The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study
Identifieur interne : 000736 ( Pmc/Corpus ); précédent : 000735; suivant : 000737The development of proliferative verrucous leukoplakia in oral lichen planus. A preliminary study
Auteurs : María-José Garcia-Pola ; Santiago Llorente-Pendás ; Manuel González-Garcia ; José-Manuel García-MartínSource :
- Medicina Oral, Patología Oral y Cirugía Bucal [ 1698-4447 ] ; 2016.
Abstract
Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus.
The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years.
The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma.
Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin.
Url:
DOI: 10.4317/medoral.20832
PubMed: 27031060
PubMed Central: 4867206
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PMC:4867206Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The development of proliferative verrucous leukoplakia
in oral lichen planus. A preliminary study</title><author><name sortKey="Garcia Pola, Maria Jose" sort="Garcia Pola, Maria Jose" uniqKey="Garcia Pola M" first="María-José" last="Garcia-Pola">María-José Garcia-Pola</name><affiliation><nlm:aff id="A1">Associate Professor of Oral Medicine. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</nlm:aff></affiliation></author><author><name sortKey="Llorente Pendas, Santiago" sort="Llorente Pendas, Santiago" uniqKey="Llorente Pendas S" first="Santiago" last="Llorente-Pendás">Santiago Llorente-Pendás</name><affiliation><nlm:aff id="A2">Medical Doctor. Oral and Maxillofacial Surgeon. Private practice of Oral and Maxillofacial Surgery. Medical Director of Head and Neck Center. Pérez de la Sala 37.33007. Oviedo. Spain</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Garcia, Manuel" sort="Gonzalez Garcia, Manuel" uniqKey="Gonzalez Garcia M" first="Manuel" last="González-Garcia">Manuel González-Garcia</name><affiliation><nlm:aff id="A3">Assistant Professor of Oral and Maxillofacial Surgery. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</nlm:aff></affiliation></author><author><name sortKey="Garcia Martin, Jose Manuel" sort="Garcia Martin, Jose Manuel" uniqKey="Garcia Martin J" first="José-Manuel" last="García-Martín">José-Manuel García-Martín</name><affiliation><nlm:aff id="A4">Assistant Professor of Oral Health & Preventive Dentistry. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27031060</idno><idno type="pmc">4867206</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867206</idno><idno type="RBID">PMC:4867206</idno><idno type="doi">10.4317/medoral.20832</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000736</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000736</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The development of proliferative verrucous leukoplakia
in oral lichen planus. A preliminary study</title><author><name sortKey="Garcia Pola, Maria Jose" sort="Garcia Pola, Maria Jose" uniqKey="Garcia Pola M" first="María-José" last="Garcia-Pola">María-José Garcia-Pola</name><affiliation><nlm:aff id="A1">Associate Professor of Oral Medicine. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</nlm:aff></affiliation></author><author><name sortKey="Llorente Pendas, Santiago" sort="Llorente Pendas, Santiago" uniqKey="Llorente Pendas S" first="Santiago" last="Llorente-Pendás">Santiago Llorente-Pendás</name><affiliation><nlm:aff id="A2">Medical Doctor. Oral and Maxillofacial Surgeon. Private practice of Oral and Maxillofacial Surgery. Medical Director of Head and Neck Center. Pérez de la Sala 37.33007. Oviedo. Spain</nlm:aff></affiliation></author><author><name sortKey="Gonzalez Garcia, Manuel" sort="Gonzalez Garcia, Manuel" uniqKey="Gonzalez Garcia M" first="Manuel" last="González-Garcia">Manuel González-Garcia</name><affiliation><nlm:aff id="A3">Assistant Professor of Oral and Maxillofacial Surgery. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</nlm:aff></affiliation></author><author><name sortKey="Garcia Martin, Jose Manuel" sort="Garcia Martin, Jose Manuel" uniqKey="Garcia Martin J" first="José-Manuel" last="García-Martín">José-Manuel García-Martín</name><affiliation><nlm:aff id="A4">Assistant Professor of Oral Health & Preventive Dentistry. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</nlm:aff></affiliation></author></analytic><series><title level="j">Medicina Oral, Patología Oral y Cirugía Bucal</title><idno type="ISSN">1698-4447</idno><idno type="eISSN">1698-6946</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus.</p></sec><sec><title>Material and Methods</title><p>The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years.</p></sec><sec><title>Results</title><p>The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma.</p></sec><sec><title>Conclusions</title><p>Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin.</p><p><bold>Key words:</bold>Oral lichen planus, proliferative verrucous oral leukoplakia, malignant oral lichen planus, multifocal verrucous oral lichen planus, proliferative verrucous oral lichen planus.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Der Meij, Eh" uniqKey="Van Der Meij E">EH van der Meij</name></author><author><name sortKey="Van Der Waal, I" uniqKey="Van Der Waal I">I van der Waal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Axell, T" uniqKey="Axell T">T Axéll</name></author><author><name sortKey="Pindborg, Jj" uniqKey="Pindborg J">JJ Pindborg</name></author><author><name sortKey="Smith, Cj" uniqKey="Smith C">CJ Smith</name></author><author><name sortKey="Van Der Waal, I" uniqKey="Van Der Waal I">I van der Waal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisen, D" uniqKey="Eisen D">D Eisen</name></author><author><name sortKey="Carrozo, M" uniqKey="Carrozo M">M Carrozo</name></author><author><name sortKey="Bagan Sebastian, Jv" uniqKey="Bagan Sebastian J">JV Bagan Sebastian</name></author><author><name sortKey="Thongprasom, K" uniqKey="Thongprasom K">K Thongprasom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voute, Ab" uniqKey="Voute A">AB Voûte</name></author><author><name sortKey="De Jong, Wf" uniqKey="De Jong W">WF de Jong</name></author><author><name sortKey="Schulten, Ea" uniqKey="Schulten E">EA Schulten</name></author><author><name sortKey="Snow, Gb" uniqKey="Snow G">GB Snow</name></author><author><name sortKey="Van Der Waal, I" uniqKey="Van Der Waal I">I van der Waal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitzpatrick, Sg" uniqKey="Fitzpatrick S">SG Fitzpatrick</name></author><author><name sortKey="Hirsch, Sa" uniqKey="Hirsch S">SA Hirsch</name></author><author><name sortKey="Gordon, Sc" uniqKey="Gordon S">SC Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eisen, D" uniqKey="Eisen D">D Eisen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tovaru, S" uniqKey="Tovaru S">S Tovaru</name></author><author><name sortKey="Parlatescu, O" uniqKey="Parlatescu O">O Parlatescu</name></author><author><name sortKey="Gheorhe, C" uniqKey="Gheorhe C">C Gheorhe</name></author><author><name sortKey="Tovaru, M" uniqKey="Tovaru M">M Tovaru</name></author><author><name sortKey="Costache, M" uniqKey="Costache M">M Costache</name></author><author><name sortKey="Sardella, M" uniqKey="Sardella M">M Sardella</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xue, Jl" uniqKey="Xue J">JL Xue</name></author><author><name sortKey="Fan, Mw" uniqKey="Fan M">MW Fan</name></author><author><name sortKey="Wang, Sz" uniqKey="Wang S">SZ Wang</name></author><author><name sortKey="Chen, Xm" uniqKey="Chen X">XM Chen</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermejo Fenoll, A" uniqKey="Bermejo Fenoll A">A Bermejo-Fenoll</name></author><author><name sortKey="Sanchez Siles, M" uniqKey="Sanchez Siles M">M Sanchez-Siles</name></author><author><name sortKey="L Pez Jornet, P" uniqKey="L Pez Jornet P">P López-Jornet</name></author><author><name sortKey="Camacho Alonso, F" uniqKey="Camacho Alonso F">F Camacho-Alonso</name></author><author><name sortKey="Salazar Sanchez, N" uniqKey="Salazar Sanchez N">N Salazar-Sánchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mignogna, Md" uniqKey="Mignogna M">MD Mignogna</name></author><author><name sortKey="Lo Muzio, L" uniqKey="Lo Muzio L">L Lo Muzio</name></author><author><name sortKey="Lo Russo, L" uniqKey="Lo Russo L">L Lo Russo</name></author><author><name sortKey="Fedele, S" uniqKey="Fedele S">S Fedele</name></author><author><name sortKey="Ruoppo, E" uniqKey="Ruoppo E">E Ruoppo</name></author><author><name sortKey="Bucci, E" uniqKey="Bucci E">E Bucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lanfranchi Tizeira, He" uniqKey="Lanfranchi Tizeira H">HE Lanfranchi-Tizeira</name></author><author><name sortKey="Aguas, Sc" uniqKey="Aguas S">SC Aguas</name></author><author><name sortKey="Sano, Sm" uniqKey="Sano S">SM Sano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carbone, M" uniqKey="Carbone M">M Carbone</name></author><author><name sortKey="Arduino, Pg" uniqKey="Arduino P">PG Arduino</name></author><author><name sortKey="Carrozo, M" uniqKey="Carrozo M">M Carrozo</name></author><author><name sortKey="Gandolfo, S" uniqKey="Gandolfo S">S Gandolfo</name></author><author><name sortKey="Argiolas, Mr" uniqKey="Argiolas M">MR Argiolas</name></author><author><name sortKey="Bertolusso, G" uniqKey="Bertolusso G">G Bertolusso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hansen, Ls" uniqKey="Hansen L">LS Hansen</name></author><author><name sortKey="Olson, Ja" uniqKey="Olson J">JA Olson</name></author><author><name sortKey="Silverman, S Jr" uniqKey="Silverman S">S Jr Silverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bagan, Jv" uniqKey="Bagan J">JV Bagán</name></author><author><name sortKey="Jimenez Soriano, Y" uniqKey="Jimenez Soriano Y">Y Jiménez-Soriano</name></author><author><name sortKey="Diaz Fernandez, Jm" uniqKey="Diaz Fernandez J">JM Diaz-Fernandez</name></author><author><name sortKey="Murillo Cortes, J" uniqKey="Murillo Cortes J">J Murillo-Cortés</name></author><author><name sortKey="Sanchis Bielsa, Jm" uniqKey="Sanchis Bielsa J">JM Sanchis-Bielsa</name></author><author><name sortKey="Poveda Roda, R" uniqKey="Poveda Roda R">R Poveda-Roda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghazali, N" uniqKey="Ghazali N">N Ghazali</name></author><author><name sortKey="Bakri, Mm" uniqKey="Bakri M">MM Bakri</name></author><author><name sortKey="Zain, Rb" uniqKey="Zain R">RB Zain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gandolfo, S" uniqKey="Gandolfo S">S Gandolfo</name></author><author><name sortKey="Castellani, R" uniqKey="Castellani R">R Castellani</name></author><author><name sortKey="Pentenero, M" uniqKey="Pentenero M">M Pentenero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerero Lapiedra, R" uniqKey="Cerero Lapiedra R">R Cerero-Lapiedra</name></author><author><name sortKey="Balade Martinez, D" uniqKey="Balade Martinez D">D Baladé-Martínez</name></author><author><name sortKey="Moreno L Pez, La" uniqKey="Moreno L Pez L">LA Moreno-López</name></author><author><name sortKey="Esparza G Mez, G" uniqKey="Esparza G Mez G">G Esparza-Gómez</name></author><author><name sortKey="Bagan, Jv" uniqKey="Bagan J">JV Bagán</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kramer, Ir" uniqKey="Kramer I">IR Kramer</name></author><author><name sortKey="Lucas, Rb" uniqKey="Lucas R">RB Lucas</name></author><author><name sortKey="Pindborg, Jj" uniqKey="Pindborg J">JJ Pindborg</name></author><author><name sortKey="Sobin, Lh" uniqKey="Sobin L">LH Sobin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Chias, B" uniqKey="Garcia Chias B">B Garcia-Chias</name></author><author><name sortKey="Casado De La Cruz, L" uniqKey="Casado De La Cruz L">L Casado-De La Cruz</name></author><author><name sortKey="Esparza G Mez, Gc" uniqKey="Esparza G Mez G">GC Esparza-Gómez</name></author><author><name sortKey="Cerero Lapiedra, R" uniqKey="Cerero Lapiedra R">R Cerero-Lapiedra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morton, Th" uniqKey="Morton T">TH Morton</name></author><author><name sortKey="Cabay, Rj" uniqKey="Cabay R">RJ Cabay</name></author><author><name sortKey="Epstein, Jb" uniqKey="Epstein J">JB Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brzak, Bl" uniqKey="Brzak B">BL Brzak</name></author><author><name sortKey="Mravak Stipeti, M" uniqKey="Mravak Stipeti M">M Mravak-Stipetić</name></author><author><name sortKey="Canjuga, I" uniqKey="Canjuga I">I Canjuga</name></author><author><name sortKey="Baricevi, M" uniqKey="Baricevi M">M Baricević</name></author><author><name sortKey="Balicevi, D" uniqKey="Balicevi D">D Balicević</name></author><author><name sortKey="Sikora, M" uniqKey="Sikora M">M Sikora</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chainani Wu, N" uniqKey="Chainani Wu N">N Chainani-Wu</name></author><author><name sortKey="Purnell, Dm" uniqKey="Purnell D">DM Purnell</name></author><author><name sortKey="Silverman, S Jr" uniqKey="Silverman S">S Jr Silverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaplan, I" uniqKey="Kaplan I">I Kaplan</name></author><author><name sortKey="Ventura Sharabi, Y" uniqKey="Ventura Sharabi Y">Y Ventura-Sharabi</name></author><author><name sortKey="Gal, G" uniqKey="Gal G">G Gal</name></author><author><name sortKey="Calderon, S" uniqKey="Calderon S">S Calderon</name></author><author><name sortKey="Anavi, Y" uniqKey="Anavi Y">Y Anavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermejo Fenoll, A" uniqKey="Bermejo Fenoll A">A Bermejo-Fenoll</name></author><author><name sortKey="Sanchez Siles, M" uniqKey="Sanchez Siles M">M Sánchez-Siles</name></author><author><name sortKey="L Pez Jornet, P" uniqKey="L Pez Jornet P">P López-Jornet</name></author><author><name sortKey="Camacho Alonso, F" uniqKey="Camacho Alonso F">F Camacho-Alonso</name></author><author><name sortKey="Salazar Sanchez, N" uniqKey="Salazar Sanchez N">N Salazar-Sánchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silverman, S Jr" uniqKey="Silverman S">S Jr Silverman</name></author><author><name sortKey="Gorsky, M" uniqKey="Gorsky M">M Gorsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thongprasom, K" uniqKey="Thongprasom K">K Thongprasom</name></author><author><name sortKey="Carrozzo, M" uniqKey="Carrozzo M">M Carrozzo</name></author><author><name sortKey="Furness, S" uniqKey="Furness S">S Furness</name></author><author><name sortKey="Lodi, G" uniqKey="Lodi G">G Lodi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petruzzi, M" uniqKey="Petruzzi M">M Petruzzi</name></author><author><name sortKey="Lucchese, A" uniqKey="Lucchese A">A Lucchese</name></author><author><name sortKey="Lajolo, C" uniqKey="Lajolo C">C Lajolo</name></author><author><name sortKey="Campus, G" uniqKey="Campus G">G Campus</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author><author><name sortKey="Serpico, R" uniqKey="Serpico R">R Serpico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poveda Roda, R" uniqKey="Poveda Roda R">R Poveda-Roda</name></author><author><name sortKey="Bagan, Jv" uniqKey="Bagan J">JV Bagan</name></author><author><name sortKey="Jimenez Soriano, Y" uniqKey="Jimenez Soriano Y">Y Jiménez-Soriano</name></author><author><name sortKey="Diaz Fernandez, Jm" uniqKey="Diaz Fernandez J">JM Díaz-Fernández</name></author><author><name sortKey="Gavalda Esteve, C" uniqKey="Gavalda Esteve C">C Gavaldá-Esteve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der, Hem" uniqKey="Van Der H">Hem van der</name></author><author><name sortKey="Egges, M" uniqKey="Egges M">M Egges</name></author><author><name sortKey="Van Der Wal, Je" uniqKey="Van Der Wal J">JE van der Wal</name></author><author><name sortKey="Roodenburg, Jl" uniqKey="Roodenburg J">JL Roodenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huerta Leteurtre, N" uniqKey="Huerta Leteurtre N">N Huerta Leteurtre</name></author><author><name sortKey="Bagan Sebastian, Jv" uniqKey="Bagan Sebastian J">JV Bagán Sebastián</name></author><author><name sortKey="Cardona Tortajada, F" uniqKey="Cardona Tortajada F">F Cardona Tortajada</name></author><author><name sortKey="Lloria De Miguel, E" uniqKey="Lloria De Miguel E">E Lloria de Miguel</name></author><author><name sortKey="Jimenez Soriano, Y" uniqKey="Jimenez Soriano Y">Y Jimenez Soriano</name></author><author><name sortKey="Basterral Alegria, J" uniqKey="Basterral Alegria J">J Basterral Alegría</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gandolfo, S" uniqKey="Gandolfo S">S Gandolfo</name></author><author><name sortKey="Castellani, R" uniqKey="Castellani R">R Castellani</name></author><author><name sortKey="Pentenero, M" uniqKey="Pentenero M">M Pentenero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Shen, Xm" uniqKey="Shen X">XM Shen</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Zhou, Zt" uniqKey="Zhou Z">ZT Zhou</name></author><author><name sortKey="Wang, Lz" uniqKey="Wang L">LZ Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aguirre Urizar, Jm" uniqKey="Aguirre Urizar J">JM Aguirre-Urizar</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Oral Patol Oral Cir Bucal</journal-id><journal-id journal-id-type="iso-abbrev">Med Oral Patol Oral Cir Bucal</journal-id><journal-id journal-id-type="publisher-id">Medicina Oral S.L.</journal-id><journal-title-group><journal-title>Medicina Oral, Patología Oral y Cirugía Bucal</journal-title></journal-title-group><issn pub-type="ppub">1698-4447</issn><issn pub-type="epub">1698-6946</issn><publisher><publisher-name>Medicina Oral S.L.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27031060</article-id><article-id pub-id-type="pmc">4867206</article-id><article-id pub-id-type="publisher-id">20832</article-id><article-id pub-id-type="doi">10.4317/medoral.20832</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject><subj-group><subject>Oral Medicine and Pathology</subject></subj-group></subj-group></article-categories><title-group><article-title>The development of proliferative verrucous leukoplakia
in oral lichen planus. A preliminary study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Garcia-Pola</surname><given-names>María-José</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Llorente-Pendás</surname><given-names>Santiago</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>González-Garcia</surname><given-names>Manuel</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>García-Martín</surname><given-names>José-Manuel</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Associate Professor of Oral Medicine. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</aff><aff id="A2"><label>2</label>Medical Doctor. Oral and Maxillofacial Surgeon. Private practice of Oral and Maxillofacial Surgery. Medical Director of Head and Neck Center. Pérez de la Sala 37.33007. Oviedo. Spain</aff><aff id="A3"><label>3</label>Assistant Professor of Oral and Maxillofacial Surgery. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</aff><aff id="A4"><label>4</label>Assistant Professor of Oral Health & Preventive Dentistry. Faculty of Medicine. Catedrático José Serrano. 33006. Oviedo University. Spain</aff><author-notes><corresp> Faculty of Medicine
Catedrático José Serrano
33006. Oviedo Spain
, E-mail: <email>mjgarcia@uniovi.es</email></corresp><fn id="FN1" fn-type="conflict"><p><bold>Conflict of interest statement:</bold> The authors have declared that no conflict of interest exist.</p></fn></author-notes><pub-date pub-type="ppub"><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>31</day><month>3</month><year>2016</year></pub-date><volume>21</volume><issue>3</issue><fpage>e328</fpage><lpage>e334</lpage><history><date date-type="accepted"><day>27</day><month>1</month><year>2016</year></date><date date-type="received"><day>17</day><month>5</month><year>2015</year></date></history><permissions><copyright-statement>Copyright: © 2016 Medicina Oral S.L.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Background</title><p>Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus.</p></sec><sec><title>Material and Methods</title><p>The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years.</p></sec><sec><title>Results</title><p>The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma.</p></sec><sec><title>Conclusions</title><p>Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin.</p><p><bold>Key words:</bold>Oral lichen planus, proliferative verrucous oral leukoplakia, malignant oral lichen planus, multifocal verrucous oral lichen planus, proliferative verrucous oral lichen planus.</p></sec></abstract></article-meta></front><body><sec><title>Introduction</title><p>Oral lichen planus and oral leukoplakia are the most common potentially malignant disorders. Oral lichen planus (OLP) is a chronic, autoimmune mucocutaneous disease, characterised by exacerbation and remission periods. OLP can present as white papules that gradually expand in a symmetrical manner to form a reticular pattern (Wickham’s striae), or as plaques, which may or may not come with atrophic, erosive, and bullous forms (<xref rid="B1" ref-type="bibr">1</xref>). Although oral leukoplakia (OL) has been defined as “predominantly white lesion of the oral mucosal that cannot be characterized as other definable lesion” (<xref rid="B2" ref-type="bibr">2</xref>), in some OLP patients, gingival location presenting as white papules or plaques may resemble leukoplakia (<xref rid="B3" ref-type="bibr">3</xref>). Even may at times be difficult to distinguish clinically from homogeneous and non-homogeneous leukoplakia (<xref rid="B4" ref-type="bibr">4</xref>).</p><p>The risk of development oral cancer in OLP patients has been the issue of much debate. The rate of transformation in individual studies ranged from 0 to 3.5% (<xref rid="B5" ref-type="bibr">5</xref>). The literature reveals that there may be a higher frequency of OLP transforming into squamous cell carcinoma in some locations, such as tongue, followed by buccal mucosa and gingival. With respect to the clinical form, results are somewhat arduous to interpret because carcinoma may be preceded by atrophic-erosive (<xref rid="B6" ref-type="bibr">6</xref>-<xref rid="B8" ref-type="bibr">8</xref>), non-erosive (<xref rid="B9" ref-type="bibr">9</xref>), in other series by plaque form (<xref rid="B10" ref-type="bibr">10</xref>), and finally there are published works that found equally atrophic-erosive or plaque form (<xref rid="B11" ref-type="bibr">11</xref>,<xref rid="B12" ref-type="bibr">12</xref>).</p><p>In 1985 Hansen <italic>et al.</italic> introduced a new subtype of OL designed as “proliferative verrucous leukoplakia” (PVL) (<xref rid="B13" ref-type="bibr">13</xref>). PVL is differentiated by slow-growing and progressive clinical course, with changes clinical and histopathologic. PVL is an aggressive form of oral leukoplakia with considerable morbidity and strong predilection to malignant transformation (<xref rid="B14" ref-type="bibr">14</xref>).</p><p>Guideline or protocols of diagnostic criteria have been published to provide diagnosis of PVL (<xref rid="B15" ref-type="bibr">15</xref>-<xref rid="B17" ref-type="bibr">17</xref>). In order to make the early and rapid diagnosis of PVL Cerero <italic>et al.</italic> (<xref rid="B17" ref-type="bibr">17</xref>) have suggested major and minor criteria that offer a great support, emphasizing the presence of histopathologic pattern such as hyperkeratosis verrucous hyperplasia or carcinoma.</p><p>Our aim was to describe the behaviour of oral lichen planus patients, characterised for presenting a clinical form that progressed to a proliferative verrucous plaque-like pattern, and monitored for a minimum period of six years by the same workgroup.</p></sec><sec><title>Material and Methods</title><p>This descriptive observational study was conducted from a cohort of patients diagnosed of OLP, between September 1984 and February 2015. OLP patients were diagnosed by the same author clinically and by biopsy, based on the World Health Organization (WHO) criteria in 1978 (<xref rid="B18" ref-type="bibr">18</xref>) and on the criteria proposed by van der Meij and van der Waal in 2003 (<xref rid="B1" ref-type="bibr">1</xref>). The following requisites must be fulfilled: bilateral papules and reticular present, which may or may not come with other clinical forms of OLP (plaque, atrophic, erosive, bullous), and a histological description of band-like inflammatory infiltrate in the subbasal layer, liquefaction degeneration in the basal layer, and no dysplasia.</p><p>From OLP patients we included in the present study, those patients with the following progression behaviour: 1) predominating plaque-like form in almost a topographical area, with roughness and thickening, white-greyish in colour or verrucous form, 2) spreading multifocal growth affecting more than two oral locations and including the attached mucosa (gingival, alveolar process in edentulous area) or the hard palate, buccal or lingual mucosa, 3) histological criterion, through a second biopsy on the plaque-like or verrucous areas, with the presence of hyperkeratosis, acanthosis, papillomatous, or hyperplasia, without band-like inflammatory infiltrate (or without dominance), 4) treatment resistant, 5) monitoring for at least 5 years by the same doctor.</p><p>The studied variable were: gender, age, toxic habits (smoking, alcohol, and narcotics), location of the OLP, clinical form of OLP, affectation of other mucosa, appendages and skin, length of the monitoring, OLP treatment, microscopic changes in the second biopsy, and type of malignancy, number of carcinomas developed and their respective treatments.</p><p>The medical treatment options for OLP were: 1) Topical corticosteroids (TC) with 0.05% Clobetasol Propionate in Orabase and in aqueous solution; 2) daily oral administration of prednisone (0.5 mg/kg weight/day) followed by every other day; 3) acitretin 25-50 mg/day orally; 4) topical retinoids 0.1% 13-cis-retinoic acid in orabase. The excision treatment involved an intervention using a scalpel and CO2 laser surgery. The laser wavelength was 10.600nm and the vaporisation occurred between 4.5-7W. Treatments for the carcinomas included scalpel surgery, radiotherapy and laser CO2. Nystatin and fluconazole were used as an adjuvant treatment for complicated cases with secondary oral candidosis.</p><p>This project was approved by the Ethics in Research Committee from the University Central Hospital of Asturias.</p></sec><sec><title>Results</title><p>Between years mentioned we recruitment a total of 515 oral lichen planus, from those, we collected a total of 14 patients (2.7%) that development proliferative verrucous leukoplakia.</p><p>The details of the demographic study for each of the 14 patients are summarised in <xref ref-type="table" rid="T1"> Table 1</xref> and <xref ref-type="table" rid="T1"> Table 1Continue</xref>. The patients were monitored for a minimum of 6.3 years and a maximum of 24.3 years, with a mean follow up time of 14.5 years.</p><p><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Clinical characteristics of the patients with oral lichen planus (OLP) that evolved into a proliferative verrucous oral leukoplakia (PVOLP).</title></caption><graphic xlink:href="medoral-21-e328-t001"></graphic></table-wrap></p><p><table-wrap id="T2" orientation="portrait" position="float"><label>Table 1Continue</label><caption><title>Clinical characteristics of the patients with oral lichen planus (OLP) that evolved into a proliferative verrucous oral leukoplakia (PVOLP).</title></caption><graphic xlink:href="medoral-21-e328-t002"></graphic></table-wrap></p><p>The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old, 58.5 years old and 48.6 years old for women and men respectively.</p><p>None of the patients smoked or took narcotics during the study. Three were ex-cigarette smokers of more than 15 years. Three male patients drank one or two glasses of wine at the weekend. The women did not drink.</p><p>The predominant initial clinical together bilateral reticular form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%).</p><p>The most common location at baseline was the bilateral buccal mucosa (n=11; 78.5%), followed by the gingiva and palate mucosa (n=11; 78.5%), and the lingual mucosa (n=3; 21.4). They all had three or more affected areas (Fig. <xref ref-type="fig" rid="F1">1</xref>). Only two female patients had affected skin, which responded positively to treatment with topical corticosteroids.</p><p><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Reticular, plaque and atrophic type of lichen planus in hard palate, and reticular-erosive in buccal mucosa at the moment of diagnosis.</p></caption><graphic xlink:href="medoral-21-e328-g001"></graphic></fig></p><p>The initial OLP treatment was topical corticosteroids in all cases. The remaining treatment options for each patient are detailed in <xref ref-type="table" rid="T1"> Table 1</xref> and <xref ref-type="table" rid="T1"> Table 1 Continue</xref>. The patients did not show adverse haematological reactions.</p><p>During the follow-up of patients, nine of them acquired clinical forms different from the initial (Fig. <xref ref-type="fig" rid="F2">2</xref>). Since the time of diagnosis, the mean time for developing plaque-like and multifocal verrucous lesions as the predominant lesion was 4 years (Fig. <xref ref-type="fig" rid="F3">3</xref>).</p><p><fig id="F2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>The same woman three years later with papular-reticular and erosive lichen planus in hard palate. </p></caption><graphic xlink:href="medoral-21-e328-g002"></graphic></fig></p><p><fig id="F3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Verrucous lichen planus in hard palate and left upper buccal sulcus in the same patient after eigth years from initial diagnosis.</p></caption><graphic xlink:href="medoral-21-e328-g003"></graphic></fig></p><p>Hyperkeratosis (parakeratin and or orthokeratin) was present in part of all specimens, acanthosis and papillomatous squamous proliferation partly in ten cases, and verrucous hyperplasia in nine cases. Four patients (28.5%) went on to become malignant, three cases of squamous cell carcinoma (SCC) were well-differentiated, and one verrucous carcinoma. The mean time to malignant transformation from the first diagnosis was 9 years. Three cases were female and one male. The most common location of carcinoma was attachment mucosa (Fig. <xref ref-type="fig" rid="F4">4</xref>), gingival and hard palate.</p><p><fig id="F4" orientation="portrait" position="float"><label>Figure 4</label><caption><p>The same patients, ten years after initial diagnosis of OLP and two years after fast-growing multifocal and verrucous, showing the clinical appearance of squamous cell carcinoma in the gingiva and left lower buccal sulcus. She also presented plaque OLP in gingiva, buccal and dorsum of the tongue.</p></caption><graphic xlink:href="medoral-21-e328-g004"></graphic></fig></p></sec><sec><title>Discussion</title><p>In the present study we describe the characteristics of PVL in patients previously diagnosed of oral lichen planus, contributing to corroborate what in recent reports have suggested, the clinical relationship between OLP and PVL (<xref rid="B19" ref-type="bibr">19</xref>) and the presence of local histopathologic pattern with lymphocytic infiltrate in some areas of PVL (<xref rid="B20" ref-type="bibr">20</xref>)</p><p>The exact prevalence of PVL is not well known, most cases reported about long time series, its appearance, behaviour, treatment and malignant transformation. In our study we present, from a set of OLP diagnosed at first visit by the same professional, a total of 2.7% patients that suffered clinical and histopathologic changes towards PVL. Brzak <italic>et al.</italic> (<xref rid="B21" ref-type="bibr">21</xref>) contributed data of 0.15% OLP joints OL in a sample that was performed during ten years. To avoid future discrepancies, our figures did not include patients who had the first day OL lesion with OLP.</p><p>With regard to possible evolution and change of the clinical form of OLP, Carbone <italic>et al.</italic> (<xref rid="B12" ref-type="bibr">12</xref>) observed that 15% patients manifested changes from red lesions to white ones with and without treatment. Furthermore, in a recent study, Chainani <italic>et al.</italic> (<xref rid="B22" ref-type="bibr">22</xref>) have described nine cases of oral leukoplakia in patients diagnosed previously of OLP, in a follow-up between two and ten years. Therefore, whether OLP can change their clinical form towards white type, the plaque-like form, the most frequent in our sample (71.4%) at the moment of diagnoses, could be the starting point to take into account in the early diagnosis of PVL derivative from OLP.</p><p>In addition, it is difficult to map and quantify the subtype given that OLP is very active in terms of its clinical forms and extension (<xref rid="B23" ref-type="bibr">23</xref>), and because most of patients can have numerous locations (<xref rid="B24" ref-type="bibr">24</xref>). In this sense, we found the same prevalence in relation to location in buccal and gingival mucosa and all patients were affected in three or more areas, and one of those always was attached mucosa (gingival or palate). From this point of view, the location of attached mucosa may play an important role in early diagnosis of PVL.</p><p>Scientific literature evidences to confirm clinical OLP diagnosis is necessary to take a biopsy. Histological behaviour of the type of OLP that we described suffered significant changes from the initial diagnosis until it became a multifocal verrucous form. A limitation of this study was the misinformation from each biopsy performed for individual patients, we have referred to first biopsy to diagnose OLP and the biopsy which histhologically confirmed PVL with predominated in the epithelium hyperkeratosis, or/and verrucous hyperplasia, and SCC, and VC. All of the patterns shown in the study were based on the literature to diagnose of PVL (<xref rid="B13" ref-type="bibr">13</xref>,<xref rid="B25" ref-type="bibr">25</xref>).</p><p>Most authors emphasize that OLP treatment should focus on the symptom-based atrophic and erosive forms, considering that papule-reticular OLP does not require treatment (<xref rid="B3" ref-type="bibr">3</xref>). The first treatment option is a corticosteroid, although on reviewing the issue, it is stated that an effective treatment to cure OLP is lacking, and that no scientific evidence of a corticosteroid being more useful than any other in the topical treatment of OLP exists (<xref rid="B26" ref-type="bibr">26</xref>). The individualisation of the treatment was other of the limitations of our sample, given that on occasions, recurrence or relapse was so common along with treatment resistance that some of the patients needed immediate action to switch and combine different alternatives.</p><p>The use of topical retinoids was proposed for the reticular and plaque-like OLP forms, and as an alternative to treatment with corticosteroids (<xref rid="B27" ref-type="bibr">27</xref>). One-third of PVL patients improved after an average of 5-6 months with topic or systemic retinoid therapy (<xref rid="B28" ref-type="bibr">28</xref>). We proposed it orally and topically on two patients (cases 3 and 12), with topical corticosteroid and CO2 laser therapy applied during rest periods. CO2 laser vaporization has been proposed as a treatment alternative for erosive OLPs resistant to corticosteroid therapy (<xref rid="B29" ref-type="bibr">29</xref>), in plaque forms (<xref rid="B30" ref-type="bibr">30</xref>) and in PVL without dysplasia (<xref rid="B14" ref-type="bibr">14</xref>). CO2 laser was the treatment for seven of our patient cases (in combination with other treatments), and four of them showed recurrence, that resistant to treatment was a cause for concern. This is another considerable difference in treatment response between our proliferative verrucous form in OLP, and oral leukoplakia derived from OLP, described by Chainani-Wu <italic>et al.</italic> (<xref rid="B22" ref-type="bibr">22</xref>), because this oral leukoplakia treated with CO2 laser has been satisfactory evolution during their follow-up.</p><p>The potential for OLP to become malignant continues to be a very controversial issue, with its incidence fluctuating between 0 and 3.5 percent (<xref rid="B5" ref-type="bibr">5</xref>). The progression from reticular forms to leukoplakia-type observed in our patients established that the malignant behaviour was very similar to that described previously in the PVL when it comes to occurring predominantly in women and located on the gum (<xref rid="B13" ref-type="bibr">13</xref>) and alveolar crest (<xref rid="B31" ref-type="bibr">31</xref>). It is estimated that the 70% of PVL goes onto become malignant (<xref rid="B25" ref-type="bibr">25</xref>) and a 28.5% figure was found among our cases. This could give rise to the thought that OLP that progresses towards the multifocal verrucous forms become malignant in the same proportion as verrucous leukoplakias (non-proliferative) (<xref rid="B32" ref-type="bibr">32</xref>), and in a lower proportion than the proliferative verrucous leukoplakia (<xref rid="B14" ref-type="bibr">14</xref>).</p><p>Mignogna <italic>et al.</italic> (<xref rid="B10" ref-type="bibr">10</xref>) detected that almost all the forms of OLP that became malignant in their study were characterised by presenting keratinous, reticular and plaque-like areas. In line with this findings, we suggest that those clinical forms of OLP should be included in the progressive monitoring protocols and closely followed.</p><p>It is evident from other studies that OLP is seen more frequently in women and that long time series revealed that the use of tobacco and alcohol do not participate in the pathogenesis of OLP (<xref rid="B12" ref-type="bibr">12</xref>). For both reasons we do not recognise the sex, tobacco and alcohol as relevant factors in the early diagnosis of PVL developed from OLP.</p><p>The term “multifocal”, has now been reused by Aguirre-Urizar (<xref rid="B33" ref-type="bibr">33</xref>) for more stringent referencing of early PVL diagnoses, and given the similarity of behaviour of these lesions in ours cases, it turns out to be very appropriate term to use for the description.</p><p>Given the usefulness of having some criteria to diagnose of PVL (<xref rid="B17" ref-type="bibr">17</xref>), we propose some clinical major, and histological criteria, because the minor criteria indicated for PVL, predominantly female and non-smokers, may not be used as they are prevalent among the patients with OLP studied. On the basis of the above, we propose the following criteria to define this type of proliferative multifocal OLP: 1) predominance of the plaque-like form of OLP with thickening of the lesion at some point during the progression; 2) at least three affected topographical areas, given that two of them in symmetry would already be included in the OLP diagnosis, highlighting the location in attached mucosa (gums and palate) 3) resistance to medical and surgical treatment, 4) to remain during at least 5 years of monitoring those parameters; and 5) histological changes in the epithelial thickness (hyperkeratosis), verrucous hyperplasia, verrucous carcinoma or oral squamous cell carcinoma, a priori the most important criteria.</p></sec><sec><title>Conclusion</title><p>Based on the different percentage of malignance in our sample (28.5%) and the present in the literature review, from 40% to 74% of PVL, additional long-term research is necessary to clear if proliferative multifocal lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin.</p></sec></body><back><ref-list><ref id="B1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van der Meij</surname><given-names>EH</given-names></name><name><surname>van der Waal</surname><given-names>I</given-names></name></person-group><article-title>Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications</article-title><source>J Oral Pathol Med</source><year>2003</year><volume>32</volume><fpage>507</fpage><lpage>12</lpage><pub-id pub-id-type="pmid">12969224</pub-id></element-citation></ref><ref id="B2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Axéll</surname><given-names>T</given-names></name><name><surname>Pindborg</surname><given-names>JJ</given-names></name><name><surname>Smith</surname><given-names>CJ</given-names></name><name><surname>van der Waal</surname><given-names>I</given-names></name></person-group><article-title>Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions</article-title><source>J Oral Pathol Med</source><year>1996</year><volume>25</volume><fpage>49</fpage><lpage>54</lpage><pub-id pub-id-type="pmid">8667255</pub-id></element-citation></ref><ref id="B3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eisen</surname><given-names>D</given-names></name><name><surname>Carrozo</surname><given-names>M</given-names></name><name><surname>Bagan Sebastian</surname><given-names>JV</given-names></name><name><surname>Thongprasom</surname><given-names>K</given-names></name></person-group><article-title>Oral lichen planus: clinical features and management</article-title><source>Oral Diseases</source><year>2005</year><volume>11</volume><fpage>338</fpage><lpage>49</lpage><pub-id pub-id-type="pmid">16269024</pub-id></element-citation></ref><ref id="B4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Voûte</surname><given-names>AB</given-names></name><name><surname>de Jong</surname><given-names>WF</given-names></name><name><surname>Schulten</surname><given-names>EA</given-names></name><name><surname>Snow</surname><given-names>GB</given-names></name><name><surname>van der Waal</surname><given-names>I</given-names></name></person-group><article-title>Possible premalignant character of oral lichen planus. The Amsterdam experience</article-title><source>J Oral Pathol Med</source><year>1992</year><volume>21</volume><fpage>326</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">1522535</pub-id></element-citation></ref><ref id="B5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fitzpatrick</surname><given-names>SG</given-names></name><name><surname>Hirsch</surname><given-names>SA</given-names></name><name><surname>Gordon</surname><given-names>SC</given-names></name></person-group><article-title>The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review</article-title><source>J Am Dent Assoc</source><year>2014</year><volume>145</volume><fpage>45</fpage><lpage>56</lpage><pub-id pub-id-type="pmid">24379329</pub-id></element-citation></ref><ref id="B6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eisen</surname><given-names>D</given-names></name></person-group><article-title>The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients</article-title><source>J Am Acad Dermatol</source><year>2002</year><volume>46</volume><fpage>207</fpage><lpage>14</lpage><pub-id pub-id-type="pmid">11807431</pub-id></element-citation></ref><ref id="B7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tovaru</surname><given-names>S</given-names></name><name><surname>Parlatescu</surname><given-names>O</given-names></name><name><surname>Gheorhe</surname><given-names>C</given-names></name><name><surname>Tovaru</surname><given-names>M</given-names></name><name><surname>Costache</surname><given-names>M</given-names></name><name><surname>Sardella</surname><given-names>M</given-names></name></person-group><article-title>Oral lichen planus: a retrospective study of 633 patients from Bucharest, Rumania</article-title><source>Med Oral Pathol Oral Cir Bucal</source><year>2013</year><volume>18</volume><fpage>e201</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">23229244</pub-id></element-citation></ref><ref id="B8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Xue</surname><given-names>JL</given-names></name><name><surname>Fan</surname><given-names>MW</given-names></name><name><surname>Wang</surname><given-names>SZ</given-names></name><name><surname>Chen</surname><given-names>XM</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name></person-group><article-title>A clinical study of 674 patients with oral lichen planus in China</article-title><source>J Oral Pathol Med</source><year>2005</year><volume>34</volume><fpage>467</fpage><lpage>72</lpage><pub-id pub-id-type="pmid">16091113</pub-id></element-citation></ref><ref id="B9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bermejo-Fenoll</surname><given-names>A</given-names></name><name><surname>Sanchez-Siles</surname><given-names>M</given-names></name><name><surname>López-Jornet</surname><given-names>P</given-names></name><name><surname>Camacho-Alonso</surname><given-names>F</given-names></name><name><surname>Salazar-Sánchez</surname><given-names>N</given-names></name></person-group><article-title>Premalignant nature of oral lichen planus. A retrospective study of 550 oral lichen planus patients from south-eastern Spain</article-title><source>Oral Oncol</source><year>2009</year><volume>45</volume><fpage>e54</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">19362039</pub-id></element-citation></ref><ref id="B10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mignogna</surname><given-names>MD</given-names></name><name><surname>Lo Muzio</surname><given-names>L</given-names></name><name><surname>Lo Russo</surname><given-names>L</given-names></name><name><surname>Fedele</surname><given-names>S</given-names></name><name><surname>Ruoppo</surname><given-names>E</given-names></name><name><surname>Bucci</surname><given-names>E</given-names></name></person-group><article-title>Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience</article-title><source>Oral Oncol</source><year>2001</year><volume>37</volume><fpage>262</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">11287280</pub-id></element-citation></ref><ref id="B11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lanfranchi-Tizeira</surname><given-names>HE</given-names></name><name><surname>Aguas</surname><given-names>SC</given-names></name><name><surname>Sano</surname><given-names>SM</given-names></name></person-group><article-title>Malignant transformation of atypical oral lichen planus: a review of 32 cases</article-title><source>Med Oral</source><year>2003</year><volume>8</volume><fpage>2</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">12556717</pub-id></element-citation></ref><ref id="B12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Carbone</surname><given-names>M</given-names></name><name><surname>Arduino</surname><given-names>PG</given-names></name><name><surname>Carrozo</surname><given-names>M</given-names></name><name><surname>Gandolfo</surname><given-names>S</given-names></name><name><surname>Argiolas</surname><given-names>MR</given-names></name><name><surname>Bertolusso</surname><given-names>G</given-names></name></person-group><article-title>Course of oral lichen planus: a retrospective study of 808 northern Italian patients</article-title><source>Oral Dis</source><year>2009</year><volume>15</volume><fpage>235</fpage><lpage>43</lpage><pub-id pub-id-type="pmid">19222766</pub-id></element-citation></ref><ref id="B13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hansen</surname><given-names>LS</given-names></name><name><surname>Olson</surname><given-names>JA</given-names></name><name><surname>Silverman</surname><given-names>S Jr</given-names></name></person-group><article-title>Proliferative verrucous leukoplakia. A long-term study of thirty patients</article-title><source>Oral Surg Oral Med Oral Pathol</source><year>1985</year><volume>60</volume><fpage>285</fpage><lpage>98</lpage><pub-id pub-id-type="pmid">3862042</pub-id></element-citation></ref><ref id="B14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bagán</surname><given-names>JV</given-names></name><name><surname>Jiménez-Soriano</surname><given-names>Y</given-names></name><name><surname>Diaz-Fernandez</surname><given-names>JM</given-names></name><name><surname>Murillo-Cortés</surname><given-names>J</given-names></name><name><surname>Sanchis-Bielsa</surname><given-names>JM</given-names></name><name><surname>Poveda-Roda</surname><given-names>R</given-names></name></person-group><article-title>Malignant transformation of proliferative verrucous leukoplakia to oral squamous cell carcinoma: a series of 55 cases</article-title><source>Oral Oncol</source><year>2011</year><volume>47</volume><fpage>732</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">21683646</pub-id></element-citation></ref><ref id="B15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ghazali</surname><given-names>N</given-names></name><name><surname>Bakri</surname><given-names>MM</given-names></name><name><surname>Zain</surname><given-names>RB</given-names></name></person-group><article-title>Aggressive, multifocal oral verrucous leukoplakia: Proliferative verrucous leukoplakia or not?</article-title><source>J Oral Pathol Med</source><year>2003</year><volume>32</volume><fpage>383</fpage><lpage>92</lpage><pub-id pub-id-type="pmid">12846784</pub-id></element-citation></ref><ref id="B16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gandolfo</surname><given-names>S</given-names></name><name><surname>Castellani</surname><given-names>R</given-names></name><name><surname>Pentenero</surname><given-names>M</given-names></name></person-group><article-title>Proliferative verrucous leukoplakia: A potentially malignant disorder involving periodontal sites</article-title><source>J Periodontol</source><year>2009</year><volume>80</volume><fpage>274</fpage><lpage>81</lpage><pub-id pub-id-type="pmid">19186968</pub-id></element-citation></ref><ref id="B17"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cerero-Lapiedra</surname><given-names>R</given-names></name><name><surname>Baladé-Martínez</surname><given-names>D</given-names></name><name><surname>Moreno-López</surname><given-names>LA</given-names></name><name><surname>Esparza-Gómez</surname><given-names>G</given-names></name><name><surname>Bagán</surname><given-names>JV</given-names></name></person-group><article-title>Proliferative verrucous leukoplakia: a proposal for diagnostic criteria</article-title><source>Med Oral Patol Oral Cir Bucal</source><year>2010</year><volume>15</volume><fpage>e839</fpage><lpage>45</lpage><pub-id pub-id-type="pmid">20173704</pub-id></element-citation></ref><ref id="B18"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kramer</surname><given-names>IR</given-names></name><name><surname>Lucas</surname><given-names>RB</given-names></name><name><surname>Pindborg</surname><given-names>JJ</given-names></name><name><surname>Sobin</surname><given-names>LH</given-names></name></person-group><article-title>Definition of leukoplakia and related lesions: an aid to studies on oral precancer</article-title><source>Oral Surg Oral Med Oral Pathol</source><year>1978</year><volume>46</volume><fpage>518</fpage><lpage>39</lpage><pub-id pub-id-type="pmid">280847</pub-id></element-citation></ref><ref id="B19"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Garcia-Chias</surname><given-names>B</given-names></name><name><surname>Casado-De La Cruz</surname><given-names>L</given-names></name><name><surname>Esparza-Gómez</surname><given-names>GC</given-names></name><name><surname>Cerero-Lapiedra</surname><given-names>R</given-names></name></person-group><article-title>Diagnostic criteria in proliferative verrucous leukoplakia: evaluation</article-title><source>Med Oral Patol Oral Cir Bucal</source><year>2014</year><volume>19</volume><fpage>e335</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">24608210</pub-id></element-citation></ref><ref id="B20"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morton</surname><given-names>TH</given-names></name><name><surname>Cabay</surname><given-names>RJ</given-names></name><name><surname>Epstein</surname><given-names>JB</given-names></name></person-group><article-title>Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases</article-title><source>J Oral Pathol Med</source><year>2007</year><volume>36</volume><fpage>315</fpage><lpage>8</lpage><pub-id pub-id-type="pmid">17448142</pub-id></element-citation></ref><ref id="B21"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Brzak</surname><given-names>BL</given-names></name><name><surname>Mravak-Stipetić</surname><given-names>M</given-names></name><name><surname>Canjuga</surname><given-names>I</given-names></name><name><surname>Baricević</surname><given-names>M</given-names></name><name><surname>Balicević</surname><given-names>D</given-names></name><name><surname>Sikora</surname><given-names>M</given-names></name></person-group><article-title>The frequency and malignant transformation rate of oral lichen planus and leukoplakia-a retrospective study</article-title><source>Coll Antropol</source><year>2012</year><volume>36</volume><fpage>773</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">23213931</pub-id></element-citation></ref><ref id="B22"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chainani-Wu</surname><given-names>N</given-names></name><name><surname>Purnell</surname><given-names>DM</given-names></name><name><surname>Silverman</surname><given-names>S Jr</given-names></name></person-group><article-title>Oral leukoplakia development in patient a with pre-existing oral lichen planus</article-title><source>J Calif Dent Assoc</source><year>2015</year><volume>43</volume><fpage>35</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">25632518</pub-id></element-citation></ref><ref id="B23"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kaplan</surname><given-names>I</given-names></name><name><surname>Ventura-Sharabi</surname><given-names>Y</given-names></name><name><surname>Gal</surname><given-names>G</given-names></name><name><surname>Calderon</surname><given-names>S</given-names></name><name><surname>Anavi</surname><given-names>Y</given-names></name></person-group><article-title>The dynamics of oral lichen planus; a retrospective clinicopathological study</article-title><source>Head Neck Pathol</source><year>2012</year><volume>6</volume><fpage>178</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">22160614</pub-id></element-citation></ref><ref id="B24"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bermejo-Fenoll</surname><given-names>A</given-names></name><name><surname>Sánchez-Siles</surname><given-names>M</given-names></name><name><surname>López-Jornet</surname><given-names>P</given-names></name><name><surname>Camacho-Alonso</surname><given-names>F</given-names></name><name><surname>Salazar-Sánchez</surname><given-names>N</given-names></name></person-group><article-title>A retrospective clinicopathological study of 550 patients with oral lichen planus in south-eastern Spain</article-title><source>J Oral Pathol Med</source><year>2010</year><volume>39</volume><fpage>491</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">20456611</pub-id></element-citation></ref><ref id="B25"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Silverman</surname><given-names>S Jr</given-names></name><name><surname>Gorsky</surname><given-names>M</given-names></name></person-group><article-title>Proliferative verrucous leukoplakia: a follow-up study of 54 cases</article-title><source>Oral Surg Oral Med Oral Pathol Oral Radiol Endod</source><year>1997</year><volume>84</volume><fpage>154</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">9269017</pub-id></element-citation></ref><ref id="B26"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thongprasom</surname><given-names>K</given-names></name><name><surname>Carrozzo</surname><given-names>M</given-names></name><name><surname>Furness</surname><given-names>S</given-names></name><name><surname>Lodi</surname><given-names>G</given-names></name></person-group><article-title>Interventions for treating oral lichen planus</article-title><source>Cochrane Database Syst Rev</source><year>2011</year><volume>7</volume><fpage>CD001168</fpage><pub-id pub-id-type="pmid">21735381</pub-id></element-citation></ref><ref id="B27"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Petruzzi</surname><given-names>M</given-names></name><name><surname>Lucchese</surname><given-names>A</given-names></name><name><surname>Lajolo</surname><given-names>C</given-names></name><name><surname>Campus</surname><given-names>G</given-names></name><name><surname>Lauritano</surname><given-names>D</given-names></name><name><surname>Serpico</surname><given-names>R</given-names></name></person-group><article-title>Topical retinoids in oral lichen planus treatment: an overview</article-title><source>Dermatology</source><year>2013</year><volume>226</volume><fpage>61</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">23548887</pub-id></element-citation></ref><ref id="B28"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Poveda-Roda</surname><given-names>R</given-names></name><name><surname>Bagan</surname><given-names>JV</given-names></name><name><surname>Jiménez-Soriano</surname><given-names>Y</given-names></name><name><surname>Díaz-Fernández</surname><given-names>JM</given-names></name><name><surname>Gavaldá-Esteve</surname><given-names>C</given-names></name></person-group><article-title>Retinoids and proliferative verrucous leukoplakia (PVL). A preliminary study</article-title><source>Med Oral Patol Oral Cir Bucal</source><year>2010</year><volume>15</volume><fpage>e3</fpage><lpage>9</lpage><pub-id pub-id-type="pmid">19680182</pub-id></element-citation></ref><ref id="B29"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van der</surname><given-names>Hem</given-names></name><name><surname>Egges</surname><given-names>M</given-names></name><name><surname>van der Wal</surname><given-names>JE</given-names></name><name><surname>Roodenburg</surname><given-names>JL</given-names></name></person-group><article-title>CO2 laser evaporation of oral lichen planus</article-title><source>Int J Oral Maxillofac Surg</source><year>2008</year><volume>37</volume><fpage>630</fpage><lpage>3</lpage><pub-id pub-id-type="pmid">18538542</pub-id></element-citation></ref><ref id="B30"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huerta Leteurtre</surname><given-names>N</given-names></name><name><surname>Bagán Sebastián</surname><given-names>JV</given-names></name><name><surname>Cardona Tortajada</surname><given-names>F</given-names></name><name><surname>Lloria de Miguel</surname><given-names>E</given-names></name><name><surname>Jimenez Soriano</surname><given-names>Y</given-names></name><name><surname>Basterral Alegría</surname><given-names>J</given-names></name></person-group><article-title>Oral lichen planus plaques and homogeneous leukoplakia: comparative results of treatment with CO2 laser</article-title><source>Acta Otorrinolaringol Esp</source><year>1999</year><volume>50</volume><fpage>543</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">10619881</pub-id></element-citation></ref><ref id="B31"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gandolfo</surname><given-names>S</given-names></name><name><surname>Castellani</surname><given-names>R</given-names></name><name><surname>Pentenero</surname><given-names>M</given-names></name></person-group><article-title>Proliferative verrucous leukoplakia: a potentially malignant disorde involving periodontal sites</article-title><source>J Periodontol</source><year>2009</year><volume>80</volume><fpage>274</fpage><lpage>81</lpage><pub-id pub-id-type="pmid">19186968</pub-id></element-citation></ref><ref id="B32"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Liu</surname><given-names>W</given-names></name><name><surname>Shen</surname><given-names>XM</given-names></name><name><surname>Liu</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>J</given-names></name><name><surname>Zhou</surname><given-names>ZT</given-names></name><name><surname>Wang</surname><given-names>LZ</given-names></name></person-group><article-title>Malignant transformation of oral verrucous leukoplakia: a clinicopathologic study of 53 cases</article-title><source>J Oral Pathol Med</source><year>2011</year><volume>40</volume><fpage>312</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">21342275</pub-id></element-citation></ref><ref id="B33"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aguirre-Urizar</surname><given-names>JM</given-names></name></person-group><article-title>Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia</article-title><source>World J Surg Oncol</source><year>2011</year><volume>9</volume><fpage>122</fpage><lpage>3</lpage><pub-id pub-id-type="pmid">21985464</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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