EdenteV2, PascalFrancis, Corpus, bibRecord, 000622

Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma

Identifieur interne : 000622 ( PascalFrancis/Corpus ); précédent : 000621; suivant : 000623

Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma

Auteurs : James S. Brown ; Derek Lowe ; Nicholas Kalavrezos ; Jacob D'Souza ; Patrick Magennis ; Julia Woolgar

Source :

Head & neck [ 1043-3074 ] ; 2002.

RBID : Pascal:02-0250313

Descripteurs français

Pascal (Inist)
- Carcinome épidermoïde, Cavité buccale, Voie abord, Invasion, Mandibule, Résection chirurgicale, Prise décision, Technique, Extension, Prospective, Physiopathologie, Complication, Traitement, Homme.

English descriptors

KwdEn :
- Complication, Decision making, Extension, Human, Invasion, Mandible, Oral cavity, Pathophysiology, Prospective, Squamous cell carcinoma, Surgical approach, Surgical resection, Technique, Treatment.

Abstract

Background.An understanding of the patterns, spread, and routes of tumor invasion of the mandible is essential in deciding the appropriate level and extent of mandibular resection in oral squamous cell carcinoma. Methods. A prospective study of histologic patterns of tumor invasion and routes of tumor entry into the mandible was performed in a consecutive series of 100 previously untreated patients. Results. The pattern of tumor invasion of the mandible depended on the depth of invasion both in the hard (p =.001) and soft tissues (p =.001). There was evidence that the pattern of invasion was related to histologic prognostic indicators of the disease, such as extracapsular spread from invaded lymph nodes (p =.03). The route of tumor entry was at the point of abutment to the mandible (direct) in all 13 cases, invading the dentate part of the mandible. Fifty-five percent (23 of 42) of tumors invading the edentulous ridge entered through the occlusal (superior) surface. Direct entry to the mandible in the edentulous ridge was more likely for tumors arising in the tongue, floor of the mouth and the buccal mucosa compared with alveolar or retromolar sites (p =.003). Conclusions. Larger or more deeply invading tumors in the soft tissue are more likely to invade the mandible and show the more aggressive (invasive) form of tumor spread, reducing the options of a more conservative (rim) resection. Tumors tend to enter the mandible at the point of abutment, which in both the dentate and edentulous jaw is often at the junction of the reflected and attached mucosa. A point of tumor entry below the occlusal ridge or gingival crest should be assumed when planning rim or marginal resections of the mandible.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 KALAVREZOS (Nicholas)`
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A11	`05`	`1`		`@1 MAGENNIS (Patrick)`
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A14	`01`			`@1 Regional Maxillofacial Unit, University Hospital Aintree @2 Longmoor Lane, Liverpool L9 7AL @3 GBR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
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C01	`01`		`ENG`	@0 Background.An understanding of the patterns, spread, and routes of tumor invasion of the mandible is essential in deciding the appropriate level and extent of mandibular resection in oral squamous cell carcinoma. Methods. A prospective study of histologic patterns of tumor invasion and routes of tumor entry into the mandible was performed in a consecutive series of 100 previously untreated patients. Results. The pattern of tumor invasion of the mandible depended on the depth of invasion both in the hard (p =.001) and soft tissues (p =.001). There was evidence that the pattern of invasion was related to histologic prognostic indicators of the disease, such as extracapsular spread from invaded lymph nodes (p =.03). The route of tumor entry was at the point of abutment to the mandible (direct) in all 13 cases, invading the dentate part of the mandible. Fifty-five percent (23 of 42) of tumors invading the edentulous ridge entered through the occlusal (superior) surface. Direct entry to the mandible in the edentulous ridge was more likely for tumors arising in the tongue, floor of the mouth and the buccal mucosa compared with alveolar or retromolar sites (p =.003). Conclusions. Larger or more deeply invading tumors in the soft tissue are more likely to invade the mandible and show the more aggressive (invasive) form of tumor spread, reducing the options of a more conservative (rim) resection. Tumors tend to enter the mandible at the point of abutment, which in both the dentate and edentulous jaw is often at the junction of the reflected and attached mucosa. A point of tumor entry below the occlusal ridge or gingival crest should be assumed when planning rim or marginal resections of the mandible.
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Format Inist (serveur)

NO :	PASCAL 02-0250313 INIST
ET :	Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma
AU :	BROWN (James S.); LOWE (Derek); KALAVREZOS (Nicholas); D'SOUZA (Jacob); MAGENNIS (Patrick); WOOLGAR (Julia)
AF :	Regional Maxillofacial Unit, University Hospital Aintree/Longmoor Lane, Liverpool L9 7AL/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Oral Pathology, University of Liverpool Dental School, Pembroke Place/Liverpool L3 5PS/Royaume-Uni (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Head & neck; ISSN 1043-3074; Etats-Unis; Da. 2002; Vol. 24; No. 4; Pp. 370-383; Bibl. 17 ref.
LA :	Anglais
EA :	Background.An understanding of the patterns, spread, and routes of tumor invasion of the mandible is essential in deciding the appropriate level and extent of mandibular resection in oral squamous cell carcinoma. Methods. A prospective study of histologic patterns of tumor invasion and routes of tumor entry into the mandible was performed in a consecutive series of 100 previously untreated patients. Results. The pattern of tumor invasion of the mandible depended on the depth of invasion both in the hard (p =.001) and soft tissues (p =.001). There was evidence that the pattern of invasion was related to histologic prognostic indicators of the disease, such as extracapsular spread from invaded lymph nodes (p =.03). The route of tumor entry was at the point of abutment to the mandible (direct) in all 13 cases, invading the dentate part of the mandible. Fifty-five percent (23 of 42) of tumors invading the edentulous ridge entered through the occlusal (superior) surface. Direct entry to the mandible in the edentulous ridge was more likely for tumors arising in the tongue, floor of the mouth and the buccal mucosa compared with alveolar or retromolar sites (p =.003). Conclusions. Larger or more deeply invading tumors in the soft tissue are more likely to invade the mandible and show the more aggressive (invasive) form of tumor spread, reducing the options of a more conservative (rim) resection. Tumors tend to enter the mandible at the point of abutment, which in both the dentate and edentulous jaw is often at the junction of the reflected and attached mucosa. A point of tumor entry below the occlusal ridge or gingival crest should be assumed when planning rim or marginal resections of the mandible.
CC :	002B10C01; 002B10B01
FD :	Carcinome épidermoïde; Cavité buccale; Voie abord; Invasion; Mandibule; Résection chirurgicale; Prise décision; Technique; Extension; Prospective; Physiopathologie; Complication; Traitement; Homme
FG :	Stomatologie; Cavité buccale pathologie; Tumeur maligne; Système ostéoarticulaire pathologie; Maxillaire pathologie; Chirurgie
ED :	Squamous cell carcinoma; Oral cavity; Surgical approach; Invasion; Mandible; Surgical resection; Decision making; Technique; Extension; Prospective; Pathophysiology; Complication; Treatment; Human
EG :	Stomatology; Oral cavity disease; Malignant tumor; Diseases of the osteoarticular system; Maxillary disease; Surgery
SD :	Carcinoma epidermoide; Cavidad bucal; Vía abordaje; Invasión; Mandíbula; Resección quirúrgica; Toma decision; Técnica; Extensión; Prospectiva; Fisiopatología; Complicación; Tratamiento; Hombre
LO :	INIST-19138.354000107939340080
ID :	02-0250313

Links to Exploration step

Pascal:02-0250313

Le document en format XML

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<term>Mandible</term>
<term>Oral cavity</term>
<term>Pathophysiology</term>
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<term>Squamous cell carcinoma</term>
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<front><div type="abstract" xml:lang="en">Background.An understanding of the patterns, spread, and routes of tumor invasion of the mandible is essential in deciding the appropriate level and extent of mandibular resection in oral squamous cell carcinoma. Methods. A prospective study of histologic patterns of tumor invasion and routes of tumor entry into the mandible was performed in a consecutive series of 100 previously untreated patients. Results. The pattern of tumor invasion of the mandible depended on the depth of invasion both in the hard (p =.001) and soft tissues (p =.001). There was evidence that the pattern of invasion was related to histologic prognostic indicators of the disease, such as extracapsular spread from invaded lymph nodes (p =.03). The route of tumor entry was at the point of abutment to the mandible (direct) in all 13 cases, invading the dentate part of the mandible. Fifty-five percent (23 of 42) of tumors invading the edentulous ridge entered through the occlusal (superior) surface. Direct entry to the mandible in the edentulous ridge was more likely for tumors arising in the tongue, floor of the mouth and the buccal mucosa compared with alveolar or retromolar sites (p =.003). Conclusions. Larger or more deeply invading tumors in the soft tissue are more likely to invade the mandible and show the more aggressive (invasive) form of tumor spread, reducing the options of a more conservative (rim) resection. Tumors tend to enter the mandible at the point of abutment, which in both the dentate and edentulous jaw is often at the junction of the reflected and attached mucosa. A point of tumor entry below the occlusal ridge or gingival crest should be assumed when planning rim or marginal resections of the mandible.</div>
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<fA11 i1="05" i2="1"><s1>MAGENNIS (Patrick)</s1>
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<fA11 i1="06" i2="1"><s1>WOOLGAR (Julia)</s1>
</fA11>
<fA14 i1="01"><s1>Regional Maxillofacial Unit, University Hospital Aintree</s1>
<s2>Longmoor Lane, Liverpool L9 7AL</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Oral Pathology, University of Liverpool Dental School, Pembroke Place</s1>
<s2>Liverpool L3 5PS</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>370-383</s1>
</fA20>
<fA21><s1>2002</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>19138</s2>
<s5>354000107939340080</s5>
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<s1>© 2002 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>17 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>02-0250313</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Head & neck</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background.An understanding of the patterns, spread, and routes of tumor invasion of the mandible is essential in deciding the appropriate level and extent of mandibular resection in oral squamous cell carcinoma. Methods. A prospective study of histologic patterns of tumor invasion and routes of tumor entry into the mandible was performed in a consecutive series of 100 previously untreated patients. Results. The pattern of tumor invasion of the mandible depended on the depth of invasion both in the hard (p =.001) and soft tissues (p =.001). There was evidence that the pattern of invasion was related to histologic prognostic indicators of the disease, such as extracapsular spread from invaded lymph nodes (p =.03). The route of tumor entry was at the point of abutment to the mandible (direct) in all 13 cases, invading the dentate part of the mandible. Fifty-five percent (23 of 42) of tumors invading the edentulous ridge entered through the occlusal (superior) surface. Direct entry to the mandible in the edentulous ridge was more likely for tumors arising in the tongue, floor of the mouth and the buccal mucosa compared with alveolar or retromolar sites (p =.003). Conclusions. Larger or more deeply invading tumors in the soft tissue are more likely to invade the mandible and show the more aggressive (invasive) form of tumor spread, reducing the options of a more conservative (rim) resection. Tumors tend to enter the mandible at the point of abutment, which in both the dentate and edentulous jaw is often at the junction of the reflected and attached mucosa. A point of tumor entry below the occlusal ridge or gingival crest should be assumed when planning rim or marginal resections of the mandible.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B10C01</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B10B01</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Carcinome épidermoïde</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Squamous cell carcinoma</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Carcinoma epidermoide</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Cavité buccale</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Oral cavity</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Cavidad bucal</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Voie abord</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Surgical approach</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Vía abordaje</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Invasion</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Invasion</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Invasión</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Mandibule</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Mandible</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Mandíbula</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Résection chirurgicale</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Surgical resection</s0>
<s5>07</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Resección quirúrgica</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Prise décision</s0>
<s5>08</s5>
</fC03>
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<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Toma decision</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Technique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Technique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Técnica</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Extension</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Extension</s0>
<s5>10</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Extensión</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Prospective</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Prospective</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Prospectiva</s0>
<s5>16</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Physiopathologie</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Pathophysiology</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Fisiopatología</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Complication</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Complication</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Complicación</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Traitement</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Treatment</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Homme</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Human</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Stomatologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Stomatology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Estomatología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Cavité buccale pathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Oral cavity disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Cavidad bucal patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système ostéoarticulaire pathologie</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0>
<s5>45</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0>
<s5>45</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maxillaire pathologie</s0>
<s5>47</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Maxillary disease</s0>
<s5>47</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Maxilar patología</s0>
<s5>47</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>53</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Surgery</s0>
<s5>53</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>53</s5>
</fC07>
<fN21><s1>147</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
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<server><NO>PASCAL 02-0250313 INIST</NO>
<ET>Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma</ET>
<AU>BROWN (James S.); LOWE (Derek); KALAVREZOS (Nicholas); D'SOUZA (Jacob); MAGENNIS (Patrick); WOOLGAR (Julia)</AU>
<AF>Regional Maxillofacial Unit, University Hospital Aintree/Longmoor Lane, Liverpool L9 7AL/Royaume-Uni (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.); Department of Oral Pathology, University of Liverpool Dental School, Pembroke Place/Liverpool L3 5PS/Royaume-Uni (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Head & neck; ISSN 1043-3074; Etats-Unis; Da. 2002; Vol. 24; No. 4; Pp. 370-383; Bibl. 17 ref.</SO>
<LA>Anglais</LA>
<EA>Background.An understanding of the patterns, spread, and routes of tumor invasion of the mandible is essential in deciding the appropriate level and extent of mandibular resection in oral squamous cell carcinoma. Methods. A prospective study of histologic patterns of tumor invasion and routes of tumor entry into the mandible was performed in a consecutive series of 100 previously untreated patients. Results. The pattern of tumor invasion of the mandible depended on the depth of invasion both in the hard (p =.001) and soft tissues (p =.001). There was evidence that the pattern of invasion was related to histologic prognostic indicators of the disease, such as extracapsular spread from invaded lymph nodes (p =.03). The route of tumor entry was at the point of abutment to the mandible (direct) in all 13 cases, invading the dentate part of the mandible. Fifty-five percent (23 of 42) of tumors invading the edentulous ridge entered through the occlusal (superior) surface. Direct entry to the mandible in the edentulous ridge was more likely for tumors arising in the tongue, floor of the mouth and the buccal mucosa compared with alveolar or retromolar sites (p =.003). Conclusions. Larger or more deeply invading tumors in the soft tissue are more likely to invade the mandible and show the more aggressive (invasive) form of tumor spread, reducing the options of a more conservative (rim) resection. Tumors tend to enter the mandible at the point of abutment, which in both the dentate and edentulous jaw is often at the junction of the reflected and attached mucosa. A point of tumor entry below the occlusal ridge or gingival crest should be assumed when planning rim or marginal resections of the mandible.</EA>
<CC>002B10C01; 002B10B01</CC>
<FD>Carcinome épidermoïde; Cavité buccale; Voie abord; Invasion; Mandibule; Résection chirurgicale; Prise décision; Technique; Extension; Prospective; Physiopathologie; Complication; Traitement; Homme</FD>
<FG>Stomatologie; Cavité buccale pathologie; Tumeur maligne; Système ostéoarticulaire pathologie; Maxillaire pathologie; Chirurgie</FG>
<ED>Squamous cell carcinoma; Oral cavity; Surgical approach; Invasion; Mandible; Surgical resection; Decision making; Technique; Extension; Prospective; Pathophysiology; Complication; Treatment; Human</ED>
<EG>Stomatology; Oral cavity disease; Malignant tumor; Diseases of the osteoarticular system; Maxillary disease; Surgery</EG>
<SD>Carcinoma epidermoide; Cavidad bucal; Vía abordaje; Invasión; Mandíbula; Resección quirúrgica; Toma decision; Técnica; Extensión; Prospectiva; Fisiopatología; Complicación; Tratamiento; Hombre</SD>
<LO>INIST-19138.354000107939340080</LO>
<ID>02-0250313</ID>
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Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma

Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma

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