Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
Identifieur interne : 002118 ( Pmc/Checkpoint ); précédent : 002117; suivant : 002119Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
Auteurs : S. Balasundaram ; K. Ranganathan ; K. Umadevi ; R. Gunaseelan ; N. Kumaraswamy ; Sunithi Solomon ; Bella Devaleenol ; Pradeep AmbroseSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2011.
Abstract
Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.
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DOI: 10.4103/0973-029X.80024
PubMed: 21731276
PubMed Central: 3125654
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases</title><author><name sortKey="Balasundaram, S" sort="Balasundaram, S" uniqKey="Balasundaram S" first="S" last="Balasundaram">S. Balasundaram</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Ranganathan, K" sort="Ranganathan, K" uniqKey="Ranganathan K" first="K" last="Ranganathan">K. Ranganathan</name><affiliation><nlm:aff id="AF0002"><italic>Ragas Dental College and Hospitals, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Umadevi, K" sort="Umadevi, K" uniqKey="Umadevi K" first="K" last="Umadevi">K. Umadevi</name><affiliation><nlm:aff id="AF0002"><italic>Ragas Dental College and Hospitals, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Gunaseelan, R" sort="Gunaseelan, R" uniqKey="Gunaseelan R" first="R" last="Gunaseelan">R. Gunaseelan</name><affiliation><nlm:aff id="AF0003"><italic>Chennai Dental Research Foundation, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumaraswamy, N" sort="Kumaraswamy, N" uniqKey="Kumaraswamy N" first="N" last="Kumaraswamy">N. Kumaraswamy</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Solomon, Sunithi" sort="Solomon, Sunithi" uniqKey="Solomon S" first="Sunithi" last="Solomon">Sunithi Solomon</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Devaleenol, Bella" sort="Devaleenol, Bella" uniqKey="Devaleenol B" first="Bella" last="Devaleenol">Bella Devaleenol</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Ambrose, Pradeep" sort="Ambrose, Pradeep" uniqKey="Ambrose P" first="Pradeep" last="Ambrose">Pradeep Ambrose</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21731276</idno><idno type="pmc">3125654</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125654</idno><idno type="RBID">PMC:3125654</idno><idno type="doi">10.4103/0973-029X.80024</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001E89</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E89</idno><idno type="wicri:Area/Pmc/Curation">001E89</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001E89</idno><idno type="wicri:Area/Pmc/Checkpoint">002118</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002118</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases</title><author><name sortKey="Balasundaram, S" sort="Balasundaram, S" uniqKey="Balasundaram S" first="S" last="Balasundaram">S. Balasundaram</name><affiliation><nlm:aff id="AF0001"></nlm:aff></affiliation></author><author><name sortKey="Ranganathan, K" sort="Ranganathan, K" uniqKey="Ranganathan K" first="K" last="Ranganathan">K. Ranganathan</name><affiliation><nlm:aff id="AF0002"><italic>Ragas Dental College and Hospitals, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Umadevi, K" sort="Umadevi, K" uniqKey="Umadevi K" first="K" last="Umadevi">K. Umadevi</name><affiliation><nlm:aff id="AF0002"><italic>Ragas Dental College and Hospitals, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Gunaseelan, R" sort="Gunaseelan, R" uniqKey="Gunaseelan R" first="R" last="Gunaseelan">R. Gunaseelan</name><affiliation><nlm:aff id="AF0003"><italic>Chennai Dental Research Foundation, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Kumaraswamy, N" sort="Kumaraswamy, N" uniqKey="Kumaraswamy N" first="N" last="Kumaraswamy">N. Kumaraswamy</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Solomon, Sunithi" sort="Solomon, Sunithi" uniqKey="Solomon S" first="Sunithi" last="Solomon">Sunithi Solomon</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Devaleenol, Bella" sort="Devaleenol, Bella" uniqKey="Devaleenol B" first="Bella" last="Devaleenol">Bella Devaleenol</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author><author><name sortKey="Ambrose, Pradeep" sort="Ambrose, Pradeep" uniqKey="Ambrose P" first="Pradeep" last="Ambrose">Pradeep Ambrose</name><affiliation><nlm:aff id="AF0004"><italic>YRGCare, Chennai, India</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Maxillofac Pathol</journal-id><journal-id journal-id-type="publisher-id">JOMFP</journal-id><journal-title-group><journal-title>Journal of Oral and Maxillofacial Pathology : JOMFP</journal-title></journal-title-group><issn pub-type="ppub">0973-029X</issn><issn pub-type="epub">1998-393X</issn><publisher><publisher-name>Medknow Publications</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21731276</article-id><article-id pub-id-type="pmc">3125654</article-id><article-id pub-id-type="publisher-id">JOMFP-15-39</article-id><article-id pub-id-type="doi">10.4103/0973-029X.80024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balasundaram</surname><given-names>S</given-names></name><xref ref-type="aff" rid="AF0001"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Ranganathan</surname><given-names>K</given-names></name><xref ref-type="aff" rid="AF0002">1</xref></contrib><contrib contrib-type="author"><name><surname>Umadevi</surname><given-names>K</given-names></name><xref ref-type="aff" rid="AF0002">1</xref></contrib><contrib contrib-type="author"><name><surname>Gunaseelan</surname><given-names>R</given-names></name><xref ref-type="aff" rid="AF0003">2</xref></contrib><contrib contrib-type="author"><name><surname>Kumaraswamy</surname><given-names>N</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Solomon</surname><given-names>Sunithi</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Devaleenol</surname><given-names>Bella</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib><contrib contrib-type="author"><name><surname>Ambrose</surname><given-names>Pradeep</given-names></name><xref ref-type="aff" rid="AF0004">3</xref></contrib></contrib-group><aff id="AF0001"><italic>Departments of Oral Pathology, Chennai Dental Research Foundation, Chennai, Tamil Nadu, India</italic></aff><aff id="AF0002"><label>1</label><italic>Ragas Dental College and Hospitals, Chennai, India</italic></aff><aff id="AF0003"><label>2</label><italic>Chennai Dental Research Foundation, Chennai, India</italic></aff><aff id="AF0004"><label>3</label><italic>YRGCare, Chennai, India</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence</bold>: <italic>Dr. S Balasundaram, Department of Oral and Maxillofacial Pathology, Chennai Dental Research Foundation, No 56 Dr. Radhakrishnan Salai, Mylapore, Chennai – 600 004, Tamil nadu, India. E-mail: <email xlink:href="bbaallaa2002@yahoo.co.in">bbaallaa2002@yahoo.co.in</email></italic></corresp></author-notes><pub-date pub-type="ppub"><season>Jan-Apr</season><year>2011</year></pub-date><volume>15</volume><issue>1</issue><fpage>39</fpage><lpage>45</lpage><permissions><copyright-statement>© Journal of Oral and Maxillofacial Pathology</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.</p></abstract><kwd-group><kwd>HIV</kwd><kwd>Nevirapine</kwd><kwd>oral lesions</kwd><kwd>Steven Johnson syndrome</kwd><kwd>ulcers</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Ambrose, Pradeep" sort="Ambrose, Pradeep" uniqKey="Ambrose P" first="Pradeep" last="Ambrose">Pradeep Ambrose</name><name sortKey="Balasundaram, S" sort="Balasundaram, S" uniqKey="Balasundaram S" first="S" last="Balasundaram">S. Balasundaram</name><name sortKey="Devaleenol, Bella" sort="Devaleenol, Bella" uniqKey="Devaleenol B" first="Bella" last="Devaleenol">Bella Devaleenol</name><name sortKey="Gunaseelan, R" sort="Gunaseelan, R" uniqKey="Gunaseelan R" first="R" last="Gunaseelan">R. Gunaseelan</name><name sortKey="Kumaraswamy, N" sort="Kumaraswamy, N" uniqKey="Kumaraswamy N" first="N" last="Kumaraswamy">N. Kumaraswamy</name><name sortKey="Ranganathan, K" sort="Ranganathan, K" uniqKey="Ranganathan K" first="K" last="Ranganathan">K. Ranganathan</name><name sortKey="Solomon, Sunithi" sort="Solomon, Sunithi" uniqKey="Solomon S" first="Sunithi" last="Solomon">Sunithi Solomon</name><name sortKey="Umadevi, K" sort="Umadevi, K" uniqKey="Umadevi K" first="K" last="Umadevi">K. Umadevi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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