Oral infection, hyperglycemia, and endothelial dysfunction
Identifieur interne : 002685 ( Pmc/Checkpoint ); précédent : 002684; suivant : 002686Oral infection, hyperglycemia, and endothelial dysfunction
Auteurs : Sok-Ja Janket ; Judith A. Jones ; Jukka H. Meurman ; Alison E. Baird ; Thomas E. Van DykeSource :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [ 1079-2104 ] ; 2007.
Abstract
Metabolic syndrome and type 2 diabetes (T2DM) resulting from sustained hyperglycemia are considered as risk factors for cardiovascular disease (CVD) but the mechanism for their contribution to cardiopathogenesis is not well understood. Hyperglycemia induces nonenzymatic glycation of protein-yielding advanced glycation end products (AGE), which are postulated to stimulate interleukin-6 (IL-6) expression, triggering the liver to secrete tissue necrosis factor α (TNF-α) and C-reactive protein (CRP) that contribute to CVD pathogenesis. Although the high prevalence of periodontitis among individuals with diabetes is well known by dental researchers, it is relatively unrecognized in the medical community. The expression of the same proinflammatory mediators implicated in hyperglycemia (i.e., IL-6, TNF-α, and CRP) have been reported to be associated with periodontal disease and increased risk for CVD. We will review published evidence related to these 2 pathways and offer a consensus.
Url:
DOI: 10.1016/j.tripleo.2007.06.027
PubMed: 17905606
PubMed Central: 2574939
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">Metabolic syndrome and type 2 diabetes (T2DM) resulting from sustained hyperglycemia are considered as risk factors for cardiovascular disease (CVD) but the mechanism for their contribution to cardiopathogenesis is not well understood. Hyperglycemia induces nonenzymatic glycation of protein-yielding advanced glycation end products (AGE), which are postulated to stimulate interleukin-6 (IL-6) expression, triggering the liver to secrete tissue necrosis factor α (TNF-α) and C-reactive protein (CRP) that contribute to CVD pathogenesis. Although the high prevalence of periodontitis among individuals with diabetes is well known by dental researchers, it is relatively unrecognized in the medical community. The expression of the same proinflammatory mediators implicated in hyperglycemia (i.e., IL-6, TNF-α, and CRP) have been reported to be associated with periodontal disease and increased risk for CVD. We will review published evidence related to these 2 pathways and offer a consensus.</p>
</div>
</front>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9508562</journal-id>
<journal-id journal-id-type="pubmed-jr-id">8728</journal-id>
<journal-id journal-id-type="nlm-ta">Oral Surg Oral Med Oral Pathol Oral Radiol Endod</journal-id>
<journal-title>Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics</journal-title>
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<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Oral infection, hyperglycemia, and endothelial dysfunction</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Janket</surname>
<given-names>Sok-Ja</given-names>
</name>
<degrees>DMD, MPH</degrees>
<xref ref-type="aff" rid="A1">a</xref>
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<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Judith A.</given-names>
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<degrees>DDS, DScD</degrees>
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<contrib contrib-type="author"><name><surname>Meurman</surname>
<given-names>Jukka H.</given-names>
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<degrees>MD, DDS, PhD</degrees>
<xref ref-type="aff" rid="A3">c</xref>
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<contrib contrib-type="author"><name><surname>Baird</surname>
<given-names>Alison E.</given-names>
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<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A4">d</xref>
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<contrib contrib-type="author"><name><surname>Van Dyke</surname>
<given-names>Thomas E.</given-names>
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<degrees>DDS, PhD</degrees>
<xref ref-type="aff" rid="A5">e</xref>
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<aff id="A1"><label>a</label>
Assistant Research Professor, Department of General Dentistry, Boston University School of Dental Medicine.</aff>
<aff id="A2"><label>b</label>
Professor and Chair, Department of General Dentistry, Boston University School of Dental Medicine.</aff>
<aff id="A3"><label>c</label>
Professor, Institute of Dentistry, University of Helsinki Central Hospital and Institute of Dentistry.</aff>
<aff id="A4"><label>d</label>
Chief, Stroke Division, National Institutes of Neurologic Disorders and Stroke, National Institutes of Health.</aff>
<aff id="A5"><label>e</label>
Professor, Department of Periodontology and Oral Biology, Department of Periodontology and Oral Biology, Boston University School of Dental Medicine.</aff>
<author-notes><corresp id="CR1"><italic>Reprint requests:</italic>
Sok-Ja Janket, DMD, MPH, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-619, Boston, MA 02118, <email>skjanket@bu.edu</email>
</corresp>
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<pub-date pub-type="nihms-submitted"><day>20</day>
<month>12</month>
<year>2007</year>
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<pub-date pub-type="epub"><day>1</day>
<month>10</month>
<year>2007</year>
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<pub-date pub-type="ppub"><month>2</month>
<year>2008</year>
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<pub-date pub-type="pmc-release"><day>28</day>
<month>10</month>
<year>2008</year>
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<volume>105</volume>
<issue>2</issue>
<fpage>173</fpage>
<lpage>179</lpage>
<abstract><p id="P1">Metabolic syndrome and type 2 diabetes (T2DM) resulting from sustained hyperglycemia are considered as risk factors for cardiovascular disease (CVD) but the mechanism for their contribution to cardiopathogenesis is not well understood. Hyperglycemia induces nonenzymatic glycation of protein-yielding advanced glycation end products (AGE), which are postulated to stimulate interleukin-6 (IL-6) expression, triggering the liver to secrete tissue necrosis factor α (TNF-α) and C-reactive protein (CRP) that contribute to CVD pathogenesis. Although the high prevalence of periodontitis among individuals with diabetes is well known by dental researchers, it is relatively unrecognized in the medical community. The expression of the same proinflammatory mediators implicated in hyperglycemia (i.e., IL-6, TNF-α, and CRP) have been reported to be associated with periodontal disease and increased risk for CVD. We will review published evidence related to these 2 pathways and offer a consensus.</p>
</abstract>
<contract-num rid="DE1">R01 DE015566-01A1</contract-num>
<contract-sponsor id="DE1">National Institute of Dental and Craniofacial Research : NIDCR</contract-sponsor>
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<tree><noCountry><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name>
<name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name>
<name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name>
<name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name>
<name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name>
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