Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region
Identifieur interne : 001E74 ( Pmc/Checkpoint ); précédent : 001E73; suivant : 001E75Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region
Auteurs : Us Buyukkaplan ; Mu GuldagSource :
- Dentomaxillofacial Radiology [ 0250-832X ] ; 2012.
Abstract
Fluoride is one of the biological trace elements with a strong affinity for osseous, cartilaginous and dental tissue. The dental and skeletal effects of high fluoride intake have already been studied in the literature, but little is known about the effects of high fluoride intake on edentulous mandibles. The purpose of this study was to evaluate the effects of high fluoride intake on mandibular bone mineral density (BMD) measured by the dual-energy X-ray absorptiometry (DXA) technique in edentulous individuals with systemic fluorosis.
32 people who were living in an endemic fluorosis area since birth and 31 people who were living in a non-endemic fluorosis area since birth (control group) participated in this study. Systemic fluorosis was diagnosed in the patients using the sialic acid (NANA)/glycosaminoglycan (GAG) ratio. The BMDs of the mandibles were determined by the DXA technique.
The serum NANA/GAG ratios in the fluorosis group were significantly lower than those in the control group (
The results of the study showed that fluoride intake higher than the optimum level causes increased mandibular BMD in edentulous individuals. Further dose-related studies are needed to determine the effects of high fluoride intake on bony structures of the stomatognathic system.
Url:
DOI: 10.1259/dmfr/20380362
PubMed: 22241885
PubMed Central: 3520348
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region</title><author><name sortKey="Buyukkaplan, Us" sort="Buyukkaplan, Us" uniqKey="Buyukkaplan U" first="Us" last="Buyukkaplan">Us Buyukkaplan</name></author><author><name sortKey="Guldag, Mu" sort="Guldag, Mu" uniqKey="Guldag M" first="Mu" last="Guldag">Mu Guldag</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22241885</idno><idno type="pmc">3520348</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520348</idno><idno type="RBID">PMC:3520348</idno><idno type="doi">10.1259/dmfr/20380362</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002299</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002299</idno><idno type="wicri:Area/Pmc/Curation">002299</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002299</idno><idno type="wicri:Area/Pmc/Checkpoint">001E74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001E74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region</title><author><name sortKey="Buyukkaplan, Us" sort="Buyukkaplan, Us" uniqKey="Buyukkaplan U" first="Us" last="Buyukkaplan">Us Buyukkaplan</name></author><author><name sortKey="Guldag, Mu" sort="Guldag, Mu" uniqKey="Guldag M" first="Mu" last="Guldag">Mu Guldag</name></author></analytic><series><title level="j">Dentomaxillofacial Radiology</title><idno type="ISSN">0250-832X</idno><idno type="eISSN">1476-542X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>Fluoride is one of the biological trace elements with a strong affinity for osseous, cartilaginous and dental tissue. The dental and skeletal effects of high fluoride intake have already been studied in the literature, but little is known about the effects of high fluoride intake on edentulous mandibles. The purpose of this study was to evaluate the effects of high fluoride intake on mandibular bone mineral density (BMD) measured by the dual-energy X-ray absorptiometry (DXA) technique in edentulous individuals with systemic fluorosis.</p></sec><sec><title>Methods</title><p>32 people who were living in an endemic fluorosis area since birth and 31 people who were living in a non-endemic fluorosis area since birth (control group) participated in this study. Systemic fluorosis was diagnosed in the patients using the sialic acid (NANA)/glycosaminoglycan (GAG) ratio. The BMDs of the mandibles were determined by the DXA technique.</p></sec><sec><title>Results</title><p>The serum NANA/GAG ratios in the fluorosis group were significantly lower than those in the control group (<italic>p</italic> < 0.001). There was also a statistically significant difference in mandibular BMD measurements (<italic>p</italic> < 0.05) between the systemic fluorosis and control groups, as measured by the DXA technique. Mandibular body BMD measurements were higher in the fluorosis group (1.25 ± 0.24 g cm<sup>−2</sup>) than in the control group (1.01 ± 0.31 g cm<sup>−2</sup>).</p></sec><sec><title>Conclusions</title><p>The results of the study showed that fluoride intake higher than the optimum level causes increased mandibular BMD in edentulous individuals. Further dose-related studies are needed to determine the effects of high fluoride intake on bony structures of the stomatognathic system.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dentomaxillofac Radiol</journal-id><journal-id journal-id-type="iso-abbrev">Dentomaxillofac Radiol</journal-id><journal-id journal-id-type="hwp">dmfr</journal-id><journal-id journal-id-type="publisher-id">dmf</journal-id><journal-title-group><journal-title>Dentomaxillofacial Radiology</journal-title></journal-title-group><issn pub-type="ppub">0250-832X</issn><issn pub-type="epub">1476-542X</issn><publisher><publisher-name>The British Institute of Radiology.</publisher-name><publisher-loc>36 Portland Place, London, W1B 1AT</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22241885</article-id><article-id pub-id-type="pmc">3520348</article-id><article-id pub-id-type="publisher-id">D11059</article-id><article-id pub-id-type="doi">10.1259/dmfr/20380362</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Evaluation of mandibular bone mineral density using the dual-energy X-ray absorptiometry technique in edentulous subjects living in an endemic fluorosis region</article-title><alt-title alt-title-type="running-head">Mandibular BMD in fluorosis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Buyukkaplan</surname><given-names>US</given-names></name><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Guldag</surname><given-names>MU</given-names></name></contrib></contrib-group><aff id="aff1"><addr-line>Department of Prosthodontics, Faculty of Dentistry, Suleyman Demirel University, Isparta, Turkey</addr-line></aff><author-notes><corresp id="cor1">Dr U Sebnem Buyukkaplan, Akdeniz University, Faculty of Dentistry, Department of Prosthodontics, 07058 Antalya, Turkey. E-mail: <email>satac@med.sdu.edu.tr</email></corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><volume>41</volume><issue>5</issue><fpage>405</fpage><lpage>410</lpage><permissions><copyright-statement>© 2012 The British Institute of Radiology</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec><title>Objectives</title><p>Fluoride is one of the biological trace elements with a strong affinity for osseous, cartilaginous and dental tissue. The dental and skeletal effects of high fluoride intake have already been studied in the literature, but little is known about the effects of high fluoride intake on edentulous mandibles. The purpose of this study was to evaluate the effects of high fluoride intake on mandibular bone mineral density (BMD) measured by the dual-energy X-ray absorptiometry (DXA) technique in edentulous individuals with systemic fluorosis.</p></sec><sec><title>Methods</title><p>32 people who were living in an endemic fluorosis area since birth and 31 people who were living in a non-endemic fluorosis area since birth (control group) participated in this study. Systemic fluorosis was diagnosed in the patients using the sialic acid (NANA)/glycosaminoglycan (GAG) ratio. The BMDs of the mandibles were determined by the DXA technique.</p></sec><sec><title>Results</title><p>The serum NANA/GAG ratios in the fluorosis group were significantly lower than those in the control group (<italic>p</italic> < 0.001). There was also a statistically significant difference in mandibular BMD measurements (<italic>p</italic> < 0.05) between the systemic fluorosis and control groups, as measured by the DXA technique. Mandibular body BMD measurements were higher in the fluorosis group (1.25 ± 0.24 g cm<sup>−2</sup>) than in the control group (1.01 ± 0.31 g cm<sup>−2</sup>).</p></sec><sec><title>Conclusions</title><p>The results of the study showed that fluoride intake higher than the optimum level causes increased mandibular BMD in edentulous individuals. Further dose-related studies are needed to determine the effects of high fluoride intake on bony structures of the stomatognathic system.</p></sec></abstract><kwd-group><kwd>endemic fluorosis</kwd><kwd>edentulism</kwd><kwd>mandible</kwd><kwd>bone mineral density</kwd><kwd>dual-energy X-ray absorptiometry</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Buyukkaplan, Us" sort="Buyukkaplan, Us" uniqKey="Buyukkaplan U" first="Us" last="Buyukkaplan">Us Buyukkaplan</name><name sortKey="Guldag, Mu" sort="Guldag, Mu" uniqKey="Guldag M" first="Mu" last="Guldag">Mu Guldag</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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