Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an in vitro study
Identifieur interne : 000245 ( Pmc/Checkpoint ); précédent : 000244; suivant : 000246Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an in vitro study
Auteurs : D. Lauritano [Italie] ; C. A. Bignozzi [Italie] ; D. Pazzi [Italie] ; F. Cura [Italie] ; F. Carinci [Italie]Source :
- Oral & Implantology [ 1974-5648 ] ; 2017.
Abstract
Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.
In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an
Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.
Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified
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DOI: 10.11138/orl/2017.10.1.001
PubMed: 28757930
PubMed Central: 5516421
Affiliations:
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Bignozzi</name><affiliation wicri:level="1"><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Pazzi, D" sort="Pazzi, D" uniqKey="Pazzi D" first="D." last="Pazzi">D. Pazzi</name><affiliation wicri:level="1"><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Cura, F" sort="Cura, F" uniqKey="Cura F" first="F." last="Cura">F. Cura</name><affiliation wicri:level="1"><nlm:aff id="af3-1-10">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, F" sort="Carinci, F" uniqKey="Carinci F" first="F." last="Carinci">F. Carinci</name><affiliation wicri:level="1"><nlm:aff id="af4-1-10">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28757930</idno><idno type="pmc">5516421</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516421</idno><idno type="RBID">PMC:5516421</idno><idno type="doi">10.11138/orl/2017.10.1.001</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002534</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002534</idno><idno type="wicri:Area/Pmc/Curation">002534</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002534</idno><idno type="wicri:Area/Pmc/Checkpoint">000245</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000245</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an <italic>in vitro</italic> study</title><author><name sortKey="Lauritano, D" sort="Lauritano, D" uniqKey="Lauritano D" first="D." last="Lauritano">D. Lauritano</name><affiliation wicri:level="1"><nlm:aff id="af1-1-10">Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza</wicri:regionArea><wicri:noRegion>Monza</wicri:noRegion></affiliation></author><author><name sortKey="Bignozzi, C A" sort="Bignozzi, C A" uniqKey="Bignozzi C" first="C. A." last="Bignozzi">C. A. Bignozzi</name><affiliation wicri:level="1"><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Pazzi, D" sort="Pazzi, D" uniqKey="Pazzi D" first="D." last="Pazzi">D. Pazzi</name><affiliation wicri:level="1"><nlm:aff id="af2-1-10">Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Cura, F" sort="Cura, F" uniqKey="Cura F" first="F." last="Cura">F. Cura</name><affiliation wicri:level="1"><nlm:aff id="af3-1-10">Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, F" sort="Carinci, F" uniqKey="Carinci F" first="F." last="Carinci">F. Carinci</name><affiliation wicri:level="1"><nlm:aff id="af4-1-10">Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oral & Implantology</title><idno type="ISSN">1974-5648</idno><idno type="eISSN">2035-2468</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><sec><title>Background</title><p>Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.</p></sec><sec><title>Purpose</title><p>In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an <italic>in vitro</italic> model.</p></sec><sec><title>Materials and methods</title><p>Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.</p></sec><sec><title>Results and conclusions</title><p>Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified <italic>Tannerella forsythia</italic> (TF) and <italic>Porphyromonas Gingivalis</italic> (PG), leads to the conclusion that the coating is capable of inactivating the microbial species penetrating the internal of the implant through the implant abutment junction.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oral Implantol (Rome)</journal-id><journal-id journal-id-type="iso-abbrev">Oral Implantol (Rome)</journal-id><journal-id journal-id-type="publisher-id">OAI</journal-id><journal-title-group><journal-title>Oral & Implantology</journal-title></journal-title-group><issn pub-type="ppub">1974-5648</issn><issn pub-type="epub">2035-2468</issn><publisher><publisher-name>CIC Edizioni Internazionali</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28757930</article-id><article-id pub-id-type="pmc">5516421</article-id><article-id pub-id-type="doi">10.11138/orl/2017.10.1.001</article-id><article-id pub-id-type="publisher-id">1-10</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research Article</subject></subj-group></article-categories><title-group><article-title>Efficacy of a new coating of implant-abutment connections in reducing bacterial loading: an <italic>in vitro</italic> study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>LAURITANO</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="af1-1-10">1</xref></contrib><contrib contrib-type="author"><name><surname>BIGNOZZI</surname><given-names>C.A.</given-names></name><xref ref-type="aff" rid="af2-1-10">2</xref></contrib><contrib contrib-type="author"><name><surname>PAZZI</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="af2-1-10">2</xref></contrib><contrib contrib-type="author"><name><surname>CURA</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="af3-1-10">3</xref></contrib><contrib contrib-type="author"><name><surname>CARINCI</surname><given-names>F.</given-names></name><xref ref-type="aff" rid="af4-1-10">4</xref><xref ref-type="corresp" rid="c1-1-10"></xref></contrib></contrib-group><aff id="af1-1-10"><label>1</label>Department of Translational Medicine and Surgery, Neuroscience Center of Milan, University of Milano Bicocca, Monza, Italy</aff><aff id="af2-1-10"><label>2</label>Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Ferrara, Italy</aff><aff id="af3-1-10"><label>3</label>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy</aff><aff id="af4-1-10"><label>4</label>Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy</aff><author-notes><corresp id="c1-1-10">Correspondence to: Prof. Francesco Carinci, MD, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy, Phone/Fax: +39.0532.455582, E-mail: <email>crc@unife.it</email>, web: <ext-link ext-link-type="uri" xlink:href="www.carinci.org">www.carinci.org</ext-link></corresp></author-notes><pub-date pub-type="collection"><season>Jan-Mar</season><year>2017</year></pub-date><pub-date pub-type="epub"><day>10</day><month>4</month><year>2017</year></pub-date><volume>10</volume><issue>1</issue><fpage>1</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright © 2017, CIC Edizioni Internazionali</copyright-statement><copyright-year>2017</copyright-year></permissions><abstract><title>SUMMARY</title><sec><title>Background</title><p>Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection.</p></sec><sec><title>Purpose</title><p>In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an <italic>in vitro</italic> model.</p></sec><sec><title>Materials and methods</title><p>Twenty implants were coated in the internal chamber with PXT and twenty were used as controls.</p></sec><sec><title>Results and conclusions</title><p>Ten of the coated implants, preliminarily tested against Gram positive and negative bacteria and fungi, showed a complete inactivation of the microbial species after a 15 min contact. On the remaining ten treated implants a series of microbiological tests and PCR analysis, after contamination of the implant external medium, in which the implant have been immersed, with genetic modified <italic>Tannerella forsythia</italic> (TF) and <italic>Porphyromonas Gingivalis</italic> (PG), leads to the conclusion that the coating is capable of inactivating the microbial species penetrating the internal of the implant through the implant abutment junction.</p></sec></abstract><kwd-group><kwd>implant-abutment connection</kwd><kwd>antimicrobial siloxane coating</kwd><kwd>peri-implantitis</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Lauritano, D" sort="Lauritano, D" uniqKey="Lauritano D" first="D." last="Lauritano">D. Lauritano</name></noRegion><name sortKey="Bignozzi, C A" sort="Bignozzi, C A" uniqKey="Bignozzi C" first="C. A." last="Bignozzi">C. A. Bignozzi</name><name sortKey="Carinci, F" sort="Carinci, F" uniqKey="Carinci F" first="F." last="Carinci">F. Carinci</name><name sortKey="Cura, F" sort="Cura, F" uniqKey="Cura F" first="F." last="Cura">F. Cura</name><name sortKey="Pazzi, D" sort="Pazzi, D" uniqKey="Pazzi D" first="D." last="Pazzi">D. Pazzi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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