Widespread Volumetric Brain Changes following Tooth Loss in Female Mice
Identifieur interne : 006D70 ( Ncbi/Merge ); précédent : 006D69; suivant : 006D71Widespread Volumetric Brain Changes following Tooth Loss in Female Mice
Auteurs : Limor Avivi-Arber [Canada] ; Ze'Ev Seltzer [Canada, Allemagne] ; Miriam Friedel [Canada] ; Jason P. Lerch [Canada] ; Massieh Moayedi [Canada] ; Karen D. Davis [Canada] ; Barry J. Sessle [Canada]Source :
- Frontiers in Neuroanatomy [ 1662-5129 ] ; 2017.
Abstract
Tooth loss is associated with altered sensory, motor, cognitive and emotional functions. These changes vary highly in the population and are accompanied by structural and functional changes in brain regions mediating these functions. It is unclear to what extent this variability in behavior and function is caused by genetic and/or environmental determinants and which brain regions undergo structural plasticity that mediates these changes. Thus, the overall goal of our research program is to identify genetic variants that control structural and functional plasticity following tooth loss. As a step toward this goal, here our aim was to determine whether structural magnetic resonance imaging (sMRI) is sensitive to detect quantifiable volumetric differences in the brains of mice of different genetic background receiving tooth extraction or sham operation. We used 67 adult female mice of 7 strains, comprising the A/J (A) and C57BL/6J (B) strains and a randomly selected sample of 5 of the 23 AXB-BXA strains (AXB1, AXB4, AXB24, BXA14, BXA24) that were produced from the A and B parental mice by recombinations and inbreeding. This panel of 25 inbred strains of genetically diverse inbred strains of mice is used for mapping chromosomal intervals throughout the genome that harbor candidate genes controlling the phenotypic variance of any trait under study. Under general anesthesia, 39 mice received extraction of 3 right maxillary molar teeth and 28 mice received sham operation. On post-extraction day 21,
Url:
DOI: 10.3389/fnana.2016.00121
PubMed: 28119577
PubMed Central: 5220047
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<author><name sortKey="Moayedi, Massieh" sort="Moayedi, Massieh" uniqKey="Moayedi M" first="Massieh" last="Moayedi">Massieh Moayedi</name>
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<author><name sortKey="Sessle, Barry J" sort="Sessle, Barry J" uniqKey="Sessle B" first="Barry J." last="Sessle">Barry J. Sessle</name>
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<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Faculty of Dentistry, University of Toronto</institution>
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<front><div type="abstract" xml:lang="en"><p>Tooth loss is associated with altered sensory, motor, cognitive and emotional functions. These changes vary highly in the population and are accompanied by structural and functional changes in brain regions mediating these functions. It is unclear to what extent this variability in behavior and function is caused by genetic and/or environmental determinants and which brain regions undergo structural plasticity that mediates these changes. Thus, the overall goal of our research program is to identify genetic variants that control structural and functional plasticity following tooth loss. As a step toward this goal, here our aim was to determine whether structural magnetic resonance imaging (sMRI) is sensitive to detect quantifiable volumetric differences in the brains of mice of different genetic background receiving tooth extraction or sham operation. We used 67 adult female mice of 7 strains, comprising the A/J (A) and C57BL/6J (B) strains and a randomly selected sample of 5 of the 23 AXB-BXA strains (AXB1, AXB4, AXB24, BXA14, BXA24) that were produced from the A and B parental mice by recombinations and inbreeding. This panel of 25 inbred strains of genetically diverse inbred strains of mice is used for mapping chromosomal intervals throughout the genome that harbor candidate genes controlling the phenotypic variance of any trait under study. Under general anesthesia, 39 mice received extraction of 3 right maxillary molar teeth and 28 mice received sham operation. On post-extraction day 21, <italic>post-mortem</italic>
whole-brain high-resolution sMRI was used to quantify the volume of 160 brain regions. Compared to sham operation, tooth extraction was associated with a significantly reduced regional and voxel-wise volumes of cortical brain regions involved in processing somatosensory, motor, cognitive and emotional functions, and increased volumes in subcortical sensorimotor and temporal limbic forebrain regions including the amygdala. Additionally, comparison of the 10 BXA14 and 21 BXA24 mice revealed significant volumetric differences between the two strains in several brain regions. These findings highlight the utility of high-resolution sMRI for studying tooth loss-induced structural brain plasticity in mice, and provide a foundation for further phenotyping structural brain changes following tooth loss in the full AXB-BXA panel to facilitate mapping genes that control brain plasticity following orofacial injury.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adachi, K" uniqKey="Adachi K">K. Adachi</name>
</author>
<author><name sortKey="Lee, J C" uniqKey="Lee J">J.-C. Lee</name>
</author>
<author><name sortKey="Hu, J W" uniqKey="Hu J">J. W. Hu</name>
</author>
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</author>
<author><name sortKey="Sessle, B J" uniqKey="Sessle B">B. J. Sessle</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Arima, T" uniqKey="Arima T">T. Arima</name>
</author>
<author><name sortKey="Yanagi, Y" uniqKey="Yanagi Y">Y. Yanagi</name>
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<biblStruct><analytic><author><name sortKey="Avivi Arber, L" uniqKey="Avivi Arber L">L. Avivi-Arber</name>
</author>
<author><name sortKey="Friedel, M" uniqKey="Friedel M">M. Friedel</name>
</author>
<author><name sortKey="Lerch, J" uniqKey="Lerch J">J. Lerch</name>
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<author><name sortKey="Hayashi, Y" uniqKey="Hayashi Y">Y. Hayashi</name>
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<author><name sortKey="Landzberg, G" uniqKey="Landzberg G">G. Landzberg</name>
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<author><name sortKey="Moayedi, M" uniqKey="Moayedi M">M. Moayedi</name>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neuroanat</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Neuroanat</journal-id>
<journal-id journal-id-type="publisher-id">Front. Neuroanat.</journal-id>
<journal-title-group><journal-title>Frontiers in Neuroanatomy</journal-title>
</journal-title-group>
<issn pub-type="epub">1662-5129</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28119577</article-id>
<article-id pub-id-type="pmc">5220047</article-id>
<article-id pub-id-type="doi">10.3389/fnana.2016.00121</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject>
<subj-group><subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Widespread Volumetric Brain Changes following Tooth Loss in Female Mice</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Avivi-Arber</surname>
<given-names>Limor</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/9544/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Seltzer</surname>
<given-names>Ze'ev</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/380711/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Friedel</surname>
<given-names>Miriam</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/104775/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Lerch</surname>
<given-names>Jason P.</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/5101/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Moayedi</surname>
<given-names>Massieh</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/379216/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Davis</surname>
<given-names>Karen D.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
<xref ref-type="aff" rid="aff9"><sup>9</sup>
</xref>
<xref ref-type="aff" rid="aff10"><sup>10</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/67071/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Sessle</surname>
<given-names>Barry J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/134368/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>University of Toronto Centre for the Study of Pain, University of Toronto</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Faculty of Dentistry, University of Toronto</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Department of Physiology, Faculty of Medicine, University of Toronto</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Department of Anesthesiology, University Health Network</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff5"><sup>5</sup>
<institution>Central Institute of Mental Health, University of Heidelberg</institution>
<country>Mannheim, Germany</country>
</aff>
<aff id="aff6"><sup>6</sup>
<institution>Mouse Imaging Centre, Hospital for Sick Children</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff7"><sup>7</sup>
<institution>Medical Biophysics, Faculty of Medicine, University of Toronto</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff8"><sup>8</sup>
<institution>Department of Surgery, University of Toronto</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff9"><sup>9</sup>
<institution>Institute of Medical Science, University of Toronto</institution>
<country>Toronto, ON, Canada</country>
</aff>
<aff id="aff10"><sup>10</sup>
<institution>Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, Toronto Western Hospital, University Health Network</institution>
<country>Toronto, ON, Canada</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: M. Mallar Chakravarty, Douglas Mental Health University Institute, McGill University, Canada</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Richard H. Dyck, University of Calgary, Canada; Michela Ferrucci, University of Pisa, Italy</p>
</fn>
<corresp id="fn001">*Correspondence: Limor Avivi-Arber <email xlink:type="simple">limor.avivi.arber@utoronto.ca</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>09</day>
<month>1</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>10</volume>
<elocation-id>121</elocation-id>
<history><date date-type="received"><day>26</day>
<month>8</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>01</day>
<month>12</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2017 Avivi-Arber, Seltzer, Friedel, Lerch, Moayedi, Davis and Sessle.</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>Avivi-Arber, Seltzer, Friedel, Lerch, Moayedi, Davis and Sessle</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Tooth loss is associated with altered sensory, motor, cognitive and emotional functions. These changes vary highly in the population and are accompanied by structural and functional changes in brain regions mediating these functions. It is unclear to what extent this variability in behavior and function is caused by genetic and/or environmental determinants and which brain regions undergo structural plasticity that mediates these changes. Thus, the overall goal of our research program is to identify genetic variants that control structural and functional plasticity following tooth loss. As a step toward this goal, here our aim was to determine whether structural magnetic resonance imaging (sMRI) is sensitive to detect quantifiable volumetric differences in the brains of mice of different genetic background receiving tooth extraction or sham operation. We used 67 adult female mice of 7 strains, comprising the A/J (A) and C57BL/6J (B) strains and a randomly selected sample of 5 of the 23 AXB-BXA strains (AXB1, AXB4, AXB24, BXA14, BXA24) that were produced from the A and B parental mice by recombinations and inbreeding. This panel of 25 inbred strains of genetically diverse inbred strains of mice is used for mapping chromosomal intervals throughout the genome that harbor candidate genes controlling the phenotypic variance of any trait under study. Under general anesthesia, 39 mice received extraction of 3 right maxillary molar teeth and 28 mice received sham operation. On post-extraction day 21, <italic>post-mortem</italic>
whole-brain high-resolution sMRI was used to quantify the volume of 160 brain regions. Compared to sham operation, tooth extraction was associated with a significantly reduced regional and voxel-wise volumes of cortical brain regions involved in processing somatosensory, motor, cognitive and emotional functions, and increased volumes in subcortical sensorimotor and temporal limbic forebrain regions including the amygdala. Additionally, comparison of the 10 BXA14 and 21 BXA24 mice revealed significant volumetric differences between the two strains in several brain regions. These findings highlight the utility of high-resolution sMRI for studying tooth loss-induced structural brain plasticity in mice, and provide a foundation for further phenotyping structural brain changes following tooth loss in the full AXB-BXA panel to facilitate mapping genes that control brain plasticity following orofacial injury.</p>
</abstract>
<kwd-group><kwd>tooth loss</kwd>
<kwd>trigeminal nerve</kwd>
<kwd>sMRI</kwd>
<kwd>brain imaging (MRI)</kwd>
<kwd>plasticity</kwd>
<kwd>neuroplasticity</kwd>
<kwd>genetic variation</kwd>
<kwd>animal model</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">Canadian Institutes of Health Research<named-content content-type="fundref-id">10.13039/501100000024</named-content>
</funding-source>
<award-id rid="cn001">MOP-4918</award-id>
</award-group>
<award-group><funding-source id="cn002">National Institutes of Health<named-content content-type="fundref-id">10.13039/100000002</named-content>
</funding-source>
<award-id rid="cn002">RO1 DE-018575</award-id>
</award-group>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="1"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="108"></ref-count>
<page-count count="13"></page-count>
<word-count count="10571"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Avivi Arber, Limor" sort="Avivi Arber, Limor" uniqKey="Avivi Arber L" first="Limor" last="Avivi-Arber">Limor Avivi-Arber</name>
</noRegion>
<name sortKey="Avivi Arber, Limor" sort="Avivi Arber, Limor" uniqKey="Avivi Arber L" first="Limor" last="Avivi-Arber">Limor Avivi-Arber</name>
<name sortKey="Davis, Karen D" sort="Davis, Karen D" uniqKey="Davis K" first="Karen D." last="Davis">Karen D. Davis</name>
<name sortKey="Davis, Karen D" sort="Davis, Karen D" uniqKey="Davis K" first="Karen D." last="Davis">Karen D. Davis</name>
<name sortKey="Davis, Karen D" sort="Davis, Karen D" uniqKey="Davis K" first="Karen D." last="Davis">Karen D. Davis</name>
<name sortKey="Davis, Karen D" sort="Davis, Karen D" uniqKey="Davis K" first="Karen D." last="Davis">Karen D. Davis</name>
<name sortKey="Friedel, Miriam" sort="Friedel, Miriam" uniqKey="Friedel M" first="Miriam" last="Friedel">Miriam Friedel</name>
<name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P." last="Lerch">Jason P. Lerch</name>
<name sortKey="Lerch, Jason P" sort="Lerch, Jason P" uniqKey="Lerch J" first="Jason P." last="Lerch">Jason P. Lerch</name>
<name sortKey="Moayedi, Massieh" sort="Moayedi, Massieh" uniqKey="Moayedi M" first="Massieh" last="Moayedi">Massieh Moayedi</name>
<name sortKey="Moayedi, Massieh" sort="Moayedi, Massieh" uniqKey="Moayedi M" first="Massieh" last="Moayedi">Massieh Moayedi</name>
<name sortKey="Seltzer, Ze Ev" sort="Seltzer, Ze Ev" uniqKey="Seltzer Z" first="Ze'Ev" last="Seltzer">Ze'Ev Seltzer</name>
<name sortKey="Seltzer, Ze Ev" sort="Seltzer, Ze Ev" uniqKey="Seltzer Z" first="Ze'Ev" last="Seltzer">Ze'Ev Seltzer</name>
<name sortKey="Seltzer, Ze Ev" sort="Seltzer, Ze Ev" uniqKey="Seltzer Z" first="Ze'Ev" last="Seltzer">Ze'Ev Seltzer</name>
<name sortKey="Seltzer, Ze Ev" sort="Seltzer, Ze Ev" uniqKey="Seltzer Z" first="Ze'Ev" last="Seltzer">Ze'Ev Seltzer</name>
<name sortKey="Sessle, Barry J" sort="Sessle, Barry J" uniqKey="Sessle B" first="Barry J." last="Sessle">Barry J. Sessle</name>
<name sortKey="Sessle, Barry J" sort="Sessle, Barry J" uniqKey="Sessle B" first="Barry J." last="Sessle">Barry J. Sessle</name>
<name sortKey="Sessle, Barry J" sort="Sessle, Barry J" uniqKey="Sessle B" first="Barry J." last="Sessle">Barry J. Sessle</name>
</country>
<country name="Allemagne"><noRegion><name sortKey="Seltzer, Ze Ev" sort="Seltzer, Ze Ev" uniqKey="Seltzer Z" first="Ze'Ev" last="Seltzer">Ze'Ev Seltzer</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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