Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann’s Thrombasthenia with Chronic Gingival Bleed: Case Report
Identifieur interne : 000385 ( Pmc/Checkpoint ); précédent : 000384; suivant : 000386Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann’s Thrombasthenia with Chronic Gingival Bleed: Case Report
Auteurs : Abhishek Ghosh ; Saurabh Kumar ; Rabin Chacko ; Arun Paul CharluSource :
- Journal of Clinical and Diagnostic Research : JCDR [ 2249-782X ] ; 2016.
Abstract
Glanzmann’s Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder affecting the megakaryocyte lineage and is characterized by lack of platelet aggregation on stimulation. The molecular basis is linked to quantitative and qualitative abnormalities of αIIbβ3 integrin. Most of the patients with severe Glanzmann’s thrombasthenia have spontaneous gum bleeding and persistent low haemoglobin levels. Often these patients are addressed with local haemostatic measures and platelet coverage. We report a case of a severe Glanzmann’s thrombasthenia with chronic gingivitis and associated spontaneous gum bleed with chronic low haemoglobin levels, managed subsequently with total dental extraction under appropriate platelet and recombinant factor VIIa coverage. Further follow up of the patient substantiated the treatment protocol with increased and stable haemoglobin levels, thus emphasizing the need for total dental extraction in patients with severe Glanzmann’s with chronic spontaneous gum bleed, as a definitive treatment option, which has not been reported so far in the literature.
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DOI: 10.7860/JCDR/2016/16383.7123
PubMed: 26894187
PubMed Central: 4740716
Affiliations:
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The molecular basis is linked to quantitative and qualitative abnormalities of αIIbβ3 integrin. Most of the patients with severe Glanzmann’s thrombasthenia have spontaneous gum bleeding and persistent low haemoglobin levels. Often these patients are addressed with local haemostatic measures and platelet coverage. We report a case of a severe Glanzmann’s thrombasthenia with chronic gingivitis and associated spontaneous gum bleed with chronic low haemoglobin levels, managed subsequently with total dental extraction under appropriate platelet and recombinant factor VIIa coverage. Further follow up of the patient substantiated the treatment protocol with increased and stable haemoglobin levels, thus emphasizing the need for total dental extraction in patients with severe Glanzmann’s with chronic spontaneous gum bleed, as a definitive treatment option, which has not been reported so far in the literature.</p></div></front></TEI><pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Diagn Res</journal-id><journal-id journal-id-type="iso-abbrev">J Clin Diagn Res</journal-id><journal-id journal-id-type="hwp">Journal of Clinical and Diagnostic Research</journal-id><journal-id journal-id-type="publisher-id">JCDR</journal-id><journal-title-group><journal-title>Journal of Clinical and Diagnostic Research : JCDR</journal-title></journal-title-group><issn pub-type="ppub">2249-782X</issn><issn pub-type="epub">0973-709X</issn><publisher><publisher-name>JCDR Research and Publications (P) Limited</publisher-name><publisher-loc>Delhi, India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26894187</article-id><article-id pub-id-type="pmc">4740716</article-id><article-id pub-id-type="doi">10.7860/JCDR/2016/16383.7123</article-id><article-categories><subj-group subj-group-type="heading"><subject>Dentistry Section</subject><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></subj-group></article-categories><title-group><article-title>Total Extraction as a Treatment for Anaemia in a Patient of Glanzmann’s Thrombasthenia with Chronic Gingival Bleed: Case Report</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ghosh</surname><given-names>Abhishek</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Kumar</surname><given-names>Saurabh</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Chacko</surname><given-names>Rabin</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Charlu</surname><given-names>Arun Paul</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib></contrib-group><aff id="aff1"><label>1</label> Fellow, Head and Neck Oncology,<institution>HCG Cancer Centre</institution>,<addr-line>(Previously Fellow at CMC Vellore), Ahmedabad, India</addr-line>.</aff><aff id="aff2"><label>2</label> Assistant Professor, Department of Oral and Maxillofaical Surgery,<institution>Christian Medical College and Hospital</institution>,<addr-line>Vellore, Tamil Nadu, India</addr-line>.</aff><aff id="aff3"><label>3</label> Head of Department Unit I, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>,<addr-line>Vellore, Tamil Nadu, India</addr-line>.</aff><aff id="aff4"><label>4</label> Associate Professor, Department of Oral and Maxillofacial Surgery,<institution>Christian Medical College and Hospital</institution>,<addr-line>Vellore, Tamil Nadu, India</addr-line>.</aff><author-notes><corresp id="cor1">NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Abhishek Ghosh, HCG Cancer Centre Sola-Science City Road, Off S.G. Highway, Sola, Ahmedabad, Gujarat-380060, India. E-mail : <email>13abhishekghosh@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>01</day><month>1</month><year>2016</year></pub-date><volume>10</volume><issue>1</issue><fpage>ZD11</fpage><lpage>ZD12</lpage><history><date date-type="received"><day>21</day><month>8</month><year>2015</year></date><date date-type="rev-request"><day>10</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>02</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© 2016 Journal of Clinical and Diagnostic Research</copyright-statement><copyright-year>2016</copyright-year></permissions><abstract><p>Glanzmann’s Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder affecting the megakaryocyte lineage and is characterized by lack of platelet aggregation on stimulation. The molecular basis is linked to quantitative and qualitative abnormalities of αIIbβ3 integrin. Most of the patients with severe Glanzmann’s thrombasthenia have spontaneous gum bleeding and persistent low haemoglobin levels. Often these patients are addressed with local haemostatic measures and platelet coverage. We report a case of a severe Glanzmann’s thrombasthenia with chronic gingivitis and associated spontaneous gum bleed with chronic low haemoglobin levels, managed subsequently with total dental extraction under appropriate platelet and recombinant factor VIIa coverage. Further follow up of the patient substantiated the treatment protocol with increased and stable haemoglobin levels, thus emphasizing the need for total dental extraction in patients with severe Glanzmann’s with chronic spontaneous gum bleed, as a definitive treatment option, which has not been reported so far in the literature.</p></abstract><kwd-group><kwd>αIIbβ3 deficiency</kwd><kwd>Platelet disorder</kwd><kwd>Recombinant factor VIIa</kwd><kwd>Spontaneous gingival hemorrhage</kwd><kwd>Total extraction</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Chacko, Rabin" sort="Chacko, Rabin" uniqKey="Chacko R" first="Rabin" last="Chacko">Rabin Chacko</name><name sortKey="Charlu, Arun Paul" sort="Charlu, Arun Paul" uniqKey="Charlu A" first="Arun Paul" last="Charlu">Arun Paul Charlu</name><name sortKey="Ghosh, Abhishek" sort="Ghosh, Abhishek" uniqKey="Ghosh A" first="Abhishek" last="Ghosh">Abhishek Ghosh</name><name sortKey="Kumar, Saurabh" sort="Kumar, Saurabh" uniqKey="Kumar S" first="Saurabh" last="Kumar">Saurabh Kumar</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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