Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients
Identifieur interne : 006E36 ( Ncbi/Merge ); précédent : 006E35; suivant : 006E37Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients
Auteurs : Beibei Wang [République populaire de Chine] ; Juan Du [République populaire de Chine] ; Zhao Zhu [République populaire de Chine] ; Zhihong Ma [République populaire de Chine] ; Songlin Wang [République populaire de Chine] ; Zhaochen Shan [République populaire de Chine]Source :
- BioMed Research International [ 2314-6133 ] ; 2017.
Abstract
Url:
DOI: 10.1155/2017/2569707
PubMed: 28251153
PubMed Central: 5306981
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients</title><author><name sortKey="Wang, Beibei" sort="Wang, Beibei" uniqKey="Wang B" first="Beibei" last="Wang">Beibei Wang</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Beijing Coloproctological Hospital (Beijing Erlonglu Hospital), Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Coloproctological Hospital (Beijing Erlonglu Hospital), Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhu, Zhao" sort="Zhu, Zhao" uniqKey="Zhu Z" first="Zhao" last="Zhu">Zhao Zhu</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ma, Zhihong" sort="Ma, Zhihong" uniqKey="Ma Z" first="Zhihong" last="Ma">Zhihong Ma</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Songlin" sort="Wang, Songlin" uniqKey="Wang S" first="Songlin" last="Wang">Songlin Wang</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shan, Zhaochen" sort="Shan, Zhaochen" uniqKey="Shan Z" first="Zhaochen" last="Shan">Zhaochen Shan</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28251153</idno><idno type="pmc">5306981</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306981</idno><idno type="RBID">PMC:5306981</idno><idno type="doi">10.1155/2017/2569707</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002934</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002934</idno><idno type="wicri:Area/Pmc/Curation">002934</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002934</idno><idno type="wicri:Area/Pmc/Checkpoint">000237</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000237</idno><idno type="wicri:Area/Ncbi/Merge">006E36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients</title><author><name sortKey="Wang, Beibei" sort="Wang, Beibei" uniqKey="Wang B" first="Beibei" last="Wang">Beibei Wang</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="I2">Beijing Coloproctological Hospital (Beijing Erlonglu Hospital), Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing Coloproctological Hospital (Beijing Erlonglu Hospital), Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhu, Zhao" sort="Zhu, Zhao" uniqKey="Zhu Z" first="Zhao" last="Zhu">Zhao Zhu</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ma, Zhihong" sort="Ma, Zhihong" uniqKey="Ma Z" first="Zhihong" last="Ma">Zhihong Ma</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Songlin" sort="Wang, Songlin" uniqKey="Wang S" first="Songlin" last="Wang">Songlin Wang</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shan, Zhaochen" sort="Shan, Zhaochen" uniqKey="Shan Z" first="Zhaochen" last="Shan">Zhaochen Shan</name><affiliation wicri:level="3"><nlm:aff id="I1">Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><italic>Background</italic>. To investigate the relationships among blood glucose, mixed saliva glucose, and parotid glucose in type 2 diabetes patients and to evaluate the diagnostic and monitoring value of salivary gland glucose in patients with type 2 diabetes (type 2DM).<italic> Material and Methods</italic>. Thirty patients with type 2DM and 30 healthy age- and sex-matched individuals were included in this study. Glucose levels in unstimulated mixed saliva and in unstimulated parotid saliva were measured by the glucose oxidase peroxidase method.<italic> Results</italic>. The blood glucose and parotid salivary glucose levels in type 2DM patients were significantly higher than those in the controls (<italic>P</italic> < 0.05). The blood glucose, parotid salivary glucose, and mixed salivary glucose were 7.46 ± 1.44 mmol/L, 0.18 ± 0.19 mmol/L, and 3.17 × 10<sup>−2</sup> ± 2.84 × 10<sup>−2</sup> mmol/L, respectively, in the type 2DM group; the corresponding glucose levels in the control group were 5.56 ± 0.71 mmol/L, 7.70 × 10<sup>−2</sup> ± 6.02 × 10<sup>−2</sup> mmol/L, and 3.47 × 10<sup>−2</sup> ± 2.79 × 10<sup>−2</sup> mmol/L. The parotid salivary and blood glucose levels in type 2DM patients were strongly correlated; the linear regression equation for blood glucose and parotid salivary glucose was <italic>Y</italic> = 6.267<italic>X</italic> + 6.360, with <italic>r</italic> = 0.810. However, mixed salivary glucose levels were not significantly different in the type 2 diabetes group compared with the control group.<italic> Conclusion</italic>. Our results suggest that parotid salivary glucose has potential as a biomarker to monitor type 2DM and as a painless, noninvasive method for the management of type 2DM.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bakianian Vaziri, P" uniqKey="Bakianian Vaziri P">P. Bakianian Vaziri</name></author><author><name sortKey="Vahedi, M" uniqKey="Vahedi M">M. Vahedi</name></author><author><name sortKey="Mortazavi, H" uniqKey="Mortazavi H">H. Mortazavi</name></author><author><name sortKey="Abdollahzadeh, Sh" uniqKey="Abdollahzadeh S">Sh. Abdollahzadeh</name></author><author><name sortKey="Hajilooi, M" uniqKey="Hajilooi M">M. Hajilooi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Motta, M" uniqKey="Motta M">M. Motta</name></author><author><name sortKey="Bennati, E" uniqKey="Bennati E">E. Bennati</name></author><author><name sortKey="Ferlito, L" uniqKey="Ferlito L">L. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Res Int</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Res Int</journal-id><journal-id journal-id-type="publisher-id">BMRI</journal-id><journal-title-group><journal-title>BioMed Research International</journal-title></journal-title-group><issn pub-type="ppub">2314-6133</issn><issn pub-type="epub">2314-6141</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28251153</article-id><article-id pub-id-type="pmc">5306981</article-id><article-id pub-id-type="doi">10.1155/2017/2569707</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Evaluation of Parotid Salivary Glucose Level for Clinical Diagnosis and Monitoring Type 2 Diabetes Mellitus Patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Beibei</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Du</surname><given-names>Juan</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhu</surname><given-names>Zhao</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Zhihong</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Songlin</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-3990-9011</contrib-id><name><surname>Shan</surname><given-names>Zhaochen</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Oral and Maxillofacial Surgery Department, School of Stomatology, Capital Medical University, Beijing, China</aff><aff id="I2"><sup>2</sup>Beijing Coloproctological Hospital (Beijing Erlonglu Hospital), Beijing, China</aff><author-notes><corresp id="cor1">*Zhaochen Shan: <email>shanzhch629@163.com</email></corresp><fn fn-type="other"><p>Academic Editor: Nicola Cirillo</p></fn></author-notes><pub-date pub-type="ppub"><year>2017</year></pub-date><pub-date pub-type="epub"><day>31</day><month>1</month><year>2017</year></pub-date><volume>2017</volume><elocation-id>2569707</elocation-id><history><date date-type="received"><day>27</day><month>8</month><year>2016</year></date><date date-type="accepted"><day>16</day><month>1</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 Beibei Wang et al.</copyright-statement><copyright-year>2017</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p><italic>Background</italic>. To investigate the relationships among blood glucose, mixed saliva glucose, and parotid glucose in type 2 diabetes patients and to evaluate the diagnostic and monitoring value of salivary gland glucose in patients with type 2 diabetes (type 2DM).<italic> Material and Methods</italic>. Thirty patients with type 2DM and 30 healthy age- and sex-matched individuals were included in this study. Glucose levels in unstimulated mixed saliva and in unstimulated parotid saliva were measured by the glucose oxidase peroxidase method.<italic> Results</italic>. The blood glucose and parotid salivary glucose levels in type 2DM patients were significantly higher than those in the controls (<italic>P</italic> < 0.05). The blood glucose, parotid salivary glucose, and mixed salivary glucose were 7.46 ± 1.44 mmol/L, 0.18 ± 0.19 mmol/L, and 3.17 × 10<sup>−2</sup> ± 2.84 × 10<sup>−2</sup> mmol/L, respectively, in the type 2DM group; the corresponding glucose levels in the control group were 5.56 ± 0.71 mmol/L, 7.70 × 10<sup>−2</sup> ± 6.02 × 10<sup>−2</sup> mmol/L, and 3.47 × 10<sup>−2</sup> ± 2.79 × 10<sup>−2</sup> mmol/L. The parotid salivary and blood glucose levels in type 2DM patients were strongly correlated; the linear regression equation for blood glucose and parotid salivary glucose was <italic>Y</italic> = 6.267<italic>X</italic> + 6.360, with <italic>r</italic> = 0.810. However, mixed salivary glucose levels were not significantly different in the type 2 diabetes group compared with the control group.<italic> Conclusion</italic>. Our results suggest that parotid salivary glucose has potential as a biomarker to monitor type 2DM and as a painless, noninvasive method for the management of type 2DM.</p></abstract><funding-group><award-group><funding-source xlink:href="http://dx.doi.org/10.13039/501100001809">National Natural Science Foundation of China</funding-source><award-id>81070843</award-id></award-group><award-group><funding-source>National Key Research and Development Program of China</funding-source><award-id>2016YFC1102604</award-id></award-group></funding-group></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>The correlation between parotid salivary glucose and blood glucose in DM group, correlation coefficient <italic>r</italic> = 0.810.</p></caption><graphic xlink:href="BMRI2017-2569707.001"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>The blood glucose, parotid salivary, and mixed salivary glucose results in DM and control groups.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"> </th><th align="center" rowspan="1" colspan="1">DM group (<italic>n</italic> = 30)</th><th align="center" rowspan="1" colspan="1">Control group (<italic>n</italic> = 30)</th><th align="center" rowspan="1" colspan="1"><italic>p</italic></th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Blood glucose</td><td align="center" rowspan="1" colspan="1">7.46 ± 1.44</td><td align="center" rowspan="1" colspan="1">5.56 ± 0.71</td><td align="center" rowspan="1" colspan="1">0.000</td></tr><tr><td align="left" rowspan="1" colspan="1">Parotid salivary glucose</td><td align="center" rowspan="1" colspan="1">0.18 ± 0.19</td><td align="center" rowspan="1" colspan="1">7.70 ± 6.02 × 10<sup>−2</sup></td><td align="center" rowspan="1" colspan="1">0.01</td></tr><tr><td align="left" rowspan="1" colspan="1">Mixed salivary glucose</td><td align="center" rowspan="1" colspan="1">3.17 ± 2.84 × 10<sup>−2</sup></td><td align="center" rowspan="1" colspan="1">3.47 ± 2.79 × 10<sup>−2</sup></td><td align="center" rowspan="1" colspan="1">0.681</td></tr></tbody></table><table-wrap-foot><fn><p>The units of glucose: mmol/L.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Beibei" sort="Wang, Beibei" uniqKey="Wang B" first="Beibei" last="Wang">Beibei Wang</name></noRegion><name sortKey="Du, Juan" sort="Du, Juan" uniqKey="Du J" first="Juan" last="Du">Juan Du</name><name sortKey="Ma, Zhihong" sort="Ma, Zhihong" uniqKey="Ma Z" first="Zhihong" last="Ma">Zhihong Ma</name><name sortKey="Shan, Zhaochen" sort="Shan, Zhaochen" uniqKey="Shan Z" first="Zhaochen" last="Shan">Zhaochen Shan</name><name sortKey="Wang, Beibei" sort="Wang, Beibei" uniqKey="Wang B" first="Beibei" last="Wang">Beibei Wang</name><name sortKey="Wang, Songlin" sort="Wang, Songlin" uniqKey="Wang S" first="Songlin" last="Wang">Songlin Wang</name><name sortKey="Zhu, Zhao" sort="Zhu, Zhao" uniqKey="Zhu Z" first="Zhao" last="Zhu">Zhao Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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