Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
Identifieur interne : 002118 ( Pmc/Checkpoint ); précédent : 002117; suivant : 002119Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
Auteurs : S. Balasundaram ; K. Ranganathan ; K. Umadevi ; R. Gunaseelan ; N. Kumaraswamy ; Sunithi Solomon ; Bella Devaleenol ; Pradeep AmbroseSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2011.
Abstract
Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.
Url:
DOI: 10.4103/0973-029X.80024
PubMed: 21731276
PubMed Central: 3125654
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases</title>
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<front><div type="abstract" xml:lang="en"><p>Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fagot, Jp" uniqKey="Fagot J">JP Fagot</name>
</author>
<author><name sortKey="Mockenhaupt, M" uniqKey="Mockenhaupt M">M Mockenhaupt</name>
</author>
<author><name sortKey="Bouwes Bavinck, Jn" uniqKey="Bouwes Bavinck J">JN Bouwes-Bavinck</name>
</author>
<author><name sortKey="Naldi, L" uniqKey="Naldi L">L Naldi</name>
</author>
<author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name>
</author>
<author><name sortKey="Roujeau Jc Euroscar Study, Group" uniqKey="Roujeau Jc Euroscar Study G">Group Roujeau JC; EuroSCAR Study</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roujeau, Jc" uniqKey="Roujeau J">JC Roujeau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Letko, E" uniqKey="Letko E">E Letko</name>
</author>
<author><name sortKey="Papaliodis, Dn" uniqKey="Papaliodis D">DN Papaliodis</name>
</author>
<author><name sortKey="Papaliodis, Gn" uniqKey="Papaliodis G">GN Papaliodis</name>
</author>
<author><name sortKey="Daoud, Yj" uniqKey="Daoud Y">YJ Daoud</name>
</author>
<author><name sortKey="Ahmed, Ar" uniqKey="Ahmed A">AR Ahmed</name>
</author>
<author><name sortKey="Foster, Cs" uniqKey="Foster C">CS Foster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roujeau, Jc" uniqKey="Roujeau J">JC Roujeau</name>
</author>
<author><name sortKey="Kelly, Jp" uniqKey="Kelly J">JP Kelly</name>
</author>
<author><name sortKey="Naldi, L" uniqKey="Naldi L">L Naldi</name>
</author>
<author><name sortKey="Rzany, B" uniqKey="Rzany B">B Rzany</name>
</author>
<author><name sortKey="Stern, Rs" uniqKey="Stern R">RS Stern</name>
</author>
<author><name sortKey="Anderson, T" uniqKey="Anderson T">T Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ranganathan, K" uniqKey="Ranganathan K">K Ranganathan</name>
</author>
<author><name sortKey="Umadevi, M" uniqKey="Umadevi M">M Umadevi</name>
</author>
<author><name sortKey="Saraswathi, Tr" uniqKey="Saraswathi T">TR Saraswathi</name>
</author>
<author><name sortKey="Kumaraswamy, N" uniqKey="Kumaraswamy N">N Kumaraswamy</name>
</author>
<author><name sortKey="Solomon, S" uniqKey="Solomon S">S Solomon</name>
</author>
<author><name sortKey="Johnson, N" uniqKey="Johnson N">N Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumarasamy, N" uniqKey="Kumarasamy N">N Kumarasamy</name>
</author>
<author><name sortKey="Vallabhaneni, S" uniqKey="Vallabhaneni S">S Vallabhaneni</name>
</author>
<author><name sortKey="Cecelia, Aj" uniqKey="Cecelia A">AJ Cecelia</name>
</author>
<author><name sortKey="Yepthomi, T" uniqKey="Yepthomi T">T Yepthomi</name>
</author>
<author><name sortKey="Balakrishnan, P" uniqKey="Balakrishnan P">P Balakrishnan</name>
</author>
<author><name sortKey="Saghayam, S" uniqKey="Saghayam S">S Saghayam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ranganathan, K" uniqKey="Ranganathan K">K Ranganathan</name>
</author>
<author><name sortKey="Hemalatha, R" uniqKey="Hemalatha R">R Hemalatha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coopman, Sa" uniqKey="Coopman S">SA Coopman</name>
</author>
<author><name sortKey="Johnson, Ra" uniqKey="Johnson R">RA Johnson</name>
</author>
<author><name sortKey="Plaft, R" uniqKey="Plaft R">R Plaft</name>
</author>
<author><name sortKey="Stern, Rs" uniqKey="Stern R">RS Stern</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blitz, M" uniqKey="Blitz M">M Blitz</name>
</author>
<author><name sortKey="Spivack, E" uniqKey="Spivack E">E Spivack</name>
</author>
<author><name sortKey="Kerpel, Sm" uniqKey="Kerpel S">SM Kerpel</name>
</author>
<author><name sortKey="Freedman, Pd" uniqKey="Freedman P">PD Freedman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Kj" uniqKey="Smith K">KJ Smith</name>
</author>
<author><name sortKey="Skeleton, Hg" uniqKey="Skeleton H">HG Skeleton</name>
</author>
<author><name sortKey="Yeager, J" uniqKey="Yeager J">J Yeager</name>
</author>
<author><name sortKey="Ledsky, R" uniqKey="Ledsky R">R Ledsky</name>
</author>
<author><name sortKey="Ng, Th" uniqKey="Ng T">TH Ng</name>
</author>
<author><name sortKey="Wagner, Kf" uniqKey="Wagner K">KF Wagner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inachi, S" uniqKey="Inachi S">S Inachi</name>
</author>
<author><name sortKey="Mizutani, H" uniqKey="Mizutani H">H Mizutani</name>
</author>
<author><name sortKey="Schimizu, M" uniqKey="Schimizu M">M Schimizu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bastuji Garin, S" uniqKey="Bastuji Garin S">S Bastuji-Garin</name>
</author>
<author><name sortKey="Rzany, B" uniqKey="Rzany B">B Rzany</name>
</author>
<author><name sortKey="Stern, Rs" uniqKey="Stern R">RS Stern</name>
</author>
<author><name sortKey="Shear, Nh" uniqKey="Shear N">NH Shear</name>
</author>
<author><name sortKey="Naldi, L" uniqKey="Naldi L">L Naldi</name>
</author>
<author><name sortKey="Roujeau, Jc" uniqKey="Roujeau J">JC Roujeau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Metry, Dw" uniqKey="Metry D">DW Metry</name>
</author>
<author><name sortKey="Lahart, Cj" uniqKey="Lahart C">CJ Lahart</name>
</author>
<author><name sortKey="Farmer, Kl" uniqKey="Farmer K">KL Farmer</name>
</author>
<author><name sortKey="Hebert, Aa" uniqKey="Hebert A">AA Hebert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riska, P" uniqKey="Riska P">P Riska</name>
</author>
<author><name sortKey="Lamson, M" uniqKey="Lamson M">M Lamson</name>
</author>
<author><name sortKey="Macgregor, T" uniqKey="Macgregor T">T MacGregor</name>
</author>
<author><name sortKey="Sabo, J" uniqKey="Sabo J">J Sabo</name>
</author>
<author><name sortKey="Hattox, S" uniqKey="Hattox S">S Hattox</name>
</author>
<author><name sortKey="Pav, J" uniqKey="Pav J">J Pav</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kumar, Ak" uniqKey="Kumar A">AK Kumar</name>
</author>
<author><name sortKey="Ramachandran, G" uniqKey="Ramachandran G">G Ramachandran</name>
</author>
<author><name sortKey="Saradha, B" uniqKey="Saradha B">B Saradha</name>
</author>
<author><name sortKey="Narendran, G" uniqKey="Narendran G">G Narendran</name>
</author>
<author><name sortKey="Swaminathan, S" uniqKey="Swaminathan S">S Swaminathan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raphal, Dolin" uniqKey="Raphal D">Dolin Raphal</name>
</author>
<author><name sortKey="Henry, Masur" uniqKey="Henry M">Masur Henry</name>
</author>
<author><name sortKey="Michael S, Saag" uniqKey="Michael S S">Saag Michael S</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Warren, Kj" uniqKey="Warren K">KJ Warren</name>
</author>
<author><name sortKey="Boxwell, De" uniqKey="Boxwell D">DE Boxwell</name>
</author>
<author><name sortKey="Kim, Ny" uniqKey="Kim N">NY Kim</name>
</author>
<author><name sortKey="Drolet, Ba" uniqKey="Drolet B">BA Drolet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anton, P" uniqKey="Anton P">P Anton</name>
</author>
<author><name sortKey="Soriano, V" uniqKey="Soriano V">V Soriano</name>
</author>
<author><name sortKey="Jimenez Nacher, I" uniqKey="Jimenez Nacher I">I Jiménez-Nãcher</name>
</author>
<author><name sortKey="Rodriguez Rosado, R" uniqKey="Rodriguez Rosado R">R Rodriguez-Rosado</name>
</author>
<author><name sortKey="Dona, Mc" uniqKey="Dona M">MC Dona</name>
</author>
<author><name sortKey="Barreiro, Pm" uniqKey="Barreiro P">PM Barreiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pollard, Rb" uniqKey="Pollard R">RB Pollard</name>
</author>
<author><name sortKey="Robinson, P" uniqKey="Robinson P">P Robinson</name>
</author>
<author><name sortKey="Dransfield, K" uniqKey="Dransfield K">K Dransfield</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gokengin, D" uniqKey="Gokengin D">D Gökengin</name>
</author>
<author><name sortKey="Yamazhan, T" uniqKey="Yamazhan T">T Yamazhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Namayanja, Gk" uniqKey="Namayanja G">GK Namayanja</name>
</author>
<author><name sortKey="Nankya, Jm" uniqKey="Nankya J">JM Nankya</name>
</author>
<author><name sortKey="Byamugisha, Jk" uniqKey="Byamugisha J">JK Byamugisha</name>
</author>
<author><name sortKey="Ssali, Fn" uniqKey="Ssali F">FN Ssali</name>
</author>
<author><name sortKey="Kityo, Cm" uniqKey="Kityo C">CM Kityo</name>
</author>
<author><name sortKey="Rwambuya, Sd" uniqKey="Rwambuya S">SD Rwambuya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaspar, R" uniqKey="Kaspar R">R Kaspar</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Maxillofac Pathol</journal-id>
<journal-id journal-id-type="publisher-id">JOMFP</journal-id>
<journal-title-group><journal-title>Journal of Oral and Maxillofacial Pathology : JOMFP</journal-title>
</journal-title-group>
<issn pub-type="ppub">0973-029X</issn>
<issn pub-type="epub">1998-393X</issn>
<publisher><publisher-name>Medknow Publications</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21731276</article-id>
<article-id pub-id-type="pmc">3125654</article-id>
<article-id pub-id-type="publisher-id">JOMFP-15-39</article-id>
<article-id pub-id-type="doi">10.4103/0973-029X.80024</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Balasundaram</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="AF0001"></xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ranganathan</surname>
<given-names>K</given-names>
</name>
<xref ref-type="aff" rid="AF0002">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Umadevi</surname>
<given-names>K</given-names>
</name>
<xref ref-type="aff" rid="AF0002">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gunaseelan</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="AF0003">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumaraswamy</surname>
<given-names>N</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Solomon</surname>
<given-names>Sunithi</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Devaleenol</surname>
<given-names>Bella</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ambrose</surname>
<given-names>Pradeep</given-names>
</name>
<xref ref-type="aff" rid="AF0004">3</xref>
</contrib>
</contrib-group>
<aff id="AF0001"><italic>Departments of Oral Pathology, Chennai Dental Research Foundation, Chennai, Tamil Nadu, India</italic>
</aff>
<aff id="AF0002"><label>1</label>
<italic>Ragas Dental College and Hospitals, Chennai, India</italic>
</aff>
<aff id="AF0003"><label>2</label>
<italic>Chennai Dental Research Foundation, Chennai, India</italic>
</aff>
<aff id="AF0004"><label>3</label>
<italic>YRGCare, Chennai, India</italic>
</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence</bold>
: <italic>Dr. S Balasundaram, Department of Oral and Maxillofacial Pathology, Chennai Dental Research Foundation, No 56 Dr. Radhakrishnan Salai, Mylapore, Chennai – 600 004, Tamil nadu, India. E-mail: <email xlink:href="bbaallaa2002@yahoo.co.in">bbaallaa2002@yahoo.co.in</email>
</italic>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Jan-Apr</season>
<year>2011</year>
</pub-date>
<volume>15</volume>
<issue>1</issue>
<fpage>39</fpage>
<lpage>45</lpage>
<permissions><copyright-statement>© Journal of Oral and Maxillofacial Pathology</copyright-statement>
<copyright-year>2011</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.</p>
</abstract>
<kwd-group><kwd>HIV</kwd>
<kwd>Nevirapine</kwd>
<kwd>oral lesions</kwd>
<kwd>Steven Johnson syndrome</kwd>
<kwd>ulcers</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ambrose, Pradeep" sort="Ambrose, Pradeep" uniqKey="Ambrose P" first="Pradeep" last="Ambrose">Pradeep Ambrose</name>
<name sortKey="Balasundaram, S" sort="Balasundaram, S" uniqKey="Balasundaram S" first="S" last="Balasundaram">S. Balasundaram</name>
<name sortKey="Devaleenol, Bella" sort="Devaleenol, Bella" uniqKey="Devaleenol B" first="Bella" last="Devaleenol">Bella Devaleenol</name>
<name sortKey="Gunaseelan, R" sort="Gunaseelan, R" uniqKey="Gunaseelan R" first="R" last="Gunaseelan">R. Gunaseelan</name>
<name sortKey="Kumaraswamy, N" sort="Kumaraswamy, N" uniqKey="Kumaraswamy N" first="N" last="Kumaraswamy">N. Kumaraswamy</name>
<name sortKey="Ranganathan, K" sort="Ranganathan, K" uniqKey="Ranganathan K" first="K" last="Ranganathan">K. Ranganathan</name>
<name sortKey="Solomon, Sunithi" sort="Solomon, Sunithi" uniqKey="Solomon S" first="Sunithi" last="Solomon">Sunithi Solomon</name>
<name sortKey="Umadevi, K" sort="Umadevi, K" uniqKey="Umadevi K" first="K" last="Umadevi">K. Umadevi</name>
</noCountry>
</tree>
</affiliations>
</record>
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