Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study
Identifieur interne : 000584 ( PascalFrancis/Corpus ); précédent : 000583; suivant : 000585Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study
Auteurs : O. W. M. Meijer ; W. P. Vandertop ; J. C. Baayen ; B. J. SlotmanSource :
- International journal of radiation oncology, biology, physics [ 0360-3016 ] ; 2003.
Abstract
Purpose: In this single-institution trial, we investigated whether fractionated stereotactic radiation therapy is superior to single-fraction linac-based radiosurgery with respect to treatment-related toxicity and local control in patients with vestibular schwannoma. Methods and Materials: All 129 vestibular schwannoma patients treated between 1992 and June 2000 at our linac-based radiosurgery facility were analyzed with respect to treatment schedule. Dentate patients were prospectively selected for a fractionated schedule of 5 x 4 Gy and later on 5 x 5 Gy at the 80% isodose in 1 week with a relocatable stereotactic frame. Edentate patients were prospectively selected for a nonfractionated treatment of 1 x 10 Gy and later on 1 x 12.5 Gy at 80% isodose with an invasive stereotactic frame. Both MRI and CT scans were made in all 129 patients within 1 week before treatment. All patients were followed yearly with MRI and physical examination. Results: A fractionated schedule was given to 80 patients and a single fraction to 49 patients. Mean follow-up time was 33 months (range: 12-107 months). There was no statistically significant difference between the single-fraction group and the fractionated group with respect to mean tumor diameter (2.6 vs. 2.5 cm) or mean follow-up time (both 33 months). Only mean age (63 years vs. 49 years) was statistically significantly different (p = 0.001). Outcome differences between the single-fraction treatment group and the fractionated treatment group with respect to 5-year local control probability (100% vs. 94%), 5-year facial nerve preservation probability (93% vs. 97%), and 5-year hearing preservation probability (75% vs. 61%) were not statistically significant. The difference in 5-year trigeminal nerve preservation (92% vs. 98%) reached statistical significance (p = 0.048). Conclusion: Linac-based single-fraction radiosurgery seems to be as good as linac-based fractionated stereotactic radiation therapy in vestibular schwannoma patients, except for a small difference in trigeminal nerve preservation rate in favor of a fractionated schedule.
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| NO : | PASCAL 03-0492770 INIST |
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| ET : | Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study |
| AU : | MEIJER (O. W. M.); VANDERTOP (W. P.); BAAYEN (J. C.); SLOTMAN (B. J.) |
| AF : | Department of Radiation Oncology, VU University Medical Center/Amsterdam/Pays-Bas (1 aut., 4 aut.); Department of Neurosurgery, VU University Medical Center/Amsterdam/Pays-Bas (2 aut., 3 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | International journal of radiation oncology, biology, physics; ISSN 0360-3016; Coden IOBPD3; Etats-Unis; Da. 2003; Vol. 56; No. 5; Pp. 1390-1396; Bibl. 31 ref. |
| LA : | Anglais |
| EA : | Purpose: In this single-institution trial, we investigated whether fractionated stereotactic radiation therapy is superior to single-fraction linac-based radiosurgery with respect to treatment-related toxicity and local control in patients with vestibular schwannoma. Methods and Materials: All 129 vestibular schwannoma patients treated between 1992 and June 2000 at our linac-based radiosurgery facility were analyzed with respect to treatment schedule. Dentate patients were prospectively selected for a fractionated schedule of 5 x 4 Gy and later on 5 x 5 Gy at the 80% isodose in 1 week with a relocatable stereotactic frame. Edentate patients were prospectively selected for a nonfractionated treatment of 1 x 10 Gy and later on 1 x 12.5 Gy at 80% isodose with an invasive stereotactic frame. Both MRI and CT scans were made in all 129 patients within 1 week before treatment. All patients were followed yearly with MRI and physical examination. Results: A fractionated schedule was given to 80 patients and a single fraction to 49 patients. Mean follow-up time was 33 months (range: 12-107 months). There was no statistically significant difference between the single-fraction group and the fractionated group with respect to mean tumor diameter (2.6 vs. 2.5 cm) or mean follow-up time (both 33 months). Only mean age (63 years vs. 49 years) was statistically significantly different (p = 0.001). Outcome differences between the single-fraction treatment group and the fractionated treatment group with respect to 5-year local control probability (100% vs. 94%), 5-year facial nerve preservation probability (93% vs. 97%), and 5-year hearing preservation probability (75% vs. 61%) were not statistically significant. The difference in 5-year trigeminal nerve preservation (92% vs. 98%) reached statistical significance (p = 0.048). Conclusion: Linac-based single-fraction radiosurgery seems to be as good as linac-based fractionated stereotactic radiation therapy in vestibular schwannoma patients, except for a small difference in trigeminal nerve preservation rate in favor of a fractionated schedule. |
| CC : | 002B |
| LO : | INIST-17180.354000119990010230 |
| ID : | 03-0492770 |
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Baayen</name><affiliation><inist:fA14 i1="02"><s1>Department of Neurosurgery, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Slotman, B J" sort="Slotman, B J" uniqKey="Slotman B" first="B. J." last="Slotman">B. J. Slotman</name><affiliation><inist:fA14 i1="01"><s1>Department of Radiation Oncology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0492770</idno><date when="2003">2003</date><idno type="stanalyst">PASCAL 03-0492770 INIST</idno><idno type="RBID">Pascal:03-0492770</idno><idno type="wicri:Area/PascalFrancis/Corpus">000584</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study</title><author><name sortKey="Meijer, O W M" sort="Meijer, O W M" uniqKey="Meijer O" first="O. W. M." last="Meijer">O. W. M. Meijer</name><affiliation><inist:fA14 i1="01"><s1>Department of Radiation Oncology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vandertop, W P" sort="Vandertop, W P" uniqKey="Vandertop W" first="W. P." last="Vandertop">W. P. Vandertop</name><affiliation><inist:fA14 i1="02"><s1>Department of Neurosurgery, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Baayen, J C" sort="Baayen, J C" uniqKey="Baayen J" first="J. C." last="Baayen">J. C. Baayen</name><affiliation><inist:fA14 i1="02"><s1>Department of Neurosurgery, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Slotman, B J" sort="Slotman, B J" uniqKey="Slotman B" first="B. J." last="Slotman">B. J. Slotman</name><affiliation><inist:fA14 i1="01"><s1>Department of Radiation Oncology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">International journal of radiation oncology, biology, physics</title><title level="j" type="abbreviated">Int. j. radiat. oncol. biol. phys.</title><idno type="ISSN">0360-3016</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of radiation oncology, biology, physics</title><title level="j" type="abbreviated">Int. j. radiat. oncol. biol. phys.</title><idno type="ISSN">0360-3016</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: In this single-institution trial, we investigated whether fractionated stereotactic radiation therapy is superior to single-fraction linac-based radiosurgery with respect to treatment-related toxicity and local control in patients with vestibular schwannoma. Methods and Materials: All 129 vestibular schwannoma patients treated between 1992 and June 2000 at our linac-based radiosurgery facility were analyzed with respect to treatment schedule. Dentate patients were prospectively selected for a fractionated schedule of 5 x 4 Gy and later on 5 x 5 Gy at the 80% isodose in 1 week with a relocatable stereotactic frame. Edentate patients were prospectively selected for a nonfractionated treatment of 1 x 10 Gy and later on 1 x 12.5 Gy at 80% isodose with an invasive stereotactic frame. Both MRI and CT scans were made in all 129 patients within 1 week before treatment. All patients were followed yearly with MRI and physical examination. Results: A fractionated schedule was given to 80 patients and a single fraction to 49 patients. Mean follow-up time was 33 months (range: 12-107 months). There was no statistically significant difference between the single-fraction group and the fractionated group with respect to mean tumor diameter (2.6 vs. 2.5 cm) or mean follow-up time (both 33 months). Only mean age (63 years vs. 49 years) was statistically significantly different (p = 0.001). Outcome differences between the single-fraction treatment group and the fractionated treatment group with respect to 5-year local control probability (100% vs. 94%), 5-year facial nerve preservation probability (93% vs. 97%), and 5-year hearing preservation probability (75% vs. 61%) were not statistically significant. The difference in 5-year trigeminal nerve preservation (92% vs. 98%) reached statistical significance (p = 0.048). Conclusion: Linac-based single-fraction radiosurgery seems to be as good as linac-based fractionated stereotactic radiation therapy in vestibular schwannoma patients, except for a small difference in trigeminal nerve preservation rate in favor of a fractionated schedule.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0360-3016</s0></fA01><fA02 i1="01"><s0>IOBPD3</s0></fA02><fA03 i2="1"><s0>Int. j. radiat. oncol. biol. phys.</s0></fA03><fA05><s2>56</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study</s1></fA08><fA11 i1="01" i2="1"><s1>MEIJER (O. W. M.)</s1></fA11><fA11 i1="02" i2="1"><s1>VANDERTOP (W. P.)</s1></fA11><fA11 i1="03" i2="1"><s1>BAAYEN (J. C.)</s1></fA11><fA11 i1="04" i2="1"><s1>SLOTMAN (B. J.)</s1></fA11><fA14 i1="01"><s1>Department of Radiation Oncology, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Neurosurgery, VU University Medical Center</s1><s2>Amsterdam</s2><s3>NLD</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA20><s1>1390-1396</s1></fA20><fA21><s1>2003</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>17180</s2><s5>354000119990010230</s5></fA43><fA44><s0>0000</s0><s1>© 2003 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>31 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>03-0492770</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>International journal of radiation oncology, biology, physics</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Purpose: In this single-institution trial, we investigated whether fractionated stereotactic radiation therapy is superior to single-fraction linac-based radiosurgery with respect to treatment-related toxicity and local control in patients with vestibular schwannoma. Methods and Materials: All 129 vestibular schwannoma patients treated between 1992 and June 2000 at our linac-based radiosurgery facility were analyzed with respect to treatment schedule. Dentate patients were prospectively selected for a fractionated schedule of 5 x 4 Gy and later on 5 x 5 Gy at the 80% isodose in 1 week with a relocatable stereotactic frame. Edentate patients were prospectively selected for a nonfractionated treatment of 1 x 10 Gy and later on 1 x 12.5 Gy at 80% isodose with an invasive stereotactic frame. Both MRI and CT scans were made in all 129 patients within 1 week before treatment. All patients were followed yearly with MRI and physical examination. Results: A fractionated schedule was given to 80 patients and a single fraction to 49 patients. Mean follow-up time was 33 months (range: 12-107 months). There was no statistically significant difference between the single-fraction group and the fractionated group with respect to mean tumor diameter (2.6 vs. 2.5 cm) or mean follow-up time (both 33 months). Only mean age (63 years vs. 49 years) was statistically significantly different (p = 0.001). Outcome differences between the single-fraction treatment group and the fractionated treatment group with respect to 5-year local control probability (100% vs. 94%), 5-year facial nerve preservation probability (93% vs. 97%), and 5-year hearing preservation probability (75% vs. 61%) were not statistically significant. The difference in 5-year trigeminal nerve preservation (92% vs. 98%) reached statistical significance (p = 0.048). Conclusion: Linac-based single-fraction radiosurgery seems to be as good as linac-based fractionated stereotactic radiation therapy in vestibular schwannoma patients, except for a small difference in trigeminal nerve preservation rate in favor of a fractionated schedule.</s0></fC01><fC02 i1="01" i2="X"><s0>002B</s0></fC02><fN21><s1>328</s1></fN21><fN82><s1>DST</s1></fN82></pA></standard><server><NO>PASCAL 03-0492770 INIST</NO><ET>Single-fraction vs. fractionated linac-based stereotactic radiosurgery for vestibular schwannoma: A single-institution study</ET><AU>MEIJER (O. W. M.); VANDERTOP (W. P.); BAAYEN (J. C.); SLOTMAN (B. J.)</AU><AF>Department of Radiation Oncology, VU University Medical Center/Amsterdam/Pays-Bas (1 aut., 4 aut.); Department of Neurosurgery, VU University Medical Center/Amsterdam/Pays-Bas (2 aut., 3 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>International journal of radiation oncology, biology, physics; ISSN 0360-3016; Coden IOBPD3; Etats-Unis; Da. 2003; Vol. 56; No. 5; Pp. 1390-1396; Bibl. 31 ref.</SO><LA>Anglais</LA><EA>Purpose: In this single-institution trial, we investigated whether fractionated stereotactic radiation therapy is superior to single-fraction linac-based radiosurgery with respect to treatment-related toxicity and local control in patients with vestibular schwannoma. Methods and Materials: All 129 vestibular schwannoma patients treated between 1992 and June 2000 at our linac-based radiosurgery facility were analyzed with respect to treatment schedule. Dentate patients were prospectively selected for a fractionated schedule of 5 x 4 Gy and later on 5 x 5 Gy at the 80% isodose in 1 week with a relocatable stereotactic frame. Edentate patients were prospectively selected for a nonfractionated treatment of 1 x 10 Gy and later on 1 x 12.5 Gy at 80% isodose with an invasive stereotactic frame. Both MRI and CT scans were made in all 129 patients within 1 week before treatment. All patients were followed yearly with MRI and physical examination. Results: A fractionated schedule was given to 80 patients and a single fraction to 49 patients. Mean follow-up time was 33 months (range: 12-107 months). There was no statistically significant difference between the single-fraction group and the fractionated group with respect to mean tumor diameter (2.6 vs. 2.5 cm) or mean follow-up time (both 33 months). Only mean age (63 years vs. 49 years) was statistically significantly different (p = 0.001). Outcome differences between the single-fraction treatment group and the fractionated treatment group with respect to 5-year local control probability (100% vs. 94%), 5-year facial nerve preservation probability (93% vs. 97%), and 5-year hearing preservation probability (75% vs. 61%) were not statistically significant. The difference in 5-year trigeminal nerve preservation (92% vs. 98%) reached statistical significance (p = 0.048). Conclusion: Linac-based single-fraction radiosurgery seems to be as good as linac-based fractionated stereotactic radiation therapy in vestibular schwannoma patients, except for a small difference in trigeminal nerve preservation rate in favor of a fractionated schedule.</EA><CC>002B</CC><LO>INIST-17180.354000119990010230</LO><ID>03-0492770</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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