Rare and Extensive Malignant Melanoma of the Oral Cavity: Report of Two Cases
Identifieur interne : 007237 ( Ncbi/Merge ); précédent : 007236; suivant : 007238Rare and Extensive Malignant Melanoma of the Oral Cavity: Report of Two Cases
Auteurs : Parviz Deyhimi [Iran] ; Sayed Mohammad Razavi [Iran] ; Shirin Shahnaseri [Iran] ; Saeedeh Khalesi [Iran] ; Solmaz Homayoni [Iran] ; Payam Tavakoli [Iran]Source :
- Journal of Dentistry [ 2345-6485 ] ; 2017.
Abstract
Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor.
This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa.
Most oral melanomas are usually asymptomatic lesions with quick growing. Thus, the most cases are detected in late stage of diagnosis. Early diagnosis with careful examination by dentists, and early biopsy of pigmented and suspicious non-pigmented lesions would have an imperative role in more survival rate and better prognosis.
Url:
PubMed: 29034279
PubMed Central: 5634364
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<front><div type="abstract" xml:lang="en"><p>Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor.
</p>
<p>This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa.
</p>
<p>Most oral melanomas are usually asymptomatic lesions with quick growing. Thus, the most cases are detected in late stage of diagnosis. Early diagnosis with careful examination by dentists, and early biopsy of pigmented and suspicious non-pigmented lesions would have an imperative role in more survival rate and better prognosis.
</p>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Razavi, Sm" uniqKey="Razavi S">SM Razavi</name>
</author>
<author><name sortKey="Jafari, M" uniqKey="Jafari M">M Jafari</name>
</author>
<author><name sortKey="Khalesi, S" uniqKey="Khalesi S">S Khalesi</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Dent (Shiraz)</journal-id>
<journal-id journal-id-type="iso-abbrev">J Dent (Shiraz)</journal-id>
<journal-title-group><journal-title>Journal of Dentistry</journal-title>
</journal-title-group>
<issn pub-type="ppub">2345-6485</issn>
<issn pub-type="epub">2345-6418</issn>
<publisher><publisher-name>Journal of Dentistry Shiraz University of Medical Sciences</publisher-name>
<publisher-loc>Iran</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29034279</article-id>
<article-id pub-id-type="pmc">5634364</article-id>
<article-id pub-id-type="publisher-id">JDS-18-3</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Reports</subject>
</subj-group>
</article-categories>
<title-group><article-title>Rare and Extensive Malignant Melanoma of the Oral Cavity: Report of Two Cases
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Deyhimi</surname>
<given-names>Parviz</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Razavi</surname>
<given-names>Sayed Mohammad</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shahnaseri</surname>
<given-names>Shirin</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khalesi</surname>
<given-names>Saeedeh</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Homayoni</surname>
<given-names>Solmaz</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tavakoli</surname>
<given-names>Payam</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Dental Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.</aff>
<aff id="aff2"><label>2</label>
Dental Implant Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.</aff>
<aff id="aff3"><label>3</label>
Dental Research Center, Dept. of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.</aff>
<aff id="aff4"><label>4</label>
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahrekord University of Medical Sciences, Shahrekord, Iran.</aff>
<aff id="aff5"><label>5</label>
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Islamic Azad University of Isfahan (Khorasgan), Isfahan, Iran.</aff>
<author-notes><corresp id="cor1"><bold>Correspondence: </bold>
Khalesi S.
Dental Materials Research Center, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
<bold> Tel:</bold>
+98-3137922879</corresp>
<corresp id="cor2">E-mail : <email>s_khalesi@dnt.mui.ac.ir</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2017</year>
</pub-date>
<volume>18</volume>
<issue>3</issue>
<fpage>227</fpage>
<lpage>233</lpage>
<history><date date-type="rev-recd"><month>8</month>
<year>2017</year>
</date>
<date date-type="accepted"><month>8</month>
<year>2017</year>
</date>
<date date-type="received"><month>8</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © Journal of Dentistry Shiraz University of Medical Sciences</copyright-statement>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor.
</p>
<p>This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa.
</p>
<p>Most oral melanomas are usually asymptomatic lesions with quick growing. Thus, the most cases are detected in late stage of diagnosis. Early diagnosis with careful examination by dentists, and early biopsy of pigmented and suspicious non-pigmented lesions would have an imperative role in more survival rate and better prognosis.
</p>
</abstract>
<kwd-group><kwd>Oral manifestations </kwd>
<kwd> Melanoma </kwd>
<kwd> Neoplasms</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Iran</li>
</country>
</list>
<tree><country name="Iran"><noRegion><name sortKey="Deyhimi, Parviz" sort="Deyhimi, Parviz" uniqKey="Deyhimi P" first="Parviz" last="Deyhimi">Parviz Deyhimi</name>
</noRegion>
<name sortKey="Homayoni, Solmaz" sort="Homayoni, Solmaz" uniqKey="Homayoni S" first="Solmaz" last="Homayoni">Solmaz Homayoni</name>
<name sortKey="Khalesi, Saeedeh" sort="Khalesi, Saeedeh" uniqKey="Khalesi S" first="Saeedeh" last="Khalesi">Saeedeh Khalesi</name>
<name sortKey="Razavi, Sayed Mohammad" sort="Razavi, Sayed Mohammad" uniqKey="Razavi S" first="Sayed Mohammad" last="Razavi">Sayed Mohammad Razavi</name>
<name sortKey="Shahnaseri, Shirin" sort="Shahnaseri, Shirin" uniqKey="Shahnaseri S" first="Shirin" last="Shahnaseri">Shirin Shahnaseri</name>
<name sortKey="Tavakoli, Payam" sort="Tavakoli, Payam" uniqKey="Tavakoli P" first="Payam" last="Tavakoli">Payam Tavakoli</name>
</country>
</tree>
</affiliations>
</record>
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