Untypical Amlodipine-Induced Gingival Hyperplasia
Identifieur interne : 000979 ( Pmc/Checkpoint ); précédent : 000978; suivant : 000980Untypical Amlodipine-Induced Gingival Hyperplasia
Auteurs : Verica Pavlic [Bosnie-Herzégovine] ; Nina Zubovic [Bosnie-Herzégovine] ; Sanja Ilic [Bosnie-Herzégovine] ; Tijana Adamovic [Bosnie-Herzégovine]Source :
- Case Reports in Dentistry [ 2090-6447 ] ; 2015.
Abstract
Amlodipine is a third generation dihydropyridine calcium channel blocker that is frequently used in therapy of hypertension. Among many side effects, amlodipine has been found associated with gingival overgrowth (GO) which usually occurs within the first three months of starting therapy at a dose of 10 mg/day. However, there are very few reports on amlodipine-induced gingival overgrowth (AIGO) at a lower dose (5 mg/day) and only after short term administration. A 64-year-old male patient with hypertension, who received amlodipine (5 mg/day) for four years, sought medical attention at the Department of Periodontology and Oral Medicine, Institute of Dentistry, Banja Luka, Bosnia and Herzegovina. The patient complained of masticatory problems due to extensive maxillary GO along with pain, bleeding, and foul odor. The clinical and the histological evidences were consistent with AIGO. The first line treatment consisted of the amlodipine substitution (amlodipine was replaced with enalapril, 5 mg/day) and the scaling and root planning/SRP. At one-month follow-up, drug replacement and SRP resulted in some reduction of the inflammation and significant reduction of symptoms. Further, gingivectomy/gingivoplasty helped overcome the effect of these drugs. The possibility of AIGO should be considered for a lower dose, as well as a late presentation.
Url:
DOI: 10.1155/2015/756976
PubMed: 25692048
PubMed Central: 4322315
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Amlodipine is a third generation dihydropyridine calcium channel blocker that is frequently used in therapy of hypertension. Among many side effects, amlodipine has been found associated with gingival overgrowth (GO) which usually occurs within the first three months of starting therapy at a dose of 10 mg/day. However, there are very few reports on amlodipine-induced gingival overgrowth (AIGO) at a lower dose (5 mg/day) and only after short term administration. A 64-year-old male patient with hypertension, who received amlodipine (5 mg/day) for four years, sought medical attention at the Department of Periodontology and Oral Medicine, Institute of Dentistry, Banja Luka, Bosnia and Herzegovina. The patient complained of masticatory problems due to extensive maxillary GO along with pain, bleeding, and foul odor. The clinical and the histological evidences were consistent with AIGO. The first line treatment consisted of the amlodipine substitution (amlodipine was replaced with enalapril, 5 mg/day) and the scaling and root planning/SRP. At one-month follow-up, drug replacement and SRP resulted in some reduction of the inflammation and significant reduction of symptoms. Further, gingivectomy/gingivoplasty helped overcome the effect of these drugs. The possibility of AIGO should be considered for a lower dose, as well as a late presentation.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Dent</journal-id>
<journal-id journal-id-type="iso-abbrev">Case Rep Dent</journal-id>
<journal-id journal-id-type="publisher-id">CRID</journal-id>
<journal-title-group><journal-title>Case Reports in Dentistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-6447</issn>
<issn pub-type="epub">2090-6455</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25692048</article-id>
<article-id pub-id-type="pmc">4322315</article-id>
<article-id pub-id-type="doi">10.1155/2015/756976</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Untypical Amlodipine-Induced Gingival Hyperplasia</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Pavlic</surname>
<given-names>Verica</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zubovic</surname>
<given-names>Nina</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ilic</surname>
<given-names>Sanja</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adamovic</surname>
<given-names>Tijana</given-names>
</name>
<xref ref-type="aff" rid="I3"><sup>3</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Department of Periodontology and Oral Medicine, Institute of Dentistry, Zdrave Korde 4, 78000 Banja Luka, Bosnia and Herzegovina</aff>
<aff id="I2"><sup>2</sup>
Department of Endodontics, Institute of Dentistry, Zdrave Korde 4, 78000 Banja Luka, Bosnia and Herzegovina</aff>
<aff id="I3"><sup>3</sup>
Department of Periodontology and Oral Medicine, Medical Faculty University of Banja Luka, Bulevar Petra Bojovica 1, 78000 Banja Luka, Bosnia and Herzegovina</aff>
<author-notes><corresp id="cor1">*Verica Pavlic: <email>dr.vericapavlic@gmail.com</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Andrea Scribante</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>27</day>
<month>1</month>
<year>2015</year>
</pub-date>
<volume>2015</volume>
<elocation-id>756976</elocation-id>
<history><date date-type="received"><day>21</day>
<month>11</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>7</day>
<month>1</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>8</day>
<month>1</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 Verica Pavlic et al.</copyright-statement>
<copyright-year>2015</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Amlodipine is a third generation dihydropyridine calcium channel blocker that is frequently used in therapy of hypertension. Among many side effects, amlodipine has been found associated with gingival overgrowth (GO) which usually occurs within the first three months of starting therapy at a dose of 10 mg/day. However, there are very few reports on amlodipine-induced gingival overgrowth (AIGO) at a lower dose (5 mg/day) and only after short term administration. A 64-year-old male patient with hypertension, who received amlodipine (5 mg/day) for four years, sought medical attention at the Department of Periodontology and Oral Medicine, Institute of Dentistry, Banja Luka, Bosnia and Herzegovina. The patient complained of masticatory problems due to extensive maxillary GO along with pain, bleeding, and foul odor. The clinical and the histological evidences were consistent with AIGO. The first line treatment consisted of the amlodipine substitution (amlodipine was replaced with enalapril, 5 mg/day) and the scaling and root planning/SRP. At one-month follow-up, drug replacement and SRP resulted in some reduction of the inflammation and significant reduction of symptoms. Further, gingivectomy/gingivoplasty helped overcome the effect of these drugs. The possibility of AIGO should be considered for a lower dose, as well as a late presentation.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Clinical presentation of generalized diffused gingival overgrowth of upper arch (at patient's first visit).</p>
</caption>
<graphic xlink:href="CRID2015-756976.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Gingival overgrowth one month after therapy (visible regression after amlodipine substitution and SRP).</p>
</caption>
<graphic xlink:href="CRID2015-756976.002"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>Bosnie-Herzégovine</li>
</country>
</list>
<tree><country name="Bosnie-Herzégovine"><noRegion><name sortKey="Pavlic, Verica" sort="Pavlic, Verica" uniqKey="Pavlic V" first="Verica" last="Pavlic">Verica Pavlic</name>
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<name sortKey="Adamovic, Tijana" sort="Adamovic, Tijana" uniqKey="Adamovic T" first="Tijana" last="Adamovic">Tijana Adamovic</name>
<name sortKey="Ilic, Sanja" sort="Ilic, Sanja" uniqKey="Ilic S" first="Sanja" last="Ilic">Sanja Ilic</name>
<name sortKey="Zubovic, Nina" sort="Zubovic, Nina" uniqKey="Zubovic N" first="Nina" last="Zubovic">Nina Zubovic</name>
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