EdenteV2, PascalFrancis, Curation, bibRecord, 000227

Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates

Identifieur interne : 000227 ( PascalFrancis/Curation ); précédent : 000226; suivant : 000228

Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates

Auteurs : Philip J. Boyne [États-Unis] ; Sergio Salina [États-Unis] ; Atsushi Nakamura [États-Unis] ; Franco Audia [États-Unis] ; Shahrokh Shabahang [États-Unis]

Source :

Cell and tissue banking [ 1389-9333 ] ; 2006.

RBID : Pascal:06-0189660

Descripteurs français

Pascal (Inist)
- Os, Régénération, Induction, Déclenchement, Type, Défaut, Personne âgée, Primates, Animal, Banque tissu, Cellule, Tissu, Primate non humain, Greffe osseuse.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Animal, Bone, Bone graft, Cell, Defect, Elderly, Induction, Nonhuman primate, Primates, Regeneration, Tissue, Tissue bank, Triggering, Type.

Abstract

Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.

A01	`01`	`1`		`@0 1389-9333`
A03		`1`		`@0 Cell tissue bank.`
A05				`@2 7`
A06				`@2 1`
A08	`01`	`1`	`ENG`	`@1 Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates`
A11	`01`	`1`		`@1 BOYNE (Philip J.)`
A11	`02`	`1`		`@1 SALINA (Sergio)`
A11	`03`	`1`		`@1 NAKAMURA (Atsushi)`
A11	`04`	`1`		`@1 AUDIA (Franco)`
A11	`05`	`1`		`@1 SHABAHANG (Shahrokh)`
A14	`01`			`@1 Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center @2 Loma Linda, CA 92450 @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
A20				`@1 1-10`
A21				`@1 2006`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 27623 @5 354000153320270010`
A44				`@0 0000 @1 © 2006 INIST-CNRS. All rights reserved.`
A45				`@0 9 ref.`
A47	`01`	`1`		`@0 06-0189660`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Cell and tissue banking`
A66	`01`			`@0 NLD`
C01	`01`		`ENG`	@0 Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.
C02	`01`	`X`		`@0 002B25`
C02	`02`	`X`		`@0 002B27D02`
C03	`01`	`X`	`FRE`	`@0 Os @5 02`
C03	`01`	`X`	`ENG`	`@0 Bone @5 02`
C03	`01`	`X`	`SPA`	`@0 Hueso @5 02`
C03	`02`	`X`	`FRE`	`@0 Régénération @5 03`
C03	`02`	`X`	`ENG`	`@0 Regeneration @5 03`
C03	`02`	`X`	`SPA`	`@0 Regeneración @5 03`
C03	`03`	`X`	`FRE`	`@0 Induction @5 05`
C03	`03`	`X`	`ENG`	`@0 Induction @5 05`
C03	`03`	`X`	`SPA`	`@0 Inducción @5 05`
C03	`04`	`X`	`FRE`	`@0 Déclenchement @5 06`
C03	`04`	`X`	`ENG`	`@0 Triggering @5 06`
C03	`04`	`X`	`SPA`	`@0 Inducción @5 06`
C03	`05`	`X`	`FRE`	`@0 Type @5 08`
C03	`05`	`X`	`ENG`	`@0 Type @5 08`
C03	`05`	`X`	`SPA`	`@0 Tipo @5 08`
C03	`06`	`X`	`FRE`	`@0 Défaut @5 09`
C03	`06`	`X`	`ENG`	`@0 Defect @5 09`
C03	`06`	`X`	`SPA`	`@0 Defecto @5 09`
C03	`07`	`X`	`FRE`	`@0 Personne âgée @5 11`
C03	`07`	`X`	`ENG`	`@0 Elderly @5 11`
C03	`07`	`X`	`SPA`	`@0 Anciano @5 11`
C03	`08`	`X`	`FRE`	`@0 Primates @2 NS @5 17`
C03	`08`	`X`	`ENG`	`@0 Primates @2 NS @5 17`
C03	`08`	`X`	`SPA`	`@0 Primates @2 NS @5 17`
C03	`09`	`X`	`FRE`	`@0 Animal @5 18`
C03	`09`	`X`	`ENG`	`@0 Animal @5 18`
C03	`09`	`X`	`SPA`	`@0 Animal @5 18`
C03	`10`	`X`	`FRE`	`@0 Banque tissu @5 19`
C03	`10`	`X`	`ENG`	`@0 Tissue bank @5 19`
C03	`10`	`X`	`SPA`	`@0 Banco tejido @5 19`
C03	`11`	`X`	`FRE`	`@0 Cellule @5 20`
C03	`11`	`X`	`ENG`	`@0 Cell @5 20`
C03	`11`	`X`	`SPA`	`@0 Célula @5 20`
C03	`12`	`X`	`FRE`	`@0 Tissu @5 21`
C03	`12`	`X`	`ENG`	`@0 Tissue @5 21`
C03	`12`	`X`	`SPA`	`@0 Tejido @5 21`
C03	`13`	`X`	`FRE`	`@0 Primate non humain @4 CD @5 96`
C03	`13`	`X`	`ENG`	`@0 Nonhuman primate @4 CD @5 96`
C03	`14`	`X`	`FRE`	`@0 Greffe osseuse @4 CD @5 97`
C03	`14`	`X`	`ENG`	`@0 Bone graft @4 CD @5 97`
C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Système ostéoarticulaire @5 37`
C07	`04`	`X`	`ENG`	`@0 Osteoarticular system @5 37`
C07	`04`	`X`	`SPA`	`@0 Sistema osteoarticular @5 37`
N21				`@1 114`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000476

Links to Exploration step

Pascal:06-0189660

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates</title>
<author><name sortKey="Boyne, Philip J" sort="Boyne, Philip J" uniqKey="Boyne P" first="Philip J." last="Boyne">Philip J. Boyne</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Salina, Sergio" sort="Salina, Sergio" uniqKey="Salina S" first="Sergio" last="Salina">Sergio Salina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Nakamura, Atsushi" sort="Nakamura, Atsushi" uniqKey="Nakamura A" first="Atsushi" last="Nakamura">Atsushi Nakamura</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Audia, Franco" sort="Audia, Franco" uniqKey="Audia F" first="Franco" last="Audia">Franco Audia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Shabahang, Shahrokh" sort="Shabahang, Shahrokh" uniqKey="Shabahang S" first="Shahrokh" last="Shabahang">Shahrokh Shabahang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0189660</idno>
<date when="2006">2006</date>
<idno type="stanalyst">PASCAL 06-0189660 INIST</idno>
<idno type="RBID">Pascal:06-0189660</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000476</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000227</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates</title>
<author><name sortKey="Boyne, Philip J" sort="Boyne, Philip J" uniqKey="Boyne P" first="Philip J." last="Boyne">Philip J. Boyne</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Salina, Sergio" sort="Salina, Sergio" uniqKey="Salina S" first="Sergio" last="Salina">Sergio Salina</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Nakamura, Atsushi" sort="Nakamura, Atsushi" uniqKey="Nakamura A" first="Atsushi" last="Nakamura">Atsushi Nakamura</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Audia, Franco" sort="Audia, Franco" uniqKey="Audia F" first="Franco" last="Audia">Franco Audia</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
<author><name sortKey="Shabahang, Shahrokh" sort="Shabahang, Shahrokh" uniqKey="Shabahang S" first="Shahrokh" last="Shabahang">Shahrokh Shabahang</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Cell and tissue banking</title>
<title level="j" type="abbreviated">Cell tissue bank.</title>
<idno type="ISSN">1389-9333</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Cell and tissue banking</title>
<title level="j" type="abbreviated">Cell tissue bank.</title>
<idno type="ISSN">1389-9333</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Bone</term>
<term>Bone graft</term>
<term>Cell</term>
<term>Defect</term>
<term>Elderly</term>
<term>Induction</term>
<term>Nonhuman primate</term>
<term>Primates</term>
<term>Regeneration</term>
<term>Tissue</term>
<term>Tissue bank</term>
<term>Triggering</term>
<term>Type</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Os</term>
<term>Régénération</term>
<term>Induction</term>
<term>Déclenchement</term>
<term>Type</term>
<term>Défaut</term>
<term>Personne âgée</term>
<term>Primates</term>
<term>Animal</term>
<term>Banque tissu</term>
<term>Cellule</term>
<term>Tissu</term>
<term>Primate non humain</term>
<term>Greffe osseuse</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1389-9333</s0>
</fA01>
<fA03 i2="1"><s0>Cell tissue bank.</s0>
</fA03>
<fA05><s2>7</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BOYNE (Philip J.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SALINA (Sergio)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>NAKAMURA (Atsushi)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>AUDIA (Franco)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SHABAHANG (Shahrokh)</s1>
</fA11>
<fA14 i1="01"><s1>Division of Oral and Maxillofacial Surgery, Department of Surgery, Loma Linda University Medical Center</s1>
<s2>Loma Linda, CA 92450</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>1-10</s1>
</fA20>
<fA21><s1>2006</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>27623</s2>
<s5>354000153320270010</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>9 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0189660</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Cell and tissue banking</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B25</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B27D02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Os</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Bone</s0>
<s5>02</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hueso</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Régénération</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Regeneration</s0>
<s5>03</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Regeneración</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Induction</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Induction</s0>
<s5>05</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Inducción</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Déclenchement</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Triggering</s0>
<s5>06</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Inducción</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Type</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Type</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Tipo</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Défaut</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Defect</s0>
<s5>09</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Defecto</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Personne âgée</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Elderly</s0>
<s5>11</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Anciano</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Primates</s0>
<s2>NS</s2>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Primates</s0>
<s2>NS</s2>
<s5>17</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Primates</s0>
<s2>NS</s2>
<s5>17</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Banque tissu</s0>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Tissue bank</s0>
<s5>19</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Banco tejido</s0>
<s5>19</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Cellule</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Cell</s0>
<s5>20</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Célula</s0>
<s5>20</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Tissu</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Tissue</s0>
<s5>21</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Tejido</s0>
<s5>21</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Primate non humain</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Nonhuman primate</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Greffe osseuse</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Bone graft</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système ostéoarticulaire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Osteoarticular system</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema osteoarticular</s0>
<s5>37</s5>
</fC07>
<fN21><s1>114</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000227 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000227 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:06-0189660
   |texte=   Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates
}}

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022

	Serveur d'exploration sur le patient édenté
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le patient édenté

Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates

Bone regeneration using rhBMP-2 induction in hemimandibulectomy type defects of elderly sub-human primates

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri