The influence of estrogen deficiency on bone around osseointegrated dental implants. An experimental study in the rat jaw model
Identifieur interne : 002053 ( Pmc/Checkpoint ); précédent : 002052; suivant : 002054The influence of estrogen deficiency on bone around osseointegrated dental implants. An experimental study in the rat jaw model
Auteurs : Gabriela Giro ; Paulo G. Coelho ; Roberto Sales Pessoa ; Rosa Maria Rodrigues Pereira ; Toshihisa Kawai ; Silvana Regina Perez OrricoSource :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [ 0278-2391 ] ; 2011.
Abstract
The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model.
This study utilized 16 female rats, which had the first molars bilaterally extracted and allowed to heal for 30 days prior to implant placement. Sixty days after implant placement, the animals were randomly submitted to sham surgery (SHAM) or ovariectomy (OVX). The animals were euthanized 90 days post-ovariectomy. Bone to implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers and TRAP positive cells were assessed for both groups.
The results showed that OVX group presented a decrease of systemic bone density, alterations on bone turnover markers, and an increase of TRAP positive cells relative to the SHAM group. However no difference relative to the bone to implant contact and bone area fraction occupancy was observed between groups.
The findings of this study demonstrate that estrogen deficiency may not be considered as a risk factor for osseointegrated implants failure in jaw bone.
Url:
DOI: 10.1016/j.joms.2011.01.028
PubMed: 21530046
PubMed Central: 3118974
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Coelho</name></author><author><name sortKey="Pessoa, Roberto Sales" sort="Pessoa, Roberto Sales" uniqKey="Pessoa R" first="Roberto Sales" last="Pessoa">Roberto Sales Pessoa</name></author><author><name sortKey="Pereira, Rosa Maria Rodrigues" sort="Pereira, Rosa Maria Rodrigues" uniqKey="Pereira R" first="Rosa Maria Rodrigues" last="Pereira">Rosa Maria Rodrigues Pereira</name></author><author><name sortKey="Kawai, Toshihisa" sort="Kawai, Toshihisa" uniqKey="Kawai T" first="Toshihisa" last="Kawai">Toshihisa Kawai</name></author><author><name sortKey="Orrico, Silvana Regina Perez" sort="Orrico, Silvana Regina Perez" uniqKey="Orrico S" first="Silvana Regina Perez" last="Orrico">Silvana Regina Perez Orrico</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21530046</idno><idno type="pmc">3118974</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118974</idno><idno type="RBID">PMC:3118974</idno><idno type="doi">10.1016/j.joms.2011.01.028</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002120</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002120</idno><idno type="wicri:Area/Pmc/Curation">002120</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002120</idno><idno type="wicri:Area/Pmc/Checkpoint">002053</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002053</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The influence of estrogen deficiency on bone around osseointegrated dental implants. An experimental study in the rat jaw model</title><author><name sortKey="Giro, Gabriela" sort="Giro, Gabriela" uniqKey="Giro G" first="Gabriela" last="Giro">Gabriela Giro</name></author><author><name sortKey="Coelho, Paulo G" sort="Coelho, Paulo G" uniqKey="Coelho P" first="Paulo G." last="Coelho">Paulo G. Coelho</name></author><author><name sortKey="Pessoa, Roberto Sales" sort="Pessoa, Roberto Sales" uniqKey="Pessoa R" first="Roberto Sales" last="Pessoa">Roberto Sales Pessoa</name></author><author><name sortKey="Pereira, Rosa Maria Rodrigues" sort="Pereira, Rosa Maria Rodrigues" uniqKey="Pereira R" first="Rosa Maria Rodrigues" last="Pereira">Rosa Maria Rodrigues Pereira</name></author><author><name sortKey="Kawai, Toshihisa" sort="Kawai, Toshihisa" uniqKey="Kawai T" first="Toshihisa" last="Kawai">Toshihisa Kawai</name></author><author><name sortKey="Orrico, Silvana Regina Perez" sort="Orrico, Silvana Regina Perez" uniqKey="Orrico S" first="Silvana Regina Perez" last="Orrico">Silvana Regina Perez Orrico</name></author></analytic><series><title level="j">Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons</title><idno type="ISSN">0278-2391</idno><idno type="eISSN">1531-5053</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model.</p></sec><sec sec-type="materials|methods" id="S2"><title>Materials and Methods</title><p id="P2">This study utilized 16 female rats, which had the first molars bilaterally extracted and allowed to heal for 30 days prior to implant placement. Sixty days after implant placement, the animals were randomly submitted to sham surgery (SHAM) or ovariectomy (OVX). The animals were euthanized 90 days post-ovariectomy. Bone to implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers and TRAP positive cells were assessed for both groups.</p></sec><sec id="S3"><title>Results</title><p id="P3">The results showed that OVX group presented a decrease of systemic bone density, alterations on bone turnover markers, and an increase of TRAP positive cells relative to the SHAM group. However no difference relative to the bone to implant contact and bone area fraction occupancy was observed between groups.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The findings of this study demonstrate that estrogen deficiency may not be considered as a risk factor for osseointegrated implants failure in jaw bone.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8206428</journal-id><journal-id journal-id-type="pubmed-jr-id">5090</journal-id><journal-id journal-id-type="nlm-ta">J Oral Maxillofac Surg</journal-id><journal-title>Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons</journal-title><issn pub-type="ppub">0278-2391</issn><issn pub-type="epub">1531-5053</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21530046</article-id><article-id pub-id-type="pmc">3118974</article-id><article-id pub-id-type="doi">10.1016/j.joms.2011.01.028</article-id><article-id pub-id-type="manuscript">NIHMS271532</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The influence of estrogen deficiency on bone around osseointegrated dental implants. An experimental study in the rat jaw model</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Giro</surname><given-names>Gabriela</given-names></name><degrees>PhD</degrees><aff id="A1">Department of Oral Diagnosis and Surgery, Araraquara Dental School, UNESP – Univ Estadual Paulista, Araraquara, SP, Brazil</aff></contrib><contrib contrib-type="author"><name><surname>Coelho</surname><given-names>Paulo G.</given-names></name><degrees>PhD</degrees><aff id="A2">Department of Biomaterials and Biomimetics, New York University, NY, USA.</aff></contrib><contrib contrib-type="author"><name><surname>Pessoa</surname><given-names>Roberto Sales</given-names></name><degrees>PhD</degrees><aff id="A3">Department of Oral Diagnosis and Surgery, Araraquara Dental School, UNESP – Univ Estadual Paulista, Araraquara, SP, Brazil.</aff></contrib><contrib contrib-type="author"><name><surname>Pereira</surname><given-names>Rosa Maria Rodrigues</given-names></name><degrees>PhD</degrees><aff id="A4">Bone Metabolism Laboratory of Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.</aff></contrib><contrib contrib-type="author"><name><surname>Kawai</surname><given-names>Toshihisa</given-names></name><degrees>PhD</degrees><aff id="A5">Department of Immunology, The Forsyth Institute, Boston, MA, USA.</aff></contrib><contrib contrib-type="author"><name><surname>Orrico</surname><given-names>Silvana Regina Perez</given-names></name><degrees>PhD</degrees><aff id="A6">Department of Oral Diagnosis and Surgery, Araraquara Dental School, UNESP – Univ Estadual Paulista, Araraquara, SP, Brazil.</aff></contrib></contrib-group><author-notes><corresp id="CR1"><italic>Corresponding Author:</italic> Gabriela Giro. Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil. Phone #: 55 (16) 3301-6377; Fax: 55 (16) 3301-6369 <email>gabi.giro@gmail.com</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>15</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>29</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>7</month><year>2012</year></pub-date><volume>69</volume><issue>7</issue><fpage>1911</fpage><lpage>1918</lpage><permissions><copyright-statement>© 2011 The American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><sec id="S1"><title>Purpose</title><p id="P1">The aim of this study was to evaluate the influence of estrogen deficiency on bone around osseointegrated dental implants in a rat jaw model.</p></sec><sec sec-type="materials|methods" id="S2"><title>Materials and Methods</title><p id="P2">This study utilized 16 female rats, which had the first molars bilaterally extracted and allowed to heal for 30 days prior to implant placement. Sixty days after implant placement, the animals were randomly submitted to sham surgery (SHAM) or ovariectomy (OVX). The animals were euthanized 90 days post-ovariectomy. Bone to implant contact, bone area fraction occupancy between implant threads, mineral density, turnover markers and TRAP positive cells were assessed for both groups.</p></sec><sec id="S3"><title>Results</title><p id="P3">The results showed that OVX group presented a decrease of systemic bone density, alterations on bone turnover markers, and an increase of TRAP positive cells relative to the SHAM group. However no difference relative to the bone to implant contact and bone area fraction occupancy was observed between groups.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The findings of this study demonstrate that estrogen deficiency may not be considered as a risk factor for osseointegrated implants failure in jaw bone.</p></sec></abstract><kwd-group><kwd>dental implants</kwd><kwd>ovariectomy</kwd><kwd>osteoporosis</kwd><kwd>estrogen deficiency</kwd><kwd>rats</kwd></kwd-group><contract-num rid="DE1">R01 DE018499-03
||DE</contract-num><contract-sponsor id="DE1">National Institute of Dental and Craniofacial Research : NIDCR</contract-sponsor></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Coelho, Paulo G" sort="Coelho, Paulo G" uniqKey="Coelho P" first="Paulo G." last="Coelho">Paulo G. Coelho</name><name sortKey="Giro, Gabriela" sort="Giro, Gabriela" uniqKey="Giro G" first="Gabriela" last="Giro">Gabriela Giro</name><name sortKey="Kawai, Toshihisa" sort="Kawai, Toshihisa" uniqKey="Kawai T" first="Toshihisa" last="Kawai">Toshihisa Kawai</name><name sortKey="Orrico, Silvana Regina Perez" sort="Orrico, Silvana Regina Perez" uniqKey="Orrico S" first="Silvana Regina Perez" last="Orrico">Silvana Regina Perez Orrico</name><name sortKey="Pereira, Rosa Maria Rodrigues" sort="Pereira, Rosa Maria Rodrigues" uniqKey="Pereira R" first="Rosa Maria Rodrigues" last="Pereira">Rosa Maria Rodrigues Pereira</name><name sortKey="Pessoa, Roberto Sales" sort="Pessoa, Roberto Sales" uniqKey="Pessoa R" first="Roberto Sales" last="Pessoa">Roberto Sales Pessoa</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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