Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis
Identifieur interne : 000465 ( PascalFrancis/Checkpoint ); précédent : 000464; suivant : 000466Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis
Auteurs : Susanna Paju [Finlande] ; Pirkko J. Pussinen [Finlande] ; Juha Sinisalo [Finlande] ; Kimmo Mattila [Finlande] ; Basak Dogan [Finlande, Turquie] ; Jari Ahlberg [Finlande] ; Ville Valtonen [Finlande] ; Markku S. Nieminen [Finlande] ; Sirkka Asikainen [Suède]Source :
- Atherosclerosis [ 0021-9150 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Appareil circulatoire pathologie, Athérosclérose, Parodontite, Infarctus myocarde, Angor instable, Infection, Cardiopathie coronaire, Edentation, Clarithromycine, Homme, Inflammation, Onde Q, Etude double insu, Etude comparative, Lipopolyoside, IgG, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Séropositivité, Traitement, Prévention, Antibactérien, Antibiotique, Haemophilus actinomycetemcomitans.
- Wicri :
- topic : Homme, Antibiotique.
English descriptors
- KwdEn :
- Actinobacillus actinomycetemcomitans, Antibacterial agent, Antibiotic, Atherosclerosis, Cardiovascular disease, Clarithromycin, Comparative study, Coronary heart disease, Double blind study, Edentulousness, Human, IgG, Infection, Inflammation, Lipopolysaccharide, Myocardial infarction, Periodontitis, Porphyromonas gingivalis, Prevention, Q wave, Seropositivity, Treatment, Variant angina.
Abstract
Inflammation leading to acute coronary syndrome may be triggered by bacteria causing periodontal infection. We investigated if recurrence of cardiovascular events in unstable coronary patients are associated with periodontitis or microbiological/serological markers of it. Periodontitis-related parameters of 141 patients with acute non-Q-wave infarction or unstable angina pectoris, who participated in a double-blind, placebo-controlled study with clarithromycin for 3 months, were adjusted to the occurrence of a recurrent cardiovascular event during a follow-up period (average 519 days). In the age group under 65 years the patients with periodontitis had a univariate odds ratios (OR) 95% confidence intervals (95% CI) of 5.0 (1.02-24.55) for a recurrent cardiovascular event in comparison with patients without periodontitis. Dental status correlated positively with serum lipopolysaccharide concentrations and combined IgG antibody response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. The end point frequency did not differ between clarithromycin and placebo groups in bacterium-positive, seropositive, or periodontitis patients. Fewer end points in clarithromycin group were seen in bacterium-negative, seronegative, edentulous, and non-periodontitis patients. Periodontitis and edentulousness are associated with recurrent cardiovascular events, especially in younger patients. Long-term clarithromycin therapy seems to be beneficial in prevention of recurrent cardiovascular events in non-periodontitis but not in periodontitis patients.
Affiliations:
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Pascal:07-0042021Le document en format XML
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Pussinen</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Division of Cardiology, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Mattila, Kimmo" sort="Mattila, Kimmo" uniqKey="Mattila K" first="Kimmo" last="Mattila">Kimmo Mattila</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Dogan, Basak" sort="Dogan, Basak" uniqKey="Dogan B" first="Basak" last="Dogan">Basak Dogan</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Basic Sciences, Faculty of Health Education, Marmara University</s1><s2>Istanbul</s2><s3>TUR</s3><sZ>5 aut.</sZ></inist:fA14><country>Turquie</country><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Ahlberg, Jari" sort="Ahlberg, Jari" uniqKey="Ahlberg J" first="Jari" last="Ahlberg">Jari Ahlberg</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Valtonen, Ville" sort="Valtonen, Ville" uniqKey="Valtonen V" first="Ville" last="Valtonen">Ville Valtonen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, Division of Cardiology, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Asikainen, Sirkka" sort="Asikainen, Sirkka" uniqKey="Asikainen S" first="Sirkka" last="Asikainen">Sirkka Asikainen</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Odontology, Division of Oral Microbiology, Umeå University, Tandlakarhogskolan</s1><s2>90187 Umeå</s2><s3>SWE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>90187 Umeå</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Atherosclerosis</title><title level="j" type="abbreviated">Atherosclerosis</title><idno type="ISSN">0021-9150</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Atherosclerosis</title><title level="j" type="abbreviated">Atherosclerosis</title><idno type="ISSN">0021-9150</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actinobacillus actinomycetemcomitans</term><term>Antibacterial agent</term><term>Antibiotic</term><term>Atherosclerosis</term><term>Cardiovascular disease</term><term>Clarithromycin</term><term>Comparative study</term><term>Coronary heart disease</term><term>Double blind study</term><term>Edentulousness</term><term>Human</term><term>IgG</term><term>Infection</term><term>Inflammation</term><term>Lipopolysaccharide</term><term>Myocardial infarction</term><term>Periodontitis</term><term>Porphyromonas gingivalis</term><term>Prevention</term><term>Q wave</term><term>Seropositivity</term><term>Treatment</term><term>Variant angina</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Appareil circulatoire pathologie</term><term>Athérosclérose</term><term>Parodontite</term><term>Infarctus myocarde</term><term>Angor instable</term><term>Infection</term><term>Cardiopathie coronaire</term><term>Edentation</term><term>Clarithromycine</term><term>Homme</term><term>Inflammation</term><term>Onde Q</term><term>Etude double insu</term><term>Etude comparative</term><term>Lipopolyoside</term><term>IgG</term><term>Actinobacillus actinomycetemcomitans</term><term>Porphyromonas gingivalis</term><term>Séropositivité</term><term>Traitement</term><term>Prévention</term><term>Antibactérien</term><term>Antibiotique</term><term>Haemophilus actinomycetemcomitans</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Antibiotique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inflammation leading to acute coronary syndrome may be triggered by bacteria causing periodontal infection. We investigated if recurrence of cardiovascular events in unstable coronary patients are associated with periodontitis or microbiological/serological markers of it. Periodontitis-related parameters of 141 patients with acute non-Q-wave infarction or unstable angina pectoris, who participated in a double-blind, placebo-controlled study with clarithromycin for 3 months, were adjusted to the occurrence of a recurrent cardiovascular event during a follow-up period (average 519 days). In the age group under 65 years the patients with periodontitis had a univariate odds ratios (OR) 95% confidence intervals (95% CI) of 5.0 (1.02-24.55) for a recurrent cardiovascular event in comparison with patients without periodontitis. Dental status correlated positively with serum lipopolysaccharide concentrations and combined IgG antibody response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. The end point frequency did not differ between clarithromycin and placebo groups in bacterium-positive, seropositive, or periodontitis patients. Fewer end points in clarithromycin group were seen in bacterium-negative, seronegative, edentulous, and non-periodontitis patients. Periodontitis and edentulousness are associated with recurrent cardiovascular events, especially in younger patients. Long-term clarithromycin therapy seems to be beneficial in prevention of recurrent cardiovascular events in non-periodontitis but not in periodontitis patients.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0021-9150</s0></fA01><fA03 i2="1"><s0>Atherosclerosis</s0></fA03><fA05><s2>188</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis</s1></fA08><fA11 i1="01" i2="1"><s1>PAJU (Susanna)</s1></fA11><fA11 i1="02" i2="1"><s1>PUSSINEN (Pirkko J.)</s1></fA11><fA11 i1="03" i2="1"><s1>SINISALO (Juha)</s1></fA11><fA11 i1="04" i2="1"><s1>MATTILA (Kimmo)</s1></fA11><fA11 i1="05" i2="1"><s1>DOGAN (Basak)</s1></fA11><fA11 i1="06" i2="1"><s1>AHLBERG (Jari)</s1></fA11><fA11 i1="07" i2="1"><s1>VALTONEN (Ville)</s1></fA11><fA11 i1="08" i2="1"><s1>NIEMINEN (Markku S.)</s1></fA11><fA11 i1="09" i2="1"><s1>ASIKAINEN (Sirkka)</s1></fA11><fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medicine, Division of Cardiology, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>3 aut.</sZ><sZ>8 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>4 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Basic Sciences, Faculty of Health Education, Marmara University</s1><s2>Istanbul</s2><s3>TUR</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Institute of Odontology, Division of Oral Microbiology, Umeå University, Tandlakarhogskolan</s1><s2>90187 Umeå</s2><s3>SWE</s3><sZ>9 aut.</sZ></fA14><fA20><s1>412-419</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>1713</s2><s5>354000143589160250</s5></fA43><fA44><s0>0000</s0><s1>© 2007 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>29 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>07-0042021</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Atherosclerosis</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>Inflammation leading to acute coronary syndrome may be triggered by bacteria causing periodontal infection. We investigated if recurrence of cardiovascular events in unstable coronary patients are associated with periodontitis or microbiological/serological markers of it. Periodontitis-related parameters of 141 patients with acute non-Q-wave infarction or unstable angina pectoris, who participated in a double-blind, placebo-controlled study with clarithromycin for 3 months, were adjusted to the occurrence of a recurrent cardiovascular event during a follow-up period (average 519 days). In the age group under 65 years the patients with periodontitis had a univariate odds ratios (OR) 95% confidence intervals (95% CI) of 5.0 (1.02-24.55) for a recurrent cardiovascular event in comparison with patients without periodontitis. Dental status correlated positively with serum lipopolysaccharide concentrations and combined IgG antibody response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis. The end point frequency did not differ between clarithromycin and placebo groups in bacterium-positive, seropositive, or periodontitis patients. Fewer end points in clarithromycin group were seen in bacterium-negative, seronegative, edentulous, and non-periodontitis patients. Periodontitis and edentulousness are associated with recurrent cardiovascular events, especially in younger patients. Long-term clarithromycin therapy seems to be beneficial in prevention of recurrent cardiovascular events in non-periodontitis but not in periodontitis patients.</s0></fC01><fC02 i1="01" i2="X"><s0>002B12B01</s0></fC02><fC02 i1="02" i2="X"><s0>002B21E01B</s0></fC02><fC02 i1="03" i2="X"><s0>002B25F</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Cardiovascular disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Athérosclérose</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Atherosclerosis</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Ateroesclerosis</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Parodontite</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Periodontitis</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parodontitis</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Infarctus myocarde</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Myocardial infarction</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Infarto miocardio</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Angor instable</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Variant angina</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Angina inestable</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Infection</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Infection</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Infección</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Cardiopathie coronaire</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Coronary heart disease</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Cardiopatía coronaria</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Edentation</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Edentulousness</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Edentación</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Clarithromycine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Clarithromycin</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Claritromicina</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Homme</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Human</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Hombre</s0><s5>10</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Inflammation</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Inflammation</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Inflamación</s0><s5>11</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Onde Q</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Q wave</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Onda Q</s0><s5>12</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Etude double insu</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Double blind study</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Estudio doble ciego</s0><s5>13</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Etude comparative</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>Comparative study</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Estudio comparativo</s0><s5>14</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Lipopolyoside</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Lipopolysaccharide</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Lipopoliósido</s0><s5>15</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>IgG</s0><s5>16</s5></fC03><fC03 i1="16" i2="X" l="ENG"><s0>IgG</s0><s5>16</s5></fC03><fC03 i1="16" i2="X" l="SPA"><s0>IgG</s0><s5>16</s5></fC03><fC03 i1="17" i2="X" l="FRE"><s0>Actinobacillus actinomycetemcomitans</s0><s2>NS</s2><s5>17</s5></fC03><fC03 i1="17" i2="X" l="ENG"><s0>Actinobacillus actinomycetemcomitans</s0><s2>NS</s2><s5>17</s5></fC03><fC03 i1="17" i2="X" l="SPA"><s0>Actinobacillus actinomycetemcomitans</s0><s2>NS</s2><s5>17</s5></fC03><fC03 i1="18" i2="X" l="FRE"><s0>Porphyromonas gingivalis</s0><s2>NS</s2><s5>18</s5></fC03><fC03 i1="18" i2="X" l="ENG"><s0>Porphyromonas gingivalis</s0><s2>NS</s2><s5>18</s5></fC03><fC03 i1="18" i2="X" l="SPA"><s0>Porphyromonas gingivalis</s0><s2>NS</s2><s5>18</s5></fC03><fC03 i1="19" i2="X" l="FRE"><s0>Séropositivité</s0><s5>19</s5></fC03><fC03 i1="19" i2="X" l="ENG"><s0>Seropositivity</s0><s5>19</s5></fC03><fC03 i1="19" i2="X" l="SPA"><s0>Seropositividad</s0><s5>19</s5></fC03><fC03 i1="20" i2="X" l="FRE"><s0>Traitement</s0><s5>20</s5></fC03><fC03 i1="20" i2="X" l="ENG"><s0>Treatment</s0><s5>20</s5></fC03><fC03 i1="20" i2="X" l="SPA"><s0>Tratamiento</s0><s5>20</s5></fC03><fC03 i1="21" i2="X" l="FRE"><s0>Prévention</s0><s5>21</s5></fC03><fC03 i1="21" i2="X" l="ENG"><s0>Prevention</s0><s5>21</s5></fC03><fC03 i1="21" i2="X" l="SPA"><s0>Prevención</s0><s5>21</s5></fC03><fC03 i1="22" i2="X" l="FRE"><s0>Antibactérien</s0><s5>78</s5></fC03><fC03 i1="22" i2="X" l="ENG"><s0>Antibacterial agent</s0><s5>78</s5></fC03><fC03 i1="22" i2="X" l="SPA"><s0>Antibacteriano</s0><s5>78</s5></fC03><fC03 i1="23" i2="X" l="FRE"><s0>Antibiotique</s0><s5>79</s5></fC03><fC03 i1="23" i2="X" l="ENG"><s0>Antibiotic</s0><s5>79</s5></fC03><fC03 i1="23" i2="X" l="SPA"><s0>Antibiótico</s0><s5>79</s5></fC03><fC03 i1="24" i2="X" l="FRE"><s0>Haemophilus actinomycetemcomitans</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pasteurellaceae</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Pasteurellaceae</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Pasteurellaceae</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Bactérie</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Bacteria</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Bacteria</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Bacteroidaceae</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Bacteroidaceae</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Bacteroidaceae</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Vaisseau sanguin pathologie</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Vascular disease</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Vaso sanguíneo patología</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Macrolide</s0><s5>38</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Macrolide</s0><s5>38</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Macrólido</s0><s5>38</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Stomatologie</s0><s5>39</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Stomatology</s0><s5>39</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Estomatología</s0><s5>39</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Parodontopathie</s0><s5>40</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Periodontal disease</s0><s5>40</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Parodontopatía</s0><s5>40</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Myocarde pathologie</s0><s5>41</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Myocardial disease</s0><s5>41</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Miocardio patología</s0><s5>41</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Dent pathologie</s0><s5>42</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Dental disease</s0><s5>42</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Diente patología</s0><s5>42</s5></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Inhibiteur synthèse protéique</s0><s5>43</s5></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Protein synthesis inhibitor</s0><s5>43</s5></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Inhibidor síntesis proteica</s0><s5>43</s5></fC07><fN21><s1>022</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Finlande</li><li>Suède</li><li>Turquie</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><region name="Uusimaa"><name sortKey="Paju, Susanna" sort="Paju, Susanna" uniqKey="Paju S" first="Susanna" last="Paju">Susanna Paju</name></region><name sortKey="Ahlberg, Jari" sort="Ahlberg, Jari" uniqKey="Ahlberg J" first="Jari" last="Ahlberg">Jari Ahlberg</name><name sortKey="Dogan, Basak" sort="Dogan, Basak" uniqKey="Dogan B" first="Basak" last="Dogan">Basak Dogan</name><name sortKey="Mattila, Kimmo" sort="Mattila, Kimmo" uniqKey="Mattila K" first="Kimmo" last="Mattila">Kimmo Mattila</name><name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. 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|texte= Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis
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