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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of custom made oral appliance for treatment of obstructive sleep apnea</title><author><name sortKey="Cilil, V R" sort="Cilil, V R" uniqKey="Cilil V" first="V. R." last="Cilil">V. R. Cilil</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sapana Varma, N K" sort="Sapana Varma, N K" uniqKey="Sapana Varma N" first="N. K." last="Sapana Varma">N. K. Sapana Varma</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gopinath, Siby" sort="Gopinath, Siby" uniqKey="Gopinath S" first="Siby" last="Gopinath">Siby Gopinath</name><affiliation><nlm:aff id="aff2"><italic>Department of Neurology, Amrita Institute of Medical Sciences, Kochi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Ajith, V V" sort="Ajith, V V" uniqKey="Ajith V" first="V. V." last="Ajith">V. V. Ajith</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26321833</idno><idno type="pmc">4549985</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549985</idno><idno type="RBID">PMC:4549985</idno><idno type="doi">10.4103/0976-237X.161881</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000268</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000268</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of custom made oral appliance for treatment of obstructive sleep apnea</title><author><name sortKey="Cilil, V R" sort="Cilil, V R" uniqKey="Cilil V" first="V. R." last="Cilil">V. R. Cilil</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sapana Varma, N K" sort="Sapana Varma, N K" uniqKey="Sapana Varma N" first="N. K." last="Sapana Varma">N. K. Sapana Varma</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Gopinath, Siby" sort="Gopinath, Siby" uniqKey="Gopinath S" first="Siby" last="Gopinath">Siby Gopinath</name><affiliation><nlm:aff id="aff2"><italic>Department of Neurology, Amrita Institute of Medical Sciences, Kochi, India</italic></nlm:aff></affiliation></author><author><name sortKey="Ajith, V V" sort="Ajith, V V" uniqKey="Ajith V" first="V. V." last="Ajith">V. V. Ajith</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Contemporary Clinical Dentistry</title><idno type="ISSN">0976-237X</idno><idno type="eISSN">0976-2361</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction:</title><p>oral appliance for the treatment of OSA is considered as an effective, low-risk alternative to CPAP. Demand for oral appliance increases as an alternative for those who cannot tolerate CPAP and refuse surgery. Oral appliances uses the traditional methods to advance the mandible thus modify the posture and their by enlarge the airway or otherwise reduce the collapsibility.</p></sec><sec id="st2"><title>Aims and Objectives:</title><p>The main objective of this study was to evaluate the efficacy of custom made oral appliance on sleep characteristics of OSA patients. Materials and Methods: Polysomnography was done on 15 patients of 24-60 years of age before (T1), and after the delivery of the custom made oral appliance (T2).</p></sec><sec id="st3"><title>Statistical Analysis:</title><p>Paired t tests were performed to determine the significance of change in the polysomnographic and cephalometric variables. <italic>P</italic> < 0.05 was considered as significant. Results: All patients with oral appliance showed an improvement in sleep parameters with an increase in sleep efficiency, and desaturation index with the use of oral appliance. ESS and cephalometric findings showed improvement in the sleep apnea in concordance with the sleep parameters.</p></sec><sec id="st4"><title>Conclusions:</title><p>Custom made oral appliance is a useful treatment option for improving quality of sleep and can be considered as an alternative treatment modality.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gotsopoulos, H" uniqKey="Gotsopoulos H">H Gotsopoulos</name></author><author><name sortKey="Kelly, Jj" uniqKey="Kelly J">JJ Kelly</name></author><author><name sortKey="Cistulli, Pa" uniqKey="Cistulli P">PA Cistulli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zancanella, E" uniqKey="Zancanella E">E Zancanella</name></author><author><name sortKey="Haddad, Fm" uniqKey="Haddad F">FM Haddad</name></author><author><name sortKey="Oliveira, La" uniqKey="Oliveira L">LA Oliveira</name></author><author><name sortKey="Nakasato, A" uniqKey="Nakasato A">A Nakasato</name></author><author><name sortKey="Duarte, Bb" uniqKey="Duarte B">BB Duarte</name></author><author><name sortKey="Soares, Cf" uniqKey="Soares C">CF Soares</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epstein, Lj" uniqKey="Epstein L">LJ Epstein</name></author><author><name sortKey="Kristo, D" uniqKey="Kristo D">D Kristo</name></author><author><name sortKey="Strollo, Pj" uniqKey="Strollo P">PJ Strollo</name></author><author><name sortKey="Friedman, N" uniqKey="Friedman N">N Friedman</name></author><author><name sortKey="Malhotra, A" uniqKey="Malhotra A">A Malhotra</name></author><author><name sortKey="Patil, Sp" uniqKey="Patil S">SP Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menn, Sj" uniqKey="Menn S">SJ Menn</name></author><author><name sortKey="Loube, Di" uniqKey="Loube D">DI Loube</name></author><author><name sortKey="Morgan, Td" uniqKey="Morgan T">TD 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Guilleminault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clark, Gt" uniqKey="Clark G">GT Clark</name></author><author><name sortKey="Blumenfeld, I" uniqKey="Blumenfeld I">I Blumenfeld</name></author><author><name sortKey="Yoffe, N" uniqKey="Yoffe N">N Yoffe</name></author><author><name sortKey="Peled, E" uniqKey="Peled E">E Peled</name></author><author><name sortKey="Lavie, P" uniqKey="Lavie P">P Lavie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferguson, Ka" uniqKey="Ferguson K">KA Ferguson</name></author><author><name sortKey="Ono, T" uniqKey="Ono T">T Ono</name></author><author><name sortKey="Lowe, Aa" uniqKey="Lowe A">AA Lowe</name></author><author><name sortKey="Keenan, Sp" uniqKey="Keenan S">SP Keenan</name></author><author><name sortKey="Love, Ll" uniqKey="Love L">LL Love</name></author><author><name sortKey="Fleetham, Ja" uniqKey="Fleetham J">JA Fleetham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Padma, A" uniqKey="Padma A">A Padma</name></author><author><name sortKey="Ramakrishnan, N" uniqKey="Ramakrishnan N">N Ramakrishnan</name></author><author><name sortKey="Narayanan, V" uniqKey="Narayanan V">V Narayanan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonham, Pe" uniqKey="Bonham P">PE Bonham</name></author><author><name sortKey="Currier, Gf" uniqKey="Currier G">GF Currier</name></author><author><name sortKey="Orr, Wc" uniqKey="Orr W">WC Orr</name></author><author><name sortKey="Othman, J" uniqKey="Othman J">J Othman</name></author><author><name sortKey="Nanda, Rs" uniqKey="Nanda R">RS Nanda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt Nowara, W" uniqKey="Schmidt Nowara W">W Schmidt-Nowara</name></author><author><name sortKey="Lowe, A" uniqKey="Lowe A">A Lowe</name></author><author><name sortKey="Wiegand, L" uniqKey="Wiegand L">L Wiegand</name></author><author><name sortKey="Cartwright, R" uniqKey="Cartwright R">R Cartwright</name></author><author><name sortKey="Perez Guerra, F" uniqKey="Perez Guerra F">F Perez-Guerra</name></author><author><name sortKey="Menn, S" uniqKey="Menn S">S Menn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lowe, Aa" uniqKey="Lowe A">AA Lowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kushida, Ca" uniqKey="Kushida C">CA Kushida</name></author><author><name sortKey="Morgenthaler, Ti" uniqKey="Morgenthaler T">TI Morgenthaler</name></author><author><name sortKey="Littner, Mr" uniqKey="Littner M">MR Littner</name></author><author><name sortKey="Alessi, Ca" uniqKey="Alessi C">CA Alessi</name></author><author><name sortKey="Bailey, D" uniqKey="Bailey D">D Bailey</name></author><author><name sortKey="Coleman, J" uniqKey="Coleman J">J 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Contemp Clin Dent</journal-id><journal-id journal-id-type="iso-abbrev">Contemp Clin Dent</journal-id><journal-id journal-id-type="publisher-id">CCD</journal-id><journal-title-group><journal-title>Contemporary Clinical Dentistry</journal-title></journal-title-group><issn pub-type="ppub">0976-237X</issn><issn pub-type="epub">0976-2361</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26321833</article-id><article-id pub-id-type="pmc">4549985</article-id><article-id pub-id-type="publisher-id">CCD-6-341</article-id><article-id pub-id-type="doi">10.4103/0976-237X.161881</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Efficacy of custom made oral appliance for treatment of obstructive sleep apnea</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cilil</surname><given-names>V. R.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Sapana Varma</surname><given-names>N. K.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gopinath</surname><given-names>Siby</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Ajith</surname><given-names>V. V.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1"><italic>Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry, Kochi, India</italic></aff><aff id="aff2"><label>1</label><italic>Department of Neurology, Amrita Institute of Medical Sciences, Kochi, India</italic></aff><author-notes><corresp id="cor1"><bold>Correspondence:</bold> Dr. V. R. Cilil, Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry, Ponekkara - 682 041, Kochi, India. E-mail: <email xlink:href="cililvr@gmail.com">cililvr@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><season>Jul-Sep</season><year>2015</year></pub-date><volume>6</volume><issue>3</issue><fpage>341</fpage><lpage>347</lpage><permissions><copyright-statement>Copyright: © Contemporary Clinical Dentistry</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Introduction:</title><p>oral appliance for the treatment of OSA is considered as an effective, low-risk alternative to CPAP. Demand for oral appliance increases as an alternative for those who cannot tolerate CPAP and refuse surgery. Oral appliances uses the traditional methods to advance the mandible thus modify the posture and their by enlarge the airway or otherwise reduce the collapsibility.</p></sec><sec id="st2"><title>Aims and Objectives:</title><p>The main objective of this study was to evaluate the efficacy of custom made oral appliance on sleep characteristics of OSA patients. Materials and Methods: Polysomnography was done on 15 patients of 24-60 years of age before (T1), and after the delivery of the custom made oral appliance (T2).</p></sec><sec id="st3"><title>Statistical Analysis:</title><p>Paired t tests were performed to determine the significance of change in the polysomnographic and cephalometric variables. <italic>P</italic> < 0.05 was considered as significant. Results: All patients with oral appliance showed an improvement in sleep parameters with an increase in sleep efficiency, and desaturation index with the use of oral appliance. ESS and cephalometric findings showed improvement in the sleep apnea in concordance with the sleep parameters.</p></sec><sec id="st4"><title>Conclusions:</title><p>Custom made oral appliance is a useful treatment option for improving quality of sleep and can be considered as an alternative treatment modality.</p></sec></abstract><kwd-group><kwd>Continuous positive airway pressure</kwd><kwd>obstructive sleep apnea</kwd><kwd>obstructive sleep apnea appliance</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>Introduction</title><p>Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep, often resulting in arterial oxygen desaturation and arousals.[<xref rid="ref1" ref-type="bibr">1</xref>] This is associated with many symptoms and comorbidities, which include excessive daytime sleepiness, cognitive problems, obesity, type 2 diabetes mellitus, hypertension, exacerbation of chronic obstructive pulmonary disease reduced quality of life, and significant increase in risk of industrial and traffic accidents. It is also considered as an independent risk factor for cardiovascular disease and ischemic stroke.[<xref rid="ref2" ref-type="bibr">2</xref>]</p><p>Clinically, the patient history reveals loud snoring, experiences apneas, nocturnal awakening, gasping or choking episodes during sleep, unrefreshing sleep, morning headaches, excessive daytime sleepiness, etc., the diagnosis of OSA is established using polysomnography (PSG).</p><p>The various imaging techniques such as lateral cephalometry, computed tomography (CT), cone-beam computed tomography, magnetic resonance imaging are used for the evaluation of upper airway. Even though lateral cephalogram provides only a two-dimensional image, it is most widely used technique in clinical practice.</p><p>The ideal treatment for OSA should be capable of normalizing breathing during sleep, consequently eliminating excessive daytime sleepiness, and neuropsychiatric and cardiovascular changes.[<xref rid="ref3" ref-type="bibr">3</xref>]</p><p>Continuous positive airway pressure (CPAP) is the primary noninvasive treatment of choice for OSA since its introduction in the early 1980s. It is associated with various problems which makes it noncomplaint to the patient such as nasal congestion, discomfort secondary to pressure sensation and air leak, mask intolerance due to skin inflammation, claustrophobia, and issues pertaining to chronic use in younger and less severe patients.[<xref rid="ref4" ref-type="bibr">4</xref>]</p><p>Other alternatives include behavioral and surgical weight-loss therapies, positional therapy, pharmacologic therapies, pharyngeal and maxillomandibular surgeries, and oral appliances (OA). Among these modalities except for the OA, clinical results with nonsurgical OSA therapies have been largely unsatisfactory.</p><p>Between the various surgical approaches the efficacies of pharyngeal surgeries for OSA range from 20% to 65%,[<xref rid="ref5" ref-type="bibr">5</xref>] and maxillomandibular advancement surgery for OSA is approximately 90%, but has not gained widespread acceptance because of its complexity, high cost, and increased morbidities compared to other therapies.[<xref rid="ref5" ref-type="bibr">5</xref>]</p><p>Thus, clinically the OA for the treatment of OSA is considered as an effective, low-risk alternative to CPAP. Demand for OA increases as an alternative for those who cannot tolerate CPAP and refuse surgery. OA uses the traditional methods to advance the mandible, thus, modify the posture and their by enlarge the airway or otherwise reduce the collapsibility. Gotsopoulos <italic>et al.</italic> stated[<xref rid="ref1" ref-type="bibr">1</xref>] that OA are a good alternative for the treatment of snoring and obstructive sleep apnea syndrome due to their relative comfort and ease of use, which can, therefore, lead to greater patient compliance.</p><p>Various designs are available which include 1 piece or 2 piece (twin block) or tongue protrusion devices, tongue repositioning or retaining devices, soft-palate lifters, tongue trainers, a combination of OA and CPAP, which delivers pressurized air directly into the oral cavity and eliminates the use of head gear or nasal mask and avoids the problems of air leaks and the claustrophobia associated with CPAP treatment.[<xref rid="ref6" ref-type="bibr">6</xref>]</p><p>Most of the commercially available appliances are expensive which restricts its use by the common man as the affordability is a major issue. Hence, in an attempt to reduce the cost without compromising the comfort and quality in terms of efficacy and other benefits of OA, a new custom made design was developed.</p><p>The aim of this study was to evaluate the efficacy of a custom made cost effective OA.</p></sec><sec sec-type="materials|methods" id="sec1-2"><title>Materials and Methods</title><p>PSG diagnosed OSA patients referred from Department of Sleep Medicine, Amrita School of Medicine was considered for the study. A sample of 15 patients, 10 males and 5 females were selected.</p><p>Patients who met the following criteria were included in the study:</p><p><list list-type="bullet"><list-item><p>The patients with mild to moderate OSA (apnea-hypopnea [AH] >5–15)</p></list-item><list-item><p>Patients with severe OSA who are noncomplaint to CPAP and who refused surgical intervention</p></list-item><list-item><p>Body mass index of <29 kg/m<sup>2</sup></p></list-item><list-item><p>Neck circumference of <17 inches.[<xref rid="ref7" ref-type="bibr">7</xref>]</p></list-item></list></p><p>Exclusion criteria were:</p><p><list list-type="bullet"><list-item><p>Patients with severe periodontal diseases</p></list-item><list-item><p>An edentulous arch, or without sufficient number of teeth for the adequate retention of the appliance</p></list-item><list-item><p>Patients with temporomandibular joint disorders</p></list-item><list-item><p>Patients with pathologic evidence of airway obstruction also were excluded.</p></list-item></list></p><p>The efficacy, as well as the merits and demerits of various treatment modalities, including OA were discussed with patients.</p><p>All selected patients agreed with the treatment plan of using a custom made OA developed at the Dental Sleep Lab, Department of Orthodontics and Dentofacial Orthopedics, Amrita School of Dentistry.</p><sec id="sec2-1"><title>Study design</title><p>Diagnostic records included detailed case history, clinical examination, pre- and post-treatment PSG, pre- and post-lateral cephalogram, and questionnaires.</p><p>The efficacy of the custom made OA was evaluated with the following parameters.</p><p><list list-type="alpha-lower"><list-item><p>Sleep characteristics were evaluated using PSG at <xref ref-type="fig" rid="F1">Figure 1</xref>:</p><p><list list-type="order"><list-item><p>Pretreatment PSG without OA T1</p></list-item><list-item><p>Posttreatment PSG with OA T2.</p></list-item></list></p></list-item><list-item><p>Airway parameters were evaluated with and without appliance using lateral cephalometry.</p></list-item></list></p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Overnight polysomnograpy</p></caption><graphic xlink:href="CCD-6-341-g001"></graphic></fig></sec><sec id="sec2-2"><title>Cephalometric analysis</title><p>Variables measured are defined herein and represented graphically in <xref ref-type="fig" rid="F2">Figure 2</xref>.</p><fig id="F2" position="float"><label>Figure 2</label><caption><p>Cephalometric parameters used in the study</p></caption><graphic xlink:href="CCD-6-341-g002"></graphic></fig><p><list list-type="order"><list-item><p>Superior airway space (SAS): The distance between the posterior pharyngeal wall and the dorsal surface of the soft palate, measured through the point midway between posterior nasal spine to tip of the soft palate (PNS-P) parallel to the line that intersects the gonion and B point</p></list-item><list-item><p>Middle airway space (MAS): The distance between the posterior pharyngeal wall and the dorsal surface of the base of the tongue, measured through the posterior tip of the soft palate (P), parallel to the line that intersects gonion and B point</p></list-item><list-item><p>Inferior airway space (IAS): The distance between the posterior pharyngeal wall and the dorsal surface of the base of the tongue, measured on the line that intersects gonion and B point</p></list-item><list-item><p>PNS-P: The length of the line that connects the posterior nasal spine and the tip of the soft palate.</p></list-item></list></p></sec><sec id="sec2-3"><title>The Epworth sleepiness scale</title><p>The Epworth sleepiness scale (ESS) is a simple and validated questionnaire for assessing subjective daytime sleepiness in the context of sleep disorders. It consists of eight questions, each scored with a degree of severity ranging from 0 to 3. This yields a total score of 0 (minimum) to 24 (maximum). All patients were asked to fill in the ESS at T1 and T2.</p></sec><sec id="sec2-4"><title>Procedure</title><p>Impressions of upper and lower arch of the selected patients were recorded. Appliances were fabricated and delivered from the sleep lab. Specific instructions were given to the patients on the insertion, removal, and storage of the appliance. The patients were recalled after 2 weeks for further adjustments if needed and evaluated once in 30 days from then on. A follow-up PSG was done to evaluate the change in sleep characteristics.</p></sec><sec id="sec2-5"><title>Oral appliance construction</title><p><xref ref-type="fig" rid="F3">Figure 3</xref> shows the armamentarium used for the construction of oral appliance. A bite registration was recorded using wax bite with the mandible advanced to about 75%[<xref rid="ref8" ref-type="bibr">8</xref>] of the maximum protrusive limit and with a vertical increase of 3–4 mm. Articulation of the models were done with the bite registration in place. The upper and lower base for the appliance were [<xref ref-type="fig" rid="F4">Figure 4</xref>] fabricated in the vacuum pressure molding device (Biostar) with a thermoplastic material (scheu dent-durasoft 1.5 mm thickness).</p><fig id="F3" position="float"><label>Figure 3</label><caption><p>Armamentarium</p></caption><graphic xlink:href="CCD-6-341-g003"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>Upper and lower thermoplastic base</p></caption><graphic xlink:href="CCD-6-341-g004"></graphic></fig><p>Posterior bite blocks similar to twin block appliance were fabricated on to the upper and lower thermoplastic base. A ball end pin placed lingual to lower incisors is positioned in such a way that it engages the acrylic trough given in the palatal area of upper anteriors, when the mouth is closed. Hooks were incorporated in the lateral and frontal side. Inter arch elastics to these hooks are provided to help prevent mouth opening during sleep [<xref ref-type="fig" rid="F5">Figure 5</xref>].</p><fig id="F5" position="float"><label>Figure 5</label><caption><p>Elastics in place</p></caption><graphic xlink:href="CCD-6-341-g005"></graphic></fig></sec></sec><sec sec-type="results" id="sec1-3"><title>Results</title><p>Statistical analysis was done using IBM SPPS 20 version Software. Continuous variables were presented as mean ± standard deviation parametric paired <italic>t</italic>-test was used for comparing the averages of sleep parameters of PSG and lateral cephalogram at different time periods (T1, T2). <italic>P</italic> < 0.05 was considered significant at the power of 80% and confidence of 95%.</p><p>Fifteen patients (10 males and 5 females) between the age group of 30 and 60 years were included in the study. All the patients using OA continuously had improvement in their subjective symptoms. Totally, 12 out of 15 patients were comfortable with the appliance.</p><p>PSG data without the OA (T1) and with the OA (T2) shows a mean reduction in the AH index (AHI) value from 23.87 ± 18.12 to 10.87 ± 11.56 [<xref ref-type="fig" rid="F6">Graph 1</xref>]. Statistically significant reduction in the AHI was obtained with a <italic>P</italic> < 0.001 between T1 and T2. 8 out of 15, that is, 53% patients showed a decrease of 50% from the initial value.</p><fig id="F6" position="float"><label>Graph 1</label><caption><p>Apnea hypopnea index</p></caption><graphic xlink:href="CCD-6-341-g006"></graphic></fig><p>The percentage of reduction from the baseline oxygen to the desaturation nadir between T1 and T2 were compared. This value showed an improvement in desaturation nadir, which was not statistically significant [<xref ref-type="fig" rid="F7">Graph 2</xref>].</p><fig id="F7" position="float"><label>Graph 2</label><caption><p>Mean percentage change in desaturation</p></caption><graphic xlink:href="CCD-6-341-g007"></graphic></fig><p>Desaturation index by definition is the number of times per hour of sleep that the oxygen level drops by 3% or more from the baseline O<sub>2</sub> saturation. Statistically significant reduction of desaturation index was obtained with a <italic>P</italic> < 0.008 with mean values of 17.5 ± 17.7 and 4.7 ± 8.8 between T1 and T2. In this sample, 8 out of 15 patients showed desaturation index of below 3 [<xref ref-type="fig" rid="F8">Graph 3</xref>].</p><fig id="F8" position="float"><label>Graph 3</label><caption><p>Mean desaturation index</p></caption><graphic xlink:href="CCD-6-341-g008"></graphic></fig><p>Statistically significant reduction in the mean heart rate showed a <italic>P</italic> < 0.003 with mean values of 70.53 ± 15.59 at T1 and 58.93 ± 6.52 at T2, which is a positive correlation showing changes following the improvement in the sleep characteristics [<xref ref-type="fig" rid="F9">Graph 4</xref>].</p><fig id="F9" position="float"><label>Graph 4</label><caption><p>Mean heart rate</p></caption><graphic xlink:href="CCD-6-341-g009"></graphic></fig><p>SAS shows a statistically significant increase was found with a <italic>P</italic> < 0.006 with mean values of 5.70 ± 2.7and 9 ± 2 for T1 and T2. This shows an improvement in the upper airway dimensions [<xref ref-type="fig" rid="F10">Graph 5</xref>].</p><fig id="F10" position="float"><label>Graph 5</label><caption><p>Mean changes of superior airway space</p></caption><graphic xlink:href="CCD-6-341-g010"></graphic></fig><p>Statistically significant increase in the MAS were found with a <italic>P</italic> < 0.015 and mean value of 5.4 ± 3.3702 and 3.9 ± 1,969 at T1 and T2 [<xref ref-type="fig" rid="F11">Graph 6</xref>].</p><fig id="F11" position="float"><label>Graph 6</label><caption><p>Mean changes of middle airway space</p></caption><graphic xlink:href="CCD-6-341-g011"></graphic></fig><p>Increase in IAS also contributed to the improvement in the airway dimension, but was not statistically significant with a <italic>P</italic> < 0.257 and mean values of 7.60 ± 3.4 at T1 and 9 ± 3.0 at T2 [<xref ref-type="fig" rid="F12">Graph 7</xref>].</p><fig id="F12" position="float"><label>Graph 7</label><caption><p>Mean changes of inferior airway space</p></caption><graphic xlink:href="CCD-6-341-g012"></graphic></fig><p>The ESS values showed an overall reduction in the score from a mean value of 12.73 ± 2.43 at T1-7.73 ± 3.39 at T2. The result obtained was statistically significant at a <italic>P</italic> < 0.000 [<xref ref-type="fig" rid="F13">Graph 8</xref>].</p><fig id="F13" position="float"><label>Graph 8</label><caption><p>Mean changes of Epworth sleepiness scale</p></caption><graphic xlink:href="CCD-6-341-g013"></graphic></fig></sec><sec sec-type="discussion" id="sec1-4"><title>Discussion</title><p>The benefit of OA has made it a popular mode of treatment for OSA. User friendliness and fewer side effects have increased its widespread acceptance.[<xref rid="ref9" ref-type="bibr">9</xref>] The evidences of the use of OA in the treatment of glossoptosis in infants with micrognathia dates back as early as 1905.[<xref rid="ref10" ref-type="bibr">10</xref>] In 1991, American Academy of Sleep Dentistry was formed and in the year 2000, a section of OA was created in the academy of sleep medicine.[<xref rid="ref10" ref-type="bibr">10</xref>] The study was done to evaluate the efficacy of custom made appliance.</p><p>Bonham <italic>et al.</italic>[<xref rid="ref11" ref-type="bibr">11</xref>] reported an improvement in the airway by the increase of velopharyngeal space following the use of OA. Schmidt-Nowara <italic>et al.</italic>[<xref rid="ref12" ref-type="bibr">12</xref>] in his review found an improvement in the efficacy of the OA by the forward positioning of the mandible. Studies by Lowe <italic>et al.</italic>[<xref rid="ref13" ref-type="bibr">13</xref>] had a similar opinion regarding the improvement in airway space using OA. According to the Kushida <italic>et al.</italic>[<xref rid="ref14" ref-type="bibr">14</xref>] OA are indicated as a primary treatment of choice for those with mild-to-moderate OSA and also as an alternative in patients with severe OSA, who failed to comply with CPAP treatment.</p><p>OA has always been preferred more for its greater patient compliance. According to the Randerath <italic>et al.</italic>[<xref rid="ref15" ref-type="bibr">15</xref>] MAD are more often indicated than CPAP, which would tend to increase patient compliance and satisfaction leading to greater adherence to treatment. This could be due to the freedom of movement of the mandible and has been supported by studies by George <italic>et al.</italic>[<xref rid="ref16" ref-type="bibr">16</xref>] and Pantin <italic>et al.</italic>[<xref rid="ref17" ref-type="bibr">17</xref>]</p><p>The various designs of OA are available, which include patented appliances and custom-made appliances. According to the Lettieri <italic>et al.</italic>[<xref rid="ref18" ref-type="bibr">18</xref>] the role of OA as a cost-effective treatment for OSA is in demand, as there is a rapid increase in the prevalence rate of sleep disordered breathing. Other factors such as easy portability and no power source for the operation increases its acceptance. Also better tolerance, therapeutic adherence, and social acceptance make it a favorable choice. According to the Eckhart[<xref rid="ref19" ref-type="bibr">19</xref>] OSA is considered as a public health problem. The cost of the OA should be taken into account before it is prescribed, and applied to a large portion of the population. Thus, it was decided to choose a custom made OA which was designed at our dental sleep lab. The choice of the appliance has been influenced by the cost of the treatment, ease of fabrication, greater mandibular movements, and the low cost.</p><p>Rose <italic>et al.</italic>[<xref rid="ref20" ref-type="bibr">20</xref>] had found a positive co-relation between the greater amounts of mandibular protrusion and its ability to reduce the AHI. According to the Clark <italic>et al.</italic>[<xref rid="ref8" ref-type="bibr">8</xref>] ideal comfortable position for the mandibular protrusion is considered to be 75% of the maximum protrusion. Hence, it was decided to keep the maximum protrusion limit to 75% in this study.</p><p>The materials selected for the fabrication were based on ease of availability and biocompatibility. According to the Marklund <italic>et al.</italic>[<xref rid="ref21" ref-type="bibr">21</xref>] occlusal changes were seen as one of the long-term effects of OA. The thermoplastic material, which is used in essix retention was used as a base material in this study. This is expected to minimize the occlusal derangement.</p><p>Posterior bite blocks with angulations of 70° similar to twin block were incorporated to hold the mandible in the forward position while the mouth is closed. Meurice <italic>et al.</italic>[<xref rid="ref22" ref-type="bibr">22</xref>] highlighted the importance of the correct therapeutic position of the mandible, which is critical for the success of appliance in OSA patients, both in terms of opening the airway, as well as patient comfort, and compliance.</p><p>Johal <italic>et al.</italic>[<xref rid="ref23" ref-type="bibr">23</xref>] showed that on the incorporation of an anterior opening in the splint is particularly helpful for those subjects with mouth breathing habit, and a two-piece device is preferred over one piece device. An appliance used in our study also had a ventilation hole and also a two-piece device, which would enable easy air passage for the patient. This was in concordance with the designs of the appliance used in the studies of Lawton[<xref rid="ref24" ref-type="bibr">24</xref>] and Schmidt.[<xref rid="ref12" ref-type="bibr">12</xref>]</p><p>Elastics engaged to the hooks reinforce the forward positioning effect of the appliance during sleep.</p><p>A pin and trough was provided on the appliance, where the pin was positioned lingual to the lower anteriors, and the trough was positioned on to the palatal aspect of the upper anterior, so that the pin gets locked on to the trough while the patient closes the mouth with the appliance in position. This prevents the appliance from slipping back during sleep.</p><p>All the patients with the appliance showed a significant decrease in the AHI; this is in par with the studies of Marklund <italic>et al.</italic>[<xref rid="ref25" ref-type="bibr">25</xref>] All the patients in this study showed a decrease in mean heart rate, which was statistically significant. This shows a positive response of the patients toward the OA treatment. The DI showed a statistically significant decrease. The decrease in this index corresponds to the improvement in the sleep conditions.</p><p>In this study, cephalometrics have played a vital role in assessing the improvements following OA. SAS and MAS showed a statistically significant improvement in the postcephalometric assessment with the OA. SAS value recorded, accounts for the most amount of increase among the linear measurements. The decrease in PNS-P corresponds to the change in the displacement of the soft palate along with tongue during the forward displacement of the mandible. Initial discomforts of excessive salivary secretion and discomfort in the muscles of mastication subsided within the first 1-month of use. O Sulluvien <italic>et al.</italic>[<xref rid="ref26" ref-type="bibr">26</xref>] has reported excessive salivation and transient discomfort in muscles of mastication as short-term complications. However, these patients reported a reduction in the excess salivation and muscle pain within 2 weeks time.</p><p>This custom made appliance has proved to be as effective as any other OA available. It was easy to fabricate due to its simple design and were superior in terms of patient comfort and efficacy. This particular design helps to overcome the unwanted effects of occlusal derangement, long-term evaluations are required. The economic viability of this appliance makes it a preferred choice for the treatment of OSA.</p></sec><sec sec-type="conclusion" id="sec1-5"><title>Conclusion</title><p>OSA is indeed a health condition, which comes with fair share of psychological trauma and may lead to confecting heart murmur and sudden death, which can be reduced to a great extent by use of this cost effective and simple to use OA. This study supports the use of OA as most of the sleep parameter evaluated showed improvement. 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