Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls
Identifieur interne : 000799 ( Pmc/Checkpoint ); précédent : 000798; suivant : 000800Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls
Auteurs : Allison Buchanan [États-Unis] ; Ruben Cohen [États-Unis] ; Stephen Looney [États-Unis] ; Sajitha Kalathingal [États-Unis] ; Scott De Rossi [États-Unis]Source :
- Imaging Science in Dentistry [ 2233-7822 ] ; 2016.
Abstract
To evaluate the upper airway dimensions of obstructive sleep apnea (OSA) and control subjects using a cone-beam computed tomography (CBCT) unit commonly applied in clinical practice in order to assess airway dimensions in the same fashion as that routinely employed in a clinical setting.
This was a retrospective analysis utilizing existing CBCT scans to evaluate the dimensions of the upper airway in OSA and control subjects. The CBCT data of sixteen OSA and sixteen control subjects were compared. The average area, average volume, total volume, and total length of the upper airway were computed. Width and anterior-posterior (AP) measurements were obtained on the smallest axial slice.
OSA subjects had a significantly smaller average airway area, average airway volume, total airway volume, and mean airway width. OSA subjects had a significantly larger airway length measurement. The mean A-P distance was not significantly different between groups.
OSA subjects have a smaller upper airway compared to controls with the exception of airway length. The lack of a significant difference in the mean A-P distance may indicate that patient position during imaging (upright vs. supine) can affect this measurement. Comparison of this study with a future prospective study design will allow for validation of these results.
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DOI: 10.5624/isd.2016.46.1.9
PubMed: 27051634
PubMed Central: 4816775
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls</title><author><name sortKey="Buchanan, Allison" sort="Buchanan, Allison" uniqKey="Buchanan A" first="Allison" last="Buchanan">Allison Buchanan</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cohen, Ruben" sort="Cohen, Ruben" uniqKey="Cohen R" first="Ruben" last="Cohen">Ruben Cohen</name><affiliation wicri:level="2"><nlm:aff id="A2">Park Avenue Oral and Facial Surgery, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Park Avenue Oral and Facial Surgery, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kalathingal, Sajitha" sort="Kalathingal, Sajitha" uniqKey="Kalathingal S" first="Sajitha" last="Kalathingal">Sajitha Kalathingal</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="De Rossi, Scott" sort="De Rossi, Scott" uniqKey="De Rossi S" first="Scott" last="De Rossi">Scott De Rossi</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27051634</idno><idno type="pmc">4816775</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816775</idno><idno type="RBID">PMC:4816775</idno><idno type="doi">10.5624/isd.2016.46.1.9</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000637</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000637</idno><idno type="wicri:Area/Pmc/Curation">000637</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000637</idno><idno type="wicri:Area/Pmc/Checkpoint">000799</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000799</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls</title><author><name sortKey="Buchanan, Allison" sort="Buchanan, Allison" uniqKey="Buchanan A" first="Allison" last="Buchanan">Allison Buchanan</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Cohen, Ruben" sort="Cohen, Ruben" uniqKey="Cohen R" first="Ruben" last="Cohen">Ruben Cohen</name><affiliation wicri:level="2"><nlm:aff id="A2">Park Avenue Oral and Facial Surgery, New York, NY, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Park Avenue Oral and Facial Surgery, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Kalathingal, Sajitha" sort="Kalathingal, Sajitha" uniqKey="Kalathingal S" first="Sajitha" last="Kalathingal">Sajitha Kalathingal</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="De Rossi, Scott" sort="De Rossi, Scott" uniqKey="De Rossi S" first="Scott" last="De Rossi">Scott De Rossi</name><affiliation wicri:level="2"><nlm:aff id="A5">Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author></analytic><series><title level="j">Imaging Science in Dentistry</title><idno type="ISSN">2233-7822</idno><idno type="eISSN">2233-7830</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate the upper airway dimensions of obstructive sleep apnea (OSA) and control subjects using a cone-beam computed tomography (CBCT) unit commonly applied in clinical practice in order to assess airway dimensions in the same fashion as that routinely employed in a clinical setting.</p></sec><sec><title>Materials and Methods</title><p>This was a retrospective analysis utilizing existing CBCT scans to evaluate the dimensions of the upper airway in OSA and control subjects. The CBCT data of sixteen OSA and sixteen control subjects were compared. The average area, average volume, total volume, and total length of the upper airway were computed. Width and anterior-posterior (AP) measurements were obtained on the smallest axial slice.</p></sec><sec><title>Results</title><p>OSA subjects had a significantly smaller average airway area, average airway volume, total airway volume, and mean airway width. OSA subjects had a significantly larger airway length measurement. The mean A-P distance was not significantly different between groups.</p></sec><sec><title>Conclusion</title><p>OSA subjects have a smaller upper airway compared to controls with the exception of airway length. The lack of a significant difference in the mean A-P distance may indicate that patient position during imaging (upright vs. supine) can affect this measurement. Comparison of this study with a future prospective study design will allow for validation of these results.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Holty, Je" uniqKey="Holty J">JE Holty</name></author><author><name sortKey="Guilleminault, C" uniqKey="Guilleminault C">C Guilleminault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Susarla, Sm" uniqKey="Susarla S">SM Susarla</name></author><author><name sortKey="Thomas, Rj" uniqKey="Thomas R">RJ Thomas</name></author><author><name sortKey="Abramson, Zr" uniqKey="Abramson Z">ZR Abramson</name></author><author><name sortKey="Kaban, Lb" uniqKey="Kaban L">LB Kaban</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogawa, T" uniqKey="Ogawa T">T Ogawa</name></author><author><name sortKey="Enciso, R" uniqKey="Enciso R">R Enciso</name></author><author><name sortKey="Shintaku, Wh" uniqKey="Shintaku W">WH 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Imaging Sci Dent</journal-id><journal-id journal-id-type="iso-abbrev">Imaging Sci Dent</journal-id><journal-id journal-id-type="publisher-id">ISD</journal-id><journal-title-group><journal-title>Imaging Science in Dentistry</journal-title></journal-title-group><issn pub-type="ppub">2233-7822</issn><issn pub-type="epub">2233-7830</issn><publisher><publisher-name>Korean Academy of Oral and Maxillofacial Radiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27051634</article-id><article-id pub-id-type="pmc">4816775</article-id><article-id pub-id-type="doi">10.5624/isd.2016.46.1.9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Cone-beam CT analysis of patients with obstructive sleep apnea compared to normal controls</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Buchanan</surname><given-names>Allison</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cohen</surname><given-names>Ruben</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Looney</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kalathingal</surname><given-names>Sajitha</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>De Rossi</surname><given-names>Scott</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Division of Radiology, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</aff><aff id="A2"><label>2</label>Park Avenue Oral and Facial Surgery, New York, NY, USA.</aff><aff id="A3"><label>3</label>Department of Biostatistics and Epidemiology, Augusta University Medical College of Georgia, Augusta, GA, USA.</aff><aff id="A4"><label>4</label>Department of Oral Health and Diagnostic Sciences, Georgia Regents University, Dental College of Georgia, Augusta, GA, USA.</aff><aff id="A5"><label>5</label>Division of Oral Medicine, Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA, USA.</aff><author-notes><corresp>Correspondence to: Dr. Allison Buchanan. Department of Oral Health and Diagnostic Sciences, Dental College of Georgia, Augusta University, GC 2248, 1120 15th Street, Augusta, GA 30912 USA. Tel) 1-706-721-2264, Fax) 1-706-721-4937, <email>ahunter@gru.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>24</day><month>3</month><year>2016</year></pub-date><volume>46</volume><issue>1</issue><fpage>9</fpage><lpage>16</lpage><history><date date-type="received"><day>26</day><month>9</month><year>2015</year></date><date date-type="rev-recd"><day>20</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>31</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2016 by Korean Academy of Oral and Maxillofacial Radiology</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>To evaluate the upper airway dimensions of obstructive sleep apnea (OSA) and control subjects using a cone-beam computed tomography (CBCT) unit commonly applied in clinical practice in order to assess airway dimensions in the same fashion as that routinely employed in a clinical setting.</p></sec><sec><title>Materials and Methods</title><p>This was a retrospective analysis utilizing existing CBCT scans to evaluate the dimensions of the upper airway in OSA and control subjects. The CBCT data of sixteen OSA and sixteen control subjects were compared. The average area, average volume, total volume, and total length of the upper airway were computed. Width and anterior-posterior (AP) measurements were obtained on the smallest axial slice.</p></sec><sec><title>Results</title><p>OSA subjects had a significantly smaller average airway area, average airway volume, total airway volume, and mean airway width. OSA subjects had a significantly larger airway length measurement. The mean A-P distance was not significantly different between groups.</p></sec><sec><title>Conclusion</title><p>OSA subjects have a smaller upper airway compared to controls with the exception of airway length. The lack of a significant difference in the mean A-P distance may indicate that patient position during imaging (upright vs. supine) can affect this measurement. Comparison of this study with a future prospective study design will allow for validation of these results.</p></sec></abstract><kwd-group><kwd>Sleep Apnea, Obstructive</kwd><kwd>Cone-Beam Computed Tomography</kwd><kwd>Sleep Apnea Syndromes</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Red area indicates the segmented airway with three-dimensional reconstruction.</title></caption><graphic xlink:href="isd-46-9-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>Linear measurements acquired on an obstructive sleep apnea subject. A. Sagittal view denoting the location of the smallest cross-sectional slice. B. Anterior-posterior distance, measured on the axial image. C. Width (lateral), measured on the axial image.</title></caption><graphic xlink:href="isd-46-9-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label><caption><title>Comparison of airway width (lateral) between an obstructive sleep apnea (OSA) and a control subject. A. Axial image of an OSA subject depicting the segmented slice. B. Three-dimensional reconstruction of the airway of the OSA subject pictured in A, pictured from the posterior (coronal) view. C. Axial image of a control subject depicting the segmented slice. D. Three-dimensional reconstruction of the airway of a control subject pictured in C. The 3-dimensional reconstruction is pictured from the posterior view of the airway (coronal view).</title></caption><graphic xlink:href="isd-46-9-g003"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Structural and non-structural risk factors for obstructive sleep apnea</title></caption><graphic xlink:href="isd-46-9-i001"></graphic></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title>Gender, age and linear measurements of width and anterior-posterior (A-P) distance in subjects with obstructive sleep apnea</title></caption><graphic xlink:href="isd-46-9-i002"></graphic><table-wrap-foot><fn><p><sup>*</sup>Obstructive sleep apnea subjects,±Value for smallest axial slice</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><title>Gender, age, and linear measurements of width and anterior-posterior (A-P) distance for control subjects</title></caption><graphic xlink:href="isd-46-9-i003"></graphic><table-wrap-foot><fn><p><sup>*</sup>Control subjects,±Value for smallest axial slice</p></fn></table-wrap-foot></table-wrap><table-wrap id="T4" orientation="portrait" position="float"><label>Table 4</label><caption><title>Width, A-P distance, area, volume, and airway length in obstructive sleep apnea (OSA) and control subjects</title></caption><graphic xlink:href="isd-46-9-i004"></graphic></table-wrap></floats-group></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Buchanan, Allison" sort="Buchanan, Allison" uniqKey="Buchanan A" first="Allison" last="Buchanan">Allison Buchanan</name></region><name sortKey="Cohen, Ruben" sort="Cohen, Ruben" uniqKey="Cohen R" first="Ruben" last="Cohen">Ruben Cohen</name><name sortKey="De Rossi, Scott" sort="De Rossi, Scott" uniqKey="De Rossi S" first="Scott" last="De Rossi">Scott De Rossi</name><name sortKey="Kalathingal, Sajitha" sort="Kalathingal, Sajitha" uniqKey="Kalathingal S" first="Sajitha" last="Kalathingal">Sajitha Kalathingal</name><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name><name sortKey="Looney, Stephen" sort="Looney, Stephen" uniqKey="Looney S" first="Stephen" last="Looney">Stephen Looney</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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