A comparative evaluation of cone beam CT and micro-CT on trabecular bone structures in the human mandible
Identifieur interne : 001B81 ( Pmc/Checkpoint ); précédent : 001B80; suivant : 001B82A comparative evaluation of cone beam CT and micro-CT on trabecular bone structures in the human mandible
Auteurs : J. Van Dessel [Belgique] ; Y. Huang [Belgique, République populaire de Chine] ; M. Depypere [Belgique] ; I. Rubira-Bullen [Brésil] ; F. Maes [Belgique] ; R. Jacobs [Belgique]Source :
- Dentomaxillofacial Radiology [ 0250-832X ] ; 2013.
Abstract
The main purpose of this study was to determine the accuracy of cone beam CT (CBCT) in measuring the trabecular bone microstructure, in comparison with micro-CT. The subobjective was to examine to what extent bone quality assessment is influenced by X-ray tube current and voltage settings as well as soft tissue surrounding the bone.
Eight human mandibular bone samples were scanned using three different clinical exposure protocol within water (W1–3) and without water (NW1–3) by a high-resolution (80 µm) CBCT machine (3D Accuitomo 170®; Morita, Kyoto, Japan). Subsequently, the samples underwent micro-CT scanning (SkyScan 1174®; SkyScan, Antwerp, Belgium). After image acquisition, similar volumes of interest of the trabecular structures captured with CBCT and micro-CT were aligned with each other. Segmentation was then performed, and the morphometric parameters were quantified within the volumes of interest by CTAn software (CTAnalyser®; SkyScan, Antwerp, Belgium). Descriptive statistical analyses and multiple comparisons between all protocols were applied in R software.
High positive Pearson's correlation coefficients were observed between CBCT and micro-CT protocols for all tested morphometric indices except for trabecular thickness. No significant differences were observed between all exposure protocols except for trabecular separation. When examining the soft-tissue effect on trabecular bone structures, no significant differences between NW (1–3) and W (1–3) protocols were observed for all variables.
The present study demonstrated the potential of high-resolution CBCT imaging for
Url:
DOI: 10.1259/dmfr.20130145
PubMed: 23833320
PubMed Central: 3922263
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Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Oral Implant Center, West China College of Stomatology, Sichuan University, Chengdu, China;</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral Implant Center, West China College of Stomatology, Sichuan University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Depypere, M" sort="Depypere, M" uniqKey="Depypere M" first="M" last="Depypere">M. Depypere</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Rubira Bullen, I" sort="Rubira Bullen, I" uniqKey="Rubira Bullen I" first="I" last="Rubira-Bullen">I. Rubira-Bullen</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Stomatology, School of Dentistry, University of São Paulo, Bauru, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Stomatology, School of Dentistry, University of São Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Maes, F" sort="Maes, F" uniqKey="Maes F" first="F" last="Maes">F. Maes</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Jacobs, R" sort="Jacobs, R" uniqKey="Jacobs R" first="R" last="Jacobs">R. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23833320</idno><idno type="pmc">3922263</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922263</idno><idno type="RBID">PMC:3922263</idno><idno type="doi">10.1259/dmfr.20130145</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002306</idno><idno type="wicri:Area/Pmc/Curation">002306</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002306</idno><idno type="wicri:Area/Pmc/Checkpoint">001B81</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B81</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A comparative evaluation of cone beam CT and micro-CT on trabecular bone structures in the human mandible</title><author><name sortKey="Van Dessel, J" sort="Van Dessel, J" uniqKey="Van Dessel J" first="J" last="Van Dessel">J. Van Dessel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Y" sort="Huang, Y" uniqKey="Huang Y" first="Y" last="Huang">Y. Huang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Oral Implant Center, West China College of Stomatology, Sichuan University, Chengdu, China;</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral Implant Center, West China College of Stomatology, Sichuan University, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author><author><name sortKey="Depypere, M" sort="Depypere, M" uniqKey="Depypere M" first="M" last="Depypere">M. Depypere</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Rubira Bullen, I" sort="Rubira Bullen, I" uniqKey="Rubira Bullen I" first="I" last="Rubira-Bullen">I. Rubira-Bullen</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Department of Stomatology, School of Dentistry, University of São Paulo, Bauru, Brazil</addr-line></nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Stomatology, School of Dentistry, University of São Paulo, Bauru</wicri:regionArea><orgName type="university">Université de São Paulo</orgName><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Maes, F" sort="Maes, F" uniqKey="Maes F" first="F" last="Maes">F. Maes</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Jacobs, R" sort="Jacobs, R" uniqKey="Jacobs R" first="R" last="Jacobs">R. Jacobs</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven, Belgium;</addr-line></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dentomaxillofacial Radiology</title><idno type="ISSN">0250-832X</idno><idno type="eISSN">1476-542X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives:</title><p>The main purpose of this study was to determine the accuracy of cone beam CT (CBCT) in measuring the trabecular bone microstructure, in comparison with micro-CT. The subobjective was to examine to what extent bone quality assessment is influenced by X-ray tube current and voltage settings as well as soft tissue surrounding the bone.</p></sec><sec><title>Methods:</title><p>Eight human mandibular bone samples were scanned using three different clinical exposure protocol within water (W1–3) and without water (NW1–3) by a high-resolution (80 µm) CBCT machine (3D Accuitomo 170<sup>®</sup>; Morita, Kyoto, Japan). Subsequently, the samples underwent micro-CT scanning (SkyScan 1174®; SkyScan, Antwerp, Belgium). After image acquisition, similar volumes of interest of the trabecular structures captured with CBCT and micro-CT were aligned with each other. Segmentation was then performed, and the morphometric parameters were quantified within the volumes of interest by CTAn software (CTAnalyser<sup>®</sup>; SkyScan, Antwerp, Belgium). Descriptive statistical analyses and multiple comparisons between all protocols were applied in R software.</p></sec><sec><title>Results:</title><p>High positive Pearson's correlation coefficients were observed between CBCT and micro-CT protocols for all tested morphometric indices except for trabecular thickness. No significant differences were observed between all exposure protocols except for trabecular separation. When examining the soft-tissue effect on trabecular bone structures, no significant differences between NW (1–3) and W (1–3) protocols were observed for all variables.</p></sec><sec><title>Conclusions:</title><p>The present study demonstrated the potential of high-resolution CBCT imaging for <italic>in vivo</italic> applications of quantitative bone morphometry and bone quality assessment. However, the overestimation of morphometric parameters and acquisition settings in CBCT must be taken into account.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dentomaxillofac Radiol</journal-id><journal-id journal-id-type="iso-abbrev">Dentomaxillofac Radiol</journal-id><journal-id journal-id-type="hwp">dmfr</journal-id><journal-id journal-id-type="publisher-id">dmf</journal-id><journal-title-group><journal-title>Dentomaxillofacial Radiology</journal-title></journal-title-group><issn pub-type="ppub">0250-832X</issn><issn pub-type="epub">1476-542X</issn><publisher><publisher-name>The British Institute of Radiology.</publisher-name><publisher-loc>48–50 St John Street, London EC1M 4DG, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23833320</article-id><article-id pub-id-type="pmc">3922263</article-id><article-id pub-id-type="publisher-id">dmr13145</article-id><article-id pub-id-type="doi">10.1259/dmfr.20130145</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>A comparative evaluation of cone beam CT and micro-CT on trabecular bone structures in the human mandible</article-title><alt-title alt-title-type="left-running-head">Comparative evaluation of CBCT and µCT on bone structures analysis</alt-title><alt-title alt-title-type="right-running-head">J Van Dessel <italic>et al</italic></alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Van Dessel</surname><given-names>J</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Y</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Depypere</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Rubira-Bullen</surname><given-names>I</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Maes</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Jacobs</surname><given-names>R</given-names></name><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="aff" rid="aff1">1</xref></contrib><aff id="aff1"><label>1</label><addr-line>Department of Oral Health Science, Oral Imaging Center, KU Leuven, Leuven, Belgium;</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Oral Implant Center, West China College of Stomatology, Sichuan University, Chengdu, China;</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Medical Image Computing, Center for Processing Speech and Images, Department of Electrical Engineering, KU Leuven, Leuven, Belgium;</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Stomatology, School of Dentistry, University of São Paulo, Bauru, Brazil</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Professor R Jacobs, Department of Oral Health Science, Oral Imaging Center, KU Leuven, 3000 Leuven, Belgium. E-mail: <email xlink:href="reinhilde.jacobs@med.kuleuven.be">reinhilde.jacobs@med.kuleuven.be</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>07</day><month>8</month><year>2013</year></pub-date><volume>42</volume><issue>8</issue><elocation-id>20130145</elocation-id><history><date date-type="received"><day>15</day><month>4</month><year>2013</year></date><date date-type="rev-recd"><day>24</day><month>6</month><year>2013</year></date><date date-type="accepted"><day>27</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 The Authors. Published by the British Institute of Radiology</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><sec><title>Objectives:</title><p>The main purpose of this study was to determine the accuracy of cone beam CT (CBCT) in measuring the trabecular bone microstructure, in comparison with micro-CT. The subobjective was to examine to what extent bone quality assessment is influenced by X-ray tube current and voltage settings as well as soft tissue surrounding the bone.</p></sec><sec><title>Methods:</title><p>Eight human mandibular bone samples were scanned using three different clinical exposure protocol within water (W1–3) and without water (NW1–3) by a high-resolution (80 µm) CBCT machine (3D Accuitomo 170<sup>®</sup>; Morita, Kyoto, Japan). Subsequently, the samples underwent micro-CT scanning (SkyScan 1174®; SkyScan, Antwerp, Belgium). After image acquisition, similar volumes of interest of the trabecular structures captured with CBCT and micro-CT were aligned with each other. Segmentation was then performed, and the morphometric parameters were quantified within the volumes of interest by CTAn software (CTAnalyser<sup>®</sup>; SkyScan, Antwerp, Belgium). Descriptive statistical analyses and multiple comparisons between all protocols were applied in R software.</p></sec><sec><title>Results:</title><p>High positive Pearson's correlation coefficients were observed between CBCT and micro-CT protocols for all tested morphometric indices except for trabecular thickness. No significant differences were observed between all exposure protocols except for trabecular separation. When examining the soft-tissue effect on trabecular bone structures, no significant differences between NW (1–3) and W (1–3) protocols were observed for all variables.</p></sec><sec><title>Conclusions:</title><p>The present study demonstrated the potential of high-resolution CBCT imaging for <italic>in vivo</italic> applications of quantitative bone morphometry and bone quality assessment. However, the overestimation of morphometric parameters and acquisition settings in CBCT must be taken into account.</p></sec></abstract><kwd-group><kwd>cone beam CT</kwd><kwd>micro-computed tomography</kwd><kwd>bone architecture</kwd><kwd>quantitative bone morphometry</kwd></kwd-group><counts><fig-count count="3"></fig-count><table-count count="2"></table-count><ref-count count="22"></ref-count><page-count count="7"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Belgique</li><li>Brésil</li><li>République populaire de Chine</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Belgique"><noRegion><name sortKey="Van Dessel, J" sort="Van Dessel, J" uniqKey="Van Dessel J" first="J" last="Van Dessel">J. Van Dessel</name></noRegion><name sortKey="Depypere, M" sort="Depypere, M" uniqKey="Depypere M" first="M" last="Depypere">M. Depypere</name><name sortKey="Huang, Y" sort="Huang, Y" uniqKey="Huang Y" first="Y" last="Huang">Y. Huang</name><name sortKey="Jacobs, R" sort="Jacobs, R" uniqKey="Jacobs R" first="R" last="Jacobs">R. Jacobs</name><name sortKey="Maes, F" sort="Maes, F" uniqKey="Maes F" first="F" last="Maes">F. Maes</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Y" sort="Huang, Y" uniqKey="Huang Y" first="Y" last="Huang">Y. Huang</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Rubira Bullen, I" sort="Rubira Bullen, I" uniqKey="Rubira Bullen I" first="I" last="Rubira-Bullen">I. Rubira-Bullen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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