Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition
Identifieur interne : 000597 ( Pmc/Corpus ); précédent : 000596; suivant : 000598Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition
Auteurs : Y. Cho ; J. Hong ; H. Ryoo ; D. Kim ; J. Park ; J. HanSource :
- Journal of Dental Research [ 0022-0345 ] ; 2015.
Abstract
Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb2O5) or tantalum oxide (Ta2O5) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.
Url:
DOI: 10.1177/0022034514566432
PubMed: 25586588
PubMed Central: 4814017
Links to Exploration step
PMC:4814017Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition</title><author><name sortKey="Cho, Y" sort="Cho, Y" uniqKey="Cho Y" first="Y." last="Cho">Y. Cho</name><affiliation><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff2-0022034514566432">Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Hong, J" sort="Hong, J" uniqKey="Hong J" first="J." last="Hong">J. Hong</name><affiliation><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Ryoo, H" sort="Ryoo, H" uniqKey="Ryoo H" first="H." last="Ryoo">H. Ryoo</name><affiliation><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Kim, D" sort="Kim, D" uniqKey="Kim D" first="D." last="Kim">D. Kim</name><affiliation><nlm:aff id="aff4-0022034514566432">Department of Advanced Materials Engineering, Sejong University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, J" sort="Park, J" uniqKey="Park J" first="J." last="Park">J. Park</name><affiliation><nlm:aff id="aff5-0022034514566432">R&D Center, Nano Business, IONES Co., Ltd., Gyeonggi-do, Korea</nlm:aff></affiliation></author><author><name sortKey="Han, J" sort="Han, J" uniqKey="Han J" first="J." last="Han">J. Han</name><affiliation><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25586588</idno><idno type="pmc">4814017</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814017</idno><idno type="RBID">PMC:4814017</idno><idno type="doi">10.1177/0022034514566432</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000597</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000597</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition</title><author><name sortKey="Cho, Y" sort="Cho, Y" uniqKey="Cho Y" first="Y." last="Cho">Y. Cho</name><affiliation><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff2-0022034514566432">Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation><affiliation><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Hong, J" sort="Hong, J" uniqKey="Hong J" first="J." last="Hong">J. Hong</name><affiliation><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Ryoo, H" sort="Ryoo, H" uniqKey="Ryoo H" first="H." last="Ryoo">H. Ryoo</name><affiliation><nlm:aff id="aff3-0022034514566432">Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Kim, D" sort="Kim, D" uniqKey="Kim D" first="D." last="Kim">D. Kim</name><affiliation><nlm:aff id="aff4-0022034514566432">Department of Advanced Materials Engineering, Sejong University, Seoul, Korea</nlm:aff></affiliation></author><author><name sortKey="Park, J" sort="Park, J" uniqKey="Park J" first="J." last="Park">J. Park</name><affiliation><nlm:aff id="aff5-0022034514566432">R&D Center, Nano Business, IONES Co., Ltd., Gyeonggi-do, Korea</nlm:aff></affiliation></author><author><name sortKey="Han, J" sort="Han, J" uniqKey="Han J" first="J." last="Han">J. Han</name><affiliation><nlm:aff id="aff1-0022034514566432">Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Dental Research</title><idno type="ISSN">0022-0345</idno><idno type="eISSN">1544-0591</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb<sub>2</sub>O<sub>5</sub>) or tantalum oxide (Ta<sub>2</sub>O<sub>5</sub>) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Dent Res</journal-id><journal-id journal-id-type="iso-abbrev">J. Dent. Res</journal-id><journal-id journal-id-type="publisher-id">JDR</journal-id><journal-id journal-id-type="hwp">spjdr</journal-id><journal-title-group><journal-title>Journal of Dental Research</journal-title></journal-title-group><issn pub-type="ppub">0022-0345</issn><issn pub-type="epub">1544-0591</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage CA: Los Angeles, CA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25586588</article-id><article-id pub-id-type="pmc">4814017</article-id><article-id pub-id-type="doi">10.1177/0022034514566432</article-id><article-id pub-id-type="publisher-id">10.1177_0022034514566432</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Reports</subject><subj-group subj-group-type="heading"><subject>Biomaterials & Bioengineering</subject></subj-group></subj-group></article-categories><title-group><article-title>Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Y.</given-names></name><xref ref-type="aff" rid="aff1-0022034514566432">1</xref><xref ref-type="aff" rid="aff2-0022034514566432">2</xref><xref ref-type="aff" rid="aff3-0022034514566432">3</xref><xref ref-type="author-notes" rid="fn1-0022034514566432">*</xref></contrib><contrib contrib-type="author"><name><surname>Hong</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="aff1-0022034514566432">1</xref><xref ref-type="author-notes" rid="fn1-0022034514566432">*</xref></contrib><contrib contrib-type="author"><name><surname>Ryoo</surname><given-names>H.</given-names></name><xref ref-type="aff" rid="aff3-0022034514566432">3</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="aff4-0022034514566432">4</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="aff5-0022034514566432">5</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Han</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="aff1-0022034514566432">1</xref></contrib></contrib-group><aff id="aff1-0022034514566432"><label>1</label>Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</aff><aff id="aff2-0022034514566432"><label>2</label>Department of Periodontology, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</aff><aff id="aff3-0022034514566432"><label>3</label>Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul, Korea</aff><aff id="aff4-0022034514566432"><label>4</label>Department of Advanced Materials Engineering, Sejong University, Seoul, Korea</aff><aff id="aff5-0022034514566432"><label>5</label>R&D Center, Nano Business, IONES Co., Ltd., Gyeonggi-do, Korea</aff><author-notes><fn fn-type="equal" id="fn1-0022034514566432"><label>*</label><p>Authors contributing equally to this article.</p></fn><corresp id="corresp1-0022034514566432">J. Han, Department of Prosthodontics, School of Dentistry, Seoul National University, 28 Yeongeon-dong, Jongno-gu, Seoul, Korea, 110-749. Email: <email>proshan@snu.ac.kr</email></corresp></author-notes><pub-date pub-type="epub-ppub"><month>3</month><year>2015</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>3</month><year>2015</year></pub-date><volume>94</volume><issue>3</issue><fpage>491</fpage><lpage>499</lpage><permissions><copyright-statement>© International & American Associations for Dental Research 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder content-type="society">International & American Associations for Dental Research</copyright-holder></permissions><abstract><p>Previously, we found that osteogenic responses to zirconia co-doped with niobium oxide (Nb<sub>2</sub>O<sub>5</sub>) or tantalum oxide (Ta<sub>2</sub>O<sub>5</sub>) are comparable with responses to titanium, which is widely used as a dental implant material. The present study aimed to evaluate the in vitro osteogenic potential of hydroxyapatite (HA)-coated zirconia by an aerosol deposition method for improved osseointegration. Surface analysis by scanning electron microscopy and x-ray diffraction proved that a thin as-deposited HA film on zirconia showed a shallow, regular, crater-like surface. Deposition of dense and uniform HA films was measured by SEM, and the contact angle test demonstrated improved wettability of the HA-coated surface. Confocal laser scanning microscopy indicated that MC3T3-E1 pre-osteoblast attachment did not differ notably between the titanium and zirconia surfaces; however, cells on the HA-coated zirconia exhibited a lower proliferation than those on the uncoated zirconia late in the culture. Nevertheless, ALP, alizarin red S staining, and bone marker gene expression analysis indicated good osteogenic responses on HA-coated zirconia. Our results suggest that HA-coating by aerosol deposition improves the quality of surface modification and is favorable to osteogenesis.</p></abstract><kwd-group><kwd>implant dentistry</kwd><kwd>biomaterial(s)</kwd><kwd>osteogenesis</kwd><kwd>surface chemistry</kwd><kwd>osseointegration</kwd><kwd>prosthetic dentistry</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000597 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000597 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:4814017
|texte= Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:25586588" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |