Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in Buccal Epithelial Cells Collected from Human Subjects
Identifieur interne : 002798 ( Pmc/Checkpoint ); précédent : 002797; suivant : 002799Intracellular Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in Buccal Epithelial Cells Collected from Human Subjects
Auteurs : Joel D. Rudney ; Ruoqiong Chen ; Gerald J. SedgewickSource :
- Infection and Immunity [ 0019-9567 ] ; 2001.
Abstract
The mouth may provide an accessible model for studying bacterial interactions with human cells in vivo. Using fluorescent in situ hybridization and laser scanning confocal microscopy, we found that human buccal epithelial cells from 23 of 24 subjects were infected with intracellular bacteria, including the periodontal pathogens
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DOI: 10.1128/IAI.69.4.2700-2707.2001
PubMed: 11254637
PubMed Central: 98209
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id><journal-id journal-id-type="publisher-id">INFECT IMMUN</journal-id><journal-title>Infection and Immunity</journal-title><issn pub-type="ppub">0019-9567</issn><issn pub-type="epub">1098-5522</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">11254637</article-id><article-id pub-id-type="pmc">98209</article-id><article-id pub-id-type="publisher-id">1119</article-id><article-id pub-id-type="doi">10.1128/IAI.69.4.2700-2707.2001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cellular Microbiology: Pathogen-Host Cell Molecular Interactions</subject></subj-group><series-title>Note</series-title></article-categories><title-group><article-title>Intracellular <italic>Actinobacillus actinomycetemcomitans</italic> and <italic>Porphyromonas gingivalis</italic> in Buccal Epithelial Cells Collected from Human Subjects</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rudney</surname><given-names>Joel D.</given-names></name><xref ref-type="aff" rid="N0x96139a8.0x98ea448">1</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Ruoqiong</given-names></name><xref ref-type="aff" rid="N0x96139a8.0x98ea448">1</xref></contrib><contrib contrib-type="author"><name><surname>Sedgewick</surname><given-names>Gerald J.</given-names></name><xref ref-type="aff" rid="N0x96139a8.0x98ea448">2</xref></contrib></contrib-group><aff id="N0x96139a8.0x98ea448"> Department of Oral Science and Minnesota Oral Health Clinical Research Center, School of Dentistry,<sup>1</sup> and Biomedical Imaging and Processing Laboratory, Department of Neuroscience,<sup>2</sup> University of Minnesota, Minneapolis, Minnesota 55455</aff><contrib-group><contrib contrib-type="editor"><name><surname>DiRita</surname><given-names>V. J.</given-names></name></contrib></contrib-group><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Department of Oral Science, University of Minnesota, 17-252 Moos Tower, 515 Delaware St., S.E., Minneapolis, MN 55455. Phone: (612) 624-7199. Fax: (612) 626-2651. E-mail: <email>jrudney@tc.umn.edu</email>.</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>2001</year></pub-date><volume>69</volume><issue>4</issue><fpage>2700</fpage><lpage>2707</lpage><history><date date-type="received"><day>4</day><month>8</month><year>2000</year></date><date date-type="rev-request"><day>2</day><month>10</month><year>2000</year></date><date date-type="accepted"><day>21</day><month>12</month><year>2000</year></date></history><copyright-statement>Copyright © 2001, American Society for Microbiology</copyright-statement><copyright-year>2001</copyright-year><abstract><p>The mouth may provide an accessible model for studying bacterial interactions with human cells in vivo. Using fluorescent in situ hybridization and laser scanning confocal microscopy, we found that human buccal epithelial cells from 23 of 24 subjects were infected with intracellular bacteria, including the periodontal pathogens <italic>Actinobacillus actinomycetemcomitans</italic> and <italic>Porphyromonas gingivalis</italic>, as well as other species which have yet to be identified. Buccal cell invasion may allow fastidious anaerobes to establish themselves in aerobic sites that otherwise present an unfavorable environment. Exfoliated buccal epithelial cells might provide a protected route for bacterial transmission between different oral sites within and between hosts.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Chen, Ruoqiong" sort="Chen, Ruoqiong" uniqKey="Chen R" first="Ruoqiong" last="Chen">Ruoqiong Chen</name><name sortKey="Rudney, Joel D" sort="Rudney, Joel D" uniqKey="Rudney J" first="Joel D." last="Rudney">Joel D. Rudney</name><name sortKey="Sedgewick, Gerald J" sort="Sedgewick, Gerald J" uniqKey="Sedgewick G" first="Gerald J." last="Sedgewick">Gerald J. Sedgewick</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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