In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(l-lactic acid) nanoparticles on microarc-oxidized titanium implants
Identifieur interne : 000642 ( Pmc/Checkpoint ); précédent : 000641; suivant : 000643In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(l-lactic acid) nanoparticles on microarc-oxidized titanium implants
Auteurs : Yicheng Cheng [République populaire de Chine] ; Bo Gao [République populaire de Chine] ; Xianghui Liu [République populaire de Chine] ; Xianghui Zhao [République populaire de Chine] ; Weige Sun [République populaire de Chine] ; Huifang Ren [République populaire de Chine] ; Jiang Wu [République populaire de Chine]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2016.
Abstract
To prevent peri-implant infection, a new antibacterial coating containing a halogenated furanone compound, (
Url:
DOI: 10.2147/IJN.S100763
PubMed: 27099494
PubMed Central: 4821396
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(<sc>l</sc>-lactic acid) nanoparticles on microarc-oxidized titanium implants</title><author><name sortKey="Cheng, Yicheng" sort="Cheng, Yicheng" uniqKey="Cheng Y" first="Yicheng" last="Cheng">Yicheng Cheng</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-1337">Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Bo" sort="Gao, Bo" uniqKey="Gao B" first="Bo" last="Gao">Bo Gao</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xianghui" sort="Liu, Xianghui" uniqKey="Liu X" first="Xianghui" last="Liu">Xianghui Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-1337">Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Xianghui" sort="Zhao, Xianghui" uniqKey="Zhao X" first="Xianghui" last="Zhao">Xianghui Zhao</name><affiliation wicri:level="1"><nlm:aff id="af4-ijn-11-1337">Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Weige" sort="Sun, Weige" uniqKey="Sun W" first="Weige" last="Sun">Weige Sun</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-1337">Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Huifang" sort="Ren, Huifang" uniqKey="Ren H" first="Huifang" last="Ren">Huifang Ren</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27099494</idno><idno type="pmc">4821396</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821396</idno><idno type="RBID">PMC:4821396</idno><idno type="doi">10.2147/IJN.S100763</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000646</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000646</idno><idno type="wicri:Area/Pmc/Curation">000646</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000646</idno><idno type="wicri:Area/Pmc/Checkpoint">000642</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000642</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(<sc>l</sc>-lactic acid) nanoparticles on microarc-oxidized titanium implants</title><author><name sortKey="Cheng, Yicheng" sort="Cheng, Yicheng" uniqKey="Cheng Y" first="Yicheng" last="Cheng">Yicheng Cheng</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-1337">Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Bo" sort="Gao, Bo" uniqKey="Gao B" first="Bo" last="Gao">Bo Gao</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xianghui" sort="Liu, Xianghui" uniqKey="Liu X" first="Xianghui" last="Liu">Xianghui Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-1337">Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Xianghui" sort="Zhao, Xianghui" uniqKey="Zhao X" first="Xianghui" last="Zhao">Xianghui Zhao</name><affiliation wicri:level="1"><nlm:aff id="af4-ijn-11-1337">Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Weige" sort="Sun, Weige" uniqKey="Sun W" first="Weige" last="Sun">Weige Sun</name><affiliation wicri:level="1"><nlm:aff id="af2-ijn-11-1337">Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing</wicri:regionArea><wicri:noRegion>Nanjing</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Huifang" sort="Ren, Huifang" uniqKey="Ren H" first="Huifang" last="Ren">Huifang Ren</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><affiliation wicri:level="1"><nlm:aff id="af1-ijn-11-1337">Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ijn-11-1337">Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an</wicri:regionArea><wicri:noRegion>Xi’an</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>To prevent peri-implant infection, a new antibacterial coating containing a halogenated furanone compound, (<italic>Z</italic>-)-4-bromo-5-(bromomethylene)-2(5<italic>H</italic>)-furanone-loaded poly(<sc>l</sc>-lactic acid) nanoparticles, has been fabricated. The current study was designed to evaluate the preventive effect of the antibacterial coating under a simulated environment of peri-implant infection in vivo. Microarc-oxidized titanium implants treated with minocycline hydrochloride ointment were used as positive control group, and microarc-oxidized titanium implants without any treatment were used as blank control group. Three kinds of implants were implanted in dogs’ mandibles, and the peri-implant infection was simulated by silk ligation and feeding high sugar diet. After 2-month implantation, the results showed that no significant differences were detected between the experimental and positive control groups (<italic>P</italic>>0.05), but the data of clinical measurements of the blank control group were significantly higher than those of the other two groups (<italic>P</italic><0.05), and the bone–implant contact rate and ultimate interfacial strength were significantly lower than those of the other two groups (<italic>P</italic><0.05). Scanning electron microscope observation and histological examination showed that more new bone was formed on the surface of the experimental and positive control groups. It can be concluded that the antibacterial coating fabricated on implants has remarkable preventive effect on peri-implant infection at the early stage.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferrigno, N" uniqKey="Ferrigno N">N Ferrigno</name></author><author><name sortKey="Laureti, M" uniqKey="Laureti M">M Laureti</name></author><author><name sortKey="Fanali, S" uniqKey="Fanali S">S Fanali</name></author><author><name sortKey="Grippaudo, G" uniqKey="Grippaudo G">G Grippaudo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simonis, P" uniqKey="Simonis P">P Simonis</name></author><author><name sortKey="Dufour, T" uniqKey="Dufour T">T Dufour</name></author><author><name sortKey="Tenenbaum, H" uniqKey="Tenenbaum H">H Tenenbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palma Carrio, C" uniqKey="Palma Carrio C">C 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Nanomedicine</journal-id><journal-id journal-id-type="iso-abbrev">Int J Nanomedicine</journal-id><journal-id journal-id-type="publisher-id">International Journal of Nanomedicine</journal-id><journal-title-group><journal-title>International Journal of Nanomedicine</journal-title></journal-title-group><issn pub-type="ppub">1176-9114</issn><issn pub-type="epub">1178-2013</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27099494</article-id><article-id pub-id-type="pmc">4821396</article-id><article-id pub-id-type="doi">10.2147/IJN.S100763</article-id><article-id pub-id-type="publisher-id">ijn-11-1337</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(<sc>l</sc>-lactic acid) nanoparticles on microarc-oxidized titanium implants</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Yicheng</given-names></name><xref ref-type="aff" rid="af1-ijn-11-1337">1</xref><xref ref-type="aff" rid="af2-ijn-11-1337">2</xref><xref ref-type="aff" rid="af3-ijn-11-1337">3</xref><xref ref-type="author-notes" rid="fn1-ijn-11-1337">*</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Bo</given-names></name><xref ref-type="aff" rid="af1-ijn-11-1337">1</xref><xref ref-type="aff" rid="af3-ijn-11-1337">3</xref><xref ref-type="author-notes" rid="fn1-ijn-11-1337">*</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Xianghui</given-names></name><xref ref-type="aff" rid="af2-ijn-11-1337">2</xref><xref ref-type="author-notes" rid="fn1-ijn-11-1337">*</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Xianghui</given-names></name><xref ref-type="aff" rid="af4-ijn-11-1337">4</xref></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Weige</given-names></name><xref ref-type="aff" rid="af2-ijn-11-1337">2</xref></contrib><contrib contrib-type="author"><name><surname>Ren</surname><given-names>Huifang</given-names></name><xref ref-type="aff" rid="af1-ijn-11-1337">1</xref><xref ref-type="aff" rid="af3-ijn-11-1337">3</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Jiang</given-names></name><xref ref-type="aff" rid="af1-ijn-11-1337">1</xref><xref ref-type="aff" rid="af3-ijn-11-1337">3</xref><xref ref-type="corresp" rid="c1-ijn-11-1337"></xref></contrib></contrib-group><aff id="af1-ijn-11-1337"><label>1</label>Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, People’s Republic of China</aff><aff id="af2-ijn-11-1337"><label>2</label>Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China</aff><aff id="af3-ijn-11-1337"><label>3</label>Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, People’s Republic of China</aff><aff id="af4-ijn-11-1337"><label>4</label>Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an, People’s Republic of China</aff><author-notes><corresp id="c1-ijn-11-1337">Correspondence: Jiang Wu, Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, No 145, West Changle Road, Xi’an, Shaanxi 710032, People’s Republic of China, Tel/fax +86 29 8477 6469, Email <email>wujiang@fmmu.edu.cn</email></corresp><fn id="fn1-ijn-11-1337"><label>*</label><p>These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>3</month><year>2016</year></pub-date><volume>11</volume><fpage>1337</fpage><lpage>1347</lpage><permissions><copyright-statement>© 2016 Cheng et al. This work is published and licensed by Dove Medical Press Limited</copyright-statement><copyright-year>2016</copyright-year><license><license-p>The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><p>To prevent peri-implant infection, a new antibacterial coating containing a halogenated furanone compound, (<italic>Z</italic>-)-4-bromo-5-(bromomethylene)-2(5<italic>H</italic>)-furanone-loaded poly(<sc>l</sc>-lactic acid) nanoparticles, has been fabricated. The current study was designed to evaluate the preventive effect of the antibacterial coating under a simulated environment of peri-implant infection in vivo. Microarc-oxidized titanium implants treated with minocycline hydrochloride ointment were used as positive control group, and microarc-oxidized titanium implants without any treatment were used as blank control group. Three kinds of implants were implanted in dogs’ mandibles, and the peri-implant infection was simulated by silk ligation and feeding high sugar diet. After 2-month implantation, the results showed that no significant differences were detected between the experimental and positive control groups (<italic>P</italic>>0.05), but the data of clinical measurements of the blank control group were significantly higher than those of the other two groups (<italic>P</italic><0.05), and the bone–implant contact rate and ultimate interfacial strength were significantly lower than those of the other two groups (<italic>P</italic><0.05). Scanning electron microscope observation and histological examination showed that more new bone was formed on the surface of the experimental and positive control groups. It can be concluded that the antibacterial coating fabricated on implants has remarkable preventive effect on peri-implant infection at the early stage.</p></abstract><kwd-group><title>Keywords</title><kwd>antibacterial coating</kwd><kwd>halogenated furanone</kwd><kwd>microarc-oxidized</kwd><kwd>nanoparticles</kwd><kwd>in vivo</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-ijn-11-1337" position="float"><label>Figure 1</label><caption><p>Procedures of the pull-out test.</p><p><bold>Notes:</bold> (<bold>A</bold>) The implant–bone blocks were embedded in poly(methyl methacrylate) resin, (<bold>B</bold>) the sample was fixed in a tensile test box, and (<bold>C</bold>) the box was stabilized in the electronic universal material test machine.</p></caption><graphic xlink:href="ijn-11-1337Fig1"></graphic></fig><fig id="f2-ijn-11-1337" position="float"><label>Figure 2</label><caption><p>Characterization of BBF-loaded PLLA nanoparticles.</p><p><bold>Notes:</bold> (<bold>A</bold>) Scanning electron microscope image at low magnification, (<bold>B</bold>) scanning electron microscope image at high magnification, and (<bold>C</bold>) size distribution.</p><p><bold>Abbreviations:</bold> BBF, (<italic>Z</italic>-)-4-bromo-5-(bromomethylene)-2(5<italic>H</italic>)-furanone; PLLA, poly(<sc>l</sc>-lactic acid).</p></caption><graphic xlink:href="ijn-11-1337Fig2"></graphic></fig><fig id="f3-ijn-11-1337" position="float"><label>Figure 3</label><caption><p>Surface morphology observed by scanning electron microscope.</p><p><bold>Notes:</bold> (<bold>A</bold>) Smooth Ti implant, (<bold>B</bold>) MAO-treated Ti implants, and (<bold>C</bold>) the antibacterial coating.</p><p><bold>Abbreviations:</bold> Ti, titanium; MAO, microarc-oxidized.</p></caption><graphic xlink:href="ijn-11-1337Fig3"></graphic></fig><fig id="f4-ijn-11-1337" position="float"><label>Figure 4</label><caption><p>X-ray radiographs.</p><p><bold>Notes:</bold> (<bold>A</bold>) The mandible third premolars before extraction, (<bold>B</bold>) implants after implantation immediately, (<bold>C</bold>) experimental group after 2-month implantation, (<bold>D</bold>) positive control group after 2-month implantation, and (<bold>E</bold>) and (<bold>F</bold>) blank control group after 2-month implantation. The arrows show the shadow around the implants.</p></caption><graphic xlink:href="ijn-11-1337Fig4"></graphic></fig><fig id="f5-ijn-11-1337" position="float"><label>Figure 5</label><caption><p>Scanning electron microscope images of polished cross-sections of the implants in bone of different groups after 2-month implantation.</p><p><bold>Notes:</bold> (<bold>A</bold>) Experimental group, (<bold>B</bold>) positive control group, and (<bold>C</bold>) blank control group.</p><p><bold>Abbreviation:</bold> Ti, titanium.</p></caption><graphic xlink:href="ijn-11-1337Fig5"></graphic></fig><fig id="f6-ijn-11-1337" position="float"><label>Figure 6</label><caption><p>Van Gieson’s staining images of polished cross-sections of the implants in bone of different groups after 2-month implantation.</p><p><bold>Notes:</bold> (<bold>A</bold>) Experimental group, (<bold>B</bold>) positive control group, and (<bold>C</bold>) blank control group. The arrows show the fibrous connective tissue.</p></caption><graphic xlink:href="ijn-11-1337Fig6"></graphic></fig><fig id="f7-ijn-11-1337" position="float"><label>Figure 7</label><caption><p>Bone–implant contact (BIC, %) rate of different groups after 2-month implantation measured by image analysis techniques.</p><p><bold>Note:</bold> *<italic>P</italic><0.05.</p></caption><graphic xlink:href="ijn-11-1337Fig7"></graphic></fig><fig id="f8-ijn-11-1337" position="float"><label>Figure 8</label><caption><p>Pull-out strength of different groups after 2-month implantation.</p><p><bold>Note:</bold> *<italic>P</italic><0.05.</p></caption><graphic xlink:href="ijn-11-1337Fig8"></graphic></fig><fig id="f9-ijn-11-1337" position="float"><label>Figure 9</label><caption><p>Scanning electron microscope images of the bone–implant interface of different groups after the pulled-out test.</p><p><bold>Notes:</bold> (<bold>A</bold>) Experimental group, (<bold>B</bold>) positive control group, and (<bold>C</bold>) blank control group.</p></caption><graphic xlink:href="ijn-11-1337Fig9"></graphic></fig><table-wrap id="t1-ijn-11-1337" position="float"><label>Table 1</label><caption><p>Clinical measurements for different groups after 2-month implantation (<italic>x</italic>±<italic>s</italic>)</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Groups</th><th valign="top" align="left" rowspan="1" colspan="1">PD (mm)</th><th valign="top" align="left" rowspan="1" colspan="1">PISF (µL)</th><th valign="top" align="left" rowspan="1" colspan="1">MOI</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Experimental group</td><td valign="top" align="left" rowspan="1" colspan="1">2.65±0.26</td><td valign="top" align="left" rowspan="1" colspan="1">0.96±0.14</td><td valign="top" align="left" rowspan="1" colspan="1">2.22±0.58</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Positive control group</td><td valign="top" align="left" rowspan="1" colspan="1">2.78±0.30</td><td valign="top" align="left" rowspan="1" colspan="1">0.89±0.15</td><td valign="top" align="left" rowspan="1" colspan="1">2.51±0.64</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Blank control group</td><td valign="top" align="left" rowspan="1" colspan="1">4.50±0.41<xref ref-type="table-fn" rid="tfn1-ijn-11-1337">*</xref></td><td valign="top" align="left" rowspan="1" colspan="1">1.72±0.25<xref ref-type="table-fn" rid="tfn1-ijn-11-1337">*</xref></td><td valign="top" align="left" rowspan="1" colspan="1">5.43±0.65<xref ref-type="table-fn" rid="tfn1-ijn-11-1337">*</xref></td></tr></tbody></table><table-wrap-foot><fn><p><bold>Note:</bold></p></fn><fn id="tfn1-ijn-11-1337"><label>*</label><p><italic>P</italic><0.05.</p></fn><fn id="tfn2-ijn-11-1337"><p><bold>Abbreviations:</bold> PD, probing depth; PISF, peri-implant sulcular fluid; MOI, mobility of implants.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cheng, Yicheng" sort="Cheng, Yicheng" uniqKey="Cheng Y" first="Yicheng" last="Cheng">Yicheng Cheng</name></noRegion><name sortKey="Cheng, Yicheng" sort="Cheng, Yicheng" uniqKey="Cheng Y" first="Yicheng" last="Cheng">Yicheng Cheng</name><name sortKey="Cheng, Yicheng" sort="Cheng, Yicheng" uniqKey="Cheng Y" first="Yicheng" last="Cheng">Yicheng Cheng</name><name sortKey="Gao, Bo" sort="Gao, Bo" uniqKey="Gao B" first="Bo" last="Gao">Bo Gao</name><name sortKey="Gao, Bo" sort="Gao, Bo" uniqKey="Gao B" first="Bo" last="Gao">Bo Gao</name><name sortKey="Liu, Xianghui" sort="Liu, Xianghui" uniqKey="Liu X" first="Xianghui" last="Liu">Xianghui Liu</name><name sortKey="Ren, Huifang" sort="Ren, Huifang" uniqKey="Ren H" first="Huifang" last="Ren">Huifang Ren</name><name sortKey="Ren, Huifang" sort="Ren, Huifang" uniqKey="Ren H" first="Huifang" last="Ren">Huifang Ren</name><name sortKey="Sun, Weige" sort="Sun, Weige" uniqKey="Sun W" first="Weige" last="Sun">Weige Sun</name><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><name sortKey="Wu, Jiang" sort="Wu, Jiang" uniqKey="Wu J" first="Jiang" last="Wu">Jiang Wu</name><name sortKey="Zhao, Xianghui" sort="Zhao, Xianghui" uniqKey="Zhao X" first="Xianghui" last="Zhao">Xianghui Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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