Theoretical Considerations and a Mathematical Model for the Analysis of the Biomechanical Response of Human Keratinized Oral Mucosa
Identifieur interne : 006A23 ( Ncbi/Merge ); précédent : 006A22; suivant : 006A24Theoretical Considerations and a Mathematical Model for the Analysis of the Biomechanical Response of Human Keratinized Oral Mucosa
Auteurs : Aikaterini Tsaira [Grèce] ; Panagiotis Karagiannidis [Grèce, Royaume-Uni] ; Margarita Sidira [Grèce] ; Spyros Kassavetis [Grèce] ; Dimitris Kugiumtzis [Grèce] ; Stergios Logothetidis [Grèce] ; Olga Naka [Grèce] ; Argirios Pissiotis [Grèce] ; Konstantinos Michalakis [Grèce, États-Unis]Source :
- Frontiers in Physiology [ 1664-042X ] ; 2016.
Abstract
Removable complete and partial dentures are supported by the residual alveolar ridges consisting of mucosa, submucosa, periosteum, and bone. An understanding of the biomechanical behavior of the oral mucosa is essential in order to improve the denture-bearing foundations for complete and partially edentulous patients. The purpose of this paper was to examine the biomechanical behavior of the soft tissues supporting a removable denture and develop a model for that reason. Keratinized oral mucosa blocks with their underlying bone were harvested from the maxillary palatal area adjacent to the edentulous ridges of a cadaver. The compressive response of the oral mucosa was tested by using atomic force microscopy. The specimens were first scanned in order their topography to be obtained. The mechanical properties of the specimens were tested using a single crystal silicon pyramidal tip, which traversed toward the keratinized oral mucosa specimens. Loading-unloading cycles were registered and four mathematical models were tested using MATLAB to note which one approximates the force-displacement curve as close as possible: a. spherical, b. conical, c. third order polynomial, d. Murphy (fourth order polynomial, non-linear Hertzian based). The third order polynomial model showed the best accuracy in representing the force-displacement data of the tested specimens. A model was developed in order to analyze the biomechanical behavior of the human oral keratinized mucosa and obtain information about its mechanical properties.
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DOI: 10.3389/fphys.2016.00364
PubMed: 27621708
PubMed Central: 5002422
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Karagiannidis</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Laboratory of Thin Films-Nanosystems and Nanometrology, School of Physics, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Engineering, Cambridge Graphene Centre, Cambridge University</institution><country>Cambridge, UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Sidira, Margarita" sort="Sidira, Margarita" uniqKey="Sidira M" first="Margarita" last="Sidira">Margarita Sidira</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Kassavetis, Spyros" sort="Kassavetis, Spyros" uniqKey="Kassavetis S" first="Spyros" last="Kassavetis">Spyros Kassavetis</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Laboratory of Thin Films-Nanosystems and Nanometrology, School of Physics, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Kugiumtzis, Dimitris" sort="Kugiumtzis, Dimitris" uniqKey="Kugiumtzis D" first="Dimitris" last="Kugiumtzis">Dimitris Kugiumtzis</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Electrical and Computer Engineering, School of Engineering, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Logothetidis, Stergios" sort="Logothetidis, Stergios" uniqKey="Logothetidis S" first="Stergios" last="Logothetidis">Stergios Logothetidis</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Laboratory of Thin Films-Nanosystems and Nanometrology, School of Physics, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Naka, Olga" sort="Naka, Olga" uniqKey="Naka O" first="Olga" last="Naka">Olga Naka</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Pissiotis, Argirios" sort="Pissiotis, Argirios" uniqKey="Pissiotis A" first="Argirios" last="Pissiotis">Argirios Pissiotis</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author><author><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University</institution><country>Thessaloniki, Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Division of Graduate and Postgraduate Prosthodontics, Tufts University School of Dental Medicine</institution><country>Boston, MA, USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Procter & Gamble Winton Hill Business Center, Cincinnati</wicri:regionArea><wicri:noRegion>Cincinnati</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in Physiology</title><idno type="eISSN">1664-042X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Removable complete and partial dentures are supported by the residual alveolar ridges consisting of mucosa, submucosa, periosteum, and bone. An understanding of the biomechanical behavior of the oral mucosa is essential in order to improve the denture-bearing foundations for complete and partially edentulous patients. The purpose of this paper was to examine the biomechanical behavior of the soft tissues supporting a removable denture and develop a model for that reason. Keratinized oral mucosa blocks with their underlying bone were harvested from the maxillary palatal area adjacent to the edentulous ridges of a cadaver. The compressive response of the oral mucosa was tested by using atomic force microscopy. The specimens were first scanned in order their topography to be obtained. The mechanical properties of the specimens were tested using a single crystal silicon pyramidal tip, which traversed toward the keratinized oral mucosa specimens. Loading-unloading cycles were registered and four mathematical models were tested using MATLAB to note which one approximates the force-displacement curve as close as possible: a. spherical, b. conical, c. third order polynomial, d. Murphy (fourth order polynomial, non-linear Hertzian based). The third order polynomial model showed the best accuracy in representing the force-displacement data of the tested specimens. A model was developed in order to analyze the biomechanical behavior of the human oral keratinized mucosa and obtain information about its mechanical properties.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ai, Z Y" uniqKey="Ai Z">Z. Y. Ai</name></author><author><name sortKey="Yue, Z Q" uniqKey="Yue Z">Z. Q. Yue</name></author><author><name sortKey="Tham, L G" uniqKey="Tham L">L. G. Tham</name></author><author><name sortKey="Yang, M" uniqKey="Yang M">M. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Physiol</journal-id><journal-id journal-id-type="publisher-id">Front. Physiol.</journal-id><journal-title-group><journal-title>Frontiers in Physiology</journal-title></journal-title-group><issn pub-type="epub">1664-042X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27621708</article-id><article-id pub-id-type="pmc">5002422</article-id><article-id pub-id-type="doi">10.3389/fphys.2016.00364</article-id><article-categories><subj-group subj-group-type="heading"><subject>Physiology</subject><subj-group><subject>Original Research</subject></subj-group></subj-group></article-categories><title-group><article-title>Theoretical Considerations and a Mathematical Model for the Analysis of the Biomechanical Response of Human Keratinized Oral Mucosa</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tsaira</surname><given-names>Aikaterini</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Karagiannidis</surname><given-names>Panagiotis</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sidira</surname><given-names>Margarita</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kassavetis</surname><given-names>Spyros</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kugiumtzis</surname><given-names>Dimitris</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/13449/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Logothetidis</surname><given-names>Stergios</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/130958/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Naka</surname><given-names>Olga</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pissiotis</surname><given-names>Argirios</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Michalakis</surname><given-names>Konstantinos</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/71378/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Department of Prosthodontics, Faculty of Health Sciences, School of Dentistry, Aristotle University</institution><country>Thessaloniki, Greece</country></aff><aff id="aff2"><sup>2</sup><institution>Laboratory of Thin Films-Nanosystems and Nanometrology, School of Physics, Aristotle University</institution><country>Thessaloniki, Greece</country></aff><aff id="aff3"><sup>3</sup><institution>Department of Engineering, Cambridge Graphene Centre, Cambridge University</institution><country>Cambridge, UK</country></aff><aff id="aff4"><sup>4</sup><institution>Department of Electrical and Computer Engineering, School of Engineering, Aristotle University</institution><country>Thessaloniki, Greece</country></aff><aff id="aff5"><sup>5</sup><institution>Division of Graduate and Postgraduate Prosthodontics, Tufts University School of Dental Medicine</institution><country>Boston, MA, USA</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Thimios Mitsiadis, University of Zurich, Switzerland</p></fn><fn fn-type="edited-by"><p>Reviewed by: Jean-Christophe Farges, Claude Bernard University Lyon 1, France; Christian Hellmich, Vienna University of Technology, Austria; Nenad Filipovic, University of Kragujevac, Serbia</p></fn><corresp id="fn001">*Correspondence: Konstantinos Michalakis <email xlink:type="simple">kmichalakis@hotmail.com</email>; <email xlink:type="simple">konstantinos.michalakis@tufts.edu</email>; <email xlink:type="simple">kmichalakis@dent.auth.gr</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Craniofacial Biology, a section of the journal Frontiers in Physiology</p></fn></author-notes><pub-date pub-type="epub"><day>29</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>7</volume><elocation-id>364</elocation-id><history><date date-type="received"><day>28</day><month>5</month><year>2016</year></date><date date-type="accepted"><day>09</day><month>8</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Tsaira, Karagiannidis, Sidira, Kassavetis, Kugiumtzis, Logothetidis, Naka, Pissiotis and Michalakis.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Tsaira, Karagiannidis, Sidira, Kassavetis, Kugiumtzis, Logothetidis, Naka, Pissiotis and Michalakis</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Removable complete and partial dentures are supported by the residual alveolar ridges consisting of mucosa, submucosa, periosteum, and bone. An understanding of the biomechanical behavior of the oral mucosa is essential in order to improve the denture-bearing foundations for complete and partially edentulous patients. The purpose of this paper was to examine the biomechanical behavior of the soft tissues supporting a removable denture and develop a model for that reason. Keratinized oral mucosa blocks with their underlying bone were harvested from the maxillary palatal area adjacent to the edentulous ridges of a cadaver. The compressive response of the oral mucosa was tested by using atomic force microscopy. The specimens were first scanned in order their topography to be obtained. The mechanical properties of the specimens were tested using a single crystal silicon pyramidal tip, which traversed toward the keratinized oral mucosa specimens. Loading-unloading cycles were registered and four mathematical models were tested using MATLAB to note which one approximates the force-displacement curve as close as possible: a. spherical, b. conical, c. third order polynomial, d. Murphy (fourth order polynomial, non-linear Hertzian based). The third order polynomial model showed the best accuracy in representing the force-displacement data of the tested specimens. A model was developed in order to analyze the biomechanical behavior of the human oral keratinized mucosa and obtain information about its mechanical properties.</p></abstract><kwd-group><kwd>human oral keratinized mucosa</kwd><kwd>atomic force microscopy</kwd><kwd>oral tissue mechanics</kwd><kwd>contact mechanics</kwd><kwd>polynomial model</kwd><kwd>mathematical model</kwd><kwd>curve fitting</kwd></kwd-group><counts><fig-count count="6"></fig-count><table-count count="1"></table-count><equation-count count="20"></equation-count><ref-count count="102"></ref-count><page-count count="10"></page-count><word-count count="7548"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Grèce</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Grèce"><noRegion><name sortKey="Tsaira, Aikaterini" sort="Tsaira, Aikaterini" uniqKey="Tsaira A" first="Aikaterini" last="Tsaira">Aikaterini Tsaira</name></noRegion><name sortKey="Karagiannidis, Panagiotis" sort="Karagiannidis, Panagiotis" uniqKey="Karagiannidis P" first="Panagiotis" last="Karagiannidis">Panagiotis Karagiannidis</name><name sortKey="Kassavetis, Spyros" sort="Kassavetis, Spyros" uniqKey="Kassavetis S" first="Spyros" last="Kassavetis">Spyros Kassavetis</name><name sortKey="Kugiumtzis, Dimitris" sort="Kugiumtzis, Dimitris" uniqKey="Kugiumtzis D" first="Dimitris" last="Kugiumtzis">Dimitris Kugiumtzis</name><name sortKey="Logothetidis, Stergios" sort="Logothetidis, Stergios" uniqKey="Logothetidis S" first="Stergios" last="Logothetidis">Stergios Logothetidis</name><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name><name sortKey="Naka, Olga" sort="Naka, Olga" uniqKey="Naka O" first="Olga" last="Naka">Olga Naka</name><name sortKey="Pissiotis, Argirios" sort="Pissiotis, Argirios" uniqKey="Pissiotis A" first="Argirios" last="Pissiotis">Argirios Pissiotis</name><name sortKey="Sidira, Margarita" sort="Sidira, Margarita" uniqKey="Sidira M" first="Margarita" last="Sidira">Margarita Sidira</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Karagiannidis, Panagiotis" sort="Karagiannidis, Panagiotis" uniqKey="Karagiannidis P" first="Panagiotis" last="Karagiannidis">Panagiotis Karagiannidis</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Michalakis, Konstantinos" sort="Michalakis, Konstantinos" uniqKey="Michalakis K" first="Konstantinos" last="Michalakis">Konstantinos Michalakis</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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