A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep
Identifieur interne : 001680 ( Pmc/Checkpoint ); précédent : 001679; suivant : 001681A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep
Auteurs : Marcella Von Salis-Soglio ; Stefan Stübinger [Suisse] ; Michéle Sidler [Suisse] ; Karina Klein ; Stephen J. Ferguson ; K Thi K Mpf ; Katalin Zlinszky ; Sabrina Buchini ; Richard Curno ; Péter Péchy ; Bjorn-Owe Aronsson ; Brigitte Von RechenbergSource :
- Journal of Functional Biomaterials [ 2079-4983 ] ; 2014.
Abstract
The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink®) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical stability. The study used two types of implants (rough or machined surface finish) each with either the multi-phosphonate Wet or Dry treatment or no treatment (control) for a total of six groups. Animals were sacrificed after 2, 8, and 52 weeks. No adverse events were observed at any time point. At two weeks, removal torque showed significantly higher values for the multi-phosphonate treated rough surface (+32% and +29%, Dry and Wet, respectively) compared to rough control. At 52 weeks, a significantly higher removal torque was observed for the multi-phosphonate treated machined surfaces (+37% and 23%, Dry and Wet, respectively). The multi-phosphonate treated groups showed a positive tendency for higher BIC with time and increased new-old bone ratio at eight weeks. SEM images revealed greater amounts of organic materials on the multi-phosphonate treated compared to control implants, with the bone fracture (from the torque test) appearing within the bone rather than at the bone to implant interface as it occurred for control implants.
Url:
DOI: 10.3390/jfb5030135
PubMed: 25215424
PubMed Central: 4192609
Affiliations:
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<author><name sortKey="Buchini, Sabrina" sort="Buchini, Sabrina" uniqKey="Buchini S" first="Sabrina" last="Buchini">Sabrina Buchini</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep</title>
<author><name sortKey="Von Salis Soglio, Marcella" sort="Von Salis Soglio, Marcella" uniqKey="Von Salis Soglio M" first="Marcella" last="Von Salis-Soglio">Marcella Von Salis-Soglio</name>
<affiliation><nlm:aff id="af1-jfb-05-00135">Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
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<author><name sortKey="Sidler, Michele" sort="Sidler, Michele" uniqKey="Sidler M" first="Michéle" last="Sidler">Michéle Sidler</name>
<affiliation><nlm:aff id="af1-jfb-05-00135">Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
(M.S.-S.);<email>stefan.stuebinger@cabmm.uzh.ch</email>
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<affiliation wicri:level="1"><nlm:aff id="af3-jfb-05-00135">Veterinary Anaesthesia Services Int (VAS), Zürcherstrasse 39, Winterthur 8400, Switzerland</nlm:aff>
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<author><name sortKey="Klein, Karina" sort="Klein, Karina" uniqKey="Klein K" first="Karina" last="Klein">Karina Klein</name>
<affiliation><nlm:aff id="af1-jfb-05-00135">Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
(M.S.-S.);<email>stefan.stuebinger@cabmm.uzh.ch</email>
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<author><name sortKey="Ferguson, Stephen J" sort="Ferguson, Stephen J" uniqKey="Ferguson S" first="Stephen J." last="Ferguson">Stephen J. Ferguson</name>
<affiliation><nlm:aff id="af4-jfb-05-00135">Institute for Biomechanics, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, Zürich 8093, Switzerland; E-Mail:<email>sferguson@ethz.ch</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="K Mpf, K Thi" sort="K Mpf, K Thi" uniqKey="K Mpf K" first="K Thi" last="K Mpf">K Thi K Mpf</name>
<affiliation><nlm:aff id="af1-jfb-05-00135">Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
(M.S.-S.);<email>stefan.stuebinger@cabmm.uzh.ch</email>
(S.S.);<email>msidler@vetclinics.uzh.ch</email>
(M.S.);<email>kklein@vetclinics.uzh.ch</email>
(K.Kl.);<email>kkaempf@vetclinics.uzh.ch</email>
(K.Kä.);<email>zlin@vetpath.uzh.ch</email>
(K.Z.)</nlm:aff>
</affiliation>
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<author><name sortKey="Zlinszky, Katalin" sort="Zlinszky, Katalin" uniqKey="Zlinszky K" first="Katalin" last="Zlinszky">Katalin Zlinszky</name>
<affiliation><nlm:aff id="af1-jfb-05-00135">Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
(M.S.-S.);<email>stefan.stuebinger@cabmm.uzh.ch</email>
(S.S.);<email>msidler@vetclinics.uzh.ch</email>
(M.S.);<email>kklein@vetclinics.uzh.ch</email>
(K.Kl.);<email>kkaempf@vetclinics.uzh.ch</email>
(K.Kä.);<email>zlin@vetpath.uzh.ch</email>
(K.Z.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buchini, Sabrina" sort="Buchini, Sabrina" uniqKey="Buchini S" first="Sabrina" last="Buchini">Sabrina Buchini</name>
<affiliation><nlm:aff id="af5-jfb-05-00135">Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland; E-Mails:<email>sabrina.buchini@nbmolecules.com</email>
(S.B.);<email>richard.curno@nbmolecules.com</email>
(R.C.);<email>peter.pechy@nbmolecules.com</email>
(P.P.);<email>bjorn-owe.aronsson@nbmolecules.com</email>
(B.-O.A.)</nlm:aff>
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<author><name sortKey="Curno, Richard" sort="Curno, Richard" uniqKey="Curno R" first="Richard" last="Curno">Richard Curno</name>
<affiliation><nlm:aff id="af5-jfb-05-00135">Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland; E-Mails:<email>sabrina.buchini@nbmolecules.com</email>
(S.B.);<email>richard.curno@nbmolecules.com</email>
(R.C.);<email>peter.pechy@nbmolecules.com</email>
(P.P.);<email>bjorn-owe.aronsson@nbmolecules.com</email>
(B.-O.A.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pechy, Peter" sort="Pechy, Peter" uniqKey="Pechy P" first="Péter" last="Péchy">Péter Péchy</name>
<affiliation><nlm:aff id="af5-jfb-05-00135">Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland; E-Mails:<email>sabrina.buchini@nbmolecules.com</email>
(S.B.);<email>richard.curno@nbmolecules.com</email>
(R.C.);<email>peter.pechy@nbmolecules.com</email>
(P.P.);<email>bjorn-owe.aronsson@nbmolecules.com</email>
(B.-O.A.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aronsson, Bjorn Owe" sort="Aronsson, Bjorn Owe" uniqKey="Aronsson B" first="Bjorn-Owe" last="Aronsson">Bjorn-Owe Aronsson</name>
<affiliation><nlm:aff id="af5-jfb-05-00135">Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland; E-Mails:<email>sabrina.buchini@nbmolecules.com</email>
(S.B.);<email>richard.curno@nbmolecules.com</email>
(R.C.);<email>peter.pechy@nbmolecules.com</email>
(P.P.);<email>bjorn-owe.aronsson@nbmolecules.com</email>
(B.-O.A.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Von Rechenberg, Brigitte" sort="Von Rechenberg, Brigitte" uniqKey="Von Rechenberg B" first="Brigitte" last="Von Rechenberg">Brigitte Von Rechenberg</name>
<affiliation><nlm:aff id="af1-jfb-05-00135">Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
(M.S.-S.);<email>stefan.stuebinger@cabmm.uzh.ch</email>
(S.S.);<email>msidler@vetclinics.uzh.ch</email>
(M.S.);<email>kklein@vetclinics.uzh.ch</email>
(K.Kl.);<email>kkaempf@vetclinics.uzh.ch</email>
(K.Kä.);<email>zlin@vetpath.uzh.ch</email>
(K.Z.)</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Functional Biomaterials</title>
<idno type="eISSN">2079-4983</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><p>The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink<sup>®</sup>
) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical stability. The study used two types of implants (rough or machined surface finish) each with either the multi-phosphonate Wet or Dry treatment or no treatment (control) for a total of six groups. Animals were sacrificed after 2, 8, and 52 weeks. No adverse events were observed at any time point. At two weeks, removal torque showed significantly higher values for the multi-phosphonate treated rough surface (+32% and +29%, Dry and Wet, respectively) compared to rough control. At 52 weeks, a significantly higher removal torque was observed for the multi-phosphonate treated machined surfaces (+37% and 23%, Dry and Wet, respectively). The multi-phosphonate treated groups showed a positive tendency for higher BIC with time and increased new-old bone ratio at eight weeks. SEM images revealed greater amounts of organic materials on the multi-phosphonate treated compared to control implants, with the bone fracture (from the torque test) appearing within the bone rather than at the bone to implant interface as it occurred for control implants.</p>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Funct Biomater</journal-id>
<journal-id journal-id-type="iso-abbrev">J Funct Biomater</journal-id>
<journal-id journal-id-type="publisher-id">jfb</journal-id>
<journal-title-group><journal-title>Journal of Functional Biomaterials</journal-title>
</journal-title-group>
<issn pub-type="epub">2079-4983</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25215424</article-id>
<article-id pub-id-type="pmc">4192609</article-id>
<article-id pub-id-type="doi">10.3390/jfb5030135</article-id>
<article-id pub-id-type="publisher-id">jfb-05-00135</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A Novel Multi-Phosphonate Surface Treatment of Titanium Dental Implants: A Study in Sheep</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>von Salis-Soglio</surname>
<given-names>Marcella</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stübinger</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
<xref ref-type="aff" rid="af2-jfb-05-00135">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sidler</surname>
<given-names>Michéle</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
<xref ref-type="aff" rid="af3-jfb-05-00135">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klein</surname>
<given-names>Karina</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferguson</surname>
<given-names>Stephen J.</given-names>
</name>
<xref ref-type="aff" rid="af4-jfb-05-00135">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kämpf</surname>
<given-names>Käthi</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zlinszky</surname>
<given-names>Katalin</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buchini</surname>
<given-names>Sabrina</given-names>
</name>
<xref ref-type="aff" rid="af5-jfb-05-00135">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Curno</surname>
<given-names>Richard</given-names>
</name>
<xref ref-type="aff" rid="af5-jfb-05-00135">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Péchy</surname>
<given-names>Péter</given-names>
</name>
<xref ref-type="aff" rid="af5-jfb-05-00135">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aronsson</surname>
<given-names>Bjorn-Owe</given-names>
</name>
<xref ref-type="aff" rid="af5-jfb-05-00135">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>von Rechenberg</surname>
<given-names>Brigitte</given-names>
</name>
<xref ref-type="aff" rid="af1-jfb-05-00135">1</xref>
<xref rid="c1-jfb-05-00135" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-jfb-05-00135"><label>1</label>
Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, Zürich 8057, Switzerland; E-Mails:<email>msalis@ethz.ch</email>
(M.S.-S.);<email>stefan.stuebinger@cabmm.uzh.ch</email>
(S.S.);<email>msidler@vetclinics.uzh.ch</email>
(M.S.);<email>kklein@vetclinics.uzh.ch</email>
(K.Kl.);<email>kkaempf@vetclinics.uzh.ch</email>
(K.Kä.);<email>zlin@vetpath.uzh.ch</email>
(K.Z.)</aff>
<aff id="af2-jfb-05-00135"><label>2</label>
Center of Applied Biotechnology and Molecular Medicine (CABMM), Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 190, Zürich 8057, Switzerland</aff>
<aff id="af3-jfb-05-00135"><label>3</label>
Veterinary Anaesthesia Services Int (VAS), Zürcherstrasse 39, Winterthur 8400, Switzerland</aff>
<aff id="af4-jfb-05-00135"><label>4</label>
Institute for Biomechanics, ETH Zürich, Vladimir-Prelog-Weg 1-5/10, Zürich 8093, Switzerland; E-Mail:<email>sferguson@ethz.ch</email>
</aff>
<aff id="af5-jfb-05-00135"><label>5</label>
Nano Bridging Molecules SA, Rte Cité Ouest 2, Gland 1196, Switzerland; E-Mails:<email>sabrina.buchini@nbmolecules.com</email>
(S.B.);<email>richard.curno@nbmolecules.com</email>
(R.C.);<email>peter.pechy@nbmolecules.com</email>
(P.P.);<email>bjorn-owe.aronsson@nbmolecules.com</email>
(B.-O.A.)</aff>
<author-notes><corresp id="c1-jfb-05-00135"><label>*</label>
Author to whom correspondence should be addressed; E-Mail: <email>bvonrechenberg@vetclinics.uzh.ch</email>
; Tel.: +41-44-635-8410; Fax: +41-44-635-8917.</corresp>
</author-notes>
<pub-date pub-type="epub"><day>10</day>
<month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><month>9</month>
<year>2014</year>
</pub-date>
<volume>5</volume>
<issue>3</issue>
<fpage>135</fpage>
<lpage>157</lpage>
<history><date date-type="received"><day>10</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>8</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>02</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement>
<copyright-year>2014</copyright-year>
<license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>The aim of the present study was to evaluate a new multi-phosphonate surface treatment (SurfLink<sup>®</sup>
) in an unloaded sheep model. Treated implants were compared to control implants in terms of bone to implant contact (BIC), bone formation, and biomechanical stability. The study used two types of implants (rough or machined surface finish) each with either the multi-phosphonate Wet or Dry treatment or no treatment (control) for a total of six groups. Animals were sacrificed after 2, 8, and 52 weeks. No adverse events were observed at any time point. At two weeks, removal torque showed significantly higher values for the multi-phosphonate treated rough surface (+32% and +29%, Dry and Wet, respectively) compared to rough control. At 52 weeks, a significantly higher removal torque was observed for the multi-phosphonate treated machined surfaces (+37% and 23%, Dry and Wet, respectively). The multi-phosphonate treated groups showed a positive tendency for higher BIC with time and increased new-old bone ratio at eight weeks. SEM images revealed greater amounts of organic materials on the multi-phosphonate treated compared to control implants, with the bone fracture (from the torque test) appearing within the bone rather than at the bone to implant interface as it occurred for control implants.</p>
</abstract>
<kwd-group><kwd>surface treatment</kwd>
<kwd>multi-phosphonate</kwd>
<kwd>bone formation</kwd>
<kwd>removal torque test</kwd>
<kwd>bone-to-implant-contact</kwd>
<kwd>scanning electron microscopy</kwd>
<kwd>osseointegration</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Suisse</li>
</country>
<region><li>Canton de Zurich</li>
</region>
<settlement><li>Zurich</li>
</settlement>
<orgName><li>Université de Zurich</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Aronsson, Bjorn Owe" sort="Aronsson, Bjorn Owe" uniqKey="Aronsson B" first="Bjorn-Owe" last="Aronsson">Bjorn-Owe Aronsson</name>
<name sortKey="Buchini, Sabrina" sort="Buchini, Sabrina" uniqKey="Buchini S" first="Sabrina" last="Buchini">Sabrina Buchini</name>
<name sortKey="Curno, Richard" sort="Curno, Richard" uniqKey="Curno R" first="Richard" last="Curno">Richard Curno</name>
<name sortKey="Ferguson, Stephen J" sort="Ferguson, Stephen J" uniqKey="Ferguson S" first="Stephen J." last="Ferguson">Stephen J. Ferguson</name>
<name sortKey="K Mpf, K Thi" sort="K Mpf, K Thi" uniqKey="K Mpf K" first="K Thi" last="K Mpf">K Thi K Mpf</name>
<name sortKey="Klein, Karina" sort="Klein, Karina" uniqKey="Klein K" first="Karina" last="Klein">Karina Klein</name>
<name sortKey="Pechy, Peter" sort="Pechy, Peter" uniqKey="Pechy P" first="Péter" last="Péchy">Péter Péchy</name>
<name sortKey="Von Rechenberg, Brigitte" sort="Von Rechenberg, Brigitte" uniqKey="Von Rechenberg B" first="Brigitte" last="Von Rechenberg">Brigitte Von Rechenberg</name>
<name sortKey="Von Salis Soglio, Marcella" sort="Von Salis Soglio, Marcella" uniqKey="Von Salis Soglio M" first="Marcella" last="Von Salis-Soglio">Marcella Von Salis-Soglio</name>
<name sortKey="Zlinszky, Katalin" sort="Zlinszky, Katalin" uniqKey="Zlinszky K" first="Katalin" last="Zlinszky">Katalin Zlinszky</name>
</noCountry>
<country name="Suisse"><region name="Canton de Zurich"><name sortKey="Stubinger, Stefan" sort="Stubinger, Stefan" uniqKey="Stubinger S" first="Stefan" last="Stübinger">Stefan Stübinger</name>
</region>
<name sortKey="Sidler, Michele" sort="Sidler, Michele" uniqKey="Sidler M" first="Michéle" last="Sidler">Michéle Sidler</name>
</country>
</tree>
</affiliations>
</record>
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