Biomechanical characteristics of regenerated cortical bone in the canine mandible
Identifieur interne : 002236 ( Pmc/Checkpoint ); précédent : 002235; suivant : 002237Biomechanical characteristics of regenerated cortical bone in the canine mandible
Auteurs : Uriel Zapata [États-Unis, Colombie] ; Lynne A. Opperman [États-Unis] ; Elias Kontogiorgos [États-Unis] ; Mohammed E. Elsalanty [États-Unis] ; Paul C. Dechow [États-Unis]Source :
- Journal of tissue engineering and regenerative medicine [ 1932-6254 ] ; 2011.
Abstract
To test the mechanical properties of regenerate cortical bone created using Mandibular Bone Transport (MBT) distraction, five adult male American foxhound dogs underwent unilateral distraction of the mandible with a novel MBT device placed to linearly repair a 30-35 mm bone defect. The animals were sacrificed 12 weeks after the beginning of the consolidation period. Fourteen cylindrical specimens were taken from the inner (lingual) and outer (buccal) plates of the reconstructed mandible and 21 control specimens were removed from the contralateral aspect of the mandible. The mechanical properties of the 35 cylindrical cortical bone specimens were assessed by using a non-destructive pulse ultrasound technique. Results showed that all of the cortical mechanical properties exhibit higher numerical values on the control side than the MBT regenerate side. In addition, both densities and the elastic moduli in the direction of maximum stiffness of the regenerate cortical bone specimens are higher on the lingual side than the buccal side. Interestingly, there is no statistical difference between elastic modulus (E1 and E2) in orthogonal directions throughout the 35 cortical specimens. The data suggest that the regenerate canine cortical bone is not only heterogeneous, but the elastic mechanical properties tend to approximate transverse isotropy at a tissue level as opposed to control cortical bone that is orthotropic. In addition, the elastic mechanical properties are not only higher on the control side but also in the lingual anatomical position, suggesting a stress shielding effect from the presence of the reconstruction plate.
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DOI: 10.1002/term.347
PubMed: 21695796
PubMed Central: 3116951
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Opperman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Kontogiorgos, Elias" sort="Kontogiorgos, Elias" uniqKey="Kontogiorgos E" first="Elias" last="Kontogiorgos">Elias Kontogiorgos</name><affiliation wicri:level="2"><nlm:aff id="A1"> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Elsalanty, Mohammed E" sort="Elsalanty, Mohammed E" uniqKey="Elsalanty M" first="Mohammed E." last="Elsalanty">Mohammed E. Elsalanty</name><affiliation wicri:level="2"><nlm:aff id="A4"> Medical College of Georgia, Augusta, GA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Medical College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Dechow, Paul C" sort="Dechow, Paul C" uniqKey="Dechow P" first="Paul C." last="Dechow">Paul C. Dechow</name><affiliation wicri:level="2"><nlm:aff id="A1"> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Journal of tissue engineering and regenerative medicine</title><idno type="ISSN">1932-6254</idno><idno type="eISSN">1932-7005</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To test the mechanical properties of regenerate cortical bone created using Mandibular Bone Transport (MBT) distraction, five adult male American foxhound dogs underwent unilateral distraction of the mandible with a novel MBT device placed to linearly repair a 30-35 mm bone defect. The animals were sacrificed 12 weeks after the beginning of the consolidation period. Fourteen cylindrical specimens were taken from the inner (lingual) and outer (buccal) plates of the reconstructed mandible and 21 control specimens were removed from the contralateral aspect of the mandible. The mechanical properties of the 35 cylindrical cortical bone specimens were assessed by using a non-destructive pulse ultrasound technique. Results showed that all of the cortical mechanical properties exhibit higher numerical values on the control side than the MBT regenerate side. In addition, both densities and the elastic moduli in the direction of maximum stiffness of the regenerate cortical bone specimens are higher on the lingual side than the buccal side. Interestingly, there is no statistical difference between elastic modulus (E<sub>1</sub> and E<sub>2</sub>) in orthogonal directions throughout the 35 cortical specimens. The data suggest that the regenerate canine cortical bone is not only heterogeneous, but the elastic mechanical properties tend to approximate transverse isotropy at a tissue level as opposed to control cortical bone that is orthotropic. In addition, the elastic mechanical properties are not only higher on the control side but also in the lingual anatomical position, suggesting a stress shielding effect from the presence of the reconstruction plate.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101308490</journal-id><journal-id journal-id-type="pubmed-jr-id">33899</journal-id><journal-id journal-id-type="nlm-ta">J Tissue Eng Regen Med</journal-id><journal-title>Journal of tissue engineering and regenerative medicine</journal-title><issn pub-type="ppub">1932-6254</issn><issn pub-type="epub">1932-7005</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21695796</article-id><article-id pub-id-type="pmc">3116951</article-id><article-id pub-id-type="doi">10.1002/term.347</article-id><article-id pub-id-type="manuscript">NIHMS221911</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Biomechanical characteristics of regenerated cortical bone in the canine mandible</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zapata</surname><given-names>Uriel</given-names></name><email>zapata_u@mercer.edu</email><email>uzapata@eafit.edu.co</email><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Opperman</surname><given-names>Lynne A.</given-names></name><email>Lopperman@bcd.tamhsc.edu</email><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Kontogiorgos</surname><given-names>Elias</given-names></name><email>ekontogiorgos@bcd.tamhsc.edu</email><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Elsalanty</surname><given-names>Mohammed E.</given-names></name><email>melsalanty@mail.mcg.edu</email><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Dechow</surname><given-names>Paul C.</given-names></name><email>PDechow@bcd.tamhsc.edu</email><xref rid="A1" ref-type="aff">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA</aff><aff id="A2"><label>2</label> Eafit University, Mechanical Engineering Department, Medellín, Colombia</aff><aff id="A3"><label>3</label> Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA, USA</aff><aff id="A4"><label>4</label> Medical College of Georgia, Augusta, GA, USA</aff><author-notes><corresp id="FN1">Address Correspondence and Proofs to: Dr. Paul C. Dechow, 3302 Gaston Avenue, Department of Biomedical Sciences, Dallas - TX - 75246. Telephone (214)370-7229, Fax number (214)874- 4538, <email>PDechow@bcd.tamhsc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>30</day><month>7</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>1</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>10</day><month>7</month><year>2012</year></pub-date><volume>5</volume><issue>7</issue><fpage>551</fpage><lpage>559</lpage><abstract><p id="P1">To test the mechanical properties of regenerate cortical bone created using Mandibular Bone Transport (MBT) distraction, five adult male American foxhound dogs underwent unilateral distraction of the mandible with a novel MBT device placed to linearly repair a 30-35 mm bone defect. The animals were sacrificed 12 weeks after the beginning of the consolidation period. Fourteen cylindrical specimens were taken from the inner (lingual) and outer (buccal) plates of the reconstructed mandible and 21 control specimens were removed from the contralateral aspect of the mandible. The mechanical properties of the 35 cylindrical cortical bone specimens were assessed by using a non-destructive pulse ultrasound technique. Results showed that all of the cortical mechanical properties exhibit higher numerical values on the control side than the MBT regenerate side. In addition, both densities and the elastic moduli in the direction of maximum stiffness of the regenerate cortical bone specimens are higher on the lingual side than the buccal side. Interestingly, there is no statistical difference between elastic modulus (E<sub>1</sub> and E<sub>2</sub>) in orthogonal directions throughout the 35 cortical specimens. The data suggest that the regenerate canine cortical bone is not only heterogeneous, but the elastic mechanical properties tend to approximate transverse isotropy at a tissue level as opposed to control cortical bone that is orthotropic. In addition, the elastic mechanical properties are not only higher on the control side but also in the lingual anatomical position, suggesting a stress shielding effect from the presence of the reconstruction plate.</p></abstract><kwd-group><kwd>Ultrasound technique</kwd><kwd>animal model</kwd><kwd>bony tissue</kwd><kwd>bone transport</kwd><kwd>distraction device</kwd><kwd>bone healing</kwd><kwd>jaw mechanics</kwd></kwd-group><contract-num rid="DE1">R43 DE017259-01A1
||DE</contract-num><contract-sponsor id="DE1">National Institute of Dental and Craniofacial Research : NIDCR</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>Colombie</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Zapata, Uriel" sort="Zapata, Uriel" uniqKey="Zapata U" first="Uriel" last="Zapata">Uriel Zapata</name></region><name sortKey="Dechow, Paul C" sort="Dechow, Paul C" uniqKey="Dechow P" first="Paul C." last="Dechow">Paul C. Dechow</name><name sortKey="Elsalanty, Mohammed E" sort="Elsalanty, Mohammed E" uniqKey="Elsalanty M" first="Mohammed E." last="Elsalanty">Mohammed E. Elsalanty</name><name sortKey="Kontogiorgos, Elias" sort="Kontogiorgos, Elias" uniqKey="Kontogiorgos E" first="Elias" last="Kontogiorgos">Elias Kontogiorgos</name><name sortKey="Opperman, Lynne A" sort="Opperman, Lynne A" uniqKey="Opperman L" first="Lynne A." last="Opperman">Lynne A. Opperman</name><name sortKey="Zapata, Uriel" sort="Zapata, Uriel" uniqKey="Zapata U" first="Uriel" last="Zapata">Uriel Zapata</name></country><country name="Colombie"><noRegion><name sortKey="Zapata, Uriel" sort="Zapata, Uriel" uniqKey="Zapata U" first="Uriel" last="Zapata">Uriel Zapata</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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