Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats
Identifieur interne : 006190 ( Ncbi/Merge ); précédent : 006189; suivant : 006191Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats
Auteurs : Jung-Bo Huh ; Joo-Hyun Kim ; Soyun Kim ; So-Hyoun Lee ; Kyung Mi Shim ; Se Eun Kim ; Seong Soo Kang ; Chang-Mo JeongSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2015.
Abstract
This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (
Url:
DOI: 10.3390/ijms161226112
PubMed: 26633376
PubMed Central: 4691059
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats</title>
<author><name sortKey="Huh, Jung Bo" sort="Huh, Jung Bo" uniqKey="Huh J" first="Jung-Bo" last="Huh">Jung-Bo Huh</name>
<affiliation><nlm:aff id="af1-ijms-16-26112">Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>identi97@hanmail.net</email>
(J.-H.K.);<email>romilove7@hanmail.net</email>
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<author><name sortKey="Kim, Joo Hyun" sort="Kim, Joo Hyun" uniqKey="Kim J" first="Joo-Hyun" last="Kim">Joo-Hyun Kim</name>
<affiliation><nlm:aff id="af1-ijms-16-26112">Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>identi97@hanmail.net</email>
(J.-H.K.);<email>romilove7@hanmail.net</email>
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<author><name sortKey="Kim, Soyun" sort="Kim, Soyun" uniqKey="Kim S" first="Soyun" last="Kim">Soyun Kim</name>
<affiliation><nlm:aff id="af2-ijms-16-26112">School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>annasoyunkim@gmail.com</email>
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<author><name sortKey="Lee, So Hyoun" sort="Lee, So Hyoun" uniqKey="Lee S" first="So-Hyoun" last="Lee">So-Hyoun Lee</name>
<affiliation><nlm:aff id="af1-ijms-16-26112">Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>identi97@hanmail.net</email>
(J.-H.K.);<email>romilove7@hanmail.net</email>
(S.-H.L.)</nlm:aff>
</affiliation>
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<author><name sortKey="Shim, Kyung Mi" sort="Shim, Kyung Mi" uniqKey="Shim K" first="Kyung Mi" last="Shim">Kyung Mi Shim</name>
<affiliation><nlm:aff id="af3-ijms-16-26112">Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea;<email>simchung-98@hanmail.net</email>
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<author><name sortKey="Kim, Se Eun" sort="Kim, Se Eun" uniqKey="Kim S" first="Se Eun" last="Kim">Se Eun Kim</name>
<affiliation><nlm:aff id="af3-ijms-16-26112">Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea;<email>simchung-98@hanmail.net</email>
(K.M.S.);<email>sen0223@gmail.com</email>
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</affiliation>
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<author><name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong Soo" last="Kang">Seong Soo Kang</name>
<affiliation><nlm:aff id="af3-ijms-16-26112">Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea;<email>simchung-98@hanmail.net</email>
(K.M.S.);<email>sen0223@gmail.com</email>
(S.E.K.)</nlm:aff>
</affiliation>
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<author><name sortKey="Jeong, Chang Mo" sort="Jeong, Chang Mo" uniqKey="Jeong C" first="Chang-Mo" last="Jeong">Chang-Mo Jeong</name>
<affiliation><nlm:aff id="af1-ijms-16-26112">Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>identi97@hanmail.net</email>
(J.-H.K.);<email>romilove7@hanmail.net</email>
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<series><title level="j">International Journal of Molecular Sciences</title>
<idno type="eISSN">1422-0067</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p>This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (<italic>n</italic>
= 10 in each group). The site of cranial subcutaneous injection was the mid-point of the interpupillary line, and the site of intraoral submucosal injection was the ridge crest 2 mm below the cervical line of the mandibular left incisor. Before and immediately after filler injection, intraoral photos and lateral cephalometric radiographs were taken for analysis and comparison of the effect of the filler on the injection sites. The filler injected areas were converted into sequential size changes (%) of the baseline. Histomorphologic examination was performed after 12 weeks. The smallest value in the filler injected area was observed during the experimental period in the normal saline group (<italic>p</italic>
< 0.001), which was almost absorbed at 4 weeks (7.19% ± 12.72%). The HA group exhibited a steady decrease in sequential size and showed a lower value than the DiHM and PDiHM groups (saline < HA < DHiM, PDHiM, <italic>p</italic>
< 0.001). DiHM and PDiHM tended to increase for the first 4 weeks and later decreased until 12 weeks. In this study on DiHM and PDiHM, there was no histological abnormality in cranial skin and oral mucosa. DiHM and PDiHM filler materials with injection system provide an excellent alternative surgical method for use in oral and craniofacial fields.</p>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Mol Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Mol Sci</journal-id>
<journal-id journal-id-type="publisher-id">ijms</journal-id>
<journal-title-group><journal-title>International Journal of Molecular Sciences</journal-title>
</journal-title-group>
<issn pub-type="epub">1422-0067</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26633376</article-id>
<article-id pub-id-type="pmc">4691059</article-id>
<article-id pub-id-type="doi">10.3390/ijms161226112</article-id>
<article-id pub-id-type="publisher-id">ijms-16-26112</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effects of PMMA and Cross-Linked Dextran Filler for Soft Tissue Augmentation in Rats</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Huh</surname>
<given-names>Jung-Bo</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-16-26112">1</xref>
<xref rid="c1-ijms-16-26112" ref-type="corresp">*</xref>
<xref ref-type="author-notes" rid="fn1-ijms-16-26112">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Joo-Hyun</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-16-26112">1</xref>
<xref ref-type="author-notes" rid="fn1-ijms-16-26112">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Soyun</given-names>
</name>
<xref ref-type="aff" rid="af2-ijms-16-26112">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>So-Hyoun</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-16-26112">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shim</surname>
<given-names>Kyung Mi</given-names>
</name>
<xref ref-type="aff" rid="af3-ijms-16-26112">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Se Eun</given-names>
</name>
<xref ref-type="aff" rid="af3-ijms-16-26112">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kang</surname>
<given-names>Seong Soo</given-names>
</name>
<xref ref-type="aff" rid="af3-ijms-16-26112">3</xref>
<xref rid="c1-ijms-16-26112" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jeong</surname>
<given-names>Chang-Mo</given-names>
</name>
<xref ref-type="aff" rid="af1-ijms-16-26112">1</xref>
<xref rid="c1-ijms-16-26112" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<contrib-group><contrib contrib-type="editor"><name><surname>Rahaman</surname>
<given-names>Mohamed N.</given-names>
</name>
<role>Academic Editor</role>
</contrib>
</contrib-group>
<aff id="af1-ijms-16-26112"><label>1</label>
Department of Prosthodontics, Dental Research Institute, School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>identi97@hanmail.net</email>
(J.-H.K.);<email>romilove7@hanmail.net</email>
(S.-H.L.)</aff>
<aff id="af2-ijms-16-26112"><label>2</label>
School of Dentistry, Pusan National University, YangSan 676-870, Korea;<email>annasoyunkim@gmail.com</email>
</aff>
<aff id="af3-ijms-16-26112"><label>3</label>
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea;<email>simchung-98@hanmail.net</email>
(K.M.S.);<email>sen0223@gmail.com</email>
(S.E.K.)</aff>
<author-notes><corresp id="c1-ijms-16-26112"><label>*</label>
Correspondence: <email>huhjb@pusan.ac.kr</email>
(J.-B.H.); <email>vetkang@chonnam.ac.kr</email>
(S.S.K.); <email>cmjeong@pusan.ac.kr</email>
(C.-M.J.); Tel.: +82-55-360-5146 (J.-B.H.); +82-62-530-2877 (S.S.K.); +82-55-360-5141 (C.-M.J.); Fax: +82-55-360-5134 (J.-B.H.); +82-62-530-2809 (S.S.K.); +82-55-360-5134 (C.-M.J.)</corresp>
<fn id="fn1-ijms-16-26112"><label>†</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>01</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><month>12</month>
<year>2015</year>
</pub-date>
<volume>16</volume>
<issue>12</issue>
<fpage>28523</fpage>
<lpage>28533</lpage>
<history><date date-type="received"><day>31</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>20</day>
<month>11</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement>
<copyright-year>2015</copyright-year>
<license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (<italic>n</italic>
= 10 in each group). The site of cranial subcutaneous injection was the mid-point of the interpupillary line, and the site of intraoral submucosal injection was the ridge crest 2 mm below the cervical line of the mandibular left incisor. Before and immediately after filler injection, intraoral photos and lateral cephalometric radiographs were taken for analysis and comparison of the effect of the filler on the injection sites. The filler injected areas were converted into sequential size changes (%) of the baseline. Histomorphologic examination was performed after 12 weeks. The smallest value in the filler injected area was observed during the experimental period in the normal saline group (<italic>p</italic>
< 0.001), which was almost absorbed at 4 weeks (7.19% ± 12.72%). The HA group exhibited a steady decrease in sequential size and showed a lower value than the DiHM and PDiHM groups (saline < HA < DHiM, PDHiM, <italic>p</italic>
< 0.001). DiHM and PDiHM tended to increase for the first 4 weeks and later decreased until 12 weeks. In this study on DiHM and PDiHM, there was no histological abnormality in cranial skin and oral mucosa. DiHM and PDiHM filler materials with injection system provide an excellent alternative surgical method for use in oral and craniofacial fields.</p>
</abstract>
<kwd-group><kwd>biocompatibility</kwd>
<kwd>efficacy</kwd>
<kwd>PMMA</kwd>
<kwd>hydroxypropyl methylcellulose</kwd>
<kwd>hyaluronic acid</kwd>
<kwd>filler</kwd>
<kwd>oral submucosa</kwd>
<kwd>cranial subcutaneous</kwd>
<kwd>rat</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Huh, Jung Bo" sort="Huh, Jung Bo" uniqKey="Huh J" first="Jung-Bo" last="Huh">Jung-Bo Huh</name>
<name sortKey="Jeong, Chang Mo" sort="Jeong, Chang Mo" uniqKey="Jeong C" first="Chang-Mo" last="Jeong">Chang-Mo Jeong</name>
<name sortKey="Kang, Seong Soo" sort="Kang, Seong Soo" uniqKey="Kang S" first="Seong Soo" last="Kang">Seong Soo Kang</name>
<name sortKey="Kim, Joo Hyun" sort="Kim, Joo Hyun" uniqKey="Kim J" first="Joo-Hyun" last="Kim">Joo-Hyun Kim</name>
<name sortKey="Kim, Se Eun" sort="Kim, Se Eun" uniqKey="Kim S" first="Se Eun" last="Kim">Se Eun Kim</name>
<name sortKey="Kim, Soyun" sort="Kim, Soyun" uniqKey="Kim S" first="Soyun" last="Kim">Soyun Kim</name>
<name sortKey="Lee, So Hyoun" sort="Lee, So Hyoun" uniqKey="Lee S" first="So-Hyoun" last="Lee">So-Hyoun Lee</name>
<name sortKey="Shim, Kyung Mi" sort="Shim, Kyung Mi" uniqKey="Shim K" first="Kyung Mi" last="Shim">Kyung Mi Shim</name>
</noCountry>
</tree>
</affiliations>
</record>
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