A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma
Identifieur interne : 000174 ( Pmc/Corpus ); précédent : 000173; suivant : 000175A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma
Auteurs : Vijay Wadhwan ; Preeti Sharma ; Vishal BansalSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2015.
Abstract
A hybrid odontogenic tumor comprising two distinct lesions is extremely rare. Nevertheless, such tumors have been reported in the literature for academic and research interest. However, it is still obscure whether they behave as a new entity or they solely present separate histopathologic patterns. Here, we present a true hybrid neoplasm of combined ameloblastoma and calcifying epithelial odontogenic tumor showing intermixed histopathologic patterns of both the tumors.
Url:
DOI: 10.4103/0973-029X.164560
PubMed: 26604514
PubMed Central: 4611946
Links to Exploration step
PMC:4611946Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma</title><author><name sortKey="Wadhwan, Vijay" sort="Wadhwan, Vijay" uniqKey="Wadhwan V" first="Vijay" last="Wadhwan">Vijay Wadhwan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sharma, Preeti" sort="Sharma, Preeti" uniqKey="Sharma P" first="Preeti" last="Sharma">Preeti Sharma</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bansal, Vishal" sort="Bansal, Vishal" uniqKey="Bansal V" first="Vishal" last="Bansal">Vishal Bansal</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral and Maxillofacial Surgery, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26604514</idno><idno type="pmc">4611946</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611946</idno><idno type="RBID">PMC:4611946</idno><idno type="doi">10.4103/0973-029X.164560</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000174</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000174</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma</title><author><name sortKey="Wadhwan, Vijay" sort="Wadhwan, Vijay" uniqKey="Wadhwan V" first="Vijay" last="Wadhwan">Vijay Wadhwan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Sharma, Preeti" sort="Sharma, Preeti" uniqKey="Sharma P" first="Preeti" last="Sharma">Preeti Sharma</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Bansal, Vishal" sort="Bansal, Vishal" uniqKey="Bansal V" first="Vishal" last="Bansal">Vishal Bansal</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral and Maxillofacial Surgery, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A hybrid odontogenic tumor comprising two distinct lesions is extremely rare. Nevertheless, such tumors have been reported in the literature for academic and research interest. However, it is still obscure whether they behave as a new entity or they solely present separate histopathologic patterns. Here, we present a true hybrid neoplasm of combined ameloblastoma and calcifying epithelial odontogenic tumor showing intermixed histopathologic patterns of both the tumors.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Reichart, Pa" uniqKey="Reichart P">PA Reichart</name></author><author><name sortKey="Philipsen, Hp" uniqKey="Philipsen H">HP Philipsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barnes, L" uniqKey="Barnes L">L Barnes</name></author><author><name sortKey="Everson, Wj" uniqKey="Everson W">WJ Everson</name></author><author><name sortKey="Reichart, P" uniqKey="Reichart P">P Reichart</name></author><author><name sortKey="Sidradinsky, D" uniqKey="Sidradinsky D">D Sidradinsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ide, F" uniqKey="Ide F">F Ide</name></author><author><name sortKey="Horie, N" uniqKey="Horie N">N Horie</name></author><author><name sortKey="Shimoyama, T" uniqKey="Shimoyama T">T Shimoyama</name></author><author><name sortKey="Sakashita, H" uniqKey="Sakashita H">H Sakashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pindborg, Jj" uniqKey="Pindborg J">JJ Pindborg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damm, Dd" uniqKey="Damm D">DD Damm</name></author><author><name sortKey="White, Dk" uniqKey="White D">DK White</name></author><author><name sortKey="Drummond, Jf" uniqKey="Drummond J">JF Drummond</name></author><author><name sortKey="Poindexter, Jb" uniqKey="Poindexter J">JB Poindexter</name></author><author><name sortKey="Henry, Bb" uniqKey="Henry B">BB Henry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bingham, Ra" uniqKey="Bingham R">RA Bingham</name></author><author><name sortKey="Adrian, Jc" uniqKey="Adrian J">JC Adrian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takeda, Y" uniqKey="Takeda Y">Y Takeda</name></author><author><name sortKey="Kudo, K" uniqKey="Kudo K">K Kudo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Etit, D" uniqKey="Etit D">D Etit</name></author><author><name sortKey="Uyaroglu, Ma" uniqKey="Uyaroglu M">MA Uyaroglu</name></author><author><name sortKey="Erdogan, N" uniqKey="Erdogan N">N Erdogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seim, P" uniqKey="Seim P">P Seim</name></author><author><name sortKey="Regezi, Ja" uniqKey="Regezi J">JA Regezi</name></author><author><name sortKey="O Yan, F" uniqKey="O Yan F">F O’Ryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kramer, Ir" uniqKey="Kramer I">IR Kramer</name></author><author><name sortKey="Pindborg, Jj" uniqKey="Pindborg J">JJ Pindborg</name></author><author><name sortKey="Shear, M" uniqKey="Shear M">M Shear</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Regezzi, Ja" uniqKey="Regezzi J">JA Regezzi</name></author><author><name sortKey="Sciubba, Jj" uniqKey="Sciubba J">JJ Sciubba</name></author><author><name sortKey="Jordan, Rc" uniqKey="Jordan R">RC Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takata, T" uniqKey="Takata T">T Takata</name></author><author><name sortKey="Ogawa, I" uniqKey="Ogawa I">I Ogawa</name></author><author><name sortKey="Miyauchi, M" uniqKey="Miyauchi M">M Miyauchi</name></author><author><name sortKey="Ijuhin, N" uniqKey="Ijuhin N">N Ijuhin</name></author><author><name sortKey="Nikai, H" uniqKey="Nikai H">H Nikai</name></author><author><name sortKey="Fujita, M" uniqKey="Fujita M">M Fujita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siar, Ch" uniqKey="Siar C">CH Siar</name></author><author><name sortKey="Ng, Kh" uniqKey="Ng K">KH Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hisatomi, M" uniqKey="Hisatomi M">M Hisatomi</name></author><author><name sortKey="Asaumi, J" uniqKey="Asaumi J">J Asaumi</name></author><author><name sortKey="Konouchi, H" uniqKey="Konouchi H">H Konouchi</name></author><author><name sortKey="Yanagi, Y" uniqKey="Yanagi Y">Y Yanagi</name></author><author><name sortKey="Kishi, K" uniqKey="Kishi K">K Kishi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Badger, Kv" uniqKey="Badger K">KV Badger</name></author><author><name sortKey="Gardner, Dg" uniqKey="Gardner D">DG Gardner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Sh" uniqKey="Chen S">SH Chen</name></author><author><name sortKey="Katayanagi, T" uniqKey="Katayanagi T">T Katayanagi</name></author><author><name sortKey="Osada, K" uniqKey="Osada K">K Osada</name></author><author><name sortKey="Hamano, H" uniqKey="Hamano H">H Hamano</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name></author><author><name sortKey="Shimono, M" uniqKey="Shimono M">M Shimono</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Maxillofac Pathol</journal-id><journal-id journal-id-type="iso-abbrev">J Oral Maxillofac Pathol</journal-id><journal-id journal-id-type="publisher-id">JOMFP</journal-id><journal-title-group><journal-title>Journal of Oral and Maxillofacial Pathology : JOMFP</journal-title></journal-title-group><issn pub-type="ppub">0973-029X</issn><issn pub-type="epub">1998-393X</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26604514</article-id><article-id pub-id-type="pmc">4611946</article-id><article-id pub-id-type="publisher-id">JOMFP-19-268b</article-id><article-id pub-id-type="doi">10.4103/0973-029X.164560</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wadhwan</surname><given-names>Vijay</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Sharma</surname><given-names>Preeti</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Bansal</surname><given-names>Vishal</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib></contrib-group><aff id="aff1"><italic>Department of Oral Pathology and Microbiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India</italic></aff><aff id="aff2"><label>1</label><italic>Department of Oral and Maxillofacial Surgery, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence: </bold><italic>Dr. Vijay Wadhwan, Department of Oral Pathology and Microbiology, Subharti Dental College, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India. E-mail: <email xlink:href="pathogen@rediffmail.com">pathogen@rediffmail.com</email></italic></corresp></author-notes><pub-date pub-type="ppub"><season>May-Aug</season><year>2015</year></pub-date><volume>19</volume><issue>2</issue><fpage seq="b">268</fpage><lpage>268</lpage><history><date date-type="received"><day>02</day><month>6</month><year>2014</year></date><date date-type="accepted"><day>27</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>Copyright: © Journal of Oral and Maxillofacial Pathology</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms</license-p></license></permissions><abstract><p>A hybrid odontogenic tumor comprising two distinct lesions is extremely rare. Nevertheless, such tumors have been reported in the literature for academic and research interest. However, it is still obscure whether they behave as a new entity or they solely present separate histopathologic patterns. Here, we present a true hybrid neoplasm of combined ameloblastoma and calcifying epithelial odontogenic tumor showing intermixed histopathologic patterns of both the tumors.</p></abstract><kwd-group><kwd>Ameloblastoma</kwd><kwd>calcifying epithelial odontogenic tumor</kwd><kwd>hybrid odontogenic tumors</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>INTRODUCTION</title><p>The process of odontogenesis is prolonged and complex and the tumors derived from epithelial, ectomesenchymal and/or mesenchymal elements that are, or have been, part of the odontogenic apparatus are called as odontogenic tumors.[<xref rid="ref1" ref-type="bibr">1</xref>] Despite the World Health Organization (WHO) classification of odontogenic tumors, unique odontogenic lesions with combined histologic features have been encountered occasionally.[<xref rid="ref2" ref-type="bibr">2</xref>] Hybrid tumors are very rare tumor entities, which are composed of two different tumor entities, each of which confirms with an exactly defined tumor category whereas a hybrid odontogenic tumor is defined as follows: “A lesion showing the combined histopathological characteristics of two or more previously recognized tumors and/or cysts of different categories.”[<xref rid="ref3" ref-type="bibr">3</xref>] Ameloblastoma is a benign odontogenic tumor arising from the odontogenic apparatus showing odontogenic epithelium with mature fibrous stroma, without ectomesenchyme. It is the best known and the most frequently seen odontogenic tumor. Calcifying epithelial odontogenic tumor (CEOT) is also benign neoplasm reported by Pindborg in 1955,[<xref rid="ref4" ref-type="bibr">4</xref>] with a frequency varying between 0.4% and 3%. It is a relatively rare occurring tumor with one of the lowest frequency rankings amongst the list of odontogenic tumors.[<xref rid="ref1" ref-type="bibr">1</xref>] A hybrid odontogenic tumor comprising two distinct lesions is extremely rare. Earlier, hybrid tumors of CEOT in association with adenomatoid odontogenic tumors (AOTs) have been reported.[<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref5" ref-type="bibr">5</xref><xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref7" ref-type="bibr">7</xref>] But, nothing indicates a true combination of two distinct and separate odontogenic tumor entities. Also, there are very few reported cases of ameloblastoma in which CEOT-like areas predominate. Only two such cases have been reported till date.[<xref rid="ref8" ref-type="bibr">8</xref><xref rid="ref9" ref-type="bibr">9</xref>] Here, we describe an extremely rare and interesting case of an intraosseous ameloblastoma associated with CEOT that appeared to be a histologic hybrid tumor.</p></sec><sec id="sec1-2"><title>CASE REPORT</title><p>A 65-year-old edentulous female patient reported to the Department of Orthopedics with a complaint of fractured leg. The Oral and Maxillofacial Surgery Department was informed with an incidental finding of huge swelling of the right maxilla causing asymmetry of the face [<xref ref-type="fig" rid="F1">Figure 1</xref>]. The massive swelling was painless and asymptomatic. The swelling was bony hard, noncompressible and nonfluctuant. The mass extended superio-inferiorly from the infraorbital region till the alveolus of the maxilla, laterally till the malar prominence, posteriorly till the anterior border of the masseter muscle and anteriorly extended till the angle of the mouth obliterating the nasolabial fold. Buccal and palatal cortical plate expansion was observed with adequate mouth opening. Intraorally, an irregular, nodular soft tissue mass was present in the vestibule of the posterior region and anteriorly over maxillary central incisor region [<xref ref-type="fig" rid="F2">Figure 2</xref>]. Patient was a hookah smoker for last 4 years. Paranasal sinus view radiograph showed a large radiopaque mass in the right maxillary region [<xref ref-type="fig" rid="F3">Figure 3</xref>]. Incisional biopsy of the lesion was sent to the Department of Oral and Maxillofacial Pathology which revealed intermingled areas of the plexiform type of ameloblastoma and CEOT [<xref ref-type="fig" rid="F4">Figure 4</xref>]. Interlacing cords and strands of odontogenic epithelium were observed within a mature fibrous connective tissue stroma. Scanty stellate reticulum-like areas were appreciated in between the interlacing cords, suggesting the plexiform type of ameloblastoma [Figures <xref ref-type="fig" rid="F5">5</xref> and <xref ref-type="fig" rid="F6">6</xref>]. However, many areas showed sheets and nests of polyhedral epithelial, eosinophilic cells which showed prominent nuclei and also cellular and nuclear pleomorphism in some areas [<xref ref-type="fig" rid="F7">Figure 7</xref>]. Some cells were binucleated and prominent intercellular bridges were observed in focal areas. Among the sheets and cords of cells, numerous homogeneous eosinophilic hyaline masses were evident in most part of the section, suggestive of amyloid-like material [<xref ref-type="fig" rid="F8">Figure 8</xref>]. Calcifications were not observed in the received specimen. The case was signed out as combined CEOT with ameloblastoma. The patient was not willing to undergo treatment for the lesion and hence was discharged from the hospital against medical advice.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>Extraoral view of the patient showing diffuse swelling of the right maxillary region causing facial asymmetry</p></caption><graphic xlink:href="JOMFP-19-268b-g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Intraoral view showing irregular and nodular swelling crossing the midline and obliterating the buccal and labial vestibule</p></caption><graphic xlink:href="JOMFP-19-268b-g002"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p>Posterior nasal spinal radiographic view showing large radioopaque mass in the right maxilla</p></caption><graphic xlink:href="JOMFP-19-268b-g003"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>Photomicrograph showing intermingled areas of calcifying epithelial odontogenic tumor and plexiform ameloblastoma (H&E stain, x100)</p></caption><graphic xlink:href="JOMFP-19-268b-g004"></graphic></fig><fig id="F5" position="float"><label>Figure 5</label><caption><p>Photomicrograph shows odontogenic epithelial cells arranged in interlacing cords suggestive of plexiform ameloblastoma (H&E stain, x100)</p></caption><graphic xlink:href="JOMFP-19-268b-g005"></graphic></fig><fig id="F6" position="float"><label>Figure 6</label><caption><p>Photomicrograph shows plexiform ameloblastoma like areas (H&E stain, x400)</p></caption><graphic xlink:href="JOMFP-19-268b-g006"></graphic></fig><fig id="F7" position="float"><label>Figure 7</label><caption><p>Photomicrograph shows slight pleomorphism, intercellular bridges and hyperchromatic nuclei in calcifying epithelial odontogenic tumor-like areas (H&E stain, x400)</p></caption><graphic xlink:href="JOMFP-19-268b-g007"></graphic></fig><fig id="F8" position="float"><label>Figure 8</label><caption><p>Photomicrograph shows acellular eosinophilic areas suggestive of amyloid-like areas (H&E stain, x400)</p></caption><graphic xlink:href="JOMFP-19-268b-g008"></graphic></fig></sec><sec sec-type="discussion" id="sec1-3"><title>DISCUSSION</title><p>According to the 1992 WHO classification, a CEOT is a locally invasive epithelial neoplasm characterized by the development of intraepithelial structures, probably of an amyloid-like nature, which may become calcified and may be liberated as the cells break down.[<xref rid="ref10" ref-type="bibr">10</xref>] CEOT arises from the reduced enamel epithelium of the closely related unerupted tooth. The peripheral variant may arise from rests of the dental lamina or from the basal cells of the oral epithelium.[<xref rid="ref1" ref-type="bibr">1</xref>] CEOT shares many clinical features with ameloblastoma. However, microscopically there is no resemblance to ameloblastoma and distinct differences will be noted radiographically.[<xref rid="ref11" ref-type="bibr">11</xref>] Solid multicystic ameloblastomas may arise from rests of a dental lamina or from the enamel organ. The basic histologic pattern of CEOTs, is characteristic and unique, is an unusual and variable combination of odontogenic epithelium and calcified structures. We observed the sheet-like proliferation of polyhedral cells along with numerous amyloid-like areas but no calcifications were evident in the received specimen histologically. Earlier literature studies have reported CEOTs without calcifications.[<xref rid="ref8" ref-type="bibr">8</xref><xref rid="ref12" ref-type="bibr">12</xref>] Intermingled areas of polyhedral cells with ameloblast-like cells were evident throughout the section. In both CEOTs and ameloblastomas, the mandible is affected twice as often as the maxilla and there is a predilection for the molar-ramus region. But in the present case, swelling was observed in the maxillary region.</p><p>Occasionally, hybrid odontogenic tumors have been reported in the literature, such as keratoameloblastoma,[<xref rid="ref13" ref-type="bibr">13</xref>] hybrid tumor of ameloblastoma and glandular odontogenic cyst,[<xref rid="ref14" ref-type="bibr">14</xref>] ameloblastoma and calcifying odontogenic cyst,[<xref rid="ref15" ref-type="bibr">15</xref>] ameloblastoma and ameloblastic fibroma.[<xref rid="ref16" ref-type="bibr">16</xref>] Also, most of them do not appear in the standard WHO classification of odontogenic tumors. These ambiguous tumors should not generally be considered true hybrids; rather they should be identified simply as anomalous histodifferentiation and/or morphodifferentiation process.[<xref rid="ref3" ref-type="bibr">3</xref>] To call them as hybrid tumors would be a misnomer. Melrose wrote that the designation hybrid tumor serves no real purpose. It is probably due to the expression of the histomorphodifferentiation potential of the epithelium and the mesenchyme and their complex inductive interaction, from which these lesions are derived.[<xref rid="ref9" ref-type="bibr">9</xref>] Ameloblastomas commonly exhibit more than one histologic type in a single lesion. Thus, in such cases, the term “hybrid” is actually a misnomer. The present reported case is a very rare hybrid neoplasm consisting histologically of plexiform ameloblastoma and CEOT, appears to be the third reported case in the literature. The clinicopathological features of the present case have been compared with the previously reported cases in <xref ref-type="table" rid="T1">Table 1</xref>. Because both these neoplasms develop from a common or similar odontogenic epithelial source, a single tumor could exhibit histological features of both neoplasms.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Clinicopathological features of all hybrid odontogenic tumors (CEOT+ameloblastoma) reported in the English literature</p></caption><graphic xlink:href="JOMFP-19-268b-g009"></graphic></table-wrap><p>Even though, the lesion was diagnosed as a hybrid odontogenic tumor showing the features of both CEOT and ameloblastoma, few shortcomings were encountered since the type of biopsy received was incisional and the entire specimen was not available for further investigations as the patient had left against medical advice. AtFirst, no calcifications could be noticed in the present tissue sections although the lesion appeared radiopaque; second, paraffin-embedded tissue was insufficient to demonstrate amyloid using special stains and immunohistochemistry and finally, the appropriate treatment regimen required for this type of rare tumor could not assessed by postoperative follow-up.</p><p>In general, the biologic behavior of hybrid odontogenic tumors does not differ from that of other solid ameloblastomas. However, since the long-term behavior of this particular hybrid neoplasm remains unknown, the most appropriate approach has yet to be determined. CEOT has invasive potential but not to the extent of ameloblastoma. It is slow growing and compromises the patient through direct extension. Although, enucleation and excision appear to cure the hybrid lesion, long-term follow-up data and additional cases are still needed to substantiate the clinical significance of these lesions.</p><p>The authors would like to suggest that such lesions should be included in the WHO classification of Odontogenic tumors as they show the propensity of exclusively occurring in the maxillary region.</p><sec id="sec2-1"><title>Financial support and sponsorship</title><p>Nil.</p></sec><sec id="sec2-2"><title>Conflicts of interest</title><p>There are no conflicts of interest.</p></sec></sec></body><back><ref-list><title>REFERENCES</title><ref id="ref1"><label>1</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Reichart</surname><given-names>PA</given-names></name><name><surname>Philipsen</surname><given-names>HP</given-names></name></person-group><article-title>Odontogenic Tumors and Allied Lesions</article-title><year>2004</year><edition>1st ed</edition><publisher-loc>London</publisher-loc><publisher-name>Quintessence</publisher-name><fpage>17</fpage><comment>74</comment></element-citation></ref><ref id="ref2"><label>2</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Barnes</surname><given-names>L</given-names></name><name><surname>Everson</surname><given-names>WJ</given-names></name><name><surname>Reichart</surname><given-names>P</given-names></name><name><surname>Sidradinsky</surname><given-names>D</given-names></name></person-group><article-title>Pathology and Genetics. Head and Neck Tumors</article-title><year>2005</year><edition>5th ed</edition><publisher-loc>Lyon</publisher-loc><publisher-name>IARC Press</publisher-name></element-citation></ref><ref id="ref3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ide</surname><given-names>F</given-names></name><name><surname>Horie</surname><given-names>N</given-names></name><name><surname>Shimoyama</surname><given-names>T</given-names></name><name><surname>Sakashita</surname><given-names>H</given-names></name></person-group><article-title>So-called hybrid odontogenic tumors: Do they really exist?</article-title><source>Oral Med Pathol</source><year>2001</year><volume>6</volume><fpage>13</fpage><lpage>21</lpage></element-citation></ref><ref id="ref4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pindborg</surname><given-names>JJ</given-names></name></person-group><article-title>Calcifying epithelial odontogenic tumors</article-title><source>Acta Pathol Microbiol Scand</source><year>1956</year><volume>1</volume><fpage>111</fpage></element-citation></ref><ref id="ref5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Damm</surname><given-names>DD</given-names></name><name><surname>White</surname><given-names>DK</given-names></name><name><surname>Drummond</surname><given-names>JF</given-names></name><name><surname>Poindexter</surname><given-names>JB</given-names></name><name><surname>Henry</surname><given-names>BB</given-names></name></person-group><article-title>Combined epithelial odontogenic tumor: A denomatoid odontogenic tumor and calcifying epithelial odontogenic tumor</article-title><source>Oral Surg Oral Med Oral Pathol</source><year>1983</year><volume>55</volume><fpage>487</fpage><lpage>96</lpage><pub-id pub-id-type="pmid">6575339</pub-id></element-citation></ref><ref id="ref6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bingham</surname><given-names>RA</given-names></name><name><surname>Adrian</surname><given-names>JC</given-names></name></person-group><article-title>Combined epithelial odontogenic tumor-adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor: Report of a case</article-title><source>J Oral Maxillofac Surg</source><year>1986</year><volume>44</volume><fpage>574</fpage><lpage>7</lpage><pub-id pub-id-type="pmid">3459843</pub-id></element-citation></ref><ref id="ref7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takeda</surname><given-names>Y</given-names></name><name><surname>Kudo</surname><given-names>K</given-names></name></person-group><article-title>Adenomatoid odontogenic tumor associated with calcifying epithelial odontogenic tumor</article-title><source>Int J Oral Maxillofac Surg</source><year>1986</year><volume>15</volume><fpage>469</fpage><lpage>73</lpage><pub-id pub-id-type="pmid">3091730</pub-id></element-citation></ref><ref id="ref8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Etit</surname><given-names>D</given-names></name><name><surname>Uyaroglu</surname><given-names>MA</given-names></name><name><surname>Erdogan</surname><given-names>N</given-names></name></person-group><article-title>Mixed odontogenic tumor: A meloblastoma and calcifying epithelial odontogenic tumor</article-title><source>Indian J Pathol Microbiol</source><year>2010</year><volume>53</volume><fpage>122</fpage><lpage>4</lpage><pub-id pub-id-type="pmid">20090240</pub-id></element-citation></ref><ref id="ref9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seim</surname><given-names>P</given-names></name><name><surname>Regezi</surname><given-names>JA</given-names></name><name><surname>O’Ryan</surname><given-names>F</given-names></name></person-group><article-title>Hybrid ameloblastoma and calcifying epithelial odontogenic tumor: Case report</article-title><source>J Oral Maxillofac Surg</source><year>2005</year><volume>63</volume><fpage>852</fpage><lpage>5</lpage><pub-id pub-id-type="pmid">15944987</pub-id></element-citation></ref><ref id="ref10"><label>10</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Kramer</surname><given-names>IR</given-names></name><name><surname>Pindborg</surname><given-names>JJ</given-names></name><name><surname>Shear</surname><given-names>M</given-names></name></person-group><article-title>Histological Typing of Odontogenic Tumors</article-title><year>1992</year><edition>2nd ed</edition><publisher-loc>Berlin</publisher-loc><publisher-name>Springer-Verlag</publisher-name><fpage>17</fpage></element-citation></ref><ref id="ref11"><label>11</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Regezzi</surname><given-names>JA</given-names></name><name><surname>Sciubba</surname><given-names>JJ</given-names></name><name><surname>Jordan</surname><given-names>RC</given-names></name></person-group><article-title>Oral Pathology Clinical Pathologic Correlations</article-title><year>2008</year><edition>5th ed</edition><publisher-loc>St. Louis</publisher-loc><publisher-name>Missouri Saunders, an imprint of Elsevier</publisher-name><fpage>268</fpage></element-citation></ref><ref id="ref12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takata</surname><given-names>T</given-names></name><name><surname>Ogawa</surname><given-names>I</given-names></name><name><surname>Miyauchi</surname><given-names>M</given-names></name><name><surname>Ijuhin</surname><given-names>N</given-names></name><name><surname>Nikai</surname><given-names>H</given-names></name><name><surname>Fujita</surname><given-names>M</given-names></name></person-group><article-title>Non-calcifying Pindborg tumor with Langerhans cells</article-title><source>J Oral Pathol Med</source><year>1993</year><volume>22</volume><fpage>378</fpage><lpage>83</lpage><pub-id pub-id-type="pmid">8283404</pub-id></element-citation></ref><ref id="ref13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Siar</surname><given-names>CH</given-names></name><name><surname>Ng</surname><given-names>KH</given-names></name></person-group><article-title>Combined ameloblastoma and odontogenic keratocyst or keratinising ameloblastoma</article-title><source>Br J Oral Maxillofac Surg</source><year>1993</year><volume>31</volume><fpage>183</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">7685634</pub-id></element-citation></ref><ref id="ref14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hisatomi</surname><given-names>M</given-names></name><name><surname>Asaumi</surname><given-names>J</given-names></name><name><surname>Konouchi</surname><given-names>H</given-names></name><name><surname>Yanagi</surname><given-names>Y</given-names></name><name><surname>Kishi</surname><given-names>K</given-names></name></person-group><article-title>A case of glandular odontogenic cyst associated with ameloblastoma: Correlation of diagnostic imaging with histopathological features</article-title><source>Dentomaxillofac Radiol</source><year>2000</year><volume>29</volume><fpage>249</fpage><lpage>53</lpage><pub-id pub-id-type="pmid">10918459</pub-id></element-citation></ref><ref id="ref15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Badger</surname><given-names>KV</given-names></name><name><surname>Gardner</surname><given-names>DG</given-names></name></person-group><article-title>The relationship of adamantinomatous craniopharyngioma to ghost cell ameloblastoma of the jaws: A histopathologic and immunohistochemical study</article-title><source>J Oral Pathol Med</source><year>1997</year><volume>26</volume><fpage>349</fpage><lpage>55</lpage><pub-id pub-id-type="pmid">9379423</pub-id></element-citation></ref><ref id="ref16"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chen</surname><given-names>SH</given-names></name><name><surname>Katayanagi</surname><given-names>T</given-names></name><name><surname>Osada</surname><given-names>K</given-names></name><name><surname>Hamano</surname><given-names>H</given-names></name><name><surname>Inoue</surname><given-names>T</given-names></name><name><surname>Shimono</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Ameloblastoma and its relationship to ameloblastic fibroma: Their histogenesis based on an unusual case and review of the literature</article-title><source>Bull Tokyo Dent Coll</source><year>1991</year><volume>32</volume><fpage>51</fpage><lpage>6</lpage><pub-id pub-id-type="pmid">1819443</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000174 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000174 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:4611946
|texte= A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:26604514" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |