A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study
Identifieur interne : 001668 ( Pmc/Checkpoint ); précédent : 001667; suivant : 001669A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study
Auteurs : Vikram Blaggana ; Amarjit Singh Gill ; Anshu BlagganaSource :
- Journal of Indian Society of Periodontology [ 0972-124X ] ; 2014.
Abstract
The ultimate goal of periodontal therapy entails regeneration of the periodontal tissues lost as a consequence of periodontitis. Predictable correction of vertical osseous defects has however posed as a constant therapeutic challenge. The aim of our present study is to evaluate the relative efficacy of demineralized freeze-dried bone allograft (DFDBA) vs anorganic bovine bone xenograft (ABBX) in the treatment of human infrabony periodontal defects.
15 patients with 30 bilaterally symmetrical defect sites in either of the arches, in the age group of 25-50 years were selected as part of split-mouth study design. Defect-A (right side) was grafted with DFDBA while Defect-B (left side) was grafted with ABBX. Various clinical and radiographic parameters viz. probing depth(PD), clinical attachment level(CAL) and linear bone fill were recorded preoperatively, 12- & 24-weeks postoperatively.
Both defect-A & defect-B sites exhibited a highly significant reduction in probing depth, and gain in clinical attachment level and linear bone fill at 12-weeks & at the end of 24-weeks. Comparative evaluation between the study groups revealed a statistically non-significant reduction in probing depth (
Within the limits of this study, both the materials viz. ABBX and DFDBA are beneficial for the treatment of periodontal infrabony defects. Both the materials were found to be equally effective in all respects except the gain in attachment level, which was found to be more with DFDBA. Long-term studies are suggested to evaluate further the relative efficacy of the two grafts.
Url:
DOI: 10.4103/0972-124X.142454
PubMed: 25425822
PubMed Central: 4239750
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study</title>
<author><name sortKey="Blaggana, Vikram" sort="Blaggana, Vikram" uniqKey="Blaggana V" first="Vikram" last="Blaggana">Vikram Blaggana</name>
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<author><name sortKey="Gill, Amarjit Singh" sort="Gill, Amarjit Singh" uniqKey="Gill A" first="Amarjit Singh" last="Gill">Amarjit Singh Gill</name>
<affiliation><nlm:aff id="aff2"><italic>Department of Periodontology, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India</italic>
</nlm:aff>
</affiliation>
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<author><name sortKey="Blaggana, Anshu" sort="Blaggana, Anshu" uniqKey="Blaggana A" first="Anshu" last="Blaggana">Anshu Blaggana</name>
<affiliation><nlm:aff id="aff3"><italic>Department of Periodontology, PDM Dental College and Research Institute, Bahadurgarh, Haryana, India</italic>
</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study</title>
<author><name sortKey="Blaggana, Vikram" sort="Blaggana, Vikram" uniqKey="Blaggana V" first="Vikram" last="Blaggana">Vikram Blaggana</name>
<affiliation><nlm:aff id="aff1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gill, Amarjit Singh" sort="Gill, Amarjit Singh" uniqKey="Gill A" first="Amarjit Singh" last="Gill">Amarjit Singh Gill</name>
<affiliation><nlm:aff id="aff2"><italic>Department of Periodontology, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India</italic>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Blaggana, Anshu" sort="Blaggana, Anshu" uniqKey="Blaggana A" first="Anshu" last="Blaggana">Anshu Blaggana</name>
<affiliation><nlm:aff id="aff3"><italic>Department of Periodontology, PDM Dental College and Research Institute, Bahadurgarh, Haryana, India</italic>
</nlm:aff>
</affiliation>
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<series><title level="j">Journal of Indian Society of Periodontology</title>
<idno type="ISSN">0972-124X</idno>
<idno type="eISSN">0975-1580</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title>
<p>The ultimate goal of periodontal therapy entails regeneration of the periodontal tissues lost as a consequence of periodontitis. Predictable correction of vertical osseous defects has however posed as a constant therapeutic challenge. The aim of our present study is to evaluate the relative efficacy of demineralized freeze-dried bone allograft (DFDBA) vs anorganic bovine bone xenograft (ABBX) in the treatment of human infrabony periodontal defects.</p>
</sec>
<sec id="st2"><title>Materials and Methods:</title>
<p>15 patients with 30 bilaterally symmetrical defect sites in either of the arches, in the age group of 25-50 years were selected as part of split-mouth study design. Defect-A (right side) was grafted with DFDBA while Defect-B (left side) was grafted with ABBX. Various clinical and radiographic parameters viz. probing depth(PD), clinical attachment level(CAL) and linear bone fill were recorded preoperatively, 12- & 24-weeks postoperatively.</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>Both defect-A & defect-B sites exhibited a highly significant reduction in probing depth, and gain in clinical attachment level and linear bone fill at 12-weeks & at the end of 24-weeks. Comparative evaluation between the study groups revealed a statistically non-significant reduction in probing depth (<italic>P</italic>
<0.1) and mean gain in linear bone fill (<italic>P</italic>
<0.1). However, there was a statistically significant gain in clinical attachment level (<italic>P</italic>
<0.05) in Defect-A (CD=0.356) as compared to Defect-B (CD=0.346).</p>
</sec>
<sec id="st4"><title>Conclusions:</title>
<p>Within the limits of this study, both the materials viz. ABBX and DFDBA are beneficial for the treatment of periodontal infrabony defects. Both the materials were found to be equally effective in all respects except the gain in attachment level, which was found to be more with DFDBA. Long-term studies are suggested to evaluate further the relative efficacy of the two grafts.</p>
</sec>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Indian Soc Periodontol</journal-id>
<journal-id journal-id-type="iso-abbrev">J Indian Soc Periodontol</journal-id>
<journal-id journal-id-type="publisher-id">JISP</journal-id>
<journal-title-group><journal-title>Journal of Indian Society of Periodontology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0972-124X</issn>
<issn pub-type="epub">0975-1580</issn>
<publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25425822</article-id>
<article-id pub-id-type="pmc">4239750</article-id>
<article-id pub-id-type="publisher-id">JISP-18-601</article-id>
<article-id pub-id-type="doi">10.4103/0972-124X.142454</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A clinical and radiological evaluation of the relative efficacy of demineralized freeze-dried bone allograft versus anorganic bovine bone xenograft in the treatment of human infrabony periodontal defects: A 6 months follow-up study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Blaggana</surname>
<given-names>Vikram</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gill</surname>
<given-names>Amarjit Singh</given-names>
</name>
<xref ref-type="aff" rid="aff2">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Blaggana</surname>
<given-names>Anshu</given-names>
</name>
<xref ref-type="aff" rid="aff3">2</xref>
</contrib>
</contrib-group>
<aff id="aff1"><italic>Department of Periodontology and Oral Implantology, Krishna Dental College, Ghaziabad, Uttar Pradesh, India</italic>
</aff>
<aff id="aff2"><label>1</label>
<italic>Department of Periodontology, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India</italic>
</aff>
<aff id="aff3"><label>2</label>
<italic>Department of Periodontology, PDM Dental College and Research Institute, Bahadurgarh, Haryana, India</italic>
</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence:</bold>
Dr. Vikram Blaggana, 7185, Sector-B, Pocket-10, Vasant Kunj, New Delhi - 110 070, India. E-mail: <email xlink:href="drblaggana@gmail.com">drblaggana@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><season>Sep-Oct</season>
<year>2014</year>
</pub-date>
<volume>18</volume>
<issue>5</issue>
<fpage>601</fpage>
<lpage>607</lpage>
<history><date date-type="received"><day>09</day>
<month>7</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>19</day>
<month>2</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © Journal of Indian Society of Periodontology</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec id="st1"><title>Background:</title>
<p>The ultimate goal of periodontal therapy entails regeneration of the periodontal tissues lost as a consequence of periodontitis. Predictable correction of vertical osseous defects has however posed as a constant therapeutic challenge. The aim of our present study is to evaluate the relative efficacy of demineralized freeze-dried bone allograft (DFDBA) vs anorganic bovine bone xenograft (ABBX) in the treatment of human infrabony periodontal defects.</p>
</sec>
<sec id="st2"><title>Materials and Methods:</title>
<p>15 patients with 30 bilaterally symmetrical defect sites in either of the arches, in the age group of 25-50 years were selected as part of split-mouth study design. Defect-A (right side) was grafted with DFDBA while Defect-B (left side) was grafted with ABBX. Various clinical and radiographic parameters viz. probing depth(PD), clinical attachment level(CAL) and linear bone fill were recorded preoperatively, 12- & 24-weeks postoperatively.</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>Both defect-A & defect-B sites exhibited a highly significant reduction in probing depth, and gain in clinical attachment level and linear bone fill at 12-weeks & at the end of 24-weeks. Comparative evaluation between the study groups revealed a statistically non-significant reduction in probing depth (<italic>P</italic>
<0.1) and mean gain in linear bone fill (<italic>P</italic>
<0.1). However, there was a statistically significant gain in clinical attachment level (<italic>P</italic>
<0.05) in Defect-A (CD=0.356) as compared to Defect-B (CD=0.346).</p>
</sec>
<sec id="st4"><title>Conclusions:</title>
<p>Within the limits of this study, both the materials viz. ABBX and DFDBA are beneficial for the treatment of periodontal infrabony defects. Both the materials were found to be equally effective in all respects except the gain in attachment level, which was found to be more with DFDBA. Long-term studies are suggested to evaluate further the relative efficacy of the two grafts.</p>
</sec>
</abstract>
<kwd-group><kwd>Anorganic bovine bone xenograft</kwd>
<kwd>bone grafts</kwd>
<kwd>demineralized freeze-dried bone allograft</kwd>
<kwd>infrabony defects</kwd>
<kwd>regeneration</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Blaggana, Anshu" sort="Blaggana, Anshu" uniqKey="Blaggana A" first="Anshu" last="Blaggana">Anshu Blaggana</name>
<name sortKey="Blaggana, Vikram" sort="Blaggana, Vikram" uniqKey="Blaggana V" first="Vikram" last="Blaggana">Vikram Blaggana</name>
<name sortKey="Gill, Amarjit Singh" sort="Gill, Amarjit Singh" uniqKey="Gill A" first="Amarjit Singh" last="Gill">Amarjit Singh Gill</name>
</noCountry>
</tree>
</affiliations>
</record>
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