Titanium nanotubes stimulate osteoblast differentiation of stem cells from pulp and adipose tissue
Identifieur interne : 001C22 ( Pmc/Checkpoint ); précédent : 001C21; suivant : 001C23Titanium nanotubes stimulate osteoblast differentiation of stem cells from pulp and adipose tissue
Auteurs : Alfonso Pozio [Italie] ; Annalisa Palmieri [Italie] ; Ambra Girardi [Italie] ; Francesca Cura [Italie] ; Francesco Carinci [Italie]Source :
- Dental Research Journal [ 1735-3327 ] ; 2012.
Abstract
Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide, anatase that is biocompatible and able to induce osseointegration.
In this study we compared the expression profiling of stem cells cultivated on two types of surface: Pure titanium disk and nanotube titanium disk in order to detect if nanotube titanium instead (NTD) surface stimulates stem cells towards osteoblast differentiation.
Stem cells cultivated on nanotube titanium disks showed the upregulation of bone-related genes RUNX2, FOSL1 and SPP1.
Results demonstrated that nanotube titanium disk surface is more osteo-induced surface compared to titanium disk, promoting the differentiation of mesenchymal stem cells in osteoblasts.
Url:
DOI: 10.4103/1735-3327.109745
PubMed: 23814578
PubMed Central: 3692168
Affiliations:
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Casaccia, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Palmieri, Annalisa" sort="Palmieri, Annalisa" uniqKey="Palmieri A" first="Annalisa" last="Palmieri">Annalisa Palmieri</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Ambra" sort="Girardi, Ambra" uniqKey="Girardi A" first="Ambra" last="Girardi">Ambra Girardi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23814578</idno><idno type="pmc">3692168</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692168</idno><idno type="RBID">PMC:3692168</idno><idno type="doi">10.4103/1735-3327.109745</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002B74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B74</idno><idno type="wicri:Area/Pmc/Curation">002B74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B74</idno><idno type="wicri:Area/Pmc/Checkpoint">001C22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001C22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Titanium nanotubes stimulate osteoblast differentiation of stem cells from pulp and adipose tissue</title><author><name sortKey="Pozio, Alfonso" sort="Pozio, Alfonso" uniqKey="Pozio A" first="Alfonso" last="Pozio">Alfonso Pozio</name><affiliation wicri:level="3"><nlm:aff id="aff1">ENEA, IDROCOMB, C.R. Casaccia, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>ENEA, IDROCOMB, C.R. Casaccia, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Palmieri, Annalisa" sort="Palmieri, Annalisa" uniqKey="Palmieri A" first="Annalisa" last="Palmieri">Annalisa Palmieri</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Girardi, Ambra" sort="Girardi, Ambra" uniqKey="Girardi A" first="Ambra" last="Girardi">Ambra Girardi</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide, anatase that is biocompatible and able to induce osseointegration.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In this study we compared the expression profiling of stem cells cultivated on two types of surface: Pure titanium disk and nanotube titanium disk in order to detect if nanotube titanium instead (NTD) surface stimulates stem cells towards osteoblast differentiation.</p></sec><sec id="st3"><title>Results:</title><p>Stem cells cultivated on nanotube titanium disks showed the upregulation of bone-related genes RUNX2, FOSL1 and SPP1.</p></sec><sec id="st4"><title>Conclusions:</title><p>Results demonstrated that nanotube titanium disk surface is more osteo-induced surface compared to titanium disk, promoting the differentiation of mesenchymal stem cells in osteoblasts.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Carinci, F" uniqKey="Carinci F">F 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Hk" uniqKey="Moe H">HK Moe</name></author><author><name sortKey="Aubin, Je" uniqKey="Aubin J">JE Aubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckee, Md" uniqKey="Mckee M">MD McKee</name></author><author><name sortKey="Farach Carson, Mc" uniqKey="Farach Carson M">MC Farach-Carson</name></author><author><name sortKey="Butler, Wt" uniqKey="Butler W">WT Butler</name></author><author><name sortKey="Hauschka, Pv" uniqKey="Hauschka P">PV Hauschka</name></author><author><name sortKey="Nanci, A" uniqKey="Nanci A">A Nanci</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="iso-abbrev">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="publisher-id">DRJ</journal-id><journal-title-group><journal-title>Dental Research Journal</journal-title></journal-title-group><issn pub-type="ppub">1735-3327</issn><issn pub-type="epub">2008-0255</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23814578</article-id><article-id pub-id-type="pmc">3692168</article-id><article-id pub-id-type="publisher-id">DRJ-9-169</article-id><article-id pub-id-type="doi">10.4103/1735-3327.109745</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Titanium nanotubes stimulate osteoblast differentiation of stem cells from pulp and adipose tissue</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Pozio</surname><given-names>Alfonso</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Palmieri</surname><given-names>Annalisa</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Girardi</surname><given-names>Ambra</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cura</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Carinci</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><label>1</label>ENEA, IDROCOMB, C.R. Casaccia, Rome, Italy</aff><aff id="aff2"><label>2</label>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</aff><aff id="aff3"><label>3</label>Department of Histology, Embryology and Applied Biology, Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Prof. Francesco Carinci, Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy. <bold>E-mail:</bold><email xlink:href="crc@unife.it">crc@unife.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><volume>9</volume><issue>Suppl 2</issue><fpage>S169</fpage><lpage>S174</lpage><history><date date-type="received"><month>6</month><year>2012</year></date><date date-type="accepted"><month>8</month><year>2012</year></date></history><permissions><copyright-statement>Copyright: © Dental Research Journal</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide, anatase that is biocompatible and able to induce osseointegration.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>In this study we compared the expression profiling of stem cells cultivated on two types of surface: Pure titanium disk and nanotube titanium disk in order to detect if nanotube titanium instead (NTD) surface stimulates stem cells towards osteoblast differentiation.</p></sec><sec id="st3"><title>Results:</title><p>Stem cells cultivated on nanotube titanium disks showed the upregulation of bone-related genes RUNX2, FOSL1 and SPP1.</p></sec><sec id="st4"><title>Conclusions:</title><p>Results demonstrated that nanotube titanium disk surface is more osteo-induced surface compared to titanium disk, promoting the differentiation of mesenchymal stem cells in osteoblasts.</p></sec></abstract><kwd-group><kwd>Gene expression</kwd><kwd>nanotubes</kwd><kwd>osteoblasts</kwd><kwd>stem cells</kwd><kwd>titanium disks</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Pozio, Alfonso" sort="Pozio, Alfonso" uniqKey="Pozio A" first="Alfonso" last="Pozio">Alfonso Pozio</name></region><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><name sortKey="Girardi, Ambra" sort="Girardi, Ambra" uniqKey="Girardi A" first="Ambra" last="Girardi">Ambra Girardi</name><name sortKey="Palmieri, Annalisa" sort="Palmieri, Annalisa" uniqKey="Palmieri A" first="Annalisa" last="Palmieri">Annalisa Palmieri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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