The discussion over the roles of genes and environment on the phenotypical specification of organisms has held a central role in science philosophy since the late 19^th century and has re-emerged in today’s debate over genetic determinism and developmental plasticity. In fin-de-siecle Vienna, this debate coincided with a philosophical debate over empiricism/materialism versus idealism/vitalism. Turn-of-the-century Vienna’s highly interdisciplinary environment was also the birthplace for the model system of the unopposed molar. The un-opposed molar system features new tissue formation at the roots of teeth and tooth drift once opposing teeth are lost. The un-opposed molar model system was revived by a group of Viennese scientists that left Vienna during the Nazi period to address Vienna’s questions about evolution and heredity and about genes and environment in Chicago’s post-WWII scientific exile community. Here we are using the colorful history of the un-opposed molar to investigate the role of culture and method in the scientific evolution of a model system.