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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of marginal bone loss and patient satisfaction in single and double-implant assisted mandibular overdenture by immediate loading</title><author><name sortKey="Tavakolizadeh, Sara" sort="Tavakolizadeh, Sara" uniqKey="Tavakolizadeh S" first="Sara" last="Tavakolizadeh">Sara Tavakolizadeh</name><affiliation><nlm:aff id="A1">TMD Center, INI Hospital, Hannover, Germany.</nlm:aff></affiliation></author><author><name sortKey="Vafaee, Fariborz" sort="Vafaee, Fariborz" uniqKey="Vafaee F" first="Fariborz" last="Vafaee">Fariborz Vafaee</name><affiliation><nlm:aff id="A2">Hamadan University of Dental Science, Hamadan, Iran.</nlm:aff></affiliation></author><author><name sortKey="Khoshhal, Masume" sort="Khoshhal, Masume" uniqKey="Khoshhal M" first="Masume" last="Khoshhal">Masume Khoshhal</name><affiliation><nlm:aff id="A2">Hamadan University of Dental Science, Hamadan, Iran.</nlm:aff></affiliation></author><author><name sortKey="Ebrahimzadeh, Zahra" sort="Ebrahimzadeh, Zahra" uniqKey="Ebrahimzadeh Z" first="Zahra" last="Ebrahimzadeh">Zahra Ebrahimzadeh</name><affiliation><nlm:aff id="A3">Periodontist, Tehran, Iran.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26140170</idno><idno type="pmc">4486614</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486614</idno><idno type="RBID">PMC:4486614</idno><idno type="doi">10.4047/jap.2015.7.3.191</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000305</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000305</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of marginal bone loss and patient satisfaction in single and double-implant assisted mandibular overdenture by immediate loading</title><author><name sortKey="Tavakolizadeh, Sara" sort="Tavakolizadeh, Sara" uniqKey="Tavakolizadeh S" first="Sara" last="Tavakolizadeh">Sara Tavakolizadeh</name><affiliation><nlm:aff id="A1">TMD Center, INI Hospital, Hannover, Germany.</nlm:aff></affiliation></author><author><name sortKey="Vafaee, Fariborz" sort="Vafaee, Fariborz" uniqKey="Vafaee F" first="Fariborz" last="Vafaee">Fariborz Vafaee</name><affiliation><nlm:aff id="A2">Hamadan University of Dental Science, Hamadan, Iran.</nlm:aff></affiliation></author><author><name sortKey="Khoshhal, Masume" sort="Khoshhal, Masume" uniqKey="Khoshhal M" first="Masume" last="Khoshhal">Masume Khoshhal</name><affiliation><nlm:aff id="A2">Hamadan University of Dental Science, Hamadan, Iran.</nlm:aff></affiliation></author><author><name sortKey="Ebrahimzadeh, Zahra" sort="Ebrahimzadeh, Zahra" uniqKey="Ebrahimzadeh Z" first="Zahra" last="Ebrahimzadeh">Zahra Ebrahimzadeh</name><affiliation><nlm:aff id="A3">Periodontist, Tehran, Iran.</nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Advanced Prosthodontics</title><idno type="ISSN">2005-7806</idno><idno type="eISSN">2005-7814</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>PURPOSE</title><p>The purpose of this study was to compare the coronal bone level and patient satisfaction in 1-implant and 2-implant assisted mandibular overdentures.</p></sec><sec><title>MATERIALS AND METHODS</title><p>Twenty patients who had maladaptive mandibular dentures were treated in this study. Patients were randomly divided into two groups. The first group received 1 implant (Simple line II, Implantium, South Korea) in their mandibular midline and the second group received 2 implants in their B and D regions (according to Misch's category). If the primary stability of each implant was at least 60 ISQ, ball attachment was placed and denture relined with soft liner. After 6 weeks, retentive cap incorporated with hard acrylic resin. In the 6 and 12 months recalls, periapical digital radiograph were made and visual analogue scale questionnaires were used to record patient satisfaction. The Friedman test was done for comparing the presurgical and postsurgical parameters in each group and the U-Mann Whitney test (<italic>P</italic><.05) was done for comparison of post-treatment results between the two groups.</p></sec><sec><title>RESULTS</title><p>All implants achieved sufficient primary stability to be immediately loaded. Patient satisfaction was high, and there were no significant differences between two groups (<italic>P</italic>>.05). In addition, mean marginal bone loss was 0.6 ± 0.67 mm in the first group and 0.6 ± 0.51 mm in the second group, after 12 month. Mean marginal bone loss showed no significant differences between two groups.</p></sec><sec><title>CONCLUSION</title><p>This preliminary one-year result indicated that mandibular overdentures anchored to a single implant can be a safe and cost-effective method as a starting step for implant-overdenture treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Redford, M" uniqKey="Redford M">M Redford</name></author><author><name sortKey="Drury, Tf" uniqKey="Drury T">TF Drury</name></author><author><name sortKey="Kingman, A" uniqKey="Kingman A">A Kingman</name></author><author><name sortKey="Brown, Lj" uniqKey="Brown L">LJ Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dias, R" uniqKey="Dias R">R Dias</name></author><author><name sortKey="Moghadam, M" uniqKey="Moghadam M">M Moghadam</name></author><author><name sortKey="Kuyinu, E" uniqKey="Kuyinu E">E 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Adv Prosthodont</journal-id><journal-id journal-id-type="iso-abbrev">J Adv Prosthodont</journal-id><journal-id journal-id-type="publisher-id">JAP</journal-id><journal-title-group><journal-title>The Journal of Advanced Prosthodontics</journal-title></journal-title-group><issn pub-type="ppub">2005-7806</issn><issn pub-type="epub">2005-7814</issn><publisher><publisher-name>The Korean Academy of Prosthodontics</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26140170</article-id><article-id pub-id-type="pmc">4486614</article-id><article-id pub-id-type="doi">10.4047/jap.2015.7.3.191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Comparison of marginal bone loss and patient satisfaction in single and double-implant assisted mandibular overdenture by immediate loading</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Tavakolizadeh</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Vafaee</surname><given-names>Fariborz</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Khoshhal</surname><given-names>Masume</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ebrahimzadeh</surname><given-names>Zahra</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>TMD Center, INI Hospital, Hannover, Germany.</aff><aff id="A2"><label>2</label>Hamadan University of Dental Science, Hamadan, Iran.</aff><aff id="A3"><label>3</label>Periodontist, Tehran, Iran.</aff><author-notes><corresp>Corresponding author: Sara Tavakolizadeh. TMD center, INI hospital, Rudolf-Pichlmayr street, 30625, Hannover, Germany. Tel: 004917646171743: <email>saratavakolizadeh@yahoo.com</email></corresp><corresp>Corresponding author: Fariborz Vafaee. Hamadan University of Dental Science, Shahid Fahmide street, Hamadan, Iran. <email>fvafaee@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>6</month><year>2015</year></pub-date><volume>7</volume><issue>3</issue><fpage>191</fpage><lpage>198</lpage><history><date date-type="received"><day>12</day><month>10</month><year>2014</year></date><date date-type="rev-recd"><day>16</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>18</day><month>3</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 The Korean Academy of Prosthodontics</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>PURPOSE</title><p>The purpose of this study was to compare the coronal bone level and patient satisfaction in 1-implant and 2-implant assisted mandibular overdentures.</p></sec><sec><title>MATERIALS AND METHODS</title><p>Twenty patients who had maladaptive mandibular dentures were treated in this study. Patients were randomly divided into two groups. The first group received 1 implant (Simple line II, Implantium, South Korea) in their mandibular midline and the second group received 2 implants in their B and D regions (according to Misch's category). If the primary stability of each implant was at least 60 ISQ, ball attachment was placed and denture relined with soft liner. After 6 weeks, retentive cap incorporated with hard acrylic resin. In the 6 and 12 months recalls, periapical digital radiograph were made and visual analogue scale questionnaires were used to record patient satisfaction. The Friedman test was done for comparing the presurgical and postsurgical parameters in each group and the U-Mann Whitney test (<italic>P</italic><.05) was done for comparison of post-treatment results between the two groups.</p></sec><sec><title>RESULTS</title><p>All implants achieved sufficient primary stability to be immediately loaded. Patient satisfaction was high, and there were no significant differences between two groups (<italic>P</italic>>.05). In addition, mean marginal bone loss was 0.6 ± 0.67 mm in the first group and 0.6 ± 0.51 mm in the second group, after 12 month. Mean marginal bone loss showed no significant differences between two groups.</p></sec><sec><title>CONCLUSION</title><p>This preliminary one-year result indicated that mandibular overdentures anchored to a single implant can be a safe and cost-effective method as a starting step for implant-overdenture treatment.</p></sec></abstract><kwd-group><kwd>Implant</kwd><kwd>Overdenture</kwd><kwd>Bone loss</kwd><kwd>Patients satisfaction</kwd></kwd-group><funding-group><award-group><funding-source country="IR">Hamadan Dental University</funding-source></award-group></funding-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Half of all conventional mandibular dentures demonstrate problems with prosthesis stability and retention, with retention being the single most important deficiency reported.<xref rid="B1" ref-type="bibr">1</xref> Introduction of osseointegrated dental implant has improved the quality of life of many edentulous patients. Implant assisted mandibular overdentures can provide a highly successful restoration of both function and esthetics.<xref rid="B2" ref-type="bibr">2</xref><xref rid="B3" ref-type="bibr">3</xref><xref rid="B4" ref-type="bibr">4</xref></p><p>In the last 30 years, use of unloaded and submerged implant according to Brånemark protocol for achieving osseointegration was necessary. Current studies have demonstrated increasing success with immediately loaded dental implants. Immediate loading of implants in anterior mandible was reported to shorten the treatment time and show comparable clinical success with the delay loading approach.<xref rid="B5" ref-type="bibr">5</xref><xref rid="B6" ref-type="bibr">6</xref><xref rid="B7" ref-type="bibr">7</xref></p><p>Traditionally, an overdenture has based the use of two or more mandibular implants. Although, it seems that increasing the number of implants may improve the treatment outcome, but many studies showed that two implants, splinted or unsplinted, are sufficient for clinical success.<xref rid="B8" ref-type="bibr">8</xref><xref rid="B9" ref-type="bibr">9</xref><xref rid="B10" ref-type="bibr">10</xref><xref rid="B11" ref-type="bibr">11</xref><xref rid="B12" ref-type="bibr">12</xref> McGill consensus statement suggested that two-implant overdenture should be the first choice of treatment for the edentulous mandible.<xref rid="B13" ref-type="bibr">13</xref></p><p>Unfortunately, two-implant mandibular overdenture is outside the financial scope of many compromised edentulous patients.<xref rid="B14" ref-type="bibr">14</xref> With the increased demand for a better denture, a more cost-effective alternative treatment with a single implant can be recommended. Improving patient's satisfaction and predictable clinical success of single implant overdenture with a delay and immediate implant loading protocol was demonstrated in some studies.<xref rid="B14" ref-type="bibr">14</xref><xref rid="B15" ref-type="bibr">15</xref><xref rid="B16" ref-type="bibr">16</xref><xref rid="B17" ref-type="bibr">17</xref><xref rid="B18" ref-type="bibr">18</xref></p><p>The aim of this study is to compare the coronal bone loss and patient satisfaction between 1 and 2 implant anchored mandibular overdenture by immediate loading protocol.</p></sec><sec sec-type="materials|methods"><title>MATERIALS AND METHODS</title><p>Twenty completely edentulous patients (9 male and 11 female), with the mean age of 59 years, were included in this study. The main complaint among the patients was poor retention and instability of mandibular denture.</p><p>Inclusion criteria dictated that the patients have been completely edentulous for at least one year, be maladaptive to the mandibular denture and have enough bone for an implant length of at least 10 mm and diameter of 3.8 mm in the anterior and inverted U shape ridge in the posterior region of the mandible.<xref rid="B5" ref-type="bibr">5</xref><xref rid="B14" ref-type="bibr">14</xref><xref rid="B19" ref-type="bibr">19</xref> Exclusion criteria included substance abuse, disorders to the implant sites that disturb bone regeneration or any physical or psychological problem that could affect the follow up. Smokers were encouraged and followed to quit for at least 2 months, but were not excluded from the study.<xref rid="B14" ref-type="bibr">14</xref> Before initiation of treatment, an informed consent was signed by all patients. Approval of the Ethic Committee for Human Clinical Research and the IRB approval were produced.</p><p>All existing dentures were evaluated with the California Dental Association (CDA) quality evaluation system.<xref rid="B20" ref-type="bibr">20</xref> Fabrication of new upper and lower dentures was done in any patients that dentures did not match with these criteria in terms of aesthetic, coordination of centric occlusion with centric relation, correct vertical dimension or absence of tissue irritation.</p><p>Preoperative cone beam computed tomography (CBCT) (Promax 3D, Planmeca, Helsinki, Finland) was taken with a radiopaque surgical stent. A transparent stent was duplicated from the final patient's mandibular denture, then drilled in B, C and D locations (according to Misch's category).<xref rid="B21" ref-type="bibr">21</xref> C location is the mandibular midline, B and D locations are the proximal contacts between the right and left lateral incisor-canine teeth, respectively. These holes were filled with gutta-percha cone (Guttapercha, Ariadent, Tehran, Iran) and polished surfaces painted with Barium sulfate (barium sulfate was mixed with dentin bonding in ratio of 1/3 and painted by 2 layers) as radiopaque materials. The bone quality and quantity of anterior mandibular ridge was analyzed with CBCT and the best implant angulations according to available bone and avoidance of anatomic structures was determined by electronic surgery on computer (<xref ref-type="fig" rid="F1">Fig. 1</xref>).</p><p>After removal of the radiopaque markers, pilot holes for the best implants positioning (according to the CBCT evaluation) were drilled. These holes diameter were matched with the initial 2 mm twist drill (<xref ref-type="fig" rid="F2">Fig. 2</xref>).</p><p>For comparison of patients comfort and function, before and after implant treatment, self-administered questionnaire that followed the Visual Analog Scale (VAS) method was filled out by the patients preoperatively and then at each scheduled recall.<xref rid="B22" ref-type="bibr">22</xref></p><p>Each VAS questionnaire consisted of a 100 mm line anchored at the beginning and end by opposing statements such as "not at all satisfied" to "extremely satisfied". The participants marked a vertical line on the horizontal VAS line to indicate feelings. Scores determined by measuring the distance (in mm) from the right starting point of the line to the intersection of the response line. Questions were in 5 categories: general satisfaction, social life, mastication of hard and soft foods and fit.<xref rid="B14" ref-type="bibr">14</xref></p><p>Patients were randomly divided into 2 groups; in the first group a single regular platform implant of 3.8 mm diameter (Simple line II, SOFX483810R, Implantium, Seoul, South Korea) installed in the mandibular midline and in the second group, two implants were installed in the B and D locations (according to Misch's category).</p><p>One hour before the surgery, all patients received single-dose prophylactic antibiotic (2 g of Amoxicillin or 600 mg of Clindamycin) orally.<xref rid="B23" ref-type="bibr">23</xref> A mouth rinse (0.2% chlorhexidineNajo, Tehran, Iran) was utilized for 60 seconds just prior to the local anesthetic: bilateral mental nerve blocks and local infiltration in the buccal and lingual sulcus with 2% HCL lidocaine with epinephrine 1:80,000 (Lidocaine, Darupakhsh, Tehran, Iran).</p><p>A minimal crestal incision was made to enable adequate visualization of the lingual aspect of the mandible and to evenly divide the available keratinized tissue. All implant installation sites were prepared using a standard dense bone drilling protocol following the manufacturer's guidelines and all sites were tapped with a 3.8 mm diameter screw tap to the full implant length.<xref rid="B21" ref-type="bibr">21</xref> The pre tap for D1 bones was done with hand ratchet (Simple line II, Implantium, Seoul, South Korea) and for D2 was done with hand piece (NSK, Tokyo, Japan).</p><p>The drilling (Surgical XT, NSK, Japan) speed was 2500 rpm and the torque was 75 Ncm. The insertion speed was 30 rpm and the torque was 75 Ncm.<xref rid="B21" ref-type="bibr">21</xref></p><p>An insertion torque of at least 45 Ncm and Resonance Frequency Analysis (RFA) (Osstell, Integration Diagnostics, Gamlestads, Sweden) of at least 60 ISQ indicated primary implant stability (<xref ref-type="fig" rid="F3">Fig. 3</xref>).<xref rid="B4" ref-type="bibr">4</xref><xref rid="B6" ref-type="bibr">6</xref> This primary stability is necessary for immediate implant loading protocol. So, the ball attachment (Simple line II, SOBA4800, Implantium, Seoul, South Korea) was connected and tightened to 25 Ncm with special torque wrench (that is connected to the ball previously). Then, the mucosa was sutured.</p><p>The 2-stage (delayed loading) protocol was considered for implants that did not have sufficient primary stability.</p><p>After the surgery, patients received antibiotic (20 capsule Amoxicillin (Amoxicillin, Darupakhsh, Tehran, Iran) 500 mg 3 times a day) and Gelofen (20 pearls, 400 mg 4 times a day) for pain control if needed.</p><p>Immediate after surgery, the tissue surface of patient's denture was relieved around the ball attachments and implants sites. Then, denture was relined with soft liner (GC Corporation, Tokyo, Japan) and delivered to the patient. This protocol is in contrast to relining with hard acrylic Resin resulted in greater post-operative comfort and uneventful healing.</p><p>Soft liners were changed every 10 days for patient's comfort. After relining the denture, a Parallel digital periapical radiograph was obtained with a custom made stent (<xref ref-type="fig" rid="F4">Fig. 4</xref>). This radiograph used as a reference for evaluation of marginal bone level before and after loading of implants. The custom made stent was an anterior region film holder that modified for repeating the same position in each schedule. Horizontal lines on the film holder dictated the position of upper and lower denture teeth. The vertical line dictated the mandibular midline in group A, and proximal contact of mandibular lateral incisor and canine in group B.</p><p>All patients were limited to a soft diet for 6 weeks and were instructed to leave the denture out at night. Patients were instructed in plaque control protocol at the time of implant placement and reinforced at subsequent reviews.</p><p>Six weeks after implant placement, dentures were relined with hard acrylic chairside material (GC Reline, GC, Alsip, IL, USA). During this relining procedure, the retentive elements (metal housing, Simple line II, Implantium, South Korea) were incorporated in denture (<xref ref-type="fig" rid="F5">Fig. 5</xref>). The dentures were reinserted and subjected to conventional relining evaluation and occlusal adjustment.</p><p>Patients were asked to refer if any unexpected problem happens. Patients recall was arranged for 6 and 12 months after surgery. In each recall schedule, self-administered questionnaire was filled by patients and parallel digital periapical radiograph was obtained.</p><p>For marginal bone loss evaluation, the distance from the first tread of the implant to the most coronal point where the bone was in contact with the implant, was measured within the aid of ×1.5 magnifications with Digora software (Digora, Sordex, Finland). Then mean bone loss of right and left side was used as the each implant bone loss (<xref ref-type="fig" rid="F6">Fig. 6</xref>).</p><p>Data were analyzed by using statistical software (SPSS, version 12, SPSS Chicago, IL, USA). The U Mann-Whitney test was used to determine differences between the mean values in the two groups (<italic>P</italic><.05). The Friedman test was used for comparing the parameters, before and after surgery, in each group.</p></sec><sec sec-type="results"><title>RESULTS</title><p>Among 20 selected patients, denture refabrication was required for 5 patients (3 male and 2 female). Denture refabrication was done by the same practitioner.</p><p>In total, 20 patients had 30 implants inserted. All of the implants fulfilled the requirements for sufficient implant stability; an insertion torque greater than 45 Ncm and a resonance frequency analysis of 60 ISQ or greater. So, in all patients, ball attachments were tightened immediately after surgery and dentures were relined with soft liner.</p><p>During the first six weeks, patients were informed to be recalled every ten days for changing the soft liner. Immediate soft loading of the dentures did not allow for postoperative swelling or inflammation to occur and cause more patients' comfort in comparison to immediate hard loading.</p><p>Dentures were relined with hard acrylic resin after 6 weeks. Two weeks after hard acryl relining, one patient in group A reported moderate masticatory muscle pain. It was, may be, because of increased occlusal perception and solved with occlusal adjustment.</p><p>In one patient of group B, soft tissue inflammation was occurred after hard acrylic relining. The tissue side of denture relieved around the affected area and relined with soft liner for extra 10 days. Patient was requested to improve his oral hygiene. There was no sign of inflammation after ten days and final reline was done.</p><p>The VAS questionnaires filled out by all patients at pretreatment, 6 and 12 months after implant placement. Friedman test were done in each group which showed a significant improvement (<italic>P</italic><.05) in all parameters of oral comfort and prostheses function from pretreatment to all post treatment recalls (<xref ref-type="fig" rid="F7">Fig. 7</xref>, <xref ref-type="fig" rid="F8">Fig. 8</xref>).</p><p>Then, U-Mann Whitney test were done for comparison of parameters of oral comfort and prosthetic function, in post treatment recalls period between the two groups. Analysis showed no significant statistical differences in all parameters between the one implant group and the two implants group (<italic>P</italic>>.05)(<xref ref-type="table" rid="T1">Table 1</xref>).</p><p>Radiograph follow-up was difficult in this study due to the clinical problems associated with film placement that interfere with denture flanges.</p><p>Digital periapical radiograph were obtained immediately after implant insertion, 6 and 12 months postoperatively. The distance from the first tread of the implant to the coronal point, where the bone was in contact with the implant, was measured. Measurements were made with ×1.5 magnification. And mean values of right and left was used as an each implant bone loss.<xref rid="B14" ref-type="bibr">14</xref></p><p>No peri-implant radiolucency was noted. There was a little increase in bone loss over time for both groups (<italic>P</italic>=.16). In the group A (one implant), bone loss was 0.6 ± 0.67 mm and for the group B (two implants), the bone loss was 0.6 ± 0.51 mm in 12 months.</p><p>When the two groups were compared, there were no statistical differences between marginal bone loss of two groups in 12 months (<xref ref-type="table" rid="T2">Table 2</xref>). In the 12 months follow-up period, no ball attachment retentive caps have loosened but three patients (two patients in group A and one patient in group B) required rubber O-ring replacement.</p></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>The aim of this prospective study was to compare the marginal bone level and patient satisfaction of simplifying single-implant mandibular overdenture with the success rate and functional improvement of two-implant assisted overdenture as a conventional treatment.</p><p>Patients randomly divided into two groups and for better comparison, patients matched (as much as possible) according to sex, age and smoking condition in the two groups. Presurgical work-up of patients in this study was simplified due to use of patient's existing denture.<xref rid="B14" ref-type="bibr">14</xref> A transparent acrylic template was duplicated from the patient's denture. Use of this template as a radiographic guide with CBCT provided the possibility of electronic surgery with evaluation of bone condition and anatomical structures. This stent was also used as a surgical guide that allowed the implant to be placed in a prosthetically-driven position. This is particularly critical when relatively large prosthetic components that occupy a significant volume of the denture space.</p><p>Immediate loading of implants allow shorter treatment time and immediate restoration of function and esthetic. According to previous studies, immediately loaded implants have predictable clinical success in the anterior mandible. <xref rid="B6" ref-type="bibr">6</xref><xref rid="B24" ref-type="bibr">24</xref><xref rid="B25" ref-type="bibr">25</xref><xref rid="B26" ref-type="bibr">26</xref> So, we used the one stage protocol in this study. All patients achieved the required implant stability (the resonance frequency analysis above 60 ISQ) before placing the ball abutment for immediate loading. This can be due to the generally excellent bone quality and quantity in the anterior mandible.</p><p>Use of soft liner material in the first 6 weeks after surgery, could be a change from immediate loading to progressive or early loading. The purpose of immediate loading or early loading is decreasing the edentulous period and in order the performance and comfort of the patient is the first goal.<xref rid="B27" ref-type="bibr">27</xref> Payne et al.<xref rid="B11" ref-type="bibr">11</xref> recommended that 6 weeks healing with soft liner prior to definitive relining is better than 2 weeks healing. Liddelow and Henry<xref rid="B14" ref-type="bibr">14</xref> also showed 6 weeks soft loading allowed more complete maturation of the periimplant mucosa. So, the use of viscoelastic soft liner instead of rigid fixation with hard material not only inhibited tissue proliferation, but also was more comfortable for the healing period of soft tissue.</p><p>There is a general lack of agreement on the appropriate implant attachment system. Unsplinted implants have been associated with greater problems in some short to medium term studies and less in others.<xref rid="B13" ref-type="bibr">13</xref><xref rid="B28" ref-type="bibr">28</xref><xref rid="B29" ref-type="bibr">29</xref> We used unsplinted ball attachment with metallic cap and rubber O-ring. Prosthetic problems were relatively low and only three patients (two patients in group A and one patient in group B) required rubber O-ring replacement because of reduced retention.</p><p>The reduced unplanned prosthodontic appointments in this study may in part be due to implant placement. The traditional position for mandibular overdentures was two implants in the canine region. These implants are placed posterior to the incisal edge and may create bending moments about the implant as it acts as a fulcrum.<xref rid="B30" ref-type="bibr">30</xref> In this situation, increased stress around the implants may cause ball attachment loosening, rapid wear of O-ring or components fracture. More anteriorly placed implants reduce this potential and for this reason, it has been suggested to place two implants in the lateral incisor regions.<xref rid="B21" ref-type="bibr">21</xref><xref rid="B30" ref-type="bibr">30</xref> In addition, if the implants are not placed parallel, the off-axis insertion and removal places greater wear on the components. In this study, implants placed in the most anterior position as possible. The single implant placed in the mandibular midline (position C according to Misch's category). And in group B, 2 implants placed between the each lateral and canine sites (position B and D according to Misch's category).<xref rid="B21" ref-type="bibr">21</xref></p><p>In addition, one of the inclusion criteria in this study was the existence of inverted U shape ridge in the posterior mandible. Good posterior ridge support is a positive factor that reduces anterior-posterior overdenture movement and decreases the unfavorable forces on the implant especially in the single implant group.</p><p>Edentulous patient's desire for improved masticatory function is often the primary reason for implant treatment. <xref rid="B31" ref-type="bibr">31</xref> But patient satisfaction is a highly complex phenomenon that is influenced by many factors. In this study, we used the existing patient's denture to evaluate the effect of implant insertion without the new denture construction as a conflicting factor. Patients had dentures with good stability and function in centric and bilateral occlusal contacts. The main complaint was a poor retention. As a result, the treatment impact was closely originating only from placement of the implants. Some studies constructed a new denture as a part of treatment protocol. They showed, satisfaction level had increased in both the implant and conventional groups but with a greater extent in the implant group.<xref rid="B15" ref-type="bibr">15</xref><xref rid="B32" ref-type="bibr">32</xref><xref rid="B33" ref-type="bibr">33</xref></p><p>Satisfaction scores, in both study groups, were significantly improved up to 6 months with maintenance of this satisfaction to 12 months. All patients reported the procedure was easier than expected and they were enthusiastic to continue the treatment.</p><p>Marginal bone loss is one of the most important implant success criteria. The use of customized radiographic stent provides repeatable condition for precise measurement of marginal bone level in each recall. Digital periapical radiograph has higher resolution with lower radiation dose rather than extra oral radiograph that used in other study.<xref rid="B14" ref-type="bibr">14</xref> The other aspect of using parallel P.A with special stent is decreasing the superimposition of anatomical structures especially genial tubercles.</p><p>The success criteria used in this study specified not more than 1 mm of marginal bone loss during the first year of loading and not more than 0.1 mm resorption per year.<xref rid="B34" ref-type="bibr">34</xref> The measurable one year bone remodeling in the single implant group was 0.6 ± 0.67 mm. These results are in agreement with Cordiolli and Kronstrom studies.<xref rid="B16" ref-type="bibr">16</xref><xref rid="B33" ref-type="bibr">33</xref> Marginal bone loss in the two implant group was 0.6 ± 0.51 mm. There were no statistical differences between the two groups. The little difference between the two groups may be, due to larger bone ridge and ticker cortical bone can be found in mandibular midline. In addition, immediate soft loading in early 6 weeks (that the bone is in the weakest condition<xref rid="B21" ref-type="bibr">21</xref>) and lack of the second stage surgery may be limiting the coronal bone loss. No implant showed mobility, peri-implant pathosis or radiolucency.</p><p>2-implant assisted mandibular overdenture has been accepted as a first treatment choice for many years.<xref rid="B10" ref-type="bibr">10</xref><xref rid="B11" ref-type="bibr">11</xref><xref rid="B12" ref-type="bibr">12</xref><xref rid="B13" ref-type="bibr">13</xref> Many patients desire to improve their complete denture to an implant assisted overdenture, but 2 implants is out of their financial scope. If the single implant overdenture can provide the main goal of treatment (maintaining the residual ridge and patient comfort), this could be a cost-effective alternative treatment for 2 implants.</p><p>Within the limitation of this study, the single implant overdenture could be a treatment choice for edentulous patients. But, these results are preliminary one-year outcomes. Use of the exact term of implant success or failure require longer term follow-up.</p></sec><sec sec-type="conclusions"><title>CONCLUSION</title><p>Within the limitation of this preliminary study, it appears that the immediately loaded single implant assisted mandibular overdenture, in a group of maladaptive patients, can provide a beneficial treatment outcome. 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(A) tissue surface, (B) polished surface.</title></caption><graphic xlink:href="jap-7-191-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label><caption><title>RFA evaluation. (A) occlusal view, (B) lateral view.</title></caption><graphic xlink:href="jap-7-191-g003"></graphic></fig><fig id="F4" orientation="portrait" position="float"><label>Fig. 4</label><caption><title>Customized radiographic stent. (A) Upper view, (B) Lateral view.</title></caption><graphic xlink:href="jap-7-191-g004"></graphic></fig><fig id="F5" orientation="portrait" position="float"><label>Fig. 5</label><caption><title>Overdentures with incorporated metallic cap and O-ring.</title></caption><graphic xlink:href="jap-7-191-g005"></graphic></fig><fig id="F6" orientation="portrait" position="float"><label>Fig. 6</label><caption><title>Digital parallel periapical. (A) immediately after insertion, (B) 12 months later.</title></caption><graphic xlink:href="jap-7-191-g006"></graphic></fig><fig id="F7" orientation="portrait" position="float"><label>Fig. 7</label><caption><title>Improvement of oral function and comfort in single implant group.</title></caption><graphic xlink:href="jap-7-191-g007"></graphic></fig><fig id="F8" orientation="portrait" position="float"><label>Fig. 8</label><caption><title>Improvement of oral function and comfort in two-implant
group.</title></caption><graphic xlink:href="jap-7-191-g008"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Comparison of improvement in comfort and function between Group A and B</title></caption><alternatives><graphic xlink:href="jap-7-191-i001"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="middle" align="center" rowspan="2" colspan="2">Index</th><th valign="middle" align="center" rowspan="1" colspan="2">Pretreatment</th><th valign="middle" align="center" rowspan="1" colspan="2">6 months</th><th valign="middle" align="center" rowspan="1" colspan="2">12 months</th></tr><tr><th valign="middle" align="center" rowspan="1" colspan="1">Mean ± SD</th><th valign="middle" align="center" rowspan="1" colspan="1"><italic>P</italic> value</th><th valign="middle" align="center" rowspan="1" colspan="1">Mean ± SD</th><th valign="middle" align="center" rowspan="1" colspan="1"><italic>P</italic> value</th><th valign="middle" align="center" rowspan="1" colspan="1">Mean ± SD</th><th valign="middle" align="center" rowspan="1" colspan="1"><italic>P</italic> value</th></tr></thead><tbody><tr><td valign="middle" align="left" rowspan="2" colspan="1">General satisfaction</td><td valign="top" align="left" rowspan="1" colspan="1">Group A</td><td valign="top" align="left" rowspan="1" colspan="1">2.7 ± 3.0</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4.5 ± 1.6</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">7.1 ± 2.03</td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group B</td><td valign="top" align="left" rowspan="1" colspan="1">4.3 ± 2.3</td><td valign="top" align="center" rowspan="1" colspan="1">.24</td><td valign="top" align="left" rowspan="1" colspan="1">6.3 ± 1.5</td><td valign="top" align="center" rowspan="1" colspan="1">.04</td><td valign="top" align="left" rowspan="1" colspan="1">7.0 ± 1.5</td><td valign="top" align="center" rowspan="1" colspan="1">.51</td></tr><tr><td valign="middle" align="left" rowspan="2" colspan="1">Social life</td><td valign="top" align="left" rowspan="1" colspan="1">Group A</td><td valign="top" align="left" rowspan="1" colspan="1">4.5 ± 2.1</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">5.8 ± 1.4</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">7.8 ± 1.1</td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group B</td><td valign="top" align="left" rowspan="1" colspan="1">5.2 ± 2.2</td><td valign="top" align="center" rowspan="1" colspan="1">.55</td><td valign="top" align="left" rowspan="1" colspan="1">6.8 ± 1.5</td><td valign="top" align="center" rowspan="1" colspan="1">.36</td><td valign="top" align="left" rowspan="1" colspan="1">8.3 ± 1.4</td><td valign="top" align="center" rowspan="1" colspan="1">.83</td></tr><tr><td valign="middle" align="left" rowspan="2" colspan="1">Chew hardfoods</td><td valign="top" align="left" rowspan="1" colspan="1">Group A</td><td valign="top" align="left" rowspan="1" colspan="1">3.4 ± 1.4</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4.8 ± 2.1</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">7.5 ± 1.2</td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group B</td><td valign="top" align="left" rowspan="1" colspan="1">3.5 ± 1.9</td><td valign="top" align="center" rowspan="1" colspan="1">.82</td><td valign="top" align="left" rowspan="1" colspan="1">6.1 ± 1.9</td><td valign="top" align="center" rowspan="1" colspan="1">.20</td><td valign="top" align="left" rowspan="1" colspan="1">7.4 ± 1.4</td><td valign="top" align="center" rowspan="1" colspan="1">.55</td></tr><tr><td valign="middle" align="left" rowspan="2" colspan="1">Comfort</td><td valign="top" align="left" rowspan="1" colspan="1">Group A</td><td valign="top" align="left" rowspan="1" colspan="1">5.0 ± 3.1</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">6.5 ± 1.3</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">8.1 ± 1.8</td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group B</td><td valign="top" align="left" rowspan="1" colspan="1">5.3 ± 2.8</td><td valign="top" align="center" rowspan="1" colspan="1">.70</td><td valign="top" align="left" rowspan="1" colspan="1">7.5 ± 1.6</td><td valign="top" align="center" rowspan="1" colspan="1">.30</td><td valign="top" align="left" rowspan="1" colspan="1">8.0 ± 1.3</td><td valign="top" align="center" rowspan="1" colspan="1">.39</td></tr><tr><td valign="middle" align="left" rowspan="2" colspan="1">Fit</td><td valign="top" align="left" rowspan="1" colspan="1">Group A</td><td valign="top" align="left" rowspan="1" colspan="1">3.6 ± 2.2</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">7.7 ± 1.1</td><td valign="top" align="center" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">8.2 ± 0.8</td><td valign="top" align="center" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group B</td><td valign="top" align="left" rowspan="1" colspan="1">3.6 ± 2.2</td><td valign="top" align="center" rowspan="1" colspan="1">.99</td><td valign="top" align="left" rowspan="1" colspan="1">8.0 ± 1.1</td><td valign="top" align="center" rowspan="1" colspan="1">.78</td><td valign="top" align="left" rowspan="1" colspan="1">9.0 ± 0.7</td><td valign="top" align="center" rowspan="1" colspan="1">.70</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Mann-Whitney Test</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title>Mean bone loss (mm) from baseline for group A and B</title></caption><alternatives><graphic xlink:href="jap-7-191-i002"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="middle" align="center" rowspan="2" colspan="2">Index</th><th valign="top" align="center" rowspan="1" colspan="2">6 months</th><th valign="top" align="center" rowspan="1" colspan="2">12 months</th></tr><tr><th valign="top" align="center" rowspan="1" colspan="1">Mean ± SD</th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic> value</th><th valign="top" align="center" rowspan="1" colspan="1">Mean ± SD</th><th valign="top" align="center" rowspan="1" colspan="1"><italic>P</italic> value</th></tr></thead><tbody><tr><td valign="middle" align="left" rowspan="2" colspan="1">Marginal bone loss</td><td valign="middle" align="left" rowspan="1" colspan="1">Group A</td><td valign="middle" align="center" rowspan="1" colspan="1">0.4 ± 0.24</td><td valign="middle" align="center" rowspan="2" colspan="1">0.91</td><td valign="middle" align="center" rowspan="1" colspan="1">0.6 ± 0.67</td><td valign="middle" align="center" rowspan="2" colspan="1">0.74</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Group B</td><td valign="top" align="center" rowspan="1" colspan="1">0.4 ± 0.16</td><td valign="top" align="center" rowspan="1" colspan="1">0.6 ± 0.51</td></tr></tbody></table></alternatives><table-wrap-foot><fn><p>Mann-Whitney Test</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document 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