The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin
Identifieur interne : 000035 ( Pmc/Checkpoint ); précédent : 000034; suivant : 000036The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin
Auteurs : Yu Zhang ; Yin-Yan Chen ; Li Huang ; Zhi-Guo Chai ; Li-Juan Shen ; Yu-Hong Xiao [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on
Url:
DOI: 10.1038/s41598-017-01686-4
PubMed: 28484255
PubMed Central: 5431568
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin</title>
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<front><div type="abstract" xml:lang="en"><p>Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on <italic>Candida albicans</italic>
ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties of a silver bromide/cationic polymer nano-composite (AgBr/NPVP)-modified PMMA-based dental resin. AgBr/NPVP was added to the PMMA resin at 0.1, 0.2, and 0.3 wt%, and PMMA resin without AgBr/NPVP served as the control. Fungal growth was inhibited on the AgBr/NPVP-modified PMMA resin compared to the control (P < 0.05), and the antifungal activity increased as the incorporation of the AgBr/NPVP antimicrobial composite increased. Confocal laser scanning microscopy (CLSM) showed that the number of fungal cells attached to the modified PMMA resin was considerably lower than in the control. The relative growth rate of HDPCs of modified groups were higher than 75%. The flexural strength (FS) and flexural modulus (FM) were not significantly different (P > 0.05) between the experimental and control groups. These data indicate that the incorporation of AgBr/NPVP conferred strong and long-lasting antifungal effects against <italic>Candida albicans</italic>
to the PMMA resin, and it has low toxicity toward HDPCs, and its mechanical properties were not significantly affected.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id>
<journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id>
<journal-title-group><journal-title>Scientific Reports</journal-title>
</journal-title-group>
<issn pub-type="epub">2045-2322</issn>
<publisher><publisher-name>Nature Publishing Group UK</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28484255</article-id>
<article-id pub-id-type="pmc">5431568</article-id>
<article-id pub-id-type="publisher-id">1686</article-id>
<article-id pub-id-type="doi">10.1038/s41598-017-01686-4</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Zhang</surname>
<given-names>Yu</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Chen</surname>
<given-names>Yin-yan</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huang</surname>
<given-names>Li</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chai</surname>
<given-names>Zhi-guo</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shen</surname>
<given-names>Li-juan</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Xiao</surname>
<given-names>Yu-hong</given-names>
</name>
<address><email>xiaoyuhong56@126.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9588 0960</institution-id>
<institution-id institution-id-type="GRID">grid.285847.4</institution-id>
<institution>Department of Stomatology, Kunming General Hospital of Chengdu Military Command,</institution>
<institution>Teaching Hospital of Kunming Medical University,</institution>
</institution-wrap>
Kunming, Yunnan China</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9852 649X</institution-id>
<institution-id institution-id-type="GRID">grid.43582.38</institution-id>
<institution>Center for Dental Research,</institution>
<institution>School of dentistry, Loma Linda University,</institution>
</institution-wrap>
Loma Linda, California USA</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 4404</institution-id>
<institution-id institution-id-type="GRID">grid.233520.5</institution-id>
<institution>State Key Laboratory of Military Stomatology & National Clinical Research Centre for Oral Diseases & Shaanxi key Laboratory of Stomatology,</institution>
<institution>Department of Prosthodontics, School of Stomatology, Fourth Military Medical University,</institution>
</institution-wrap>
Xi’an, Shaanxi China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>8</day>
<month>5</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>8</day>
<month>5</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>7</volume>
<elocation-id>1547</elocation-id>
<history><date date-type="received"><day>22</day>
<month>11</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>31</day>
<month>3</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p>Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on <italic>Candida albicans</italic>
ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties of a silver bromide/cationic polymer nano-composite (AgBr/NPVP)-modified PMMA-based dental resin. AgBr/NPVP was added to the PMMA resin at 0.1, 0.2, and 0.3 wt%, and PMMA resin without AgBr/NPVP served as the control. Fungal growth was inhibited on the AgBr/NPVP-modified PMMA resin compared to the control (P < 0.05), and the antifungal activity increased as the incorporation of the AgBr/NPVP antimicrobial composite increased. Confocal laser scanning microscopy (CLSM) showed that the number of fungal cells attached to the modified PMMA resin was considerably lower than in the control. The relative growth rate of HDPCs of modified groups were higher than 75%. The flexural strength (FS) and flexural modulus (FM) were not significantly different (P > 0.05) between the experimental and control groups. These data indicate that the incorporation of AgBr/NPVP conferred strong and long-lasting antifungal effects against <italic>Candida albicans</italic>
to the PMMA resin, and it has low toxicity toward HDPCs, and its mechanical properties were not significantly affected.</p>
</abstract>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><noCountry><name sortKey="Chai, Zhi Guo" sort="Chai, Zhi Guo" uniqKey="Chai Z" first="Zhi-Guo" last="Chai">Zhi-Guo Chai</name>
<name sortKey="Chen, Yin Yan" sort="Chen, Yin Yan" uniqKey="Chen Y" first="Yin-Yan" last="Chen">Yin-Yan Chen</name>
<name sortKey="Huang, Li" sort="Huang, Li" uniqKey="Huang L" first="Li" last="Huang">Li Huang</name>
<name sortKey="Shen, Li Juan" sort="Shen, Li Juan" uniqKey="Shen L" first="Li-Juan" last="Shen">Li-Juan Shen</name>
<name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Xiao, Yu Hong" sort="Xiao, Yu Hong" uniqKey="Xiao Y" first="Yu-Hong" last="Xiao">Yu-Hong Xiao</name>
</region>
</country>
</tree>
</affiliations>
</record>
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