Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease
Identifieur interne : 002660 ( Pmc/Checkpoint ); précédent : 002659; suivant : 002661Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease
Auteurs : Thomas DietrichSource :
- Circulation [ 0009-7322 ] ; 2008.
Abstract
Several epidemiologic studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent.
We evaluated the association between clinical and radiographic measures of periodontitis, edentulism and incident CHD (angina, myocardial infarction or fatal CHD) among 1,203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed with triennial comprehensive medical and dental exams up to 35 yrs (median: 24 yrs). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant, dose-dependent association between periodontitis and CHD incidence among men younger than 60 yrs of age (HR 2.12, 95% CI 1.26, 3.60 comparing highest vs. lowest category of radiographic bone loss, p for trend = 0.02), independent of age, BMI, smoking, alcohol intake, diabetes, fasting glucose, total cholesterol, HDL cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income and occupation. No association was found among men older than 60 yrs. Similar results were found using the sum of probing pocket depths as a measure of periodontitis. Among men 60+ yrs, edentulous men tended to have higher risk of CHD compared to dentate men in the lowest bone loss (HR 1.61, 95% CI 0.95, 2.73) and lowest pocket depth categories (HR 1.72, 95% CI 1.03, 2.85), independent of confounders.
Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.
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DOI: 10.1161/CIRCULATIONAHA.107.711507
PubMed: 18362228
PubMed Central: 2582144
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease</title><author><name sortKey="Dietrich, Thomas" sort="Dietrich, Thomas" uniqKey="Dietrich T" first="Thomas" last="Dietrich">Thomas Dietrich</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18362228</idno><idno type="pmc">2582144</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582144</idno><idno type="RBID">PMC:2582144</idno><idno type="doi">10.1161/CIRCULATIONAHA.107.711507</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">002074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002074</idno><idno type="wicri:Area/Pmc/Curation">002074</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002074</idno><idno type="wicri:Area/Pmc/Checkpoint">002660</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002660</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease</title><author><name sortKey="Dietrich, Thomas" sort="Dietrich, Thomas" uniqKey="Dietrich T" first="Thomas" last="Dietrich">Thomas Dietrich</name></author></analytic><series><title level="j">Circulation</title><idno type="ISSN">0009-7322</idno><idno type="eISSN">1524-4539</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background:</title><p id="P1">Several epidemiologic studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent.</p></sec><sec id="S2"><title>Methods and Results:</title><p id="P2">We evaluated the association between clinical and radiographic measures of periodontitis, edentulism and incident CHD (angina, myocardial infarction or fatal CHD) among 1,203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed with triennial comprehensive medical and dental exams up to 35 yrs (median: 24 yrs). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant, dose-dependent association between periodontitis and CHD incidence among men younger than 60 yrs of age (HR 2.12, 95% CI 1.26, 3.60 comparing highest vs. lowest category of radiographic bone loss, p for trend = 0.02), independent of age, BMI, smoking, alcohol intake, diabetes, fasting glucose, total cholesterol, HDL cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income and occupation. No association was found among men older than 60 yrs. Similar results were found using the sum of probing pocket depths as a measure of periodontitis. Among men 60+ yrs, edentulous men tended to have higher risk of CHD compared to dentate men in the lowest bone loss (HR 1.61, 95% CI 0.95, 2.73) and lowest pocket depth categories (HR 1.72, 95% CI 1.03, 2.85), independent of confounders.</p></sec><sec id="S3"><title>Conclusions:</title><p id="P3">Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0147763</journal-id><journal-id journal-id-type="pubmed-jr-id">2979</journal-id><journal-id journal-id-type="nlm-ta">Circulation</journal-id><journal-title>Circulation</journal-title><issn pub-type="ppub">0009-7322</issn><issn pub-type="epub">1524-4539</issn></journal-meta><article-meta><article-id pub-id-type="pmid">18362228</article-id><article-id pub-id-type="pmc">2582144</article-id><article-id pub-id-type="doi">10.1161/CIRCULATIONAHA.107.711507</article-id><article-id pub-id-type="manuscript">NIHMS75676</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease</article-title><subtitle>Dietrich, Periodontitis and CHD</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dietrich</surname><given-names>Thomas</given-names></name><degrees>DMD, MD, MPH</degrees><aff id="A1">Dept. of Health Policy and Health Services Research, Dept. of Periodontology and Oral Biology, Boston University Goldman School of Dental Medicine, Boston, USA and Dept. of Oral Surgery, The School of Dentistry, University of Birmingham, Birmingham, UK</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Jimenez</surname><given-names>Monik</given-names></name><degrees>MSc</degrees><aff id="A2">Dept. of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Dept. of Oral Health Policy and Epidemiology, Harvard School of Public Health, Boston, USA</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Krall Kaye</surname><given-names>Elizabeth A.</given-names></name><degrees>MPH, PhD</degrees><aff id="A3">Dept. of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Boston, USA</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Vokonas</surname><given-names>Pantel S.</given-names></name><degrees>MD</degrees><aff id="A4">VA Normative Aging Study, VA Boston Healthcare System, and Dept. of Medicine, Boston University School of Medicine, Boston, USA</aff></contrib></contrib-group><contrib-group><contrib contrib-type="author"><name><surname>Garcia</surname><given-names>Raul I.</given-names></name><degrees>DMD, MMSc</degrees><aff id="A5">VA Dental Longitudinal Study, VA Boston Healthcare System, and Dept. of Health Policy and Health Services Research, Boston University Goldman School of Dental Medicine, Boston, USA</aff></contrib></contrib-group><author-notes><corresp id="CR1"><bold>Address for correspondence:</bold> Thomas Dietrich Dept of Oral Surgery The School of Dentistry University of Birmingham St Chad's Queensway Birmingham, B4 6NN United Kingdom Tel. +44-121-237-2827 Fax: +44-121-237-2825 Email: <email>t.dietrich@bham.ac.uk</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>10</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>24</day><month>3</month><year>2008</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>4</month><year>2008</year></pub-date><pub-date pub-type="pmc-release"><day>11</day><month>11</month><year>2008</year></pub-date><volume>117</volume><issue>13</issue><fpage>1668</fpage><lpage>1674</lpage><abstract><sec id="S1"><title>Background:</title><p id="P1">Several epidemiologic studies have suggested periodontitis as a risk factor for coronary heart disease (CHD), but results have been inconsistent.</p></sec><sec id="S2"><title>Methods and Results:</title><p id="P2">We evaluated the association between clinical and radiographic measures of periodontitis, edentulism and incident CHD (angina, myocardial infarction or fatal CHD) among 1,203 men in the VA Normative Aging and Dental Longitudinal Studies who were followed with triennial comprehensive medical and dental exams up to 35 yrs (median: 24 yrs). Cox proportional hazards models with time-varying effects of exposure and potential confounders were fit. We found a significant, dose-dependent association between periodontitis and CHD incidence among men younger than 60 yrs of age (HR 2.12, 95% CI 1.26, 3.60 comparing highest vs. lowest category of radiographic bone loss, p for trend = 0.02), independent of age, BMI, smoking, alcohol intake, diabetes, fasting glucose, total cholesterol, HDL cholesterol, triglycerides, hypertension, systolic and diastolic blood pressure, education, marital status, income and occupation. No association was found among men older than 60 yrs. Similar results were found using the sum of probing pocket depths as a measure of periodontitis. Among men 60+ yrs, edentulous men tended to have higher risk of CHD compared to dentate men in the lowest bone loss (HR 1.61, 95% CI 0.95, 2.73) and lowest pocket depth categories (HR 1.72, 95% CI 1.03, 2.85), independent of confounders.</p></sec><sec id="S3"><title>Conclusions:</title><p id="P3">Chronic periodontitis is associated with incidence of CHD among younger men, independent of established cardiovascular risk factors.</p></sec></abstract><kwd-group><kwd>coronary disease</kwd><kwd>epidemiology</kwd><kwd>infection</kwd><kwd>inflammation</kwd><kwd>risk factors</kwd></kwd-group><contract-num rid="DE1">R03 DE016357-01A1</contract-num><contract-sponsor id="DE1">National Institute of Dental and Craniofacial Research : NIDCR</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Dietrich, Thomas" sort="Dietrich, Thomas" uniqKey="Dietrich T" first="Thomas" last="Dietrich">Thomas Dietrich</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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