EdenteV2, PascalFrancis, Corpus, bibRecord, 000109

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Identifieur interne : 000109 ( PascalFrancis/Corpus ); précédent : 000108; suivant : 000110

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Auteurs : J. Bassil ; K. Senni ; S. Changotade ; B. Baroukh ; C. Kassis ; N. Naaman ; G. Godeau

Source :

Journal of periodontal research [ 0022-3484 ] ; 2011.

RBID : Pascal:11-0481927

Descripteurs français

Pascal (Inist)
- Os, Bovin, Homme, Stomatologie, Greffe osseuse.

English descriptors

KwdEn :
- Bone, Bone graft, Bovine, Human, Stomatology.

Abstract

Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0022-3484`
A03		`1`		`@0 J. periodontal res.`
A05				`@2 46`
A06				`@2 6`
A08	`01`	`1`	`ENG`	`@1 Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human`
A11	`01`	`1`		`@1 BASSIL (J.)`
A11	`02`	`1`		`@1 SENNI (K.)`
A11	`03`	`1`		`@1 CHANGOTADE (S.)`
A11	`04`	`1`		`@1 BAROUKH (B.)`
A11	`05`	`1`		`@1 KASSIS (C.)`
A11	`06`	`1`		`@1 NAAMAN (N.)`
A11	`07`	`1`		`@1 GODEAU (G.)`
A14	`01`			`@1 Faculty of Dental Medicine, St Joseph University @2 Beirut @3 LBN @Z 1 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 LBPS-CSPBAT/ UMR CNRS 7244, Paris 13 University @2 Bobigny @3 FRA @Z 2 aut. @Z 3 aut.`
A14	`03`			`@1 Innovation Department, Seadev-Fermensys SA @2 Plouzané @3 FRA @Z 2 aut.`
A14	`04`			`@1 Faculty of Dental Surgery, Paris-Descartes University @2 Montrouge @3 FRA @Z 4 aut. @Z 7 aut.`
A20				`@1 756-762`
A21				`@1 2011`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 15072 @5 354000505568370160`
A44				`@0 0000 @1 © 2011 INIST-CNRS. All rights reserved.`
A45				`@0 47 ref.`
A47	`01`	`1`		`@0 11-0481927`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of periodontal research`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.
C02	`01`	`X`		`@0 002B10`
C03	`01`	`X`	`FRE`	`@0 Os @5 07`
C03	`01`	`X`	`ENG`	`@0 Bone @5 07`
C03	`01`	`X`	`SPA`	`@0 Hueso @5 07`
C03	`02`	`X`	`FRE`	`@0 Bovin @5 08`
C03	`02`	`X`	`ENG`	`@0 Bovine @5 08`
C03	`02`	`X`	`SPA`	`@0 Bovino @5 08`
C03	`03`	`X`	`FRE`	`@0 Homme @5 09`
C03	`03`	`X`	`ENG`	`@0 Human @5 09`
C03	`03`	`X`	`SPA`	`@0 Hombre @5 09`
C03	`04`	`X`	`FRE`	`@0 Stomatologie @5 13`
C03	`04`	`X`	`ENG`	`@0 Stomatology @5 13`
C03	`04`	`X`	`SPA`	`@0 Estomatología @5 13`
C03	`05`	`X`	`FRE`	`@0 Greffe osseuse @4 CD @5 96`
C03	`05`	`X`	`ENG`	`@0 Bone graft @4 CD @5 96`
C03	`05`	`X`	`SPA`	`@0 Injerto óseo @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Artiodactyla @2 NS`
C07	`01`	`X`	`ENG`	`@0 Artiodactyla @2 NS`
C07	`01`	`X`	`SPA`	`@0 Artiodactyla @2 NS`
C07	`02`	`X`	`FRE`	`@0 Ungulata @2 NS`
C07	`02`	`X`	`ENG`	`@0 Ungulata @2 NS`
C07	`02`	`X`	`SPA`	`@0 Ungulata @2 NS`
C07	`03`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 332`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 11-0481927 INIST
ET :	Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human
AU :	BASSIL (J.); SENNI (K.); CHANGOTADE (S.); BAROUKH (B.); KASSIS (C.); NAAMAN (N.); GODEAU (G.)
AF :	Faculty of Dental Medicine, St Joseph University/Beirut/Liban (1 aut., 5 aut., 6 aut.); LBPS-CSPBAT/ UMR CNRS 7244, Paris 13 University/Bobigny/France (2 aut., 3 aut.); Innovation Department, Seadev-Fermensys SA/Plouzané/France (2 aut.); Faculty of Dental Surgery, Paris-Descartes University/Montrouge/France (4 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of periodontal research; ISSN 0022-3484; Royaume-Uni; Da. 2011; Vol. 46; No. 6; Pp. 756-762; Bibl. 47 ref.
LA :	Anglais
EA :	Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.
CC :	002B10
FD :	Os; Bovin; Homme; Stomatologie; Greffe osseuse
FG :	Artiodactyla; Ungulata; Mammalia; Vertebrata
ED :	Bone; Bovine; Human; Stomatology; Bone graft
EG :	Artiodactyla; Ungulata; Mammalia; Vertebrata
SD :	Hueso; Bovino; Hombre; Estomatología; Injerto óseo
LO :	INIST-15072.354000505568370160
ID :	11-0481927

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Pascal:11-0481927

Le document en format XML

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<front><div type="abstract" xml:lang="en">Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.</div>
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<fC01 i1="01" l="ENG"><s0>Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.</s0>
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<server><NO>PASCAL 11-0481927 INIST</NO>
<ET>Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human</ET>
<AU>BASSIL (J.); SENNI (K.); CHANGOTADE (S.); BAROUKH (B.); KASSIS (C.); NAAMAN (N.); GODEAU (G.)</AU>
<AF>Faculty of Dental Medicine, St Joseph University/Beirut/Liban (1 aut., 5 aut., 6 aut.); LBPS-CSPBAT/ UMR CNRS 7244, Paris 13 University/Bobigny/France (2 aut., 3 aut.); Innovation Department, Seadev-Fermensys SA/Plouzané/France (2 aut.); Faculty of Dental Surgery, Paris-Descartes University/Montrouge/France (4 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of periodontal research; ISSN 0022-3484; Royaume-Uni; Da. 2011; Vol. 46; No. 6; Pp. 756-762; Bibl. 47 ref.</SO>
<LA>Anglais</LA>
<EA>Background and Objective: The aim of the present study was to analyse the expression of MMP-2, MMP-9 and MMP-13 in newly formed bone following maxillary sinus augmentation using inorganic bovine bone substitute, because these MMPs play a major role in bone remodeling and bone resorption. Material and Methods: Deproteinized bovine bone (Bio-Oss®) was used to fill cavities after elevating the sinus mucosa. Twenty patients with edentulous posterior maxilla were treated with 20 sinus-augmentation procedures using a two-stage technique. Forty-nine Straumann® endosseous implants were used to complete the implant-prosthetic rehabilitation. One cylinder-shaped bone biopsy from each patient was taken from the augmented maxillary region using trephine burs at the second stage of surgery, 8 months after grafting. A biopsy was also taken as a control from the upper molar region from six different patients who did not undergo the sinus procedure. All biopsies were subjected to biochemical analysis and staining for TRAP. Results: No implant losses or failures occurred. The large number of TRAP-positive multinucleated osteoclasts in resorption lacunae indicated that the resorption was very active in all grafts, in contrast with the control group. Zymography and western blot analysis demonstrated a significantly increased expression of MMP-2, MMP-9 and MMP-13 in the newly formed bone compared with controls (p < 0.05). Conclusion: The quantity of osteoclastic cells and the increased expression of proteolytic enzymes suggest that 8 months after grafting, inorganic bovine bone is slowly resorbing and is the site of important remodeling of the newly formed bone by means of resorption and synthesis.</EA>
<CC>002B10</CC>
<FD>Os; Bovin; Homme; Stomatologie; Greffe osseuse</FD>
<FG>Artiodactyla; Ungulata; Mammalia; Vertebrata</FG>
<ED>Bone; Bovine; Human; Stomatology; Bone graft</ED>
<EG>Artiodactyla; Ungulata; Mammalia; Vertebrata</EG>
<SD>Hueso; Bovino; Hombre; Estomatología; Injerto óseo</SD>
<LO>INIST-15072.354000505568370160</LO>
<ID>11-0481927</ID>
</server>
</inist>
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Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

Expression of MMP-2, 9 and 13 in newly formed bone after sinus augmentation using inorganic bovine bone in human

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