Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann’s Thrombasthenia with Chronic Gingival Bleed: Case Report</title>
<author><name sortKey="Ghosh, Abhishek" sort="Ghosh, Abhishek" uniqKey="Ghosh A" first="Abhishek" last="Ghosh">Abhishek Ghosh</name>
<affiliation><nlm:aff id="aff1"> Fellow, Head and Neck Oncology,<institution>HCG Cancer Centre</institution>
,<addr-line>(Previously Fellow at CMC Vellore), Ahmedabad, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kumar, Saurabh" sort="Kumar, Saurabh" uniqKey="Kumar S" first="Saurabh" last="Kumar">Saurabh Kumar</name>
<affiliation><nlm:aff id="aff2"> Assistant Professor, Department of Oral and Maxillofaical Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chacko, Rabin" sort="Chacko, Rabin" uniqKey="Chacko R" first="Rabin" last="Chacko">Rabin Chacko</name>
<affiliation><nlm:aff id="aff3"> Head of Department Unit I, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Charlu, Arun Paul" sort="Charlu, Arun Paul" uniqKey="Charlu A" first="Arun Paul" last="Charlu">Arun Paul Charlu</name>
<affiliation><nlm:aff id="aff4"> Associate Professor, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26894187</idno>
<idno type="pmc">4740716</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740716</idno>
<idno type="RBID">PMC:4740716</idno>
<idno type="doi">10.7860/JCDR/2016/16383.7123</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000507</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000507</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann’s Thrombasthenia with Chronic Gingival Bleed: Case Report</title>
<author><name sortKey="Ghosh, Abhishek" sort="Ghosh, Abhishek" uniqKey="Ghosh A" first="Abhishek" last="Ghosh">Abhishek Ghosh</name>
<affiliation><nlm:aff id="aff1"> Fellow, Head and Neck Oncology,<institution>HCG Cancer Centre</institution>
,<addr-line>(Previously Fellow at CMC Vellore), Ahmedabad, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kumar, Saurabh" sort="Kumar, Saurabh" uniqKey="Kumar S" first="Saurabh" last="Kumar">Saurabh Kumar</name>
<affiliation><nlm:aff id="aff2"> Assistant Professor, Department of Oral and Maxillofaical Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chacko, Rabin" sort="Chacko, Rabin" uniqKey="Chacko R" first="Rabin" last="Chacko">Rabin Chacko</name>
<affiliation><nlm:aff id="aff3"> Head of Department Unit I, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Charlu, Arun Paul" sort="Charlu, Arun Paul" uniqKey="Charlu A" first="Arun Paul" last="Charlu">Arun Paul Charlu</name>
<affiliation><nlm:aff id="aff4"> Associate Professor, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical and Diagnostic Research : JCDR</title>
<idno type="ISSN">2249-782X</idno>
<idno type="eISSN">0973-709X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Glanzmann’s Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder affecting the megakaryocyte lineage and is characterized by lack of platelet aggregation on stimulation. The molecular basis is linked to quantitative and qualitative abnormalities of αIIbβ3 integrin. Most of the patients with severe Glanzmann’s thrombasthenia have spontaneous gum bleeding and persistent low haemoglobin levels. Often these patients are addressed with local haemostatic measures and platelet coverage. We report a case of a severe Glanzmann’s thrombasthenia with chronic gingivitis and associated spontaneous gum bleed with chronic low haemoglobin levels, managed subsequently with total dental extraction under appropriate platelet and recombinant factor VIIa coverage. Further follow up of the patient substantiated the treatment protocol with increased and stable haemoglobin levels, thus emphasizing the need for total dental extraction in patients with severe Glanzmann’s with chronic spontaneous gum bleed, as a definitive treatment option, which has not been reported so far in the literature.</p>
</div>
</front>
</TEI>
<pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Diagn Res</journal-id>
<journal-id journal-id-type="iso-abbrev">J Clin Diagn Res</journal-id>
<journal-id journal-id-type="hwp">Journal of Clinical and Diagnostic Research</journal-id>
<journal-id journal-id-type="publisher-id">JCDR</journal-id>
<journal-title-group><journal-title>Journal of Clinical and Diagnostic Research : JCDR</journal-title>
</journal-title-group>
<issn pub-type="ppub">2249-782X</issn>
<issn pub-type="epub">0973-709X</issn>
<publisher><publisher-name>JCDR Research and Publications (P) Limited</publisher-name>
<publisher-loc>Delhi, India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26894187</article-id>
<article-id pub-id-type="pmc">4740716</article-id>
<article-id pub-id-type="doi">10.7860/JCDR/2016/16383.7123</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Dentistry Section</subject>
<subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann’s Thrombasthenia with Chronic Gingival Bleed: Case Report</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ghosh</surname>
<given-names>Abhishek</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Saurabh</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chacko</surname>
<given-names>Rabin</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Charlu</surname>
<given-names>Arun Paul</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Fellow, Head and Neck Oncology,<institution>HCG Cancer Centre</institution>
,<addr-line>(Previously Fellow at CMC Vellore), Ahmedabad, India</addr-line>
.</aff>
<aff id="aff2"><label>2</label>
Assistant Professor, Department of Oral and Maxillofaical Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</aff>
<aff id="aff3"><label>3</label>
Head of Department Unit I, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</aff>
<aff id="aff4"><label>4</label>
Associate Professor, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>
,<addr-line>Vellore, Tamil Nadu, India</addr-line>
.</aff>
<author-notes><corresp id="cor1">NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Abhishek Ghosh, HCG Cancer Centre Sola-Science City Road, Off S.G. Highway, Sola, Ahmedabad, Gujarat-380060, India. E-mail : <email>13abhishekghosh@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>01</day>
<month>1</month>
<year>2016</year>
</pub-date>
<volume>10</volume>
<issue>1</issue>
<fpage>ZD11</fpage>
<lpage>ZD12</lpage>
<history><date date-type="received"><day>21</day>
<month>8</month>
<year>2015</year>
</date>
<date date-type="rev-request"><day>10</day>
<month>10</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>02</day>
<month>11</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Journal of Clinical and Diagnostic Research</copyright-statement>
<copyright-year>2016</copyright-year>
</permissions>
<abstract><p>Glanzmann’s Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder affecting the megakaryocyte lineage and is characterized by lack of platelet aggregation on stimulation. The molecular basis is linked to quantitative and qualitative abnormalities of αIIbβ3 integrin. Most of the patients with severe Glanzmann’s thrombasthenia have spontaneous gum bleeding and persistent low haemoglobin levels. Often these patients are addressed with local haemostatic measures and platelet coverage. We report a case of a severe Glanzmann’s thrombasthenia with chronic gingivitis and associated spontaneous gum bleed with chronic low haemoglobin levels, managed subsequently with total dental extraction under appropriate platelet and recombinant factor VIIa coverage. Further follow up of the patient substantiated the treatment protocol with increased and stable haemoglobin levels, thus emphasizing the need for total dental extraction in patients with severe Glanzmann’s with chronic spontaneous gum bleed, as a definitive treatment option, which has not been reported so far in the literature.</p>
</abstract>
<kwd-group><kwd>αIIbβ3 deficiency</kwd>
<kwd>Platelet disorder</kwd>
<kwd>Recombinant factor VIIa</kwd>
<kwd>Spontaneous gingival hemorrhage</kwd>
<kwd>Total extraction</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0005078 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0005078 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Pmc |étape= Corpus |type= RBID |clé= |texte= }}
![]() | This area was generated with Dilib version V0.6.32. | ![]() |