Vascular endothelial growth factor in gingival crevicular fluid around dental implants
Identifieur interne : 002287 ( Pmc/Checkpoint ); précédent : 002286; suivant : 002288Vascular endothelial growth factor in gingival crevicular fluid around dental implants
Auteurs : E. Mierzwinska-Nastalska [Pologne] ; L. Lomzynski [Pologne] ; M. Jaworska-Zaremba [Pologne] ; J. Kostrzewa-Janicka [Pologne]Source :
- European Journal of Medical Research [ 0949-2321 ] ; 2010.
Abstract
Angiogenesis occurs under physiological and pathological conditions and is regulated by cytokines and growth factors. Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine that plays a significant role in inflammation and immune responses implicated in the pathogenesis of inflammatory processes in the implant- surrounding tissues.
The study investigated the concentration of VEGF in gingival crevicular fluid (GCF) in healthy and diseased soft tissues surrounding implants.
Clinical examinations were focused on assessing the periodontal status of soft tissues around dental implants with the use of Florida Probe. Bone loss was examined radiologically. VEGF concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA).
VEGF concentrations were found higher in crevicular fluid around implants than in clinically healthy sites. They were also strongly correlated with the pocket depth.
The presence of VEGF in gingival crevicular fluid in patients with peri-implants can be implicated in the progression of peri-implantitis, possibly by promoting the formation of new blood vessels during angiogenic processes.
Url:
DOI: 10.1186/2047-783X-15-S2-88
PubMed: 21147629
PubMed Central: 4360367
Affiliations:
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<author><name sortKey="Jaworska Zaremba, M" sort="Jaworska Zaremba, M" uniqKey="Jaworska Zaremba M" first="M" last="Jaworska-Zaremba">M. Jaworska-Zaremba</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Angiogenesis occurs under physiological and pathological conditions and is regulated by cytokines and growth factors. Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine that plays a significant role in inflammation and immune responses implicated in the pathogenesis of inflammatory processes in the implant- surrounding tissues.</p>
</sec>
<sec><title>Objective</title>
<p>The study investigated the concentration of VEGF in gingival crevicular fluid (GCF) in healthy and diseased soft tissues surrounding implants.</p>
</sec>
<sec><title>Material and methods</title>
<p>Clinical examinations were focused on assessing the periodontal status of soft tissues around dental implants with the use of Florida Probe. Bone loss was examined radiologically. VEGF concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA).</p>
</sec>
<sec><title>Results</title>
<p>VEGF concentrations were found higher in crevicular fluid around implants than in clinically healthy sites. They were also strongly correlated with the pocket depth.</p>
</sec>
<sec><title>Conclusions</title>
<p>The presence of VEGF in gingival crevicular fluid in patients with peri-implants can be implicated in the progression of peri-implantitis, possibly by promoting the formation of new blood vessels during angiogenic processes.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur J Med Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Eur. J. Med. Res</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Vascular endothelial growth factor in gingival crevicular fluid around dental implants</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Mierzwinska-Nastalska</surname>
<given-names>E</given-names>
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<contrib contrib-type="author" id="A2"><name><surname>Lomzynski</surname>
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<contrib contrib-type="author" id="A3"><name><surname>Jaworska-Zaremba</surname>
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<contrib contrib-type="author" id="A4"><name><surname>Kostrzewa-Janicka</surname>
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<aff id="I1"><label>1</label>
Department of Prosthodontics, Warsaw Medical University, Warsaw, Poland</aff>
<pub-date pub-type="collection"><year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>4</day>
<month>11</month>
<year>2010</year>
</pub-date>
<volume>15</volume>
<issue>Suppl 2</issue>
<supplement><named-content content-type="supplement-title">International Conference Advances in Pneumology</named-content>
<named-content content-type="supplement-editor">Mieczyslaw Pokorski</named-content>
</supplement>
<fpage>88</fpage>
<lpage>91</lpage>
<permissions><copyright-statement>Copyright © 2010 I. Holzapfel Publishers</copyright-statement>
<copyright-year>2010</copyright-year>
<copyright-holder>I. Holzapfel Publishers</copyright-holder>
</permissions>
<self-uri xlink:href="http://www.eurjmedres.com/content/15/S2/88"></self-uri>
<abstract><sec><title>Introduction</title>
<p>Angiogenesis occurs under physiological and pathological conditions and is regulated by cytokines and growth factors. Vascular endothelial growth factor (VEGF) is a multifunctional angiogenic cytokine that plays a significant role in inflammation and immune responses implicated in the pathogenesis of inflammatory processes in the implant- surrounding tissues.</p>
</sec>
<sec><title>Objective</title>
<p>The study investigated the concentration of VEGF in gingival crevicular fluid (GCF) in healthy and diseased soft tissues surrounding implants.</p>
</sec>
<sec><title>Material and methods</title>
<p>Clinical examinations were focused on assessing the periodontal status of soft tissues around dental implants with the use of Florida Probe. Bone loss was examined radiologically. VEGF concentrations were assessed by enzyme-linked immunoabsorbent assay (ELISA).</p>
</sec>
<sec><title>Results</title>
<p>VEGF concentrations were found higher in crevicular fluid around implants than in clinically healthy sites. They were also strongly correlated with the pocket depth.</p>
</sec>
<sec><title>Conclusions</title>
<p>The presence of VEGF in gingival crevicular fluid in patients with peri-implants can be implicated in the progression of peri-implantitis, possibly by promoting the formation of new blood vessels during angiogenic processes.</p>
</sec>
</abstract>
<kwd-group><kwd>dental implants</kwd>
<kwd>blood vessels</kwd>
<kwd>peri-implants</kwd>
<kwd>vascular endothelial growth factor</kwd>
</kwd-group>
<conference><conf-date>27-29 May 2010</conf-date>
<conf-name>International Conference Advances in Pneumology</conf-name>
<conf-loc>Warsaw, Poland</conf-loc>
</conference>
</article-meta>
</front>
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<affiliations><list><country><li>Pologne</li>
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<name sortKey="Kostrzewa Janicka, J" sort="Kostrzewa Janicka, J" uniqKey="Kostrzewa Janicka J" first="J" last="Kostrzewa-Janicka">J. Kostrzewa-Janicka</name>
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