<xref rid="R16" ref-type="bibr">16</xref>], routine autogenous bone harvesting techniques (especially those at extraoral sites) are associated with risks such as donor-site morbidity, limited bone availability, drooping of the chin, paresthesia due to nerve damage, tooth devitalization, gingival recession, increased postoperative discomfort, infection, and blood loss [<xref rid="R17" ref-type="bibr">17</xref>].</p><p>However, one disadvantage of autogenous bone grafts is that they require two simultaneous surgeries. This study was performed to evaluate a simple method for ridge augmentation in limited edentulous areas involving the harvest of bone grafts from the external oblique ridge. Verdugoe <italic>et al.</italic> evaluated bone graft donor sites in different areas of the mandible and found that the second and third molar regions could provide high-quality bone with a mean thickness of 2.8 ± 0.6 mm [<xref rid="R18" ref-type="bibr">18</xref>]. The technique described in the present study was a simple, non-aggressive operation beginning with the elevation of an envelope flap limited to the edentulous area. Bone blocks harvested with trephine drills were placed into the envelope, with no need for fixation. </p><p>In routine procedures, the recipient site is decorticated to enhance the blood supply. Such decortication is not necessary with the novel method described here because the bone blocks are small. If the periosteum remains undisturbed, it can provide sufficient nutrients for the graft. As it was mentioned before, in cases of periostal damage during flap elevation, the bone grafts were resorbed.</p><p>We think that the simplicity and the lack of a need for recipient site decortication or screw fixation in this technique, are its main advantages. The significant increase in mean bone width observed in this study was comparable to the results of studies which have been performed on the other more difficult techniques. For instance, Acocella <italic>et al.</italic> (2009) used bone blocks obtained from the mandibular ramus for lateral augmentation and reported a 4 ± 0.77 mm increase in ridge width [<xref rid="R2" ref-type="bibr">2</xref>]. Funaki <italic>et al.</italic> used distraction osteogenesis and bisection techniques to increase ridge width by 2.7 and 1.7 mm, respectively [<xref rid="R19" ref-type="bibr">19</xref>]. Another advantage of this technique is the shorter time required for complete healing. We were able to place implants after 3 months in all cases, whereas a healing period of at least 4-5 months before implant placement is recommended following other graft techniques [<xref rid="R20" ref-type="bibr">20</xref>,<xref rid="R21" ref-type="bibr"> 21</xref>]. Rapid vascularization of the bone block is essential for successful remodeling and new bone formation [<xref rid="R22" ref-type="bibr">22</xref>].Revascularization of cortical transplants begins 6 days after graft placement and is completed in 1-2 months [<xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R24" ref-type="bibr"> 24</xref>]. The short healing time observed in this study seems sensible, as the bone blocks were small. </p><p>This study has several limitations. First, the sample was small, although the power of the results was 92%. Second, because we were attempting to prove the principles of this easy technique, we did not perform comparison with another group; like conventional grafting using fixed bone graft to such analysis should be conducted in the context of a larger trial. Lack of graft fixation using screws, can be considered as the main advantage because it simplifies this technique, on the other hand it might have some deleterious effects on bone healing and undesired consequences due to graft movement. We used a limited envelope flap to retain the grafted blocks in proper position</p></sec><sec sec-type="conclusion"><title>CONCLUSION</title><p>This pilot study demonstrated that this non-invasive and simple method provides an acceptable increase in ridge width. As our sample was small, we recommend further clinical investigation with larger samples to confirm that this technique may be used successfully as an alternative to current, invasive augmentation methods. 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</p></caption><graphic xlink:href="TODENTJ-10-1_F1"></graphic></fig><fig id="F2" position="float"><label>Fig. (2)</label><caption><p>Cone beam computed tomographic image of the recipient site before surgery.</p></caption><graphic xlink:href="TODENTJ-10-1_F2"></graphic></fig><fig id="F3" position="float"><label>Fig. (3)</label><caption><p>Crestal incision and insufficient bone at the recipient site.</p></caption><graphic xlink:href="TODENTJ-10-1_F3"></graphic></fig><fig id="F4" position="float"><label>Fig. (4)</label><caption><p>Incision at the donor site.</p></caption><graphic xlink:href="TODENTJ-10-1_F4"></graphic></fig><fig id="F5" position="float"><label>Fig. (5)</label><caption><p>Harvest of bone blocks from the external oblique ridge.</p></caption><graphic xlink:href="TODENTJ-10-1_F5"></graphic></fig><fig id="F6" position="float"><label>Fig. (6)</label><caption><p>Placement of bone blocks at the recipient site.</p></caption><graphic xlink:href="TODENTJ-10-1_F6"></graphic></fig><fig id="F7" position="float"><label>Fig. (7)</label><caption><p>Recipient site 3 months after surgery.
</p></caption><graphic xlink:href="TODENTJ-10-1_F7"></graphic></fig><fig id="F8" position="float"><label>Fig. (8)</label><caption><p>Cone beam computed tomographic image of the recipient site 3 months postoperatively.
</p></caption><graphic xlink:href="TODENTJ-10-1_F8"></graphic></fig><fig id="F9" position="float"><label>Fig. (9)</label><caption><p>Augmented ridge.
</p></caption><graphic xlink:href="TODENTJ-10-1_F9"></graphic></fig><fig id="F10" position="float"><label>Fig. (10)</label><caption><p>Implant placement.
</p></caption><graphic xlink:href="TODENTJ-10-1_F10"></graphic></fig><fig id="F11" position="float"><label>Fig. (11)</label><caption><p>Box plot showing bone width before and after augmentation.
</p></caption><graphic xlink:href="TODENTJ-10-1_F11"></graphic></fig><fig id="F12" position="float"><label>Fig. (12)</label><caption><p>Same patient after 6 years.
</p></caption><graphic xlink:href="TODENTJ-10-1_F12"></graphic></fig><fig id="F13" position="float"><label>Fig. (13)</label><caption><p>Radiographic images of the patient at baseline (<bold>A</bold>) and after 6 years (<bold>B</bold>).
</p></caption><graphic xlink:href="TODENTJ-10-1_F13"></graphic></fig><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Pre- and postoperative volumetric data for all patients.</p></caption><table frame="border" rules="all" width="100%"><thead><tr><th align="center" rowspan="1" colspan="1">Patient</th><th align="center" rowspan="1" colspan="1">Preoperative bone width (mm)</th><th align="center" rowspan="1" colspan="1">Postoperative bone width (mm)</th></tr></thead><tbody><tr><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">2.9</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">4</td><td align="center" rowspan="1" colspan="1">0.75</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">5</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">7</td></tr><tr><td align="center" rowspan="1" colspan="1">6</td><td align="center" rowspan="1" colspan="1">1.5</td><td align="center" rowspan="1" colspan="1">6</td></tr><tr><td align="center" rowspan="1" colspan="1">7</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">8</td><td align="center" rowspan="1" colspan="1">2.9</td><td align="center" rowspan="1" colspan="1">4</td></tr><tr><td align="center" rowspan="1" colspan="1">9</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">4</td></tr><tr><td align="center" rowspan="1" colspan="1">10</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">45</td></tr><tr><td align="center" rowspan="1" colspan="1">11</td><td align="center" rowspan="1" colspan="1">1.5</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">12</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">4.5</td></tr><tr><td align="center" rowspan="1" colspan="1">13</td><td align="center" rowspan="1" colspan="1">3.5</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">14</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">15</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">16</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">17</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">18</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">4.5</td></tr><tr><td align="center" rowspan="1" colspan="1">19</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">20</td><td align="center" rowspan="1" colspan="1">3</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">21</td><td align="center" rowspan="1" colspan="1">1</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">22</td><td align="center" rowspan="1" colspan="1">2</td><td align="center" rowspan="1" colspan="1">4.5</td></tr><tr><td align="center" rowspan="1" colspan="1">23</td><td align="center" rowspan="1" colspan="1">1.75</td><td align="center" rowspan="1" colspan="1">5</td></tr><tr><td align="center" rowspan="1" colspan="1">24</td><td align="center" rowspan="1" colspan="1">2.5</td><td align="center" rowspan="1" colspan="1">5.5</td></tr><tr><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">3.5</td><td align="center" rowspan="1" colspan="1">6</td></tr></tbody></table></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Comparison of pre- and post-operation bone width.</p></caption><table frame="border" rules="all" width="100%"><thead><tr><th align="center" rowspan="1" colspan="1">Ridge width</th><th align="center" rowspan="1" colspan="1">Number of samples</th><th align="center" rowspan="1" colspan="1">Mean<break></break>(mm)</th><th align="center" rowspan="1" colspan="1">SD</th><th align="center" rowspan="1" colspan="1">T</th><th align="center" rowspan="1" colspan="1">Pv</th></tr></thead><tbody><tr><td align="center" rowspan="1" colspan="1">Pre-operation</td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">2.232</td><td align="center" rowspan="1" colspan="1">0.7945</td><td rowspan="3" align="center" colspan="1">16.383</td><td rowspan="3" align="center" colspan="1">0.000</td></tr><tr><td align="center" rowspan="1" colspan="1">Post-operation</td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">5.160</td><td align="center" rowspan="1" colspan="1">0.6879</td></tr><tr><td align="center" rowspan="1" colspan="1">Difference</td><td align="center" rowspan="1" colspan="1">25</td><td align="center" rowspan="1" colspan="1">2.928</td><td align="center" rowspan="1" colspan="1">0.8936</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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