Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid
Identifieur interne : 002437 ( Pmc/Checkpoint ); précédent : 002436; suivant : 002438Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid
Auteurs : Li Baofeng ; Yuan Zhi ; Chen Bei [République populaire de Chine] ; Meng Guolin ; Yin Qingshui ; Liu JianSource :
- Acta Orthopaedica [ 1745-3674 ] ; 2010.
Abstract
Experimental models of osteoporosis in rabbits are useful to investigate anabolic agents because rabbits have an active Haversian remodeling and achieve skeletal maturiaty quickly. In this study, an experimental model of osteoporosis in rabbits induced by a combination of ovariectomy and glucocorticoid was characterized to provide a useful model for prevention and therapy of osteoporosis.
32 skeletally mature female rabbits were divided randomly into 4 groups: sham control, bilateral ovariectomy (OVX), 1mg/kg/day methylprednisolone (MP) for 8 weeks, and OVX in combination with MP. All rabbits were killed 10 weeks after surgery. Bone mineral density (BMD) of lumbar spine was measured by dual-energy X-ray absorptiometry at baseline, and at 6 and 10 weeks postoperatively. Bone microarchitecture and mechanical properties of lumbar vertebrae were investigated by high-resolution micro-computed tomography and compression test, respectively, after killing.
Mean BMD of the OVX+MP group at 10 weeks was reduced by about 36% from baseline (p < 0.001). Bone microarchitecture of lumbar vertebrae in the OVX+MP group indicated osteoporosis-associated deterioration. There was a statistically significant reduction in maximum load, stiffness, and energy absorption capacity of lumbar vertebrae in the OVX+MP group, but not in the OVX group, compared to the sham control. In the MP group, BMD and some microarchitecture parameters such as trabecular thickness and bone volume fraction were reduced. The mechanical properties were not statistically significantly different from those in the sham control group, however, although a negative trend was observed.
Osteopenia can be induced experimentally in rabbits through a combination of OVX and MP, and can be evaluated by BMD, bone microstructure, and mechanical parameters.
Url:
DOI: 10.3109/17453674.2010.483986
PubMed: 20446884
PubMed Central: 2876847
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:2876847Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid</title>
<author><name sortKey="Baofeng, Li" sort="Baofeng, Li" uniqKey="Baofeng L" first="Li" last="Baofeng">Li Baofeng</name>
</author>
<author><name sortKey="Zhi, Yuan" sort="Zhi, Yuan" uniqKey="Zhi Y" first="Yuan" last="Zhi">Yuan Zhi</name>
<affiliation><nlm:aff id="AF0002"><institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bei, Chen" sort="Bei, Chen" uniqKey="Bei C" first="Chen" last="Bei">Chen Bei</name>
<affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department ofOncology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou</institution>
<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guolin, Meng" sort="Guolin, Meng" uniqKey="Guolin M" first="Meng" last="Guolin">Meng Guolin</name>
<affiliation><nlm:aff id="AF0002"><institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Qingshui, Yin" sort="Qingshui, Yin" uniqKey="Qingshui Y" first="Yin" last="Qingshui">Yin Qingshui</name>
<affiliation><nlm:aff id="AF0001"><institution>Department of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jian, Liu" sort="Jian, Liu" uniqKey="Jian L" first="Liu" last="Jian">Liu Jian</name>
<affiliation><nlm:aff id="AF0002"><institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20446884</idno>
<idno type="pmc">2876847</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876847</idno>
<idno type="RBID">PMC:2876847</idno>
<idno type="doi">10.3109/17453674.2010.483986</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">002802</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002802</idno>
<idno type="wicri:Area/Pmc/Curation">002802</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002802</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002437</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002437</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid</title>
<author><name sortKey="Baofeng, Li" sort="Baofeng, Li" uniqKey="Baofeng L" first="Li" last="Baofeng">Li Baofeng</name>
</author>
<author><name sortKey="Zhi, Yuan" sort="Zhi, Yuan" uniqKey="Zhi Y" first="Yuan" last="Zhi">Yuan Zhi</name>
<affiliation><nlm:aff id="AF0002"><institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bei, Chen" sort="Bei, Chen" uniqKey="Bei C" first="Chen" last="Bei">Chen Bei</name>
<affiliation wicri:level="1"><nlm:aff id="AF0003"><institution>Department ofOncology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou</institution>
<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guolin, Meng" sort="Guolin, Meng" uniqKey="Guolin M" first="Meng" last="Guolin">Meng Guolin</name>
<affiliation><nlm:aff id="AF0002"><institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Qingshui, Yin" sort="Qingshui, Yin" uniqKey="Qingshui Y" first="Yin" last="Qingshui">Yin Qingshui</name>
<affiliation><nlm:aff id="AF0001"><institution>Department of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou</institution>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jian, Liu" sort="Jian, Liu" uniqKey="Jian L" first="Liu" last="Jian">Liu Jian</name>
<affiliation><nlm:aff id="AF0002"><institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Acta Orthopaedica</title>
<idno type="ISSN">1745-3674</idno>
<idno type="eISSN">1745-3682</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background and purpose</title>
<p>Experimental models of osteoporosis in rabbits are useful to investigate anabolic agents because rabbits have an active Haversian remodeling and achieve skeletal maturiaty quickly. In this study, an experimental model of osteoporosis in rabbits induced by a combination of ovariectomy and glucocorticoid was characterized to provide a useful model for prevention and therapy of osteoporosis.</p>
</sec>
<sec><title>Methods</title>
<p>32 skeletally mature female rabbits were divided randomly into 4 groups: sham control, bilateral ovariectomy (OVX), 1mg/kg/day methylprednisolone (MP) for 8 weeks, and OVX in combination with MP. All rabbits were killed 10 weeks after surgery. Bone mineral density (BMD) of lumbar spine was measured by dual-energy X-ray absorptiometry at baseline, and at 6 and 10 weeks postoperatively. Bone microarchitecture and mechanical properties of lumbar vertebrae were investigated by high-resolution micro-computed tomography and compression test, respectively, after killing.</p>
</sec>
<sec><title>Results</title>
<p>Mean BMD of the OVX+MP group at 10 weeks was reduced by about 36% from baseline (p < 0.001). Bone microarchitecture of lumbar vertebrae in the OVX+MP group indicated osteoporosis-associated deterioration. There was a statistically significant reduction in maximum load, stiffness, and energy absorption capacity of lumbar vertebrae in the OVX+MP group, but not in the OVX group, compared to the sham control. In the MP group, BMD and some microarchitecture parameters such as trabecular thickness and bone volume fraction were reduced. The mechanical properties were not statistically significantly different from those in the sham control group, however, although a negative trend was observed.</p>
</sec>
<sec><title>Interpretation</title>
<p>Osteopenia can be induced experimentally in rabbits through a combination of OVX and MP, and can be evaluated by BMD, bone microstructure, and mechanical parameters.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adinoff, Ad" uniqKey="Adinoff A">AD Adinoff</name>
</author>
<author><name sortKey="Hollister, Jr" uniqKey="Hollister J">JR Hollister</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cao, T" uniqKey="Cao T">T Cao</name>
</author>
<author><name sortKey="Shirota, T" uniqKey="Shirota T">T Shirota</name>
</author>
<author><name sortKey="Ohno, K" uniqKey="Ohno K">K Ohno</name>
</author>
<author><name sortKey="Michi, Ki" uniqKey="Michi K">KI Michi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castaneda, S" uniqKey="Castaneda S">S Castaneda</name>
</author>
<author><name sortKey="Largo, R" uniqKey="Largo R">R Largo</name>
</author>
<author><name sortKey="Calvo, E" uniqKey="Calvo E">E Calvo</name>
</author>
<author><name sortKey="Rodriguez Salvanes, F" uniqKey="Rodriguez Salvanes F">F Rodriguez-Salvanes</name>
</author>
<author><name sortKey="Marcos, Me" uniqKey="Marcos M">ME Marcos</name>
</author>
<author><name sortKey="Diaz Curiel, M" uniqKey="Diaz Curiel M">M Diaz-Curiel</name>
</author>
<author><name sortKey="Herrero Beaumont, G" uniqKey="Herrero Beaumont G">G Herrero-Beaumont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Castaneda, S" uniqKey="Castaneda S">S Castaneda</name>
</author>
<author><name sortKey="Calvo, E" uniqKey="Calvo E">E Calvo</name>
</author>
<author><name sortKey="Largo, R" uniqKey="Largo R">R Largo</name>
</author>
<author><name sortKey="Gonzalez Gonzalez, R" uniqKey="Gonzalez Gonzalez R">R Gonzalez-Gonzalez</name>
</author>
<author><name sortKey="De La Piedra, C" uniqKey="De La Piedra C">C De La Piedra</name>
</author>
<author><name sortKey="Diaz Curiel, M" uniqKey="Diaz Curiel M">M Diaz-Curiel</name>
</author>
<author><name sortKey="Herrero Beaumont, G" uniqKey="Herrero Beaumont G">G Herrero-Beaumont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eberhardt, Aw" uniqKey="Eberhardt A">AW Eberhardt</name>
</author>
<author><name sortKey="Yeager Jones, A" uniqKey="Yeager Jones A">A Yeager-Jones</name>
</author>
<author><name sortKey="Blair, Hc" uniqKey="Blair H">HC Blair</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frost, Hm" uniqKey="Frost H">HM Frost</name>
</author>
<author><name sortKey="Jee, Ws" uniqKey="Jee W">WS Jee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilsanz, V" uniqKey="Gilsanz V">V Gilsanz</name>
</author>
<author><name sortKey="Roe, Tf" uniqKey="Roe T">TF Roe</name>
</author>
<author><name sortKey="Gibbens, Dt" uniqKey="Gibbens D">DT Gibbens</name>
</author>
<author><name sortKey="Schulz, Ee" uniqKey="Schulz E">EE Schulz</name>
</author>
<author><name sortKey="Carlson, Me" uniqKey="Carlson M">ME Carlson</name>
</author>
<author><name sortKey="Gonzalez, O" uniqKey="Gonzalez O">O Gonzalez</name>
</author>
<author><name sortKey="Boechat, Mi" uniqKey="Boechat M">MI Boechat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grardel, B" uniqKey="Grardel B">B Grardel</name>
</author>
<author><name sortKey="Sutter, B" uniqKey="Sutter B">B Sutter</name>
</author>
<author><name sortKey="Flautre, B" uniqKey="Flautre B">B Flautre</name>
</author>
<author><name sortKey="Viguier, E" uniqKey="Viguier E">E Viguier</name>
</author>
<author><name sortKey="Lavaste, F" uniqKey="Lavaste F">F Lavaste</name>
</author>
<author><name sortKey="Hardouin, P" uniqKey="Hardouin P">P Hardouin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gurgul, S" uniqKey="Gurgul S">S Gurgul</name>
</author>
<author><name sortKey="Erdal, N" uniqKey="Erdal N">N Erdal</name>
</author>
<author><name sortKey="Yilmaz, Sn" uniqKey="Yilmaz S">SN Yilmaz</name>
</author>
<author><name sortKey="Yildiz, A" uniqKey="Yildiz A">A Yildiz</name>
</author>
<author><name sortKey="Ankarali, H" uniqKey="Ankarali H">H Ankarali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalu, Dn" uniqKey="Kalu D">DN Kalu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lelovas, Pp" uniqKey="Lelovas P">PP Lelovas</name>
</author>
<author><name sortKey="Xanthos, Tt" uniqKey="Xanthos T">TT Xanthos</name>
</author>
<author><name sortKey="Thoma, Se" uniqKey="Thoma S">SE Thoma</name>
</author>
<author><name sortKey="Lyritis, Gp" uniqKey="Lyritis G">GP Lyritis</name>
</author>
<author><name sortKey="Dontas, Ia" uniqKey="Dontas I">IA Dontas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lill, Ca" uniqKey="Lill C">CA Lill</name>
</author>
<author><name sortKey="Gerlach, Uv" uniqKey="Gerlach U">UV Gerlach</name>
</author>
<author><name sortKey="Eckhardt, C" uniqKey="Eckhardt C">C Eckhardt</name>
</author>
<author><name sortKey="Goldhahn, J" uniqKey="Goldhahn J">J Goldhahn</name>
</author>
<author><name sortKey="Schneider, E" uniqKey="Schneider E">E Schneider</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mittra, E" uniqKey="Mittra E">E Mittra</name>
</author>
<author><name sortKey="Rubin, C" uniqKey="Rubin C">C Rubin</name>
</author>
<author><name sortKey="Gruber, B" uniqKey="Gruber B">B Gruber</name>
</author>
<author><name sortKey="Qin, Yx" uniqKey="Qin Y">YX Qin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mori, H" uniqKey="Mori H">H Mori</name>
</author>
<author><name sortKey="Manabe, M" uniqKey="Manabe M">M Manabe</name>
</author>
<author><name sortKey="Kurachi, Y" uniqKey="Kurachi Y">Y Kurachi</name>
</author>
<author><name sortKey="Nagumo, M" uniqKey="Nagumo M">M Nagumo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mosekilde, L" uniqKey="Mosekilde L">L Mosekilde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Newman, E" uniqKey="Newman E">E Newman</name>
</author>
<author><name sortKey="Turner, As" uniqKey="Turner A">AS Turner</name>
</author>
<author><name sortKey="Wark, Jd" uniqKey="Wark J">JD Wark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Norris, Sa" uniqKey="Norris S">SA Norris</name>
</author>
<author><name sortKey="Pettifor, Jm" uniqKey="Pettifor J">JM Pettifor</name>
</author>
<author><name sortKey="Gray, Da" uniqKey="Gray D">DA Gray</name>
</author>
<author><name sortKey="Buffenstein, R" uniqKey="Buffenstein R">R Buffenstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peng, Z" uniqKey="Peng Z">Z Peng</name>
</author>
<author><name sortKey="Tuukkanen, J" uniqKey="Tuukkanen J">J Tuukkanen</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Jamsa, T" uniqKey="Jamsa T">T Jamsa</name>
</author>
<author><name sortKey="Vaananen, Hk" uniqKey="Vaananen H">HK Vaananen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodgers, Jb" uniqKey="Rodgers J">JB Rodgers</name>
</author>
<author><name sortKey="Monier Faugere, Mc" uniqKey="Monier Faugere M">MC Monier-Faugere</name>
</author>
<author><name sortKey="Malluche, H" uniqKey="Malluche H">H Malluche</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Southard, Te" uniqKey="Southard T">TE Southard</name>
</author>
<author><name sortKey="Southard, Ka" uniqKey="Southard K">KA Southard</name>
</author>
<author><name sortKey="Krizan, Ke" uniqKey="Krizan K">KE Krizan</name>
</author>
<author><name sortKey="Hillis, Sl" uniqKey="Hillis S">SL Hillis</name>
</author>
<author><name sortKey="Haller, Jw" uniqKey="Haller J">JW Haller</name>
</author>
<author><name sortKey="Keller, J" uniqKey="Keller J">J Keller</name>
</author>
<author><name sortKey="Vannier, Mw" uniqKey="Vannier M">MW Vannier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Dd" uniqKey="Thompson D">DD Thompson</name>
</author>
<author><name sortKey="Simmons, Ha" uniqKey="Simmons H">HA Simmons</name>
</author>
<author><name sortKey="Pirie, Cm" uniqKey="Pirie C">CM Pirie</name>
</author>
<author><name sortKey="Ke, Hz" uniqKey="Ke H">HZ Ke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turner, Ch" uniqKey="Turner C">CH Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turner, Rt" uniqKey="Turner R">RT Turner</name>
</author>
<author><name sortKey="Maran, A" uniqKey="Maran A">A Maran</name>
</author>
<author><name sortKey="Lotinun, S" uniqKey="Lotinun S">S Lotinun</name>
</author>
<author><name sortKey="Hefferan, T" uniqKey="Hefferan T">T Hefferan</name>
</author>
<author><name sortKey="Evans, Gl" uniqKey="Evans G">GL Evans</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
<author><name sortKey="Sibonga, Jd" uniqKey="Sibonga J">JD Sibonga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Goh, J" uniqKey="Goh J">J Goh</name>
</author>
<author><name sortKey="Das De, S" uniqKey="Das De S">S Das De</name>
</author>
<author><name sortKey="Ge, Z" uniqKey="Ge Z">Z Ge</name>
</author>
<author><name sortKey="Ouyang, H" uniqKey="Ouyang H">H Ouyang</name>
</author>
<author><name sortKey="Chong, Js" uniqKey="Chong J">JS Chong</name>
</author>
<author><name sortKey="Low, Sl" uniqKey="Low S">SL Low</name>
</author>
<author><name sortKey="Lee, Eh" uniqKey="Lee E">EH Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warman, M" uniqKey="Warman M">M Warman</name>
</author>
<author><name sortKey="Boskey, Al" uniqKey="Boskey A">AL Boskey</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Orthop</journal-id>
<journal-id journal-id-type="publisher-id">ORT</journal-id>
<journal-title-group><journal-title>Acta Orthopaedica</journal-title>
</journal-title-group>
<issn pub-type="ppub">1745-3674</issn>
<issn pub-type="epub">1745-3682</issn>
<publisher><publisher-name>Informa Healthcare</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20446884</article-id>
<article-id pub-id-type="pmc">2876847</article-id>
<article-id pub-id-type="doi">10.3109/17453674.2010.483986</article-id>
<article-id pub-id-type="publisher-id">SORT_A_483986_O</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid</article-title>
</title-group>
<contrib-group><contrib id="a1" contrib-type="author"><name><surname>Baofeng</surname>
<given-names>Li</given-names>
</name>
<xref ref-type="aff" rid="AF0001 AF0002"><sup>1,2</sup>
</xref>
</contrib>
<contrib id="a2" contrib-type="author"><name><surname>Zhi</surname>
<given-names>Yuan</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib id="a3" contrib-type="author"><name><surname>Bei</surname>
<given-names>Chen</given-names>
</name>
<xref ref-type="aff" rid="AF0003"><sup>3</sup>
</xref>
</contrib>
<contrib id="a4" contrib-type="author"><name><surname>Guolin</surname>
<given-names>Meng</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib id="a5" contrib-type="author"><name><surname>Qingshui</surname>
<given-names>Yin</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib id="a6" contrib-type="author" corresp="yes"><name><surname>Jian</surname>
<given-names>Liu</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<aff id="AF0001"><sup>1</sup>
<institution>Department of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou</institution>
</aff>
<aff id="AF0002"><sup>2</sup>
<institution>Department of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xi'an</institution>
</aff>
<aff id="AF0003"><sup>3</sup>
<institution>Department ofOncology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou</institution>
<country>China</country>
</aff>
</contrib-group>
<author-notes><corresp id="c1">Correspondence: Liu Jian (<email>bzcheese@163.com</email>
)</corresp>
<fn id="FN0001"><p>Li Baofeng and Yun Zhi contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>21</day>
<month>5</month>
<year>2010</year>
</pub-date>
<volume>81</volume>
<issue>3</issue>
<fpage>396</fpage>
<lpage>401</lpage>
<history><date date-type="received"><day>06</day>
<month>3</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>18</day>
<month>12</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © Nordic Orthopedic Federation</copyright-statement>
<copyright-year>2010</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background and purpose</title>
<p>Experimental models of osteoporosis in rabbits are useful to investigate anabolic agents because rabbits have an active Haversian remodeling and achieve skeletal maturiaty quickly. In this study, an experimental model of osteoporosis in rabbits induced by a combination of ovariectomy and glucocorticoid was characterized to provide a useful model for prevention and therapy of osteoporosis.</p>
</sec>
<sec><title>Methods</title>
<p>32 skeletally mature female rabbits were divided randomly into 4 groups: sham control, bilateral ovariectomy (OVX), 1mg/kg/day methylprednisolone (MP) for 8 weeks, and OVX in combination with MP. All rabbits were killed 10 weeks after surgery. Bone mineral density (BMD) of lumbar spine was measured by dual-energy X-ray absorptiometry at baseline, and at 6 and 10 weeks postoperatively. Bone microarchitecture and mechanical properties of lumbar vertebrae were investigated by high-resolution micro-computed tomography and compression test, respectively, after killing.</p>
</sec>
<sec><title>Results</title>
<p>Mean BMD of the OVX+MP group at 10 weeks was reduced by about 36% from baseline (p < 0.001). Bone microarchitecture of lumbar vertebrae in the OVX+MP group indicated osteoporosis-associated deterioration. There was a statistically significant reduction in maximum load, stiffness, and energy absorption capacity of lumbar vertebrae in the OVX+MP group, but not in the OVX group, compared to the sham control. In the MP group, BMD and some microarchitecture parameters such as trabecular thickness and bone volume fraction were reduced. The mechanical properties were not statistically significantly different from those in the sham control group, however, although a negative trend was observed.</p>
</sec>
<sec><title>Interpretation</title>
<p>Osteopenia can be induced experimentally in rabbits through a combination of OVX and MP, and can be evaluated by BMD, bone microstructure, and mechanical parameters.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="Baofeng, Li" sort="Baofeng, Li" uniqKey="Baofeng L" first="Li" last="Baofeng">Li Baofeng</name>
<name sortKey="Guolin, Meng" sort="Guolin, Meng" uniqKey="Guolin M" first="Meng" last="Guolin">Meng Guolin</name>
<name sortKey="Jian, Liu" sort="Jian, Liu" uniqKey="Jian L" first="Liu" last="Jian">Liu Jian</name>
<name sortKey="Qingshui, Yin" sort="Qingshui, Yin" uniqKey="Qingshui Y" first="Yin" last="Qingshui">Yin Qingshui</name>
<name sortKey="Zhi, Yuan" sort="Zhi, Yuan" uniqKey="Zhi Y" first="Yuan" last="Zhi">Yuan Zhi</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Bei, Chen" sort="Bei, Chen" uniqKey="Bei C" first="Chen" last="Bei">Chen Bei</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002437 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 002437 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:2876847 |texte= Characterization of a rabbit osteoporosis model induced by ovariectomy and glucocorticoid }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:20446884" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |