Number of teeth, C-reactive protein, and fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnish cohort
Identifieur interne : 001901 ( Pmc/Checkpoint ); précédent : 001900; suivant : 001902Number of teeth, C-reactive protein, and fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnish cohort
Auteurs : Sok-Ja Janket [États-Unis] ; Alison E. Baird [États-Unis] ; Judith A. Jones [États-Unis] ; Elizabeth A. Jackson [États-Unis] ; Markku Surraka [Finlande] ; Wen Tao [États-Unis] ; Jukka H. Meurman [Finlande] ; Thomas E. Van Dyke [États-Unis]Source :
- Journal of clinical periodontology [ 0303-6979 ] ; 2013.
Abstract
To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.
The Kuopio Oral Health and Heart study initiated a case-control study in 1995–1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender matched controls. We appended the mortality data and formulated a longitudinal study. By May 31st, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) – consisting of 10 teeth – with cardiovascular and all-cause mortality after 15.8 years of median follow-up.
In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular (CVD) mortality with a Hazard Ratio (HR) 0.73, P-value = 0.02 but not with all-cause mortality (HR= 0.87, p=0.13). The findings were not mediated by CRP levels ≥ 3 mg/L or by median fibrinogen levels but were mediated by CRP levels > 5 mg/L.
Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.
Url:
DOI: 10.1111/jcpe.12192
PubMed: 24354534
PubMed Central: 3934352
Affiliations:
- Finlande, États-Unis
- Massachusetts, Michigan, Uusimaa, État de New York
- Helsinki
- Université d'Helsinki
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Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University Henry M. Goldman School of Dental Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name><affiliation wicri:level="2"><nlm:aff id="A2">Neurological disorders and Stroke, SUNY Downstate Medical Center, Brooklyn, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neurological disorders and Stroke, SUNY Downstate Medical Center, Brooklyn, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name><affiliation wicri:level="2"><nlm:aff id="A1">Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Boston University Henry M. Goldman School of Dental Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jackson, Elizabeth A" sort="Jackson, Elizabeth A" uniqKey="Jackson E" first="Elizabeth A." last="Jackson">Elizabeth A. 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Meurman</name><affiliation wicri:level="4"><nlm:aff id="A6">Department of Oral and Maxillofacial Diseases, Helsinki Central Hospital, and Institute of Dentistry, University of Helsinki, Helsinki, Finland</nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Oral and Maxillofacial Diseases, Helsinki Central Hospital, and Institute of Dentistry, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name><affiliation wicri:level="2"><nlm:aff id="A7">Forsyth Institute, Periodontology, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forsyth Institute, Periodontology, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Journal of clinical periodontology</title><idno type="ISSN">0303-6979</idno><idno type="eISSN">1600-051X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Aim(s)</title><p id="P1">To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">The Kuopio Oral Health and Heart study initiated a case-control study in 1995–1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender matched controls. We appended the mortality data and formulated a longitudinal study. By May 31<sup>st</sup>, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) – consisting of 10 teeth – with cardiovascular and all-cause mortality after 15.8 years of median follow-up.</p></sec><sec id="S3"><title>Results</title><p id="P3">In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular (CVD) mortality with a Hazard Ratio (HR) 0.73, P-value = 0.02 but not with all-cause mortality (HR= 0.87, p=0.13). The findings were not mediated by CRP levels ≥ 3 mg/L or by median fibrinogen levels but were mediated by CRP levels > 5 mg/L.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0425123</journal-id><journal-id journal-id-type="pubmed-jr-id">4645</journal-id><journal-id journal-id-type="nlm-ta">J Clin Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Periodontol.</journal-id><journal-title-group><journal-title>Journal of clinical periodontology</journal-title></journal-title-group><issn pub-type="ppub">0303-6979</issn><issn pub-type="epub">1600-051X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24354534</article-id><article-id pub-id-type="pmc">3934352</article-id><article-id pub-id-type="doi">10.1111/jcpe.12192</article-id><article-id pub-id-type="manuscript">NIHMS541869</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Number of teeth, C-reactive protein, and fibrinogen and cardiovascular mortality: A 15-year follow-up study in a Finnish cohort</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Janket</surname><given-names>Sok-Ja</given-names></name><degrees>DMD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Baird</surname><given-names>Alison E.</given-names></name><degrees>MD, MPH, PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Judith A.</given-names></name><degrees>DDS, DSc.D</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jackson</surname><given-names>Elizabeth A.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Surraka</surname><given-names>Markku</given-names></name><degrees>DDS, MS</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Tao</surname><given-names>Wen</given-names></name><degrees>MS, BS</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Meurman</surname><given-names>Jukka H.</given-names></name><degrees>MD, DDS, PhD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Van Dyke</surname><given-names>Thomas E.</given-names></name><degrees>DDS, PhD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib></contrib-group><aff id="A1"><label>1</label>Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA</aff><aff id="A2"><label>2</label>Neurological disorders and Stroke, SUNY Downstate Medical Center, Brooklyn, NY, USA</aff><aff id="A3"><label>3</label>University of Michigan, Department of internal medicine, Ann Arbor, MI, USA</aff><aff id="A4"><label>4</label>Otorhinolaryngology/Oral and Maxillofacial Surgery, Kuopio University, Kuopio, Finland</aff><aff id="A5"><label>5</label>Department of Biostatistics, Boston University, Boston, MA, USA</aff><aff id="A6"><label>6</label>Department of Oral and Maxillofacial Diseases, Helsinki Central Hospital, and Institute of Dentistry, University of Helsinki, Helsinki, Finland</aff><aff id="A7"><label>7</label>Forsyth Institute, Periodontology, Cambridge, MA, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author: Sok-Ja Janket, DMD, MPH, Boston University School of Dental Medicine, 100 East Newton Street, Rm. G-107C, Boston, MA 02118, <email>skjanket@bu.edu</email>, Fax: (617) 414-1061, Tel: (617) 414-1060</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>11</day><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2015</year></pub-date><volume>41</volume><issue>2</issue><fpage>131</fpage><lpage>140</lpage><pmc-comment>elocation-id from pubmed: 10.1111/jcpe.12192</pmc-comment>
<abstract><sec id="S1"><title>Aim(s)</title><p id="P1">To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">The Kuopio Oral Health and Heart study initiated a case-control study in 1995–1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender matched controls. We appended the mortality data and formulated a longitudinal study. By May 31<sup>st</sup>, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) – consisting of 10 teeth – with cardiovascular and all-cause mortality after 15.8 years of median follow-up.</p></sec><sec id="S3"><title>Results</title><p id="P3">In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular (CVD) mortality with a Hazard Ratio (HR) 0.73, P-value = 0.02 but not with all-cause mortality (HR= 0.87, p=0.13). The findings were not mediated by CRP levels ≥ 3 mg/L or by median fibrinogen levels but were mediated by CRP levels > 5 mg/L.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.</p></sec></abstract><kwd-group><kwd>CVD mortality</kwd><kwd>Number of teeth</kwd><kwd>C-reactive protein</kwd><kwd>fibrinogen</kwd><kwd>mediation analyses</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG045136 || AG</award-id></award-group><award-group><funding-source country="United States">National Center for Research Resources : NCRR</funding-source><award-id>M01 RR002602 || RR</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>Finlande</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>Michigan</li><li>Uusimaa</li><li>État de New York</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Janket, Sok Ja" sort="Janket, Sok Ja" uniqKey="Janket S" first="Sok-Ja" last="Janket">Sok-Ja Janket</name></region><name sortKey="Baird, Alison E" sort="Baird, Alison E" uniqKey="Baird A" first="Alison E." last="Baird">Alison E. Baird</name><name sortKey="Jackson, Elizabeth A" sort="Jackson, Elizabeth A" uniqKey="Jackson E" first="Elizabeth A." last="Jackson">Elizabeth A. Jackson</name><name sortKey="Jones, Judith A" sort="Jones, Judith A" uniqKey="Jones J" first="Judith A." last="Jones">Judith A. Jones</name><name sortKey="Tao, Wen" sort="Tao, Wen" uniqKey="Tao W" first="Wen" last="Tao">Wen Tao</name><name sortKey="Van Dyke, Thomas E" sort="Van Dyke, Thomas E" uniqKey="Van Dyke T" first="Thomas E." last="Van Dyke">Thomas E. Van Dyke</name></country><country name="Finlande"><noRegion><name sortKey="Surraka, Markku" sort="Surraka, Markku" uniqKey="Surraka M" first="Markku" last="Surraka">Markku Surraka</name></noRegion><name sortKey="Meurman, Jukka H" sort="Meurman, Jukka H" uniqKey="Meurman J" first="Jukka H." last="Meurman">Jukka H. Meurman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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