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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parathyroid Hormone Applications in the Craniofacial Skeleton</title><author><name sortKey="Chan, H L" sort="Chan, H L" uniqKey="Chan H" first="H. L." last="Chan">H. L. Chan</name><affiliation><nlm:aff id="aff1-0022034512464779">Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Mccauley, L K" sort="Mccauley, L K" uniqKey="Mccauley L" first="L. K." last="Mccauley">L. K. Mccauley</name><affiliation><nlm:aff id="aff1-0022034512464779">Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff2-0022034512464779">Department of Pathology, University of Michigan, Medical School, Ann Arbor, MI, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23071071</idno><idno type="pmc">3521450</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521450</idno><idno type="RBID">PMC:3521450</idno><idno type="doi">10.1177/0022034512464779</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000593</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000593</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parathyroid Hormone Applications in the Craniofacial Skeleton</title><author><name sortKey="Chan, H L" sort="Chan, H L" uniqKey="Chan H" first="H. L." last="Chan">H. L. Chan</name><affiliation><nlm:aff id="aff1-0022034512464779">Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA</nlm:aff></affiliation></author><author><name sortKey="Mccauley, L K" sort="Mccauley, L K" uniqKey="Mccauley L" first="L. K." last="Mccauley">L. K. Mccauley</name><affiliation><nlm:aff id="aff1-0022034512464779">Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA</nlm:aff></affiliation><affiliation><nlm:aff id="aff2-0022034512464779">Department of Pathology, University of Michigan, Medical School, Ann Arbor, MI, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Dental Research</title><idno type="ISSN">0022-0345</idno><idno type="eISSN">1544-0591</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Parathyroid hormone (PTH) is known for its ability to ‘build’ bone, with research in this area centered on its use as an osteoporosis therapeutic. Recent interest has developed regarding its potential for regenerative applications such as fracture healing and osseous defects of the oral cavity. Many years of investigation using murine gene-targeted models substantiate a role for signaling at the PTH/PTH-related protein (PTHrP) receptor (PPR) in intramembranous bone formation in the craniofacial region as well as in tooth development. Pre-clinical studies clearly support a positive role of intermittent PTH administration in craniofacial bones and in fracture healing and implant integration. A few human clinical studies have shown favorable responses with teriparatide (the biologically active fragment of PTH) administration. Favorable outcomes have emerged with teriparatide administration in patients with osteonecrosis of the jaw (ONJ). New delivery strategies are in development to optimize targeted application of PTH and to help maximize local approaches. The promising host-modulating potential of PTH requires more information to further its effectiveness for craniofacial regeneration and osseous wound-healing, including a better delineation of cellular targets, temporal effects of PTH action, and improved approaches for local/targeted delivery of PTH.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Dent Res</journal-id><journal-id journal-id-type="iso-abbrev">J. Dent. Res</journal-id><journal-id journal-id-type="publisher-id">JDR</journal-id><journal-id journal-id-type="hwp">spjdr</journal-id><journal-title-group><journal-title>Journal of Dental Research</journal-title></journal-title-group><issn pub-type="ppub">0022-0345</issn><issn pub-type="epub">1544-0591</issn><publisher><publisher-name>SAGE Publications</publisher-name><publisher-loc>Sage CA: Los Angeles, CA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23071071</article-id><article-id pub-id-type="pmc">3521450</article-id><article-id pub-id-type="doi">10.1177/0022034512464779</article-id><article-id pub-id-type="publisher-id">10.1177_0022034512464779</article-id><article-categories><subj-group subj-group-type="heading"><subject>Reviews</subject><subj-group subj-group-type="heading"><subject>Critical Reviews in Oral Biology & Medicine</subject></subj-group></subj-group></article-categories><title-group><article-title>Parathyroid Hormone Applications in the Craniofacial Skeleton</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chan</surname><given-names>H.L.</given-names></name><xref ref-type="aff" rid="aff1-0022034512464779">1</xref></contrib><contrib contrib-type="author"><name><surname>McCauley</surname><given-names>L.K.</given-names></name><xref ref-type="aff" rid="aff1-0022034512464779">1</xref><xref ref-type="aff" rid="aff2-0022034512464779">2</xref><xref ref-type="corresp" rid="corresp1-0022034512464779">*</xref></contrib></contrib-group><aff id="aff1-0022034512464779"><label>1</label>Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA</aff><aff id="aff2-0022034512464779"><label>2</label>Department of Pathology, University of Michigan, Medical School, Ann Arbor, MI, USA</aff><author-notes><corresp id="corresp1-0022034512464779"><label>*</label><email>mccauley@umich.edu</email></corresp></author-notes><pub-date pub-type="epub-ppub"><month>1</month><year>2013</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>1</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>1</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and
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<volume>92</volume><issue>1</issue><fpage>18</fpage><lpage>25</lpage><history><date date-type="received"><day>28</day><month>7</month><year>2012</year></date><date date-type="rev-recd"><day>20</day><month>9</month><year>2012</year></date><date date-type="accepted"><day>22</day><month>9</month><year>2012</year></date></history><permissions><copyright-statement>© 2013 International & American Associations for Dental Research</copyright-statement><copyright-year>2013</copyright-year><copyright-holder content-type="society">International & American Associations for Dental Research</copyright-holder></permissions><abstract><p>Parathyroid hormone (PTH) is known for its ability to ‘build’ bone, with research in this area centered on its use as an osteoporosis therapeutic. Recent interest has developed regarding its potential for regenerative applications such as fracture healing and osseous defects of the oral cavity. Many years of investigation using murine gene-targeted models substantiate a role for signaling at the PTH/PTH-related protein (PTHrP) receptor (PPR) in intramembranous bone formation in the craniofacial region as well as in tooth development. Pre-clinical studies clearly support a positive role of intermittent PTH administration in craniofacial bones and in fracture healing and implant integration. A few human clinical studies have shown favorable responses with teriparatide (the biologically active fragment of PTH) administration. Favorable outcomes have emerged with teriparatide administration in patients with osteonecrosis of the jaw (ONJ). New delivery strategies are in development to optimize targeted application of PTH and to help maximize local approaches. The promising host-modulating potential of PTH requires more information to further its effectiveness for craniofacial regeneration and osseous wound-healing, including a better delineation of cellular targets, temporal effects of PTH action, and improved approaches for local/targeted delivery of PTH.</p></abstract><kwd-group><kwd>anabolic</kwd><kwd>bone</kwd><kwd>osseointegration</kwd><kwd>osteonecrosis</kwd><kwd>osteoblast</kwd><kwd>teriparatide</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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