EdenteV2, PascalFrancis, Corpus, bibRecord, 000006

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Identifieur interne : 000006 ( PascalFrancis/Corpus ); précédent : 000005; suivant : 000007

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Auteurs : Stefano Masi ; Nikolaos Gkranias ; KAWA LI ; Klelia D. Salpea ; Mohamed Parkar ; Marco Orlandi ; Jean E. Suvan ; Heng L. Eng ; Stefano Taddei ; Kalpesh Patel ; Ulpee Darbar ; Nikos Donos ; John E. Deanfield ; Steve Hurel ; Steve E. Humphries ; Francesco D'Aiuto

Source :

Diabetes care [ 0149-5992 ] ; 2014.

RBID : Pascal:14-0109613

Descripteurs français

Pascal (Inist)
- Parodontite, Association, Leucocyte, Diabète, Télomère, Longueur, Grave, Etude transversale, Surveillance, Enquête, Endocrinologie, Maladie métabolique, Nutrition, Homme.

English descriptors

KwdEn :
- Association, Cross sectional study, Diabetes mellitus, Endocrinology, Human, Length, Leukocyte, Metabolic diseases, Nutrition, Periodontitis, Severe, Surveillance, Survey, Telomere.

Abstract

OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`02`	`1`		`@1 GKRANIAS (Nikolaos)`
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A11	`04`	`1`		`@1 SALPEA (Klelia D.)`
A11	`05`	`1`		`@1 PARKAR (Mohamed)`
A11	`06`	`1`		`@1 ORLANDI (Marco)`
A11	`07`	`1`		`@1 SUVAN (Jean E.)`
A11	`08`	`1`		`@1 ENG (Heng L.)`
A11	`09`	`1`		`@1 TADDEI (Stefano)`
A11	`10`	`1`		`@1 PATEL (Kalpesh)`
A11	`11`	`1`		`@1 DARBAR (Ulpee)`
A11	`12`	`1`		`@1 DONOS (Nikos)`
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C01	`01`		`ENG`	@0 OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.
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Format Inist (serveur)

NO :	PASCAL 14-0109613 INIST
ET :	Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey
AU :	MASI (Stefano); GKRANIAS (Nikolaos); KAWA LI; SALPEA (Klelia D.); PARKAR (Mohamed); ORLANDI (Marco); SUVAN (Jean E.); ENG (Heng L.); TADDEI (Stefano); PATEL (Kalpesh); DARBAR (Ulpee); DONOS (Nikos); DEANFIELD (John E.); HUREL (Steve); HUMPHRIES (Steve E.); D'AIUTO (Francesco)
AF :	Vascular Physiology Unit, Institute of Cardiovascular Science, University College London/London/Royaume-Uni (1 aut., 13 aut.); Department of Trauma, Emergency, and Acute Medicine, King's College Hospital, National Health Service Foundation Trust/London/Royaume-Uni (1 aut., 9 aut.); Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute/London/Royaume-Uni (2 aut., 5 aut., 6 aut., 7 aut., 8 aut., 10 aut., 11 aut., 12 aut., 16 aut.); Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London/London/Royaume-Uni (3 aut., 4 aut., 15 aut.); Department of Endocrinology, University College London Hospital/London/Royaume-Uni (14 aut.)
DT :	Publication en série; Niveau analytique
SO :	Diabetes care; ISSN 0149-5992; Coden DICAD2; Etats-Unis; Da. 2014; Vol. 37; No. 4; Pp. 1140-1147; Bibl. 33 ref.
LA :	Anglais
EA :	OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.
CC :	002B21E01A; 002B22; 002B10C
FD :	Parodontite; Association; Leucocyte; Diabète; Télomère; Longueur; Grave; Etude transversale; Surveillance; Enquête; Endocrinologie; Maladie métabolique; Nutrition; Homme
FG :	Stomatologie; Parodontopathie; Endocrinopathie
ED :	Periodontitis; Association; Leukocyte; Diabetes mellitus; Telomere; Length; Severe; Cross sectional study; Surveillance; Survey; Endocrinology; Metabolic diseases; Nutrition; Human
EG :	Stomatology; Periodontal disease; Endocrinopathy
SD :	Parodontitis; Asociación; Leucocito; Diabetes; Telómero; Longitud; Grave; Estudio transversal; Vigilancia; Encuesta; Endocrinología; Metabolismo patología; Nutrición; Hombre
LO :	INIST-18054.354000503200100340
ID :	14-0109613

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Pascal:14-0109613

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey</title>
<author><name sortKey="Masi, Stefano" sort="Masi, Stefano" uniqKey="Masi S" first="Stefano" last="Masi">Stefano Masi</name>
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<author><name sortKey="Orlandi, Marco" sort="Orlandi, Marco" uniqKey="Orlandi M" first="Marco" last="Orlandi">Marco Orlandi</name>
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<s2>London</s2>
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<author><name sortKey="Suvan, Jean E" sort="Suvan, Jean E" uniqKey="Suvan J" first="Jean E." last="Suvan">Jean E. Suvan</name>
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<s2>London</s2>
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<author><name sortKey="Eng, Heng L" sort="Eng, Heng L" uniqKey="Eng H" first="Heng L." last="Eng">Heng L. Eng</name>
<affiliation><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1>
<s2>London</s2>
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<author><name sortKey="Taddei, Stefano" sort="Taddei, Stefano" uniqKey="Taddei S" first="Stefano" last="Taddei">Stefano Taddei</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Trauma, Emergency, and Acute Medicine, King's College Hospital, National Health Service Foundation Trust</s1>
<s2>London</s2>
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<author><name sortKey="Patel, Kalpesh" sort="Patel, Kalpesh" uniqKey="Patel K" first="Kalpesh" last="Patel">Kalpesh Patel</name>
<affiliation><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1>
<s2>London</s2>
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<author><name sortKey="Darbar, Ulpee" sort="Darbar, Ulpee" uniqKey="Darbar U" first="Ulpee" last="Darbar">Ulpee Darbar</name>
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<s2>London</s2>
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<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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</author>
<author><name sortKey="Donos, Nikos" sort="Donos, Nikos" uniqKey="Donos N" first="Nikos" last="Donos">Nikos Donos</name>
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<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
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<author><name sortKey="Deanfield, John E" sort="Deanfield, John E" uniqKey="Deanfield J" first="John E." last="Deanfield">John E. Deanfield</name>
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<s2>London</s2>
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<sZ>1 aut.</sZ>
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<author><name sortKey="Hurel, Steve" sort="Hurel, Steve" uniqKey="Hurel S" first="Steve" last="Hurel">Steve Hurel</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Endocrinology, University College London Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
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</affiliation>
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<author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E." last="Humphries">Steve E. Humphries</name>
<affiliation><inist:fA14 i1="04"><s1>Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London</s1>
<s2>London</s2>
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<author><name sortKey="D Aiuto, Francesco" sort="D Aiuto, Francesco" uniqKey="D Aiuto F" first="Francesco" last="D'Aiuto">Francesco D'Aiuto</name>
<affiliation><inist:fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1>
<s2>London</s2>
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<series><title level="j" type="main">Diabetes care</title>
<title level="j" type="abbreviated">Diabetes care</title>
<idno type="ISSN">0149-5992</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Diabetes care</title>
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<idno type="ISSN">0149-5992</idno>
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</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Cross sectional study</term>
<term>Diabetes mellitus</term>
<term>Endocrinology</term>
<term>Human</term>
<term>Length</term>
<term>Leukocyte</term>
<term>Metabolic diseases</term>
<term>Nutrition</term>
<term>Periodontitis</term>
<term>Severe</term>
<term>Surveillance</term>
<term>Survey</term>
<term>Telomere</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parodontite</term>
<term>Association</term>
<term>Leucocyte</term>
<term>Diabète</term>
<term>Télomère</term>
<term>Longueur</term>
<term>Grave</term>
<term>Etude transversale</term>
<term>Surveillance</term>
<term>Enquête</term>
<term>Endocrinologie</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.</div>
</front>
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<fA11 i1="01" i2="1"><s1>MASI (Stefano)</s1>
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<fA11 i1="02" i2="1"><s1>GKRANIAS (Nikolaos)</s1>
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<fA11 i1="03" i2="1"><s1>KAWA LI</s1>
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<fA14 i1="01"><s1>Vascular Physiology Unit, Institute of Cardiovascular Science, University College London</s1>
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</fA14>
<fA14 i1="02"><s1>Department of Trauma, Emergency, and Acute Medicine, King's College Hospital, National Health Service Foundation Trust</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
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</fA14>
<fA14 i1="04"><s1>Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Endocrinology, University College London Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>14 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.</s0>
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<fC03 i1="09" i2="X" l="SPA"><s0>Vigilancia</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Enquête</s0>
<s5>12</s5>
</fC03>
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<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Encuesta</s0>
<s5>12</s5>
</fC03>
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<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Endocrinology</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Endocrinología</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Maladie métabolique</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Metabolic diseases</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Metabolismo patología</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Nutrition</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Nutrition</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Nutrición</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Homme</s0>
<s5>25</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Human</s0>
<s5>25</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Hombre</s0>
<s5>25</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Stomatologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Stomatology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Estomatología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Parodontopathie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Periodontal disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Parodontopatía</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>39</s5>
</fC07>
<fN21><s1>146</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 14-0109613 INIST</NO>
<ET>Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey</ET>
<AU>MASI (Stefano); GKRANIAS (Nikolaos); KAWA LI; SALPEA (Klelia D.); PARKAR (Mohamed); ORLANDI (Marco); SUVAN (Jean E.); ENG (Heng L.); TADDEI (Stefano); PATEL (Kalpesh); DARBAR (Ulpee); DONOS (Nikos); DEANFIELD (John E.); HUREL (Steve); HUMPHRIES (Steve E.); D'AIUTO (Francesco)</AU>
<AF>Vascular Physiology Unit, Institute of Cardiovascular Science, University College London/London/Royaume-Uni (1 aut., 13 aut.); Department of Trauma, Emergency, and Acute Medicine, King's College Hospital, National Health Service Foundation Trust/London/Royaume-Uni (1 aut., 9 aut.); Periodontology Unit, Department of Clinical Research, University College London Eastman Dental Institute/London/Royaume-Uni (2 aut., 5 aut., 6 aut., 7 aut., 8 aut., 10 aut., 11 aut., 12 aut., 16 aut.); Division of Cardiovascular Genetics, British Heart Foundation Laboratories, Institute of Cardiovascular Science, Department of Medicine, University College London/London/Royaume-Uni (3 aut., 4 aut., 15 aut.); Department of Endocrinology, University College London Hospital/London/Royaume-Uni (14 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Diabetes care; ISSN 0149-5992; Coden DICAD2; Etats-Unis; Da. 2014; Vol. 37; No. 4; Pp. 1140-1147; Bibl. 33 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVE Shortened leukocyte telomere length (LTL) and diagnosis of periodontitis are associated with an increased risk of complications and mortality in diabetes. This study investigated the association between LTL, endotoxemia, and severity of periodontitis in a large cohort of people with diabetes. RESEARCH DESIGN AND METHODS Six hundred thirty individuals (371 with type 2 and 259 with type 1 diabetes) were recruited from the University College Hospital in London, U.K. During a baseline visit, blood was collected for standard biochemical tests and DNA extraction, while a dental examination was performed to determine diagnosis and extent of periodontitis. LTL was measured by real-time PCR, and endotoxemia was assessed by the limulus amoebocyte lysate method. RESULTS Two hundred fifty-five individuals were diagnosed with gingivitis, 327 with periodontitis (114 with moderate and 213 with severe disease), and 48 with edentulous. Diagnosis of periodontitis was associated with shorter LTL (P = 0.04). A negative association between LTL and endotoxemia was found in the severe periodontitis and type 2 diabetes groups (P = 0.01 for both). Shorter LTL was associated with increased extent of periodontitis (P = 0.01) and increased insulin resistance (homeostatic model assessment). Multiple adjustments for biochemical, anthropometric, and medication-use variables did not affect the results. CONCLUSIONS LTL is associated with endotoxemia and diagnosis of periodontitis in people with diabetes. LTL shortening might represent a novel biological pathway accounting for previous epidemiological data that documented higher prevalence of diabetes and its complications in people with periodontitis and vice versa.</EA>
<CC>002B21E01A; 002B22; 002B10C</CC>
<FD>Parodontite; Association; Leucocyte; Diabète; Télomère; Longueur; Grave; Etude transversale; Surveillance; Enquête; Endocrinologie; Maladie métabolique; Nutrition; Homme</FD>
<FG>Stomatologie; Parodontopathie; Endocrinopathie</FG>
<ED>Periodontitis; Association; Leukocyte; Diabetes mellitus; Telomere; Length; Severe; Cross sectional study; Surveillance; Survey; Endocrinology; Metabolic diseases; Nutrition; Human</ED>
<EG>Stomatology; Periodontal disease; Endocrinopathy</EG>
<SD>Parodontitis; Asociación; Leucocito; Diabetes; Telómero; Longitud; Grave; Estudio transversal; Vigilancia; Encuesta; Endocrinología; Metabolismo patología; Nutrición; Hombre</SD>
<LO>INIST-18054.354000503200100340</LO>
<ID>14-0109613</ID>
</server>
</inist>
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Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

Association Between Short Leukocyte Telomere Length, Endotoxemia, and Severe Periodontitis in People With Diabetes: A Cross-Sectional Survey

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