Comparing alveolar bone regeneration using Bio-Oss and autogenous bone grafts in humans: a systematic review and meta-analysis
Identifieur interne : 002570 ( Pmc/Checkpoint ); précédent : 002569; suivant : 002571Comparing alveolar bone regeneration using Bio-Oss and autogenous bone grafts in humans: a systematic review and meta-analysis
Auteurs : Alireza Akbarzadeh Baghban ; Azam Dehghani ; Farzin Ghanavati ; Farid Zayeri ; Farzam GhanavatiSource :
- Iranian Endodontic Journal [ 1735-7497 ] ; 2009.
Abstract
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PubMed: 24019832
PubMed Central: 3766618
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparing alveolar bone regeneration using Bio-Oss and autogenous bone grafts in humans: a systematic review and meta-analysis</title>
<author><name sortKey="Akbarzadeh Baghban, Alireza" sort="Akbarzadeh Baghban, Alireza" uniqKey="Akbarzadeh Baghban A" first="Alireza" last="Akbarzadeh Baghban">Alireza Akbarzadeh Baghban</name>
<affiliation><nlm:aff id="aff1"><italic>Department of Biostatistics, Paramedical School, Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
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<author><name sortKey="Dehghani, Azam" sort="Dehghani, Azam" uniqKey="Dehghani A" first="Azam" last="Dehghani">Azam Dehghani</name>
<affiliation><nlm:aff id="aff2"><italic>Paramedical School, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
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<author><name sortKey="Ghanavati, Farzin" sort="Ghanavati, Farzin" uniqKey="Ghanavati F" first="Farzin" last="Ghanavati">Farzin Ghanavati</name>
<affiliation><nlm:aff id="aff3"><italic>Department of Periodontics, Perio-implant Dept., Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zayeri, Farid" sort="Zayeri, Farid" uniqKey="Zayeri F" first="Farid" last="Zayeri">Farid Zayeri</name>
<affiliation><nlm:aff id="aff4"><italic>Department of Biostatistics, Paramedical School, Shahid Beheshti University of Medical Science, Tehran, Iran</italic>
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</affiliation>
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<author><name sortKey="Ghanavati, Farzam" sort="Ghanavati, Farzam" uniqKey="Ghanavati F" first="Farzam" last="Ghanavati">Farzam Ghanavati</name>
<affiliation><nlm:aff id="aff5"><italic>Department of Maxillofacial Surgery, Newcastle, UK</italic>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparing alveolar bone regeneration using Bio-Oss and autogenous bone grafts in humans: a systematic review and meta-analysis</title>
<author><name sortKey="Akbarzadeh Baghban, Alireza" sort="Akbarzadeh Baghban, Alireza" uniqKey="Akbarzadeh Baghban A" first="Alireza" last="Akbarzadeh Baghban">Alireza Akbarzadeh Baghban</name>
<affiliation><nlm:aff id="aff1"><italic>Department of Biostatistics, Paramedical School, Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dehghani, Azam" sort="Dehghani, Azam" uniqKey="Dehghani A" first="Azam" last="Dehghani">Azam Dehghani</name>
<affiliation><nlm:aff id="aff2"><italic>Paramedical School, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghanavati, Farzin" sort="Ghanavati, Farzin" uniqKey="Ghanavati F" first="Farzin" last="Ghanavati">Farzin Ghanavati</name>
<affiliation><nlm:aff id="aff3"><italic>Department of Periodontics, Perio-implant Dept., Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zayeri, Farid" sort="Zayeri, Farid" uniqKey="Zayeri F" first="Farid" last="Zayeri">Farid Zayeri</name>
<affiliation><nlm:aff id="aff4"><italic>Department of Biostatistics, Paramedical School, Shahid Beheshti University of Medical Science, Tehran, Iran</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ghanavati, Farzam" sort="Ghanavati, Farzam" uniqKey="Ghanavati F" first="Farzam" last="Ghanavati">Farzam Ghanavati</name>
<affiliation><nlm:aff id="aff5"><italic>Department of Maxillofacial Surgery, Newcastle, UK</italic>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Iranian Endodontic Journal</title>
<idno type="ISSN">1735-7497</idno>
<idno type="eISSN">2008-2746</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><p><bold>INTRODUCTION:</bold>
Bone regeneration grafts (BRG) are widely used in the treatment of osseous defects and oral surgery. The various techniques and associated success rates of bone augmentation require evaluation by systematic review and meta-analysis of eligible studies. The aim of this systematic review was to compare alveolar bone regeneration in humans using Bio-Oss and autogenous bone graft.</p>
<p><bold>MATERIALS AND METHODS:</bold>
The computerized bibliographical databases including Pubmed, Google, ScienceDirect and Cochrane were searched for randomized and cohort studies in which autogenous grafts were compared to Bio-Oss in the treatment of periodontal defects. The inclusion criteria were human studies in English that were published 1998-2009. Exclusion criteria included non randomized observation and cohort studies, papers which provided summary statistics without the variance estimates, and studies that did not use BRG intervention alone, were excluded. The screening of eligible studies, assessment of the methodological quality of the trials and data extraction were collected by two observers independently<italic>.</italic>
For comparing autogenous grafts used alone against Bio-Oss used alone 5 situations were investigated. Thirteen studies were included in the review which compared autogenous against Bio-Oss, autogenous combined with guided tissue regeneration (GTR) against GTR, Bio-Oss combined with GTR versus GTR, autogenous alone versus Open Flap Debridement (OFD), Bio-Oss versus OFD. In meta-analysis, changes in bone level (bone fill) was used as the measure. Data were analyzed using Bayesian meta-analysis by WinBUGS and Boa software.</p>
<p><bold>RESULTS:</bold>
Only one comparison demonstrated that the difference in bone augmentation between Bio-Oss and OFD was statistically significant.</p>
<p><bold>CONCLUSION:</bold>
There is insufficient evidence to show that Bio-Oss is superior to autogenous grafts in bone augmentation techniques however autogenous bone involves donor site surgery and thus donor site morbidity, so we can conclude that Bio-Oss is better than autogenous for alveolar regeneration. [Iranian Endodontic Journal 2009;4(4):125-30]</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Iran Endod J</journal-id>
<journal-id journal-id-type="iso-abbrev">Iran Endod J</journal-id>
<journal-id journal-id-type="publisher-id">IEJ</journal-id>
<journal-title-group><journal-title>Iranian Endodontic Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">1735-7497</issn>
<issn pub-type="epub">2008-2746</issn>
<publisher><publisher-name>Iranian Center for Endodontic Research</publisher-name>
<publisher-loc>Tehran, Iran</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24019832</article-id>
<article-id pub-id-type="pmc">3766618</article-id>
<article-id pub-id-type="publisher-id">iej-04-125</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Meta-Analysis</subject>
</subj-group>
</article-categories>
<title-group><article-title>Comparing alveolar bone regeneration using Bio-Oss and autogenous bone grafts in humans: a systematic review and meta-analysis</article-title>
<alt-title alt-title-type="short">Alveolar bone regeneration</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Akbarzadeh Baghban</surname>
<given-names>Alireza</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dehghani</surname>
<given-names>Azam</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghanavati</surname>
<given-names>Farzin</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zayeri</surname>
<given-names>Farid</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ghanavati</surname>
<given-names>Farzam</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<italic>Department of Biostatistics, Paramedical School, Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</aff>
<aff id="aff2"><label>2</label>
<italic>Paramedical School, International Branch of Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</aff>
<aff id="aff3"><label>3</label>
<italic>Department of Periodontics, Perio-implant Dept., Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran</italic>
</aff>
<aff id="aff4"><label>4</label>
<italic>Department of Biostatistics, Paramedical School, Shahid Beheshti University of Medical Science, Tehran, Iran</italic>
</aff>
<aff id="aff5"><label>5</label>
<italic>Department of Maxillofacial Surgery, Newcastle, UK</italic>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author at: Alireza Akbarzadeh Baghban, Department of Biostatistics, Paramedical School, Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Tel: +98-212720734, E-mail: <email>akbarzad@sbmu.ac.ir</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>10</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><season>Fall</season>
<year>2009</year>
</pub-date>
<volume>4</volume>
<issue>4</issue>
<fpage>125</fpage>
<lpage>130</lpage>
<history><date date-type="received"><day>21</day>
<month>6</month>
<year>2009</year>
</date>
<date date-type="rev-recd"><day>17</day>
<month>8</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>9</day>
<month>9</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© 2009, Iranian Center for Endodontic Research</copyright-statement>
<copyright-year>2009</copyright-year>
<license><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
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<abstract><p><bold>INTRODUCTION:</bold>
Bone regeneration grafts (BRG) are widely used in the treatment of osseous defects and oral surgery. The various techniques and associated success rates of bone augmentation require evaluation by systematic review and meta-analysis of eligible studies. The aim of this systematic review was to compare alveolar bone regeneration in humans using Bio-Oss and autogenous bone graft.</p>
<p><bold>MATERIALS AND METHODS:</bold>
The computerized bibliographical databases including Pubmed, Google, ScienceDirect and Cochrane were searched for randomized and cohort studies in which autogenous grafts were compared to Bio-Oss in the treatment of periodontal defects. The inclusion criteria were human studies in English that were published 1998-2009. Exclusion criteria included non randomized observation and cohort studies, papers which provided summary statistics without the variance estimates, and studies that did not use BRG intervention alone, were excluded. The screening of eligible studies, assessment of the methodological quality of the trials and data extraction were collected by two observers independently<italic>.</italic>
For comparing autogenous grafts used alone against Bio-Oss used alone 5 situations were investigated. Thirteen studies were included in the review which compared autogenous against Bio-Oss, autogenous combined with guided tissue regeneration (GTR) against GTR, Bio-Oss combined with GTR versus GTR, autogenous alone versus Open Flap Debridement (OFD), Bio-Oss versus OFD. In meta-analysis, changes in bone level (bone fill) was used as the measure. Data were analyzed using Bayesian meta-analysis by WinBUGS and Boa software.</p>
<p><bold>RESULTS:</bold>
Only one comparison demonstrated that the difference in bone augmentation between Bio-Oss and OFD was statistically significant.</p>
<p><bold>CONCLUSION:</bold>
There is insufficient evidence to show that Bio-Oss is superior to autogenous grafts in bone augmentation techniques however autogenous bone involves donor site surgery and thus donor site morbidity, so we can conclude that Bio-Oss is better than autogenous for alveolar regeneration. [Iranian Endodontic Journal 2009;4(4):125-30]</p>
</abstract>
<kwd-group><title>Key Words</title>
<kwd>Autogenous grafts</kwd>
<kwd>Bio-Oss</kwd>
<kwd>Bone regeneration</kwd>
<kwd>Intrabony defect</kwd>
<kwd>Meta-analysis</kwd>
<kwd>Systematic review</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Akbarzadeh Baghban, Alireza" sort="Akbarzadeh Baghban, Alireza" uniqKey="Akbarzadeh Baghban A" first="Alireza" last="Akbarzadeh Baghban">Alireza Akbarzadeh Baghban</name>
<name sortKey="Dehghani, Azam" sort="Dehghani, Azam" uniqKey="Dehghani A" first="Azam" last="Dehghani">Azam Dehghani</name>
<name sortKey="Ghanavati, Farzam" sort="Ghanavati, Farzam" uniqKey="Ghanavati F" first="Farzam" last="Ghanavati">Farzam Ghanavati</name>
<name sortKey="Ghanavati, Farzin" sort="Ghanavati, Farzin" uniqKey="Ghanavati F" first="Farzin" last="Ghanavati">Farzin Ghanavati</name>
<name sortKey="Zayeri, Farid" sort="Zayeri, Farid" uniqKey="Zayeri F" first="Farid" last="Zayeri">Farid Zayeri</name>
</noCountry>
</tree>
</affiliations>
</record>
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