Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans
Identifieur interne : 000C76 ( Pmc/Checkpoint ); précédent : 000C75; suivant : 000C77Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans
Auteurs : Paulo José Pasquali [Brésil] ; Marcelo Lucchesi Teixeira [Brésil] ; Thiago Altro De Oliveira [Brésil] ; Luis Guilherme Scavone De Macedo [Brésil] ; Antonio Carlos Aloise [Brésil] ; André Antonio Pelegrine [Brésil]Source :
- International Journal of Biomaterials [ 1687-8787 ] ; 2015.
Abstract
Url:
DOI: 10.1155/2015/121286
PubMed: 26543482
PubMed Central: 4620258
Affiliations:
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PMC:4620258Le document en format XML
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<author><name sortKey="Pasquali, Paulo Jose" sort="Pasquali, Paulo Jose" uniqKey="Pasquali P" first="Paulo José" last="Pasquali">Paulo José Pasquali</name>
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<author><name sortKey="Teixeira, Marcelo Lucchesi" sort="Teixeira, Marcelo Lucchesi" uniqKey="Teixeira M" first="Marcelo Lucchesi" last="Teixeira">Marcelo Lucchesi Teixeira</name>
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<author><name sortKey="De Oliveira, Thiago Altro" sort="De Oliveira, Thiago Altro" uniqKey="De Oliveira T" first="Thiago Altro" last="De Oliveira">Thiago Altro De Oliveira</name>
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<author><name sortKey="De Macedo, Luis Guilherme Scavone" sort="De Macedo, Luis Guilherme Scavone" uniqKey="De Macedo L" first="Luis Guilherme Scavone" last="De Macedo">Luis Guilherme Scavone De Macedo</name>
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<author><name sortKey="Aloise, Antonio Carlos" sort="Aloise, Antonio Carlos" uniqKey="Aloise A" first="Antonio Carlos" last="Aloise">Antonio Carlos Aloise</name>
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<author><name sortKey="Pelegrine, Andre Antonio" sort="Pelegrine, Andre Antonio" uniqKey="Pelegrine A" first="André Antonio" last="Pelegrine">André Antonio Pelegrine</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans</title>
<author><name sortKey="Pasquali, Paulo Jose" sort="Pasquali, Paulo Jose" uniqKey="Pasquali P" first="Paulo José" last="Pasquali">Paulo José Pasquali</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas</wicri:regionArea>
<wicri:noRegion>13045-755 Campinas</wicri:noRegion>
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<author><name sortKey="Teixeira, Marcelo Lucchesi" sort="Teixeira, Marcelo Lucchesi" uniqKey="Teixeira M" first="Marcelo Lucchesi" last="Teixeira">Marcelo Lucchesi Teixeira</name>
<affiliation wicri:level="1"><nlm:aff id="I2">Department of Prosthodontics, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Prosthodontics, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas</wicri:regionArea>
<wicri:noRegion>13045-755 Campinas</wicri:noRegion>
</affiliation>
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<author><name sortKey="De Oliveira, Thiago Altro" sort="De Oliveira, Thiago Altro" uniqKey="De Oliveira T" first="Thiago Altro" last="De Oliveira">Thiago Altro De Oliveira</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas</wicri:regionArea>
<wicri:noRegion>13045-755 Campinas</wicri:noRegion>
</affiliation>
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<author><name sortKey="De Macedo, Luis Guilherme Scavone" sort="De Macedo, Luis Guilherme Scavone" uniqKey="De Macedo L" first="Luis Guilherme Scavone" last="De Macedo">Luis Guilherme Scavone De Macedo</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas</wicri:regionArea>
<wicri:noRegion>13045-755 Campinas</wicri:noRegion>
</affiliation>
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<author><name sortKey="Aloise, Antonio Carlos" sort="Aloise, Antonio Carlos" uniqKey="Aloise A" first="Antonio Carlos" last="Aloise">Antonio Carlos Aloise</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas</wicri:regionArea>
<wicri:noRegion>13045-755 Campinas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pelegrine, Andre Antonio" sort="Pelegrine, Andre Antonio" uniqKey="Pelegrine A" first="André Antonio" last="Pelegrine">André Antonio Pelegrine</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas</wicri:regionArea>
<wicri:noRegion>13045-755 Campinas</wicri:noRegion>
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<series><title level="j">International Journal of Biomaterials</title>
<idno type="ISSN">1687-8787</idno>
<idno type="eISSN">1687-8795</idno>
<imprint><date when="2015">2015</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p><italic>Purpose</italic>
. To investigate the regenerative results obtained with the association of bone marrow aspirate concentrate using the Bone Marrow Aspirate Concentrate (BMAC) method to a xenogeneic bone graft (Bio-Oss) in sinus floor elevation. <italic>Materials and Methods</italic>
. Using a randomized controlled study design in eight consecutive patients (age of 55.4 ± 9.2 years), 16 sinus floor lift procedures were performed with Bio-Oss alone (control group, CG, <italic>n</italic>
= 8) or combined with bone marrow aspirate concentrate obtained via the BMAC method (test group, TG, <italic>n</italic>
= 8). Six months after the grafting procedures, bone biopsies were harvested during implant placement and were analyzed by histomorphometry. <italic>Results</italic>
. Histomorphometric analysis revealed a significantly higher amount (<italic>p</italic>
< 0.05) of vital mineralized tissue in TG when compared to the CG (55.15 ± 20.91% and 27.30 ± 5.55%, resp.). For nonvital mineralized tissue, TG presented a statistically higher level of Bio-Oss resorption (<italic>p</italic>
< 0.05) when compared with the CG (6.32 ± 12.03% and 22.79 ± 9.60%, resp.). Both groups (TG and CG) showed no significantly different levels (<italic>p</italic>
> 0.05) of nonmineralized tissue (38.53 ± 13.08% and 49.90 ± 7.64%, resp.). <italic>Conclusion</italic>
. The use of bone marrow concentrate obtained by BMAC method increased bone formation in sinus lift procedures.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Biomater</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Biomater</journal-id>
<journal-id journal-id-type="publisher-id">IJBM</journal-id>
<journal-title-group><journal-title>International Journal of Biomaterials</journal-title>
</journal-title-group>
<issn pub-type="ppub">1687-8787</issn>
<issn pub-type="epub">1687-8795</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26543482</article-id>
<article-id pub-id-type="pmc">4620258</article-id>
<article-id pub-id-type="doi">10.1155/2015/121286</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Maxillary Sinus Augmentation Combining Bio-Oss with the Bone Marrow Aspirate Concentrate: A Histomorphometric Study in Humans</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Pasquali</surname>
<given-names>Paulo José</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teixeira</surname>
<given-names>Marcelo Lucchesi</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Oliveira</surname>
<given-names>Thiago Altro</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Macedo</surname>
<given-names>Luis Guilherme Scavone</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aloise</surname>
<given-names>Antonio Carlos</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pelegrine</surname>
<given-names>André Antonio</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Department of Implant Dentistry, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</aff>
<aff id="I2"><sup>2</sup>
Department of Prosthodontics, São Leopoldo Mandic Dental School, 13 José Rocha Junqueira Street, 13045-755 Campinas, Brazil</aff>
<author-notes><corresp id="cor1">*André Antonio Pelegrine: <email>pelegrineandre@gmail.com</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Sean Peel</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>12</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>2015</volume>
<elocation-id>121286</elocation-id>
<history><date date-type="received"><day>14</day>
<month>6</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><day>3</day>
<month>9</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>27</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 Paulo José Pasquali et al.</copyright-statement>
<copyright-year>2015</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p><italic>Purpose</italic>
. To investigate the regenerative results obtained with the association of bone marrow aspirate concentrate using the Bone Marrow Aspirate Concentrate (BMAC) method to a xenogeneic bone graft (Bio-Oss) in sinus floor elevation. <italic>Materials and Methods</italic>
. Using a randomized controlled study design in eight consecutive patients (age of 55.4 ± 9.2 years), 16 sinus floor lift procedures were performed with Bio-Oss alone (control group, CG, <italic>n</italic>
= 8) or combined with bone marrow aspirate concentrate obtained via the BMAC method (test group, TG, <italic>n</italic>
= 8). Six months after the grafting procedures, bone biopsies were harvested during implant placement and were analyzed by histomorphometry. <italic>Results</italic>
. Histomorphometric analysis revealed a significantly higher amount (<italic>p</italic>
< 0.05) of vital mineralized tissue in TG when compared to the CG (55.15 ± 20.91% and 27.30 ± 5.55%, resp.). For nonvital mineralized tissue, TG presented a statistically higher level of Bio-Oss resorption (<italic>p</italic>
< 0.05) when compared with the CG (6.32 ± 12.03% and 22.79 ± 9.60%, resp.). Both groups (TG and CG) showed no significantly different levels (<italic>p</italic>
> 0.05) of nonmineralized tissue (38.53 ± 13.08% and 49.90 ± 7.64%, resp.). <italic>Conclusion</italic>
. The use of bone marrow concentrate obtained by BMAC method increased bone formation in sinus lift procedures.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Cone-beam computed tomography scans of the posterior maxillary region.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Bone marrow was collected from all the patients by aspiration through a puncture 2 cm laterocaudally from the superior posterior iliac crest.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>After centrifugation for 14 minutes, two phases were obtained within the container: (1) the supernatant plasma above and (2) precipitated bone marrow cells concentrate below.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>The Schneiderian membrane seen through the lateral window in the maxillary sinus.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>Maxillary sinus was grafted with xenogeneic bone from bovine hydroxyapatite.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.005"></graphic>
</fig>
<fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label>
<caption><p>Xenograft combined with the bone marrow concentrate, immediately before being used.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.006"></graphic>
</fig>
<fig id="fig7" orientation="portrait" position="float"><label>Figure 7</label>
<caption><p>Bone specimens removed by a trephine bur.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.007"></graphic>
</fig>
<fig id="fig8" orientation="portrait" position="float"><label>Figure 8</label>
<caption><p>Dental implants (Blackfix, AS Technology, São José dos Campos, Brazil) immediately after they are placed.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.008"></graphic>
</fig>
<fig id="fig9" orientation="portrait" position="float"><label>Figure 9</label>
<caption><p>(a) Histological image of control group, stained by Masson's trichrome technique. Augmentation 20x. (b) Histological image of experimental group, stained by Masson's trichrome technique. Augmentation 20x.</p>
</caption>
<graphic xlink:href="IJBM2015-121286.009"></graphic>
</fig>
<table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label>
<caption><p>Statistical comparison of mean values (in percentage, %) between CG and TG.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="center" colspan="4" rowspan="1">Histomorphometric intergroup analysis</th>
</tr>
<tr><th align="left" rowspan="2" colspan="1">Tissues</th>
<th align="center" colspan="2" rowspan="1">Groups</th>
<th align="center" rowspan="2" colspan="1"><italic>p</italic>
value</th>
</tr>
<tr><th align="center" rowspan="1" colspan="1">CG</th>
<th align="center" rowspan="1" colspan="1">TG</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">NVMT</td>
<td align="center" rowspan="1" colspan="1">22.79 ± 9.60</td>
<td align="center" rowspan="1" colspan="1">6.32 ± 12.03</td>
<td align="center" rowspan="1" colspan="1">0.006</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">VMT</td>
<td align="center" rowspan="1" colspan="1">27.30 ± 5.55</td>
<td align="center" rowspan="1" colspan="1">55.15 ± 20.91</td>
<td align="center" rowspan="1" colspan="1">0.002</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">NMT</td>
<td align="center" rowspan="1" colspan="1">49.90 ± 7.64</td>
<td align="center" rowspan="1" colspan="1">38.53 ± 13.08</td>
<td align="center" rowspan="1" colspan="1">0.09</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>NVMT: nonvital mineralized tissue, VMT: vital mineralized tissue, NMT: nonmineralized tissue, CG: control group, and TG: test group.</p>
</fn>
<fn><p>Statistically significant <italic>p</italic>
≤ 0.05 (Mann-Whitney with correction by Sidak-Bonferroni test).</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Brésil</li>
</country>
</list>
<tree><country name="Brésil"><noRegion><name sortKey="Pasquali, Paulo Jose" sort="Pasquali, Paulo Jose" uniqKey="Pasquali P" first="Paulo José" last="Pasquali">Paulo José Pasquali</name>
</noRegion>
<name sortKey="Aloise, Antonio Carlos" sort="Aloise, Antonio Carlos" uniqKey="Aloise A" first="Antonio Carlos" last="Aloise">Antonio Carlos Aloise</name>
<name sortKey="De Macedo, Luis Guilherme Scavone" sort="De Macedo, Luis Guilherme Scavone" uniqKey="De Macedo L" first="Luis Guilherme Scavone" last="De Macedo">Luis Guilherme Scavone De Macedo</name>
<name sortKey="De Oliveira, Thiago Altro" sort="De Oliveira, Thiago Altro" uniqKey="De Oliveira T" first="Thiago Altro" last="De Oliveira">Thiago Altro De Oliveira</name>
<name sortKey="Pelegrine, Andre Antonio" sort="Pelegrine, Andre Antonio" uniqKey="Pelegrine A" first="André Antonio" last="Pelegrine">André Antonio Pelegrine</name>
<name sortKey="Teixeira, Marcelo Lucchesi" sort="Teixeira, Marcelo Lucchesi" uniqKey="Teixeira M" first="Marcelo Lucchesi" last="Teixeira">Marcelo Lucchesi Teixeira</name>
</country>
</tree>
</affiliations>
</record>
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