EdenteV2, PascalFrancis, Corpus, bibRecord, 000346

Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies

Identifieur interne : 000346 ( PascalFrancis/Corpus ); précédent : 000345; suivant : 000347

Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies

Auteurs : Melissa S. Morris ; Yeonju Lee ; Mark T. Lavin ; Peter J. Giannini ; Marian J. Schmid ; David B. Marx ; Richard A. Reinhardt

Source :

Journal of periodontology [ 0022-3492 ] ; 2008.

RBID : Pascal:08-0392504

Descripteurs français

Pascal (Inist)
- Simvastatine, Histologie, Injection, Alvéole dentaire, Os, Régénération, Cément, Médicament, Traitement, Plaie, Cicatrisation, Cicatrisant, Dentisterie, Hypolipémiant, Hypocholestérolémiant.

English descriptors

KwdEn :
- Antilipemic agent, Bone, Cementum, Cicatrization, Dentistry, Drug, Healing agent, Histology, Hypocholesterolemic agent, Injection, Regeneration, Simvastatin, Tooth alveolus, Treatment, Wound.

Abstract

Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P= 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P= 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 LAVIN (Mark T.)`
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A11	`05`	`1`		`@1 SCHMID (Marian J.)`
A11	`06`	`1`		`@1 MARX (David B.)`
A11	`07`	`1`		`@1 REINHARDT (Richard A.)`
A14	`01`			`@1 Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center @2 Lincoln, NE @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 7 aut.`
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A14	`03`			`@1 Department of Biometry, University of Nebraska-Lincoln @2 Lincoln, NE @3 USA @Z 6 aut.`
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C01	`01`		`ENG`	@0 Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P= 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P= 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.
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Format Inist (serveur)

NO :	PASCAL 08-0392504 INIST
ET :	Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies
AU :	MORRIS (Melissa S.); LEE (Yeonju); LAVIN (Mark T.); GIANNINI (Peter J.); SCHMID (Marian J.); MARX (David B.); REINHARDT (Richard A.)
AF :	Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center/Lincoln, NE/Etats-Unis (1 aut., 2 aut., 3 aut., 7 aut.); Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center/Etats-Unis (4 aut., 5 aut.); Department of Biometry, University of Nebraska-Lincoln/Lincoln, NE/Etats-Unis (6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of periodontology; ISSN 0022-3492; Etats-Unis; Da. 2008; Vol. 79; No. 8; Pp. 1465-1473; Bibl. 21 ref.
LA :	Anglais
EA :	Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P= 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P= 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.
CC :	002B10
FD :	Simvastatine; Histologie; Injection; Alvéole dentaire; Os; Régénération; Cément; Médicament; Traitement; Plaie; Cicatrisation; Cicatrisant; Dentisterie; Hypolipémiant; Hypocholestérolémiant
FG :	Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Inhibiteur enzyme; Dérivé de la statine; Inhibiteur de l'HMG-CoA reductase
ED :	Simvastatin; Histology; Injection; Tooth alveolus; Bone; Regeneration; Cementum; Drug; Treatment; Wound; Cicatrization; Healing agent; Dentistry; Antilipemic agent; Hypocholesterolemic agent
EG :	Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Enzyme inhibitor; Statin derivative; HMG-CoA reductase inhibitor
SD :	Simvastatina; Histología; Inyección; Alvéolo dental; Hueso; Regeneración; Cemento(anatomia); Medicamento; Tratamiento; Herida; Cicatrización; Cicatrizante; Odontología; Hipolipemiante; Hipocolesterolemiante
LO :	INIST-874.354000196254590180
ID :	08-0392504

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P= 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P= 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3492</s0>
</fA01>
<fA03 i2="1"><s0>J. periodontol.</s0>
</fA03>
<fA05><s2>79</s2>
</fA05>
<fA06><s2>8</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MORRIS (Melissa S.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LEE (Yeonju)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>LAVIN (Mark T.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>GIANNINI (Peter J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>SCHMID (Marian J.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>MARX (David B.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>REINHARDT (Richard A.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center</s1>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Biometry, University of Nebraska-Lincoln</s1>
<s2>Lincoln, NE</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA20><s1>1465-1473</s1>
</fA20>
<fA21><s1>2008</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
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<fA64 i1="01" i2="1"><s0>Journal of periodontology</s0>
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</fA66>
<fC01 i1="01" l="ENG"><s0>Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P= 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P= 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.</s0>
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<s5>08</s5>
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<s5>17</s5>
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<s5>17</s5>
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<s5>18</s5>
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<s5>38</s5>
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<server><NO>PASCAL 08-0392504 INIST</NO>
<ET>Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies</ET>
<AU>MORRIS (Melissa S.); LEE (Yeonju); LAVIN (Mark T.); GIANNINI (Peter J.); SCHMID (Marian J.); MARX (David B.); REINHARDT (Richard A.)</AU>
<AF>Department of Surgical Specialties, College of Dentistry, University of Nebraska Medical Center/Lincoln, NE/Etats-Unis (1 aut., 2 aut., 3 aut., 7 aut.); Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center/Etats-Unis (4 aut., 5 aut.); Department of Biometry, University of Nebraska-Lincoln/Lincoln, NE/Etats-Unis (6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of periodontology; ISSN 0022-3492; Etats-Unis; Da. 2008; Vol. 79; No. 8; Pp. 1465-1473; Bibl. 21 ref.</SO>
<LA>Anglais</LA>
<EA>Background: Topical injection of simvastatin in methylcellulose gel was shown to stimulate bone growth and inflammation over mouse calvaria and in rat mandible models. The purpose of these pilot studies was to evaluate the potential of locally injected simvastatin in human-sized periodontal defects. Methods: Chronic periodontal defects were created bilaterally in seven 1-year-old beagle dogs: 3-walled intrabony defects distal of the mandibular second premolar and mesial of the fourth premolar and Class II furcation defects at the buccal furcation of the mandibular first molars. The edentulous space distal to the mandibular canine was left undisturbed. After 16 weeks of healing, defect sites were treated with scaling and root planing, and mandible sides were randomly selected to receive three weekly injections of 0.5 mg simvastatin in 30 μl methylcellulose gel and contralateral gel alone (n = 3) or 2.0 mg simvastatin/methylcellulose gel and contralateral gel alone (n = 4). Two months following drug application, block sections, including teeth and surrounding tissues, and submandibular lymph nodes were obtained for histomorphometric analysis. Results: Two trends were noted in this pilot study: buccal edentulous ridge thickness was 29% greater with simvastatin, 0.5 mg, compared to gel alone (P= 0.0845), and the simvastatin groups had bone-height loss in interproximal intrabony and furcation defects, but the length of new cementum in the interproximal intrabony defects was greater with simvastatin, 0.5 mg (0.35 ± 0.14 mm), compared to gel alone (0.06 ± 0.15 mm; P= 0.069). No new cementum was found in furcations. Conclusions: Multiple injections of simvastatin are not appropriate for the treatment of intrabony or furcation defects. However, this approach shows potential to augment bone thickness in closed alveolar environments.</EA>
<CC>002B10</CC>
<FD>Simvastatine; Histologie; Injection; Alvéole dentaire; Os; Régénération; Cément; Médicament; Traitement; Plaie; Cicatrisation; Cicatrisant; Dentisterie; Hypolipémiant; Hypocholestérolémiant</FD>
<FG>Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Inhibiteur enzyme; Dérivé de la statine; Inhibiteur de l'HMG-CoA reductase</FG>
<ED>Simvastatin; Histology; Injection; Tooth alveolus; Bone; Regeneration; Cementum; Drug; Treatment; Wound; Cicatrization; Healing agent; Dentistry; Antilipemic agent; Hypocholesterolemic agent</ED>
<EG>Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Enzyme; Enzyme inhibitor; Statin derivative; HMG-CoA reductase inhibitor</EG>
<SD>Simvastatina; Histología; Inyección; Alvéolo dental; Hueso; Regeneración; Cemento(anatomia); Medicamento; Tratamiento; Herida; Cicatrización; Cicatrizante; Odontología; Hipolipemiante; Hipocolesterolemiante</SD>
<LO>INIST-874.354000196254590180</LO>
<ID>08-0392504</ID>
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Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies

Injectable Simvastatin in Periodontal Defects and Alveolar Ridges : Pilot Studies

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